• Journal of Physiology & Pathology in Korean Medicine
• /
• v.24 no.3
• /
• pp.519-524
• /
• 2010

This clinical study was done to examine comparison the prevalence of metabolic syndrome and obesity index between patients with silent lacunar infarction and normal controls. We compared the components of metabolic syndrome and obesity index between patients silent lacunar infarction(n=62) and normal controls(n=72). The analysis of the data was done by Frequency Analysis, two sample t-test, Chi-square Test. Hypertension and diabetes mellitus was significantly higher in patients of silent lacunar infarctions. Body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome were higher significantly in patients of silent lacunar infarctions than normal controls. Although statistically insignificant, waist circumference showed relatively higher in patients of silent lacunar infarction. This result emphasizes the importance of managing that hypertension, diabetes, body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome in silent lacunar infarction.

• Journal of The Korean Society of Integrative Medicine
• /
• v.9 no.4
• /
• pp.139-147
• /
• 2021

Purpose : The purpose of this study is to verify the effectiveness of combined marine healing programs by analyzing the physical composition of metabolic patients, blood lipids and the effects of the inflammatory factors, the C -reactive protein(CRP). Methods : the combined marine treatment program was conducted for 6 hours a day, 5 days a week on the 10 adult patients with metabolic diseases and the results of their body composition, blood lipids and CRP were analyzed before and after the subjects completed the program. For the statistical analysis, the mean and standard deviation (M±SD) of each variable were calculated using SPSS version 20 and a paired t-test was conducted in order to test for the differences before and after the combined marine treatment program. All significant levels were set to 𝛼=.05. As a result of the experiment Results : First, regarding the changes in body composition and blood pressure after the 5-day combined marine treatment program was completed, there were statistically significant differences found in weight (p<.01) and systolic blood pressure (p<.05). Second, regarding the changes in blood lipids and CRP after the program was conducted, there were statistically significant differences found in total cholesterol (p<.05) while there was no statistically significant difference found in the variables of neutral fat, low-density lipoprotein cholesterol and CRP. Conclusion : the study results were integrated, the 5-day combined marine treatment program had a positive effect on weight, blood pressure and total cholesterol in the patients with metabolic diseases. Therefore, the short-term marine treatment program was thought to be effective for them. However, considering no significant differences were found in neutral fat, low-density lipoprotein cholesterol and CRP, further development and research on combined marine treatment programs should be conducted in the long term to create an effective program for patients with metabolic diseases.

• Journal of Korean Academy of Nursing
• /
• v.52 no.3
• /
• pp.261-277
• /
• 2022

Purpose: This study developed an integrated health management program for metabolic syndrome in psychiatric patients and examined its effects on self-efficacy, healthy lifestyle, physiological indicators, knowledge of metabolic syndrome, attitudes toward healthy behavior, and social support. Methods: A non-equivalent control group pretest posttest design was used. The participants were 65 psychiatric patients with metabolic syndrome in psychiatric rehabilitation centers, with 33 in the experimental group and 32 in the control group. The experimental group participants engaged in daily mobile application and walking exercises three times a week for more than 40 minutes over 8 weeks, while those in the control group were provided education booklets. The outcomes were measured using self-report questionnaires, anthropometrics, and blood analyses. Intervention effects were analyzed using the independent t-test, Mann-Whitney U test, ANCOVA, and Ranked ANCOVA. Results: The experimental group showed a significant increase in self-efficacy (F = 8.85, p = .004, η_p² = .13) and knowledge of metabolic syndrome (t = 2.60, p = .012, d = 0.60) compared to the control group. Additionally, the experimental group demonstrated a significant decrease in waist circumference (Z = - 2.34, p = .009, d = 0.58) and body mass index (Z = - 1.91, p = .028, d = 0.47) compared to the control group. Conclusion: The integrated health management program for psychiatric patients with metabolic syndrome is effective in improving self-efficacy and knowledge of metabolic syndrome and decreasing physiological indicators such as waist circumference and body mass index.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.5 no.1
• /
• pp.116-125
• /
• 2005

Orthotopic liver transplantation is the treatment of choice for inherited metabolic diseases. However, the supply of donor organs is limiting and therefore many patients cannot benefit from this therapy. In contrast, hepatocytes can be isolated from a single donor liver. They can be transplanted into several recipients, and this procedure may help overcome the shortage of donor livers. A great deal of work with animal models indicates that hepatocytes transplanted into the liver or spleen can survive, function, and participate in the normal regenerative process. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to whole organ transplantation and for providing metabolic support during liver failure and for replacing whole organ transplantation in certain inherited metabolic diseases. Nowadays, hepatocytes from various stem cells have been regarded as an another cell source for treatment of inherited metabolic diseases. Although cell therapy using stem cells for inherited metabolic disease patient has been accepted only as an experimental trial yet, hepatocytes from stem cells can solve a lot of obstacles in the treatment of inherited metabolic diseases.

• Clinical and Experimental Pediatrics
• /
• v.53 no.10
• /
• pp.892-897
• /
• 2010

Purpose: This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD). Methods: Thirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference, hip circumference, and blood pressure were measured, and the clinical and hormonal features were reviewed retrospectively. We evaluated measures of metabolic derangement in the enrolled patients and in the data of healthy adults aged 20 to 29 years taken from the 2005 Korean National Health and Nutrition Examination Survey (KNHANES) as part of the National Cholesterol Education Program-the Adult Treatment Panel III. Results: Compared with the KNHANES participants, patients with ACOHGHD had significantly large waist circumference (men and women), high systolic blood pressure (BP) (women) and diastolic BP (men), and high serum triglyceride levels (women). The duration of illness correlated significantly with central obesity ($r^2$=0.546, $P$=0.003). The prevalence of MetS was 10% in patients with ACOHGHD and 2.3% in KNHANES participants. The prevalence of central obesity and MetS was higher in patients with ACOHGHD than in KNHANES participants ($P$<0.001 and $P$=0.042, respectively). Conclusion: Abdominal obesity correlated with the duration of illness in patients with ACOHGHD. Waist circumference should be measured in the clinic to prevent MetS, particularly in patients with a long history of ACOHGHD, regardless of age or sex.

• Journal of Interdisciplinary Genomics
• /
• v.4 no.2
• /
• pp.35-38
• /
• 2022

Background: Prader-Willi syndrome (PWS) is a complex genetic disease associated with growth impairment, severe obesity and metabolic dysfunctions. High proportion of PWS patients are born small for gestational age (SGA) than normal children, which also increase the risk of growth impairment and metabolic dysfunction in PWS. We aimed to compare growth outcome and metabolic profiles between SGA and appropriate for gestational age (AGA) PWS patients. Methods: Data of 55 PWS children and adults aged more than 2 years old (32 male and 23 female, age 2-18.8 years) from single center were studied. Only patients who were treated with GH were included. The clinical characteristics and laboratory findings were reviewed retrospectively. Results: Among 55 subjects, 39 had 15q11-13 deletion and 16 had uniparental disomy (UPD). Twenty (36.3%) were born SGA. All patients received GH treatment, and 11 (20%) discontinued GH treatment. Mean age at GH treatment initiation was 2.5 (range 0.3-12.4) years, and mean duration of treatment was 6.3 (range 1.0-11.3) years. Current height-SDS (-0.36 vs -0.16) and BMI-SDS (1.44 vs 1.33) did not differ between AGA and SGA group. Two patients in SGA group, but none in AGA group had diabetes mellitus. Mean glucose level was also higher in SGA group (100.1 vs 114.4 mg/dL). Conclusion: Our report gives an overview of growth profile and metabolic dysfunctions recorded in GH treated PWS patients. Growth profile did not differ between AGA and SGA group. Glucose level was higher in SGA group, so more careful monitoring and prevention for DM will be required in SGA group.

• Korean Journal of Psychosomatic Medicine
• /
• v.22 no.2
• /
• pp.104-111
• /
• 2014

Objectives : The aim of this study was to investigate the relationship between metabolic syndrome and cognitive functions among chronic schizophrenia patients. Methods : The survey participants were 105(40 metabolic syndrome and 65 non-metabolic syndrome) chronic schizophrenia patients at Yang-san Hospital. Each score of cognitive test(A Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet, stroop test), Positive and Negative Syndrome Scale, Hamilton rating scale for Depression were assessed. Statistical analysis of the relationship between various tests of A Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet and metabolic syndrome were performed using ANCOVA and logistic regression. Results : Schizophrenia patients with lower score on construction praxia were likely to be included in Metabolic syndrome group. However, there were no significant relationships in other tests between the two groups. Conclusions : This study found metabolic syndrome caused cognitive decline in chronic schizophrenia patients, especially Construction praxia. This study could be a basis to show metabolic syndrome has to be treated appropriately in schizophrenia patients and suggests the necessity of following longitudinal designed study.

• Journal of agricultural medicine and community health
• /
• v.42 no.2
• /
• pp.79-86
• /
• 2017

Objectives: Metabolic syndrome and depression are interconnected disorders. Although many studies have assessed the association between dietary intake and each disorder independently, few studies have examined the association between depression and dietary intake in patients with metabolic syndrome. Our study examined the association between depression and dietary intake in adults with metabolic syndrome. Methods: We analyzed the second data set (2014) from the sixth KNHNES. Of the patients with metabolic syndrome, the final study population comprised 1,334 patients, aged 20 to 60 years, with metabolic syndrome as defined by KNHNES and depression diagnosed by a physician. We examined the patients' dietary intake obtained using the 24-h recollection method in KNHNES. Results: Depression group had a lower niacin dietary intake than those without depression in both male and female (male P=0.047, female P=0.025). None of the other components had any association between depression group and those without depression group in both male and female. Conclusions: This study demonstrates that a low dietary intake of niacin may be related to the depression in patients with metabolic syndrome. The results indicate that it is worthwhile to evaluate the nutritional status in patients who have been diagnosed with both metabolic syndrome and depression.

• The Korean Journal of Rehabilitation Nursing
• /
• v.8 no.1
• /
• pp.59-67
• /
• 2005

Purpose: The purpose of this study is to investigate the effect of Self-Efficacy Promoting Program on Self-Efficacy, Metabolic Control and Self-Care Behaviors in Patients with NIDDM. Method: Data was collected from March 15th to July 15th, 2001. The subjects of the study consisted of 23 NIDDM patients who had visited regularly the endocrinology out-patient department of Gwangju Christian Hospital. The instrument used in the study Paek's self-efficacy measurement scale, was modified by the researcher, self-care behaviors were created by health care teams, and HbA1c for the sugar metabolic control were measured from the patients blood. The Interventions of the self efficacy promoting program were applied 4 hours a week for 6weeks. Data were analyzed with SPSS/PC+, using T-test and Wilcoxon rank sum test. Result: The mean score for self-efficacy was $70.61{\pm}15.48$ of a 140 point scale, the mean score for $HbA_{1c}$ level was $8.07{\pm}1.86%$. The self efficacy promoting program significantly increased the score of self efficacy(Z=-4.198, P=.000). And the self efficacy promoting program was significantly decreased in metabolic control(Z=-2.585, p=.010). Taking medicine and controlling alcohol were the best self care behaviors of this program. Conclusion: It was established that the self efficacy promoting program was effective for improving self efficacy, metabolic level and self care behaviors in patients with NIDDM.

• Korean Journal of Head & Neck Oncology
• /
• v.37 no.1
• /
• pp.17-22
• /
• 2021

Background/Objectives: To evaluate clinical significance of FDG PET-CT for detection of residual cancer cells after curative radiation therapy or chemoradiotherapy for patients with squamous cell carcinoma (SCC) of Head and Neck Materials & Methods: A retrospective analysis of patients with SCC of Head and neck with curative radiotherapy or chemoradiotherpy between June 2011 and Jan. 2019 was performed. Sixty patients were treated with Intensity-modulated radiotherapy (IMRT). The Metabolic responses were evaluated on the post-treatment FDG PET-CT at 12 weeks after curative radiotherapy completion. Results: Median follow up was 51.5 months (3-102). The overall survival (OS), disease free survival (DFS), local control rate (LCR), and Distant metastasis free survival (DMFS) at 5 years were 80.5%, 80.1%, 87.7% and 89.1%. Metabolic CR was found in 43 (71.7%) and partial metabolic response (PR) was noted in 17 (14.6%). Metabolic CR was significantly correlated with OS, DFS, LCR, and DMFS. On multivariate analysis, Metabolic CR remained significant for DFS and LCR. Conclusion: Metabolic CR on post-radiotherapy FDG PET-CT is highly predictive of increased DFS and LCR in patients with head and neck cancer.