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http://dx.doi.org/10.21593/kjhno/2021.37.1.17

Clinical Significance of FDG PET-CT Scan at 12 Weeks after Curative Radiation Therapy in Patients with Head and Neck Cancer  

Kim, Young-il (Department of Radiation oncology, Chungnam National University Hospital)
Kim, Jun-sang (Department of Radiation oncology, Chungnam National University Hospital)
Kwon, Jeanny (Department of Radiation oncology, Chungnam National University Hospital)
Kim, Sup (Department of Radiation oncology, Chungnam National University Hospital)
Seo, Youngduk (Department of Nuclear medicine, Chungnam National University Sejong Hospital)
Koo, Bon-seok (Department of Otolaryngology, Chungnam National University Hospital)
Chang, Jae-won (Department of Otolaryngology, Chungnam National University Hospital)
Cho, Moon-June (Department of Radiation oncology, Chungnam National University Hospital)
Publication Information
Korean Journal of Head & Neck Oncology / v.37, no.1, 2021 , pp. 17-22 More about this Journal
Abstract
Background/Objectives: To evaluate clinical significance of FDG PET-CT for detection of residual cancer cells after curative radiation therapy or chemoradiotherapy for patients with squamous cell carcinoma (SCC) of Head and Neck Materials & Methods: A retrospective analysis of patients with SCC of Head and neck with curative radiotherapy or chemoradiotherpy between June 2011 and Jan. 2019 was performed. Sixty patients were treated with Intensity-modulated radiotherapy (IMRT). The Metabolic responses were evaluated on the post-treatment FDG PET-CT at 12 weeks after curative radiotherapy completion. Results: Median follow up was 51.5 months (3-102). The overall survival (OS), disease free survival (DFS), local control rate (LCR), and Distant metastasis free survival (DMFS) at 5 years were 80.5%, 80.1%, 87.7% and 89.1%. Metabolic CR was found in 43 (71.7%) and partial metabolic response (PR) was noted in 17 (14.6%). Metabolic CR was significantly correlated with OS, DFS, LCR, and DMFS. On multivariate analysis, Metabolic CR remained significant for DFS and LCR. Conclusion: Metabolic CR on post-radiotherapy FDG PET-CT is highly predictive of increased DFS and LCR in patients with head and neck cancer.
Keywords
Head and neck cancer; Radiotherapy; PET-CT;
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