• 대한지역사회영양학회지
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• 제13권1호
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• pp.91-99
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• 2008

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged $\geq$ 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.

• 약학회지
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• 제8권1호
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• pp.1-5
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• 1964

Present experiment in vivo shows that some conversions of active groups in chloramphenicol residue of ester, that is hydrolytic cleavage of dichloracetamide and glucuronide formation, seem to take place prior to hydrolysis. This result suggest that the enzymatic hydrolysis rate in vitro, is not available as an index for the evaluation of the chlorampherical ester potency.

• 한국산학기술학회논문지
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• 제16권6호
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• pp.3934-3943
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• 2015

본 연구는 대상증후군 발생률과 대사증후군 발생과 관련된 위험요인을 알아보고자 지역사회 주민을 대상으로 2006년부터 2010년까지 5년 간격으로 동일인을 추적조사하였다. 1차 기초조사와 2차 추적조사에 참여한 대상자는 620명이었으며, 이중 1차 기초조사에서 대사증후군에 진단되지 않았던 460명이 본 연구의 최종 연구대상자가 되었다. 2차 추적조사에서 새로이 대사증후군으로 판정된 대상자는 108명(23.5%)이었으며, 대사증후군의 발생률은 1,000인년당 25.2이었다. 대사증후군의 발생률은 남자가 여자보다 유의하게 높았고(p<0.01), 정상체중에 비해 과체중일때와 비만일때 유의하게 높았으며 (p<0.01), 비흡연보다 과거흡연이나 현재흡연 상태일 때 대사증후군의 발생률이 유의하게 높았다(p<0.01). 연령, 교육수준, 배우자유무, 경제상태, 직업유무, 총콜레스테롤수치, 음주, 운동에서는 유의한 차이가 없었다. 대사증후군의 위험요인을 파악하고자 다중로지스틱회귀분석을 실시한 결과 비만이 다른 변수들은 보정한 후에도 유의한 변수로 선정되었으며, 정상체중에 비해 과체중일수록(OR=2.691, 95% CI=1.170-6.192), 정상체중에 비해 비만일수록(OR=4.727, 95% CI=2.137-10.457) 대사증후군의 발생률이 높았다. 따라서 대사증후군의 관리를 위하여 비만에 대한 관리가 매우 중요하며, 이를 충분히 고려한 건강관리지원이 필요하리라 여겨진다.

• 융합정보논문지
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• 제11권3호
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• pp.54-67
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• 2021

본 연구는 국민건강영양조사 제 7기 3차 년도(2018년) 자료를 이용하여 대사증후군 노인과 골다공증을 동반한 대사증후군 노인의 삶의 질에 영향을 미치는 요인을 분석한 2차 자료 연구이다. 연구 대상은 대사증후군 노인 639명, 골다공증을 동반한 대사증후군 노인 161명이 참여하였다. 자료분석은 복합표본 Rao-Scott χ2검정, 일반선형 모형 t-검정 및 회귀모형을 이용하였다. 연구 결과 대사증후군 노인의 삶의 질 저하 요인은 연령, 배우자 동거, 근력운동, 주관적 건강상태, 활동제한, 체질량지수 및 우울이었으며 설명력은 50.4%였다(F=515.96, p<.001). 골다공증을 동반한 대사증후군 노인에서는 연령, 주관적 건강상태, 활동제한 및 스트레스가 삶의 질 저하 요인이었으며 설명력은 48.6%였다(F=10.42, p<.001). 이 결과를 토대로 골다공증 동반 대사증후군 노인에게는 건강상태에 대한 긍정적 수용, 도구적·사회적지지 및 돌봄 지원을 통한 활동제한 문제 해결 및 스트레스 감소 관리를 위한 집중적이고 공격적인 프로그램 개발 및 제공이 필요하다.

• Nutrition Research and Practice
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• 제16권6호
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• pp.755-764
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• 2022

BACKGROUND/OBJECTIVES: Cardiovascular diseases (CVDs) are the leading cause of death in Koreans, and eating habits, including diet quality, are among the etiologies of these diseases. Recently, various studies on regional health disparities have been conducted. However, there are limited studies on their relationship with nutritional factors. This study aimed to identify the magnitude of regional disparities in diet quality and prevalence of CVD in Korean adults. SUBJECTS/METHODS: This study included 17,646 participants aged ≥ 20 years from the 7^th (2013-2016) Korean National Health and Nutrition Examination Survey. Participants were classified into four groups based on their residential areas: City 1, City 2, City 3, and non-city. Demographic characteristics, health-related factors, body mass index (BMI), metabolic syndrome index, diet quality, and CVD prevalence were evaluated. RESULTS: In terms of demographic characteristics, age (P < 0.001), marital status (P < 0.001), educational level (P < 0.001), and income (P < 0.001) were lower in the non-city category. Health-related factors such as monthly drinking rate (P < 0.01) and mental stress (P < 0.05) were the highest in City 1 and lowest in the non-city group. Conversely, the current smoking rate (P < 0.05), BMI (P < 0.05), and prevalence of metabolic syndrome (P < 0.001) were the highest in the non-city group (P < 0.05). The non-city group also had the highest prevalence of CVDs (35.6%). This group had the lowest diet quality index (68.36 ± 0.22, P < 0.01), caused by low intake of fruit and calcium, a lack of sodium moderation, and an overall imbalance in the macronutrient and fatty acid ratio. When the diet quality index was increased by 1, the odds ratio for the prevalence of CVDs was reduced by 0.991 (P < 0.001), but this was not the case in all regions. CONCLUSIONS: This study provides useful information and data in identifying and resolving the regional health disparities related to CVD prevalence and implementation of public health nutrition systems.

• 대한지역사회영양학회지
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• 제16권1호
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• pp.51-61
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• 2011

Elevated serum concentration of inflammation markers is known as an independent risk factor of metabolic syndrome (MS) and dietary intake is an important factor to control MS. The purpose of this study was to investigated the hypothesis that inflammatory indices are associated with dietary intake and diet quality index-international (DQI-I) in subjects with MS. A cross-sectional study was conducted on 156 men and 73 postmenopausal women with MS, defined by three or more risk factors of the modified Adult Treatment Panel III criteria. Serum levels of high sensitive C-reactive protein (hs-CRP), adiponectin were examined and nutrients intake and DQI-I were assessed using a semiquantitative food frequency questionnaire. The total DQI-I score was significantly higher in female subjects ($65.87{\pm}9.86$) than in male subjects ($62.60{\pm}8.95$). There was a positive association between hs-CRP and polyunsaturated fatty acid intake (p < 0.05) and a negative association between adiponectin and lipid (p < 0.05), total sugar (p < 0.01), and total fatty acids (p < 0.05). When the subjects were divided into 5 groups by quintile according to serum adiponectin and hs-CRP level, there was no association between DQI-I score and hs-CRP levels. Moderation score of DQI-I was significantly higher in highest quintile group than the lower quintile groups. Therefore, our results provide some evidence that dietary intake and diet quality are associated with inflammation markers and dietary modification might be a predictor to decrease risk for metabolic syndrome complications. However further research is needed to develop the dietary quality index reflecting the inflammatory change by considering the dietary habit and pattern of Koreans.

• Clinical and Experimental Pediatrics
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• 제63권3호
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• pp.110-114
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• 2020

Background: Subclinical hypothyroidism (SH) is a common condition in obese children. However, its effect on glucose and lipid metabolism in obese children remains controversial. Purpose: The present study aimed to investigate the association between SH and metabolic parameters. Methods: A total of 215 obese children and adolescents aged 6-18 years were included in this retrospective cross-sectional study. The patients' anthropometric measurements such as thyrotropin (TSH), free thyroxine (fT4), fasting plasma glucose, and insulin levels, as well as homeostasis model assessment for insulin resistance (HOMA-IR) index, and lipid profiles were evaluated. The patients were allocated to the SH group (fT4 normal, TSH 5-10 mIU/L) (n=77) or the control group (fT4 normal, TSH<5 mIU/L) (n=138). The glucose and lipid metabolisms of the 2 groups were compared. Results: SH was identified in 77 of 215 patients (36%). Mean body mass index was similar in both groups. The mean serum insulin, HOMA-IR, and triglyceride (TG) levels were higher and the mean high-density lipoprotein cholesterol level was lower in the SH group than in the control group (P=0.007, P=0.004, P=0.01, and P=0.02, respectively). A positive correlation was observed between TSH level and insulin level, HOMA-IR, and TG level. Conclusion: SH was identified in some of the obese children and adolescents. A clear association was observed between SH, insulin resistance, and dyslipidemia in obese children.

• 전기학회논문지
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• 제58권4호
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• pp.849-856
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• 2009

Truncal obesity associated with insulin resistance and metabolic syndrome increase the likelihood of hypertension, various cardiovascular diseases, hyperlipidemia and coronary heart diseases. International Diabetes Federation (IDF) experts recognized that it is necessary to develop the simple diagnostic tool which is applicable to diagnose truncal obesity worldwide, and proposed the method using a waist circumference but there is a limit to estimate subcutaneous fat distribution. However, waist line is also influenced by total fat capacity less than the intra abdominal fat. The more having severe obesity, the more correlation coefficient between waist line and intra abdominal fat is low. Therefore, this thesis defines a new abdominal impedance measurement position and impedance-index to analysis central obesity. This proposes the new model to estimate abdominal obesity using the abdominal impedance-index and CT images acquired fro 160 Korean subjects. The proposed model shows that the abdominal fat distribution has a higher correlation than waist line. (Adj R2=0.809, 0.667 and 0.687 with abdominal fat area, visceral fat area and subcutaneous fat area respectively).

• 대한임상검사과학회지
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• 제46권1호
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• pp.31-37
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• 2014

Metabolic syndrome such as, hypertension, diabetes, obesity, dyslipidemia etc are well known lifestyle diseases which threaten a health state. The purpose of this study is to evaluate antioxidant status and reactive oxygen species (ROS) in various stressful conditions. A group of persons (n=28) were enrolled in this study and stress status was evaluated using questionnaire of psychological well-being index (PWI-SF) and hematologic analysis of free oxygen radical defense (FORD), free oxygen radical test (FORT), lipid profiles and serum cortisol level. Analysis was done according to stress index, BMI status and overtime working. Blood samples from diabetics were used for control. Results are as in followings: Higher PWI-SF group showed higher FORT. Obese persons with BMI > $25kg/m^2$ showed statistically lower FORD (p<0.05) and higher FORT level (p<0.01). When compare with diabetics, an overweight group had similar levels in FORD and FORT while a normal body weight group showed quite different with diabetics in FORD (p<0.001). Higher ROS group has higher triglyceride, CRP and insulin levels but lower in FORD and HDL-cholesterol levels. Overtime working at night showed no meaningful result against our expectations. These results suggested that obesity showed most unfavorable correlations in an antioxidant status in various situations.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.577-578
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• 2017

기존의 운동 관리 시스템들은 사용자에게 운동과 관련된 정보를 제공하였다. 그러나 사용자의 신체 정보를 분석하고 이에 따른 정보를 제공하는 알고리즘의 부재로 정확도가 낮은 문제점이 있었다. 이를 해결하기 위해 본 논문에서는 BMI(Body Mass Index) 지수와 BMR(Basal Metabolic Rate) 수치를 분석하여 사용자의 신체 정보를 분석한다. 또한 추천 알고리즘을 통해 사용자에게 운동 강도와 운동량을 추천하고 사용자가 사용했던 운동 기구 히스토리를 그래프로 명시한다. 이를 통해 사용자의 신체에 해당하는 정보를 제공받고 운동 관리를 진행할 수 있을 것으로 사료된다.