• Environmental Analysis Health and Toxicology
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• v.7 no.3_4
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• pp.57-67
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• 1992

BPMC (2-Sec-butylphenyl N-methylcarbamate) was treated at the level of 100mg/kg/day in oral administration for 12th days in rat. It was investigated not only that the hematogram and the serological parameters, but also the content of cytochrome P-450, the activity of TBA, glucose-6-phosphatase, cholinesterase and carboxylesterase in rat. The results were as follows: The hematogram was not found any alteration but the value of AST, ALT, LDH and the content of glucose in serum were significantly increased compare with that of control group. The content of cytochrome P-450 in liver was increased significantly on the contrary cytochrome P-450 in kideny and NADPH-cytochrome c reductase in liver and Kidney were not significantly increased. After the final 12th day, the value of TBA and the activity of glucose-6-phosphatase appeared to the tendency of increasement in the liver. The activity of cholinesterase and carboxylesterase both in serum and liver were decreased. Especially the activity of cholinesterase was more significantly decreased. It was conclusion that the function of this insectivide should be due th the inhibition of cholinesterase activity.

• Journal of Environmental Health Sciences
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• v.16 no.2
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• pp.75-82
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• 1990

Carbaryl was degradaded to monomethylamine(MA) by bacterium. which isolated from lake sediment. Its carbaryl degradation was maximized when grown on mineral salt medium conditioning 20 $\mu$M of carbaryl as a sole carbon source at 26${\circ}$C and initial pH 7.0-9.0 Its degradation ability was minimized at initial pH 3.0 and 5.0 The percent conversions { (moles of MA in excess of control / mole of carbaryl added) $\times$ 100} for 10. 20. 40 and 80 $\mu$M of carbaryl were 18.6. 16.1. 18.1 and 11.6 respectively. It suggests that increasing amount of carbaryl added above 80 $\mu$M. the percent conversion should be decreased. The MA production by the bacterium was lineary related to the cultural time. After 7days culture. its percent conversion was 46.2. and this result suggests that a half amount of carbaryl would be hydrolyzed to MA by the bacterium within 8 days.

• Journal of Environmental Health Sciences
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• v.21 no.1
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• pp.74-77
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• 1995

The insecticidal and antibacterial activity of new synthesized carbamate derivatives(8-Hydroxy-5-chloroquinolyl-N-methylcarbamate(I), 8-Hydroxy-5-chloroquinolyl-N-ethylcarbamate(II)) was examined using 0.2 w/v% acetone solutiolas and 50 r/ml~1000 r/m N,N'-dimethylformamide-$H_2O$(2:3) solutions of each compounds, respectively. 1) Two carbamates exerted insecticidal effects on Sogata furcifera HORVATH, Delphacodes Striatella FAUEN, Whereas no significant effects were observed on the Nilaparvate lugens STAL, Inazuma dorasails MOISCHIULSKY and Nephateffix apicalis Cincticeps UHLER. 2) These compounds exhibited growth-inhibitory activity against Staphylococcus aureus, Salmonella paratyphi A, Shigella dysenteriae 1a, Escherichia coli NL 1401,at the concentration range of 100~500 r/ml in general.

• Korean Journal of Environmental Agriculture
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• v.8 no.2
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• pp.103-118
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• 1989

In order to investigate the uptake of the systemic insecticide, carbofuran, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl-N-methyl(arbamate) residues, fresh and aged, by rice plants, they were grown for 42 days in soils containing freshly treated (T-1), 3-month-aged (T-2), and 6-month-aged residues (T-3). The amounts of $^{14}CO_2$ evolved from $^{14}C-carbofuran$ during the 3-and 6-month aging in soil (temp. $22{\pm}1^{\circ}C$ ; moisture, 50% of the maximum water-holding capacity) were 8.9 and 26.7% of the original radioactivity applied, respectively. Mineralization of $^{14}C-carbofuran$ in soil to $^{14}CO_2$ during 42 days of rice growing was 4.4% (T-1), 11.0% (T-2), and 15.7 (T-3). The methanol extract of the 3-and 6-month-aged soils revealed that 3-keto carbofuran phenol (2,3-dihydro-2,2-dimethyl-3-oxo-7-benzofuranol) was the major metabolite, where as 3-hydroxy carbofuran (2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl-N-methylcarbamate) turned out to be the major metabolite in the shoots by the enzymatic cleavage of the possible conjugate present in the methanol extract. Volatilization of $^{14}C-carbofuran$ in soil during 3-and 6-month-aging, and 42 days of rice growing was 0.026, 0.05, and 0.012-0.018% of the applied radioactivity, respectively. The $^{14}C-radioactivity$ which was absorbed from the soils by rice plants during 42 days of the growing period and persisted in rice plant tissues was 26.8, 21.4, and 10.3% in T-1, T-2, and T-3, respectively. The non-extractable bound residues were 8.3, 37.9, and 54.6% of the originally applied carbofuran in T-1. T-2, and T-3, respectively. The small translocation of $^{14}C-radioactivity$ in T-3 upwards suggests that major metabolite 3-keto carbofuran phenol is conjugated in roots and the low recovery in T-1 indicates the loss of carbofuran from the shoots.