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The effects of pomegranate peel added bread on anthropometric measurements, metabolic and oxidative parameters in individuals with type 2 diabetes: a double-blind, randomized, placebo-controlled study

  • Ozlem Ozpak Akkus;Ugurcan Metin;Zeynep Camlik
    • Nutrition Research and Practice
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    • v.17 no.4
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    • pp.698-716
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    • 2023
  • BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the sensory properties of antioxidant-rich bread made by adding pomegranate peels and their effects on anthropometric measurements and metabolic and oxidative parameters of individuals with type 2 diabetes after consumption. SUBJECTS/METHODS: This randomized, double-blind, placebo-controlled study was conducted with 22 individuals aged between 19 and 64 years who had been diagnosed with type 2 diabetes for at least 5 years, used only metformin, did not lose more than 10% of their body weight in the last 6 months, and had a body mass index of ≥ 25.0 kg/m2. While the study group (n = 11) consumed bread containing 500 mg pomegranate peel daily for 8 wk, the control group (n = 11) consumed standard bread. Anthropometric measurements and metabolic and oxidative parameters of individuals were evaluated at the beginning and end of the study. RESULTS: Decreases were detected in the waist circumference, waist/hip and waist/height ratios, body fat percentages, blood pressure, and serum insulin, triglyceride, and total cholesterol levels in the individuals in the treatment group, compared with those in the control group (P < 0.05). CONCLUSIONS: Pomegranate peel consumption by individuals with type 2 diabetes may have positive effects on anthropometric measurements and glycemic and lipid parameters.

Production and development of porcine tetraploid parthenogenetic embryos

  • Lin, Tao;Lee, Jae Eun;Shin, Hyeon Yeong;Lee, Joo Bin;Kim, So Yeon;Jin, Dong Il
    • Journal of Animal Science and Technology
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    • v.61 no.4
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    • pp.225-233
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    • 2019
  • The aim of this study was to produce porcine tetraploid (4N) parthenogenetic embryos using various methods and evaluate their developmental potential. In method 1 (M1), porcine 4N parthenogenetic embryos were obtained by inhibiting extrusion of both first (PB1) and second (PB2) polar bodies; in methods 2 (M2) and 3 (M3), 4N parthenogenetic embryos were obtained by electrofusion of 2-cell stage diploid parthenogenetic embryos derived from inhibition of PB2 or PB1 extrusion, respectively. We found no differences in the rates of cleavage or blastocyst formation or the proportion of 4N embryos among M1, M2, and M3 groups. The different methods also did not influence apoptosis rates (number of TUNEL-positive cells/number of total cells) or expression levels of apoptosis-related BAX and BCL2L1 genes. However, total cell and EdU (5-ethynyl-2'-deoxyuridine)-positive cell numbers in 4N parthenogenetic blastocysts derived from M1 were higher (p < 0.05) than those for M2 and M3 groups. Our results suggest that, although porcine 4N parthenogenetic embryos could be produced by a variety of methods, inhibition of PB1 and PB2 extrusion (M1) is superior to electrofusion of 2-cell stage diploid parthenogenetic embryos derived from inhibition of PB2 (M2) or PB1 (M3) extrusion.

Effect of Homogeneous Mixing of Sintering Additives by Coprecipitation Method on Mechanical Properties of Pressureless-Sintered $Si_3N_4$ (공침법에 의한 소결첨가제의 균일혼합이 $Si_3N_4$ 상압소결체의 기계적 특성에 미치는 영향)

  • 김지순
    • Journal of the Korean Ceramic Society
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    • v.30 no.4
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    • pp.265-272
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    • 1993
  • Effect of mixing homogeneity in powder mixtures of Si3N4 and sintering additive (10mol% YAG) prepared by coprecipitation on the mechanical properties of pressureless-sintered body was investigated. Sintering was performed in a graphtie furnace at 1850℃ for 0.5h under 0.15MPa N2 atmosphere using Si3N4 powder bed. Results from the measurement of Young's modulus, Vickers hardness, 4-point-bending strength, and KIC for the coprecipitation-treated (CP) and the mechanically-mixed specimens(MM) showed that a remarkable improvement in flexural strength and Weibull parameter can be achieved for the CPspecimens: (677±68MPa, 12.0) for CP samples and (539±108MPa, 5.5) for MM. Other properties were almost same irrespective of preparation methods.

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Xiang Study: an association of breastmilk composition with maternal body mass index and infant growth during the first 3 month of life

  • Peng, Xuyi;Li, Jie;Yan, Shuyuan;Chen, Juchun;Lane, Jonathan;Malard, Patrice;Liu, Feitong
    • Nutrition Research and Practice
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    • v.15 no.3
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    • pp.367-381
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    • 2021
  • BACKGROUND/OBJECTIVES: This study aimed to establish a mother and child cohort in the Chinese population, and investigate human breastmilk (HBM) composition and its relationship with maternal body mass index (BMI) and infant growth during the first 3 mon of life. SUBJECTS/METHODS: A total of 101 Chinese mother and infant pairs were included in this prospective cohort. Alterations in the milk macronutrients of Chinese mothers at 1 mon (T1), 2 mon (T2), and 3 mon (T3) lactation were analyzed. HBM fatty acid (FA) profiles were measured by gas chromatography (GC), and HBM proteomic profiling was achieved by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). RESULTS: During the first 3 mon of lactation (P < 0.05), significant decreases were determined in the levels of total energy, fat, protein, and osteopontin (OPN), as well as ratios of long-chain saturated FA (including C16:0, C22:0 and C24:0), monounsaturated FA (including C16:1), and n-6 poly unsaturated FA (PUFA) (including C20:3n-6 and C20:4n-6, and n-6/n-3). Conversely, butyrate, C6:0 and n-3 PUFA C18:3n-3 (α-linolenic acid, ALA) were significantly increased during the first 3 mon (P < 0.05). HBM proteomic analyses distinguished compositional protein differences over time (P = 0.001). Personalized motherinfant analyses demonstrated that HBM from high BMI mothers presented increased total energy, fat, protein and OPN, and increased content of n-6 PUFA (including C18:3n-6, C20:3n-6 and n-6/n-3 ratio) as compared with low BMI mothers (P < 0.05). Furthermore, BMI of the mothers positively correlated with the head circumference (HC) of infants as well as the specific n-6 PUFA C20:3n-6 over the 3 time points examined. Infant HC was negatively associated with C18:0. CONCLUSION: This study provides additional evidence to the Chinese HBM database, and further knowledge of FA function. It also helps to establish future maternal strategies that support the healthy growth and development of Chinese infants.

Effects of Task-Specific Obstacle Crossing Training on Functional Gait Capability in Patients with Cerebellar Ataxia: Feasibility Study

  • Park, Jin-Hoon
    • The Journal of Korean Physical Therapy
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    • v.27 no.2
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    • pp.112-117
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    • 2015
  • Purpose: The purpose of this study was to examine the effects of a task-specific obstacle crossing rehabilitation program on functional gait ability in patients with cerebellar ataxia. Overall, we sought to provide ataxia-specific locomotor rehabilitation guidelines for use in clinical practice based on quantitative evidence using relevant analysis of gait kinematics including valid clinical tests. Methods: Patients with cerebellar disease (n=13) participated in obstacle crossing training focusing on maintenance of dynamic balance and posture, stable transferring of body weight, and production of coordinated limb movements for 8 weeks, 2 times per week, 90 minutes per session. Throughout the training of body weight transfer, the instructions emphasized conscious perception and control of the center of body stability, trunk and limb alignment, and stepping kinematics during the practice of each walking phase. Results: According to the results, compared with pre-training data, foot clearance, pre-&post-obstacle distance, delay time, and total obstacle crossing time were increased after intervention. In addition, body COM measures indicated that body sway and movement variability, therefore posture stability during obstacle crossing, showed improvement after training. Based on these results, body sway was reduced and stepping pattern became more consistent during obstacle crossing gait after participation in patients with cerebellar ataxia. Conclusion: Findings of this study suggest that task-relevant obstacle crossing training may have a beneficial effect on recovery of functional gait ability in patients with cerebellar disease.

Carcass traits, meat yield and fatty acid composition of adipose tissues and Supraspinatus muscle in goats fed blend of canola oil and palm oil

  • Adeyemi, K.D.;Ebrahimi, M.;Samsudin, A.A.;Sabow, A.B.;Sazili, A.Q.
    • Journal of Animal Science and Technology
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    • v.57 no.12
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    • pp.42.1-42.14
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    • 2015
  • Background: Dietary fats can alter the deposition and distribution of body fats in ruminants. The deposition and distribution of body fat play a vital role in the quality of ruminant carcasses and are of great commercial value since they influence the profitability and consumer acceptability of ruminant meat. The current study examined the effects of dietary blend of 80 % canola oil and 20 % palm oil (BCPO) on carcass characteristics, meat yield and accretion of fatty acid (FA) in subcutaneous, omental, perirenal, and mesentery adipose depots and m. supraspinatus (SS) in goats. Methods: Twenty four Boer crossbred bucks (BW $20.54{\pm}0.47kg$) were randomly assigned to diets containing on DM basis 0, 4 and 8 % BCPO, fed for 100 d and harvested. Results: Diet had no effect (P > 0.05) on slaughter weight, dressing percentage, carcass and non-carcass components, meat yield, color, moisture and carotenoid contents and weight of adipose tissues in goats. The proportion of C18:1n-9 and cis-9 trans-11 CLA in the omental, perirenal and SS was higher (P < 0.05) in goats fed 4 and 8 % BCPO compared with the control goats. Dietary BCPO reduced (P < 0.05) the proportion of C14:0 in the omental, perirenal and mesentery depots, C18:0 in the perirenal depot, C16:0 in the SS and C16:1n-7 in the SS, omental and perirenal tissues. Dietary BCPO enhanced the proportion of C18:1 trans-11 Vaccenic and C18:3n-3 in SS and C20:5n-3 in SS and mesentery depot. No significant changes were found in the FA composition of subcutaneous depot. Conclusions: Results indicate that dietary BCPO can be utilized to alter the FA composition of adipose tissues without detrimental effects on carcass characteristics in goats. Nonetheless, dietary BCPO is not an effective repartitioning agent for body fats in goats.

Statistical Investigateion of Fatigue Life Predictioin of the Spot Welded Lap Joint(II) ; to verity reliabilty of fatigue strength estimatioin method (Spot 용접이음재의 피로수명 예측에 관한 확률적 검토(II) : 피로강도 평가법의 신뢰성 검증)

  • 손일선;배동호
    • Transactions of the Korean Society of Automotive Engineers
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    • v.7 no.7
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    • pp.242-249
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    • 1999
  • Spot welding is very important and useful technology in fabrication of an automobile body structure. Because fatigue strength of the spot welding point is however considerably lower than parent metal due to stress concentration at the nugget edge, accurate stress analysis and fatigue stength evaluation of spot welded lap joint are very important to valuate the reliability and durability of automobile body structure and to establish a criterion of long life fatigue design. Many invetigators have studied so far onsystematic fatigue strength evaluation with various methods. It is however necessary to verify their reliability and abailability for practical application to fatigue design of spot welded structure, Thus,in this study, fatigue strength evaluation methods of spot welded lap joint. which are the maximum principal stress method. the fracture and availability with the Weibull probability distribution. From the results, it was found that reliability and availability withe the Weibull probaility distribution. From the results, it was found that reliability and availability of the suggest fatigue strength estimation methods methods were higher than $\Delta$P-$N_f$ relation. However, among them , reliability of the maximum pricipal stress method was the highest.

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The Effects of Whole Body Vibration Exercise on Balance and Lower Extremity Muscle Activity in Stroke Patients (전신진동운동이 뇌졸중 환자의 균형 및 하지 근활성도에 미치는 영향)

  • Kim, Je-Ho
    • The Journal of Korean Physical Therapy
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    • v.25 no.5
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    • pp.266-272
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    • 2013
  • Purpose: The purpose of this study was to determine the influence of whole body vibration (WBV) exercise on balance and lower extremity muscle activity according to different intensity of vibration in stroke patients. Methods: Thirty subjects were randomly divided into three groups: experimental group II (n=10), III (n=10), and control group I (n=10). Each subject was exposed to three WBV conditions, as follows: 1. no WBV (group I), 2. 10 Hz (group II), 3. 30 Hz (group III) in semi squat position. The exercise program was conducted for six weeks (five times per week; 16 minutes per day). Subjects were measured on balance (limited of stability: LOS) and lower extremity muscle activity. Results: Significant difference in balance and lower extremity muscle activity was observed in the experimental group (II, III), compared with the control group (I). Results of post-hoc analysis, showed a significant difference in balance (LOS) in on group II and group III compared with group I, but no significant difference in on group II compared with group III, and a significant difference in lower extremity muscle activity in on group II and group III compared with group I, and a significant difference on in group II compared with group III. Conclusion: WBV exercise may be helpful in improvement of balance and lower extremity muscle activity in stroke patients.

Effects of Isokinetic Exercise on Muscular Performance and Thickness of the Quadriceps Muscle (넙다리네갈래근의 근수행력과 근두께에 대한 등속성 운동의 효과)

  • Han, Sang-Wan;Lee, Jeong-Woo
    • The Journal of Korean Physical Therapy
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    • v.22 no.4
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    • pp.49-55
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    • 2010
  • Purpose: The purpose of this study was to investigate the effects of isokinetic exercise on muscular performance and thickness of the quadriceps muscle. Methods: Twenty one healthy male students participated in this study. Participants were divided into 2 groups: $60^{\circ}/sec$ of isokinetic exercise (n=7), $180^{\circ}/sec$ (n=7) and $300^{\circ}/sec$ (n=7). Each group did isokinetic exercises 3 times a week for 6 weeks. Each group was measured for peak torque per body weight, average power and total work using a Biodex System 4. Rectus femoris, vastus laterails and vastus medialis were measured for muscle thickness using a SONOACE 6000C. Data were analyzed by repeated measures ANOVA using SPSS 12.0. Results: There was a significant time-related effect in peak torque per body weight, average power and total work. There was a significant time-related effect in the vastus medialis and rectus femoris muscle thickness. However, there was a significant group by time interaction for vastus laterlis muscle thickness. Conclusion: Isokinetic exercise may be an effective method for improving quadriceps muscle performance regardless of angular velocity. However, the thickness of the rectus femoris and vastus medialis muscle may be increased regardless of the angular velocity of the quadriceps muscle the vastus lateralis muscle may only be remarkably improved when doing exercise with low angular velocity.

Distance from Skin to Lumbar Epidural Space in Obstetric Parturients (산모에서 피부로부터 요추부 경막외강까지의 거리)

  • Yoon, Jin-Seok;Cho, Sung-Kyoung;Joung, Bung-Kee;Bak, Young-Ok;Kim, Young-Soo;Ha, Joung-Seong
    • The Korean Journal of Pain
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    • v.9 no.1
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    • pp.130-134
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    • 1996
  • Background: This study was designed to determine the distance from skin to lumbar epidural space in obstetric parturients and whether weight, height, or PI (ponderal index, $kg/m^2$) might influence the epidural depth. Methods: 71 obstetric patients undergoing elective cesarean section during epidural anesthesia in L2-3 level were partitioned into groups according to their prepregnant BMI(body mass index), and in each group weight, height, PI, epidural depth were measured. Results: All patients were classified as underweight(n=18), normal(n=49), overweight(n=4) and no one was partitioned into obese group. the distance from skin to lumbar epidural space was found to be 3.7 cm(underweight), 4.1 cm(normal), 4.7 cm(over weight) and total mean distance was found to be 4.0 cm. The epidural depth had correlation with weight and height in underweight, and weight and PI in normal, but had no correlation with any measurements in overweight group. Conclusion: These results suggest body weight may be a useful parameter for predicting the distance from skin to lumbar epidural space in underweight and normal weight obstetric parturients.

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