• 대한물리의학회지
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• 제14권1호
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• pp.53-61
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• 2019

PURPOSE: This study examined the dynamic range of motion (ROM) of the hip, knee, and ankle joint when wearing different shoe sole lifts, as well as the limb asymmetry of the range according to the leg length discrepancy (LLD) during normal speed walking. METHODS: The participants were 40 healthy adults. A motion analysis system was used to collect kinematic ROM data. The participants had 40 markers attached to their lower extremities and were asked to walk on a 6 m walkway, under three different shoe lift conditions (without an insole, 1 cm insole, and 2 cm insole). Visual3D professional software was used to coordinate kinematic ROM data. RESULTS: Most of the ROM variables of the short limbs were similar under each insole lift condition (p>.05). In contrast, when wearing a shoe with a 2 cm insole lift, the long limbs showed significant increases in flexion and extension of the knee joint as well as; plantarflexion, dorsiflexion, pronation, eversion, and inversion of the ankle joint (p<.05). Of the shoes with the insole lifts, significant differences in all ROM variables were observed between the left and right knees, except for the knee internal rotation (p<.05). CONCLUSION: As the insole lift was increased, more ROM differences were observed between the left and right limbs, and the asymmetry of the bilateral lower limbs increased. Therefore, appropriate interventions for LLD are needed because an artificial mild LLD of less than 2.0 cm could lead to a range of musculoskeletal problems of the lower extremities, such as knee and ankle osteoarthritis.

• Investigative Magnetic Resonance Imaging
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• 제19권3호
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• pp.146-152
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• 2015

Purpose: The purpose of this study was to evaluate the associated brain parenchymal abnormalities of developmental venous anomalies (DVA) with susceptibility-weighted image (SWI). Materials and Methods: Between January 2012 and June 2013, 2356 patients underwent brain MR examinations with contrast enhancement. We retrospectively reviewed their MR examinations and data were collected as per the following criteria: incidence, locations, and associated parenchymal signal abnormalities of DVAs on T2-weighted image, fluid-attenuated inversion recovery (FLAIR), and SWI. Contrast enhanced T1-weighted image was used to diagnose DVA. Results: Of the 2356 patients examined, 57 DVAs were detected in 57 patients (2.4%); 47 (82.4%) were in either lobe of the supratentorial brain, 9 (15.7%) were in the cerebellum, and 1 (1.7%) was in the pons. Of the 57 DVAs identified, 20 (35.1%) had associated parenchymal abnormalities in the drainage area. Among the 20 DVAs which had associated parenchymal abnormalities, 13 showed hemorrhagic foci on SWI, and 7 demonstrated only increased parenchymal signal abnormalities on T2-weighted and FLAIR images. In 5 of the 13 patients (38.5%) who had hemorrhagic foci, the hemorrhagic lesions were demonstrated only on SWI. Conclusion: The overall incidence of DVAs was 2.4%. Parenchymal abnormalities were associated with DVAs in 35.1% of the cases. On SWI, hemorrhage was detected in 22.8% of DVAs. Thus, we conclude that SWI might give a potential for understanding of the pathophysiology of parenchymal abnormalities in DVAs.

• Journal of Radiation Protection and Research
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• 제43권2호
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• pp.75-84
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• 2018

Background: Gamma-ray spectrometry helps in radiation shielding problems and different applications of radioisotopes. Experimental arrangements including broad beam geometries are widely used. The aim is to investigate and evaluate the ${\gamma}-ray$ spectra via attenuation by environmental materials. Materials and Methods: The photo peak to nominated parts in the ${\gamma}-ray$ spectra and the attenuation coefficients ${\mu}_b/{\rho}$ from broad beam geometries are measured for the materials water, soil, sand and cement at the energies 0.662, 1.25, and 1.332 MeV with a $3{^{\prime}^{\prime}}{\times}3{^{\prime}^{\prime}}$ NaI(Tl) detector. Results and Discussion: The ${\gamma}-ray$ spectra vary according to changes in the effective atomic number $Z_{eff}$ of the attenuator, the photon energy and the solid angle. The peak to total ratios are the most sensitive parts to variations in the experimental conditions and overturn in the region 0.663 MeV to 1.332 MeV. This is indicated as inversion trend. The results are discussed in view of $Z_{eff}$ and the experimental conditions. The intensity build-up is larger at the lower energy and larger scattering angles in agreement with Klein-Nishina formula and other results. The build-up factor B is$${\sim_=}$$1 at high ${\gamma}-energies$ and small scattering angles. Conclusion: The sensitivity to material characteristics decrease gradually from peak: to total, to Compton valley, to Compton plateau ratios. Rigorous collimation is necessary at small energies. Cement, of the largest $Z_{eff}$, is characterized by the maximum broad beam mass attenuation coefficients ${\mu}_b/{\rho}$. The obtained results provide information to decide for the suitable experimental set-up based on aim of the work.

• Journal of Korean Neurosurgical Society
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• 제29권1호
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• pp.101-107
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• 2000

Objectives : The evaluation of peripheral nerve injuries has traditionally relied on a clinical history, physical examination, and electrodiagnostic studies. The purpose of the present study was to examine serial magnetic resonance image(MRI) changes following acute muscle denervation under experimental conditions and to identify potential advantages and disadvantages of this use of MRI. Methods : An experimental transection of right sciatic nerve on Spargue-Dawley rats was performed. MRI was performed with T1-weighted spin-echo and STIR sequences. The imaging findings were compared with EMG in order to determine its sensitivity relative to this standard procedure. A simultaneous histopathological study provided information about the morphological basis of the imaging findings. Signal intensities were expressed as a ratio of abnormal to normal. Results : The signal intensity ratio of muscles with the STIR sequence was increased significantly at 2 weeks after sciatic nerve transection(p<0.05), although definite signal change was seen as early as 4 days postdenervation in one. EMG revealed significant denervation potential from 3 days after nerve transection. Diffuse cell atrophy was revealed hostologically at 2 weeks after transection, which was at the same time of significant signal change in MRI. Conclusion : MRI signal changes in denervated muscles secondary to nerve injury correlate with the degree of muscle atrophy on histologic examination. In addition to EMG, MRI can document the course of muscle atrophy and mesenchymal abnormalities in denervation. These results indicate that MRI can play a complementary role in the evaluation of patients with denervation.

• 지구물리와물리탐사
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• 제14권4호
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• pp.316-323
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• 2011

대형 고분의 발굴 조사를 위한 전기비저항 탐사법의 적용 가능성을 시험하기 위하여, 나주 복암리 3호분에 대하여 3차원 전기비저항 탐사를 수행하였다. 높은 해상도의 지하구조 영상을 얻기 위해서는 고분의 정확한 지형 구조 및 전극 위치에 대한 정보 획득이 필수적이다. 이에 따라 문화재 발굴 조사에서 사용하는 방법인 실을 이용한 구획설정법을 응용하여 전극을 설치하였다. 탐사 자료는, 전극 간격은 2 m, 측선 간격은 1 m로 하여 얻었으며, 각 탐사 측선은 상대적으로 1 m 엇갈리게 배열함으로써 전체적으로 고분에 대하여 1 m ${\times}$ 1m 크기의 격자망으로 구성하였다. 탐사 자료에 대하여 3차원 전기비저항 영상화를 수행하고 이를 기존의 발굴 조사 결과와 대비하였으며, 이로부터 확인된 매장 유구 분포와 전기비저항 영상이 매우 잘 일치함을 확인하였다. 이 연구를 통하여 대형 고분에서 매장 유구를 조사할 때 3차원 전기비저항 영상화 기술이 매우 유용함을 밝혔다.

• Investigative Magnetic Resonance Imaging
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• 제20권2호
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• pp.81-87
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• 2016

Purpose: To analyze the feasibility of three-dimensional (3D) diffusion-weighted (DW) PSIF (reversed FISP [fast imaging with steady-state free precession]) sequence in order to evaluate peripheral nerves in the elbow. Materials and Methods: Ten normal, asymptomatic volunteers were enrolled (6 men, 4 women, mean age 27.9 years). The following sequences of magnetic resonance images (MRI) of the elbow were obtained using a 3.0-T machine: 3D DW PSIF, 3D T2 SPACE (sampling perfection with application optimized contrasts using different flip angle evolution) with SPAIR (spectral adiabatic inversion recovery) and 2D T2 TSE (turbo spin echo) with modified Dixon (m-Dixon) sequence. Two observers used a 5-point grading system to analyze the image quality of the ulnar, median, and radial nerves. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of each nerve were measured. We compared 3D DW PSIF images with other sequences using the Wilcoxon-signed rank test and Friedman test. Inter-observer agreement was measured using intraclass correlation coefficient (ICC) analysis. Results: The mean 5-point scores of radial, median, and ulnar nerves in 3D DW PSIF (3.9/4.2/4.5, respectively) were higher than those in 3D T2 SPACE SPAIR (1.9/2.8/2.8) and 2D T2 TSE m-Dixon (1.7/2.8/2.9) sequences (P < 0.05). The mean SNR in 3D DW PSIF was lower than 3D T2 SPACE SPAIR, but there was no difference between 3D DW PSIF and 2D T2 TSE m-Dixon in all of the three nerves. The mean CNR in 3D DW PSIF was lower than 3D T2 SPACE SPAIR and 2D T2 TSE m-Dixon in the median and ulnar nerves, but no difference among the three sequences in the radial nerve. Conclusion: The three-dimensional DW PSIF sequence may be feasible to evaluate the peripheral nerves around the elbow in MR imaging. However, further optimization of the image quality (SNR, CNR) is required.

• Journal of Korean Neurosurgical Society
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• 제46권1호
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• pp.38-44
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• 2009

Objective : The authors studied the risk factors of silent cerebral microbleeds (MBs) and old hematomas (OHs) and their association with concurrent magnetic resonance (MR) imaging findings in the patients of intracerebral hemorrhages (ICHs). Methods : From April 2002 to June 2007, we retrospectively studied 234 patients of primary hemorrhagic stroke. All patients were evaluated with computed tomography (CT) and 3.0-tesla MR imaging studies within the first week of admission. MBs and OHs were assessed by using $T2^{\ast}$-weighted gradient-echo (GRE) MR imaging. The patients were divided into 2 groups, depending on whether or not they had two GRE lesions of chronic hemorrhages. A correlation between MBs and OHs lesions were also statistically tested. Lacunes and white matter and periventricular hyperintensities (WMHs, PVHs) were checked by T1- and T2-weighted spin-echo and fluid attenuated inversion recovery sequences. Variables on the clinical and laboratory data and MR imaging abnormalities were compared between both groups with or without MBs and OHs. Results : MBs were observed in 186 (79.5%) patients and a total of 46 OHs were detected in 45 (19.2%) patients. MBs (39.6%), OHs (80.4%), and ICHs (69.7%) were most commonly located in the ganglionic/thalamic region. Both MBs and OHs groups were more frequently related to chronic hypertension and advanced WMHs and PVHs. The prevalence and number of MBs were more closely associated with OHs groups than non-OH patients. Conclusion : This study clearly demonstrated the presence of MBs and OHs and their correlation with hypertension and cerebral white matter microangiopathy in the ICHs patients. Topographic correlation between the three lesions (MBs, OHs, and ICHs) was also noted in the deep thalamo-basal location.

• 생물정신의학
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• 제20권3호
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• pp.97-103
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• 2013

Objectives We aimed to identify the neuroimaging marker for prediction of the use of atypical antipsychotics (AAP) in dementia patients. Methods From April 2010 to March 2013, 31 patients who were diagnosed as dementia at the psychiatric department of Soonchunhyang University Hospital, completed the brain magnetic resonance imaging scan and cognitive test for dementia. Ten patients were treated with AAP for the improvement of behavioral and psychological symptoms of dementia (BPSD) and the other 21patients were not. Using T1 weighted and Fluid Attenuated Inversion Recovery (FLAIR) images of brain, areas of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and white matter hyperintensities (WMH) have been segmented and measured. Multivariate logistic regression models were applied for assessment of association between AAP use and the GM/WM ratio, the WMH/whole brain (GM + WM + CSF) ratio. Results There was a significant association between AAP use and the GM/WM ratio (odds ratio, OR = 1.18, 95% confidence interval, CI 1.01-1.38, p = 0.037), while there was no association between AAP use and the WMH/whole brain ratio (OR = 0.82, 95% CI 0.27-2.48, p = 0.73). Conclusions The GM/WM ratio could be a biological marker for the prediction of AAP use and BPSD in patients with dementia. It was more likely to increase as dementia progress since atrophy of WM was more prominent than that of GM over aging.

• 한국지반공학회논문집
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• 제33권8호
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• pp.5-16
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• 2017

근입깊이가 직경에 비하여 상대적으로 작은 말뚝은 편심이 큰 횡방향 하중을 받는 경우 전도되어 파괴된다. 지금까지 횡방향하중을 받는 짧은말뚝의 지지거동에 대해서는 주로 모형실험을 적용한 연구가 수행되었지만, 전주, 표지판, 가로등 기초와 같이 매우 큰 모멘트를 받는 짧은말뚝의 지지거동은 아직까지 명확히 규명된 바 없다. 본 연구에서는 직경 750mm의 실물크기 말뚝에 대한 재하시험을 수행하였다. 실제 하중조건을 모사하기 위하여 기초로 부터 8m 이격된 지점에 횡방향 하중을 가하여 매우 큰 모멘트를 유발하였으며, 말뚝의 근입깊이를 2.0m, 2.5m, 3.0m로 변화시킨 3회의 시험을 수행하였다. 시험결과 큰 모멘트를 받는 짧은말뚝은 파괴 직전까지 변위나 회전각이 거의 발생하지 않다가 전도로 인해 급격한 변위가 발생하는 취성형태로 파괴 되었다. 이러한 거동은 기존의 횡방향 위주의 하중을 받는 짧은말뚝에서 나타난 연성파괴 거동과는 대조적이다. 기존에 제안된 세 종류의 지지력 예측식으로 부터 구한 짧은말뚝의 극한 횡방향지지력을 시험결과와 비교하였으며, 말뚝 근입깊이가 상대적으로 작은 경우는 말뚝선단 중심의 회전을 가정한 제안식이 적절하지만, 근입깊이가 커지면서 회전점을 중심으로 응력방향이 반전되는 토압분포를 가정한 제안식이 보다 적절한 것으로 평가되었다.

• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.522-530
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• 2022

In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications. According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared. Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated. Adding ZnO-NPs significantly improved the hydrogel's antibacterial activity as determined by bacteriostatic zone and colony counting. The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy. In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms. CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h. These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure. In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.