• 약학회지
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• 제41권5호
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• pp.582-587
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• 1997

The 6.7-dichloroquinoline-5,8-dione (I) was reacted with ethyl acetoacetate in the presence of sodium ethoxide to yield 6-(${\alpha}$-acetyl-${\alpha}$-ethoxycarbonyl methyl)-7-chloro-qui noline-5,8-dione(II). When this compound II was reacted with some arylamine (phenyl, p-toluyl, p-fluorophenyl, p-chlorophenyl. p-bromophenyl, p-iodophenyl, p-trifluoromethylphenyl, p-dimethylaminophenyl,indanyl), 1N-aryl-2-methyl-3-ethoxycarbonyl pyridino[2,3-f]-indole-4.9-dione(IIIa-I) were obtained via intramolecular cyclization.

• Archives of Pharmacal Research
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• 제17권3호
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• pp.190-193
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• 1994

Friedel-Crafts reaction isopropoxybenzene with methyl $\alpha$-chloro-$\alpha$-(maethylthio)acetate 1 afforded methyl $\alpha$-methylthio-p-isopropoxyphenylacetate 2d, which was readily converted into methyl p-isopropoxyphenylacetate 3 by reductive desulfurization with zinc dust in acetic acid. Methylation of 3 with sodium hydride and methyl iodide gave methyl $\alpha$-(p-isopropoxyphenyl)propionate 5. Methyl p-hydroxyphenylakanoates (4,6), useful intermediates for some medicines, were easily prepared by treatment of 3 and 5 with titanium tetrachloride, respectively.

• 한국연초학회지
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• 제19권1호
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• pp.51-56
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• 1997

This experiment was conducted to reduce the cost of orient leaf using izmir, samsun and basma scraps in cigarettes manufacturing process. We manufactured rolled and paper sheet tobacco using orient scraps and substituted orient leaf in Pine tree to the rolled and paper sheet tobacco using orient scraps. Orient scraps were lower in total sugar, total sugar/nicotine and total nitrogen/nicotine, higher in nicotine and crude ash than those of orient leaves. Izmir and basma scraps were higher of 2-methyl butanoic, 3-methyl butanoic and 3-methyl pentanoic acid, but the chemical contents in samw scraps were lower than those of orient leaves. The specific gravity thickness, flness index, filling value were similar between orient scraps blended sheet tobacco and present sheet tobacco. The physical characteristics of orient scraps blended sheet tobacco were within Present sheet tobacco quality specification. The sheet tobacco using orient scraps was higher 2-metal butanoic, 3-methyl butanoic and 3-methyl pentanoic acid than those of present sheet tobacco. The rolled processed sheet tobacco using orient scraps was higher 2-methyl butanoic, 3-methyl butanoic and 3-methyl Pentanoic acid than those of paper sheet tobacco using orient scraps. The sample cigarettes using orient scraps sheet tobacco were lower 2-methyl butanoic, 3-mettwl butanoic and 3-mettwl Pentanoic acid than those of control cigarettes. The result of sensory test showed no great difference compared with sample of orient scraps and control cigarettes. This result shows that we can possible to substitute orient leaf to orient scraps to reduce the cost of orient leaf.

• 약학회지
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• 제37권1호
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• pp.49-53
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• 1993

Arylalkanoic acid derivatives are known as good non-steroidal antiinflamatory and antirheumatic agents. The new arylalkanoic acid derivatives were synthesized when 2-chloro-3-($\alpha$-cyano-$\alpha$-ethoxycarbonyl-methyl)-1, 4-naphthoquinone was reacted with some arylamines.

• Applied Biological Chemistry
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• 제37권4호
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• pp.310-314
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• 1994

솔잎으로부터 프리 라디칼 소거 작용이 있는 물질을 분리하고, 여러 기기 분석 결과에 근거하여 4-hydroxy-5-methyl-3[2H]-furanone으로 동정하였다. 아울러 xylose와 glycine의 Maillard 반응을 통하여 이 물질을 합성하였다. 이 물질은 1,1-diphenyl-2-picrylhydrazyl(DPPH) 프리 라디칼에 대해 소거 작용을 보였으며(100 M의 DPPH의 50%를 환원 시키는데 필요한 농도, 즉 $SC_{50}=26\;{\mu}M$) 이는 구조적으로 유사한 공지의 항산화 물질인 $4-hydroxy-2,5-dimethyl-3[2H]-furanone(SC_{50}=53\;{\mu}M)$과 $3-hydroxy-2-methyl-{\gamma}-pyrone(SC_{50}=4.0\;mM)$에 비해 강력한 것이다. 4-Hydroxy-5-methyl-3[2H]-furanone은 3,4-dihydroxyphenylalanine과 linolenic acid의 자동 산화에 대해서 억제 작용을 나타내었다.

• 한국응용과학기술학회지
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• 제5권2호
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• pp.9-15
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• 1988

In order to investigate the amino acid and fatty acid content in Thuja biotae water extract treated with alkaline, it was performed. There are 16 kinds of different amino acid and 20 kinds of different fatty acid in Thuja biotae water extract. An aspartic acid was contained 52％ and proline was contained 10％, particulary, r-aminobutyric acid was analysed. Essential fatty acids; linoleic acid, linolenic acid and arachidonic acid were cotained a lot amount. There are 11 different unknown materials which were identified by GC-MS spectrum, such as N-[($4{\alpha},5{\alpha}$)-cholestan-4-yl]-acetamide; 22,26-Epithio-furost-5-en-3-ol; 2-Methyl-6-(4-methyl-3-cyclohexen-1-yl)-4-heptanone; 3,12,14-Tris(acetyloxy)-pregnane-15,20-dione;22-Methyl-26-thio-furost-5-en-3-ol; 7-Ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrene carboxyaldehyde; Methoxyiminopro-panedioic acid; 13-Methyl-13-${\beta}$-Methyl-13-vinyl-dodecaarp-7-en-3-3-ol; 22-Methyl-26-thio-furost-6-methyl-3-ol; $5{\alpha}-Androstane-2$,11-dione; 9-Methyl-heptadecanoic acid.

• Bulletin of the Korean Chemical Society
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• 제14권2호
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• pp.188-191
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• 1993

The reaction between methyl 2,3-di-O-benzyl-4,6-di-O-mesyl-${\alpha}$-D-glucopyranoside (1b) and potassium superoxide resulted in hydrolysis, and gave methyl 2,3-di-O-benzyl-${\alpha}$-D-glucopyranoside (1) as a sole product. When the reaction was performed with a vicinal dimesylate, methyl 4,6-O-benzylidene-2,3-di-O-mesyl-${\alpha}$-D-altropyranoside (4b), again the hydrolysis product, methyl 4,6-O-benzylidene-${\alpha}$-D-altropyranoside (4) was obtained. However, the reaction of potassium superoxide with another vicinal dimesylate, methyl 4,6-O-benzylidene-2,3-di-O-mesyl-${\alpha}$-D-glucopyranoside (3b), nucleophilic displacement took place to afford methyl 4,6-O-benzylidene-${\alpha}$-D-altropyranoside (4). Apparently different results from two trans vicinal dimesylates, 3b and 4b are explained by the transient formation of epoxides, methyl 2,3-anhydro-4,6-O-benzylidene-${\alpha}$-D-allopyranoside (8) and methyl 2,3-anhydro-4,6-O-benzylidene-${\alpha}$-D-mannopyranoside (9) by $KO_2$. The reaction between the allo epoxide 8 and $KO_2$ gave altro 4. The manno epoxide 9 also afforded altro 4 as the major product. Facile epoxide formation by the reaction of a vicinal dimesylate and superoxide was also observed with 3-O-benzyl-1,2-O-isopropylidene-5,6-di-O-mesyl-${\alpha}$-D-glucofuranose: 5,6-anhydro-3-O-benzyl-1,2-O-isopropylidene-${\beta}$-L-idofuranose was obtained.

• 약학회지
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• 제35권4호
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• pp.308-313
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• 1991

The synthesis of 1-[(2-phenyl-1, 3-benzodioxol-2-yl)methyl]-1H-imidazole derivatives is described starting with 2-bromoacetophenones and catechols. 1-[(2-Phenyl-1, 3-benzodioxol-2-yl)methyl]-1H-imidazole (9-$_{12}$) showed potent broad-spectrum activity, not only against Candida species but also Cr. neofortnans, S. cerevisiae and T. mentagrophytes.

• Nuclear Engineering and Technology
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• 제9권1호
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• pp.39-44
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• 1977

N-methyl-C-phenylalkyl ketimine 이성질체, Ph-CR=N$CH_3$ (R=H, $CH_3$, $CH_3$CH$_2$)의 배치와 형태를 EHT 분자궤도함수법으로 연구하였다. 계산결과는 C=N 이중결함에 대하여 E-형의 배치가 Z-형의 배치보다 안전함을 나타내고 있다. N-methyl-C-phenylaldimine과 N-methyl-C-phenylmethylketimine에서는 phenyl 고러 회전자가 C=N 평면과 동일평면에 있는 형태가 안정하다. N-methyl-C-phenylethylketimine에서는 phenyl 고리와 C=N결합이 동일평면에 있고 회전자 $CH_3$CH$_2$-가 C=N 평면과 90$^{\circ}$인 gauche형이 가장 안정하다.

• 농약과학회지
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• 제6권2호
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• pp.64-71
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• 2002

Pseudomonas cepacia로부터 유래한 quinolinone 대사물질인 2-(2-hepteny)-3-methyl-4-quinolinone (1), 2-heptyl-3-methyl-4-quinolinone, 2-nonyl-3-methyl-4-quinolinone 및 합성물질 ethyl 2-methyl-3-alkyl-4-quinolinone carboxylate의 식물생장촉진 효과를 보기 위해 종자발아검정 및 경엽처리 후의 생장량을 측정하였다. 또한 종자침지 및 관주 처리후의 초고, 생체중, 과실수도 조사하였다. 화합물 1은 종자발아 효과와 경엽처리 후에 일관된 생장촉진 효과를 보였다. 종자침지와 관주처리 후에, 화합물 1과 합성물질 ethyl 2-methyl-4-quinolinone-3-carboxylate (5)를 처리한 식물에서의 생체중과 과실수는 크게 증가하였다. 화합물1과 5는 대조관보다 각각 44%와 84%의 과실수 증가를 나타냈다.