• Biomolecules & Therapeutics
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• 제22권6호
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• pp.570-576
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• 2014

Studies have demonstrated that electromagnetic waves, as the one of the most important physical factors, may alter cognitive and non-cognitive behaviors, depending on the frequency and energy. Moreover, non-ionizing radiation of low energy waves e.g. very low frequency waves could alter this phenomenon via alterations in neurotransmitters and neurohormones. In this study, short, medium, and long-term exposure to the extremely low frequency electromagnetic field (ELF-EMF) (1 and 5 Hz radiation) on behavioral, hormonal, and metabolic changes in male Wistar rats (250 g) were studied. In addition, changes in plasma concentrations for two main stress hormones, noradrenaline and adrenocorticotropic hormone (ACTH) were evaluated. ELF-EMF exposure did not alter body weight, and food and water intake. Plasma glucose level was increased and decreased in the groups which exposed to the 5 and 1Hz wave, respectively. Plasma ACTH concentration increased in both using frequencies, whereas noradrenaline concentration showed overall reduction. At last, numbers of rearing, sniffing, locomotor activity was increased in group receiving 5 Hz wave over the time. In conclusions, these data showed that the effects of 1 and 5 Hz on the hormonal, metabolic and stress-like behaviors may be different. Moreover, the influence of waves on stress system is depending on time of exposure.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.273-273
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• 2022

The increasing number of Westernized eating patterns based on wheat flour in Korea has led to an increase in the rate of diseases such as obesity and diabetes, which has become a social problem. Wheat consumption is increasing due to changes in eating habits, but domestic wheat has low price competitiveness and has stagnated recently, so it is necessary to secure new resources to differentiate from imported wheat. Resistant starch, a newly created resource in domestic wheat, can act as a prebiotic similar to dietary fiber in the body, inducing microbial changes in the gut and having beneficial effects on metabolic syndrome. Wheat research on resistant starch was carried out based on the breeding of high amylose. A genome-wide association study (GWAS) was used to perform SNP identification and expression analysis related to wheat amylose through phenotype and genotype. 561 wheat core collection gene sources were investigated for amylose content in wheat, and related genes were extracted and analyzed. In the GWAS analysis, the model formulas BLIMK, FarmCPU, GLM, MLM, and MLMM were used to derive results such as QQ plots and Manhattan plots through phenotypic data. Among these models, BLAST was conducted to find the association between the SNPs identified using FarmCPU and genes related to starch, and 15 were found. Using the identified markers, it becomes easier to develop and browse related wheat cultivars according to their amylose content.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2005년도 제30회 춘계학술대회
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• pp.32-34
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• 2005

Purpose: To investigate the metabolic changes in the motor and motor association cortices following axonal injury in the internal capsule that was caused by deep intracerebral hematoma. Materials and Methods: Using proton magnetic resonance spectroscopy (1H MRS), the authors studied the primary motor cortices (M-1) and supplementary motor areas (SMA) of 9 hemiparetic patients with documentable hemiparesis of varying severity, and we studied 10 normal volunteers as controls. To measure the M-1 and SMA biochemical changes, 4 separate single volumes of interest (VOIs) were located bilaterally in the affected and unaffected hemisphere (AH and UH). Results: 1H MRS provided a neuronal and axonal viability index by measuring levels of N-acetylaspartate (NAA) and creatine/phosphocreatine (Cr). The M-1/SMA NAA/Cr ratios of the AH and UH in patients, and the AH and normal volunteers were compared. The NAA/Cr ratios of the M-1 and SMA in AH, and the SMA in UH were significantly lower than those of normal volunteers. Conclusion: These 1H MRS findings indicate that axonal injury in the descending motor pathway at the level of internal capsule could induce metabolic changes in the higher centers of the motor pathway.

• 농약과학회지
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• 제2권3호
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• pp.1-20
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• 1998

Chlorsulfuron, one of sulfonylurea herbicides acts through inhibition of acetolactate syuthase (EC 4.1.3.18; ALS, also known as acetohydroxyacid synthase) in the branched-chain amino acid biosynthesis process. After chlorsulfuron-ALS interaction, many physiological and metabolic disruptions occur in plants. However, it is not clear how this chlorsulfuron-ALS interaction affects those physiological and metabolic processes and how this interaction leads subsequently to plant death. Several researchers suggested that the death of chlorsulfuron-treated plants might be due to a shortage of the branched-chain amino acids, an accumulation of toxic metabolites, and/or a depletion of photoassimilates. It remains as a mystery presently, however, if such changes result in the plant death. In this review, we discussed how the chlorsulfuran-ALS interaction leads to physiological and metabolic disruptions in plants.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8053-8058
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• 2016

Metformin is known as a hypoglycaemic agent that regulates glucose homeostasis by inhibiting liver glucose production and increasing muscle glucose uptake. Colorectal cancer (CRC) is one of the most common cancers worldwide, with about a million new cases diagnosed each year. The risk factors for CRC include advanced age, smoking, black race, obesity, low fibre diet, insulin resistance, and the metabolic syndrome. We have searched Medline for the metabolic syndrome and its relation to CRC, and metformin as a potential treatment of colorectal cancer. Administration of metformin alone or in combination with chemotherapy has been shown to suppress CRC. The mechanism that explains how insulin resistance is associated with CRC is complex and not fully understood. In this review we have summarised studies which showed an association with the metabolic syndrome as well as studies which tackled metformin as a potential treatment of CRC. In addition, we have also provided a summary of how metformin at the cellular level can induce changes that suppress the activity of cancer cells.

• Toxicological Research
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• 제18권3호
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• pp.293-300
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• 2002

Chemical carcinogen-induced alteration of aldehyde metabolic enzymes were examined in clone 9 cell. Diethylnitrosamine (DENA), N-nitrosoethylurea (NEU) and N-nitrosomorpholine (NNM) were wed as model carcinogens. Changes in enzyme activities by repetitive treatment of DENA, NEU or NNM were analyzed in terms of specific activities and activity stainings of the enzymes on the gel. Upon treatment of DENA, lipid peroxide level increased upto 10 fold, indicating strong oxidative stress state of the cell. Notable enhancement of ADH and ALDH activity occurred after DENA treatment, while glutathione-S-transferase activity was slightly increased. Furthermore, about 2.5 fold higher superoxide dismutase (SOD) activity was detected during deactivation of catalase (CAT) activity by repetitive treatment of DENA. However in NEU-treated cell, about 2.3 fold higher ALDH activity was found while ADH activity was slightly increased. Notable increase CAT and SOD could also be found. In contrast, maximum 3.5 fold higher CAT activity occurred during SOD deactivation in NNM-treated cell. These results suggest that there might be different enzymatic responses in relation to cell protection against DENA, NEU or NNM.

• 제어로봇시스템학회논문지
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• 제11권10호
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• pp.843-850
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• 2005

FBA(flux balance analysis) with Boolean rules for representing regulatory events has correctly predicted cellular behaviors, such as optimal flux distribution, maximal growth rate, metabolic by-product, and substrate concentration changes, with various environmental conditions. However, until now, since FBA has not taken into account a hierarchical regulatory network, it has limited the representation of the whole transcriptional regulation mechanism and interactions between specific regulatory proteins and genes. In this paper, in order to solve these problems, we describe the construction of hierarchical regulatory network with defined symbols and the introduction of a weight for representing interactions between symbols. Finally, the whole cellular behaviors with time were simulated through the linkage of a hierarchical regulatory network module and dynamic simulation module including FBA. The central metabolic network of E. coli was chosen as the basic model to identify our suggested modeling method.

• 대한유전성대사질환학회지
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• 제22권1호
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• pp.15-20
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• 2022

The most common urea cycle disorder is ornithine transcarbamylase deficiency. More than 80 percent of patients with symptomatic ornithine transcarbamylase deficiency are late-onset, which can present various phenotypes from infancy to adulthood. With no regards to the severity of the disease, characteristic fluctuating courses due to hyperammonemia may develop unexpectedly, and can be precipitated by various metabolic stressors. Late-onset ornithine transcarbamylase deficiency is not merely related to a type of genetic variation, but also to the complex relationship between genetic and environmental factors that result in hyperammonemia; therefore, it is difficult to predict the prevalence of neurological symptoms in late-onset ornithine transcarbamylase deficiency. Most common acute neurological manifestations include psychological changes, seizures, cerebral edema, and death; subacute neurological manifestations include developmental delays, learning disabilities, intellectual disabilities, attention-deficit/hyperactivity disorder, executive function deficits, and emotional and behavioral problems. This review aims to increase awareness of late-onset ornithine transcarbamylase deficiency, allowing for an efficient use of biochemical and genetic tests available for diagnosis, ultimately leading to earlier treatment of patients.

• 대한유전성대사질환학회지
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• 제22권1호
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• pp.9-14
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• 2022

Glutaric aciduria type 1 (GA1; OMIM #231670) is a rare autosomal recessive inherited neurometabolic disorder caused by the deficiency of glutaryl-CoA dehydrogenase. Infantile-onset GA1 is the most common form characterized by striatal injury and progressive movement disorder, and it is often triggered by an acute encephalopathic crisis within the first three years of life. Once this crisis occurs, there is a high likelihood for ineffective or limited conventional interventions, neurological disorders, or even death. Therefore, early diagnosis and immediate preventive management, such as dietary therapy, is essential. In the past decades, newborn screening (NBS) by tandem mass spectrometry for GA1 has been largely introduced in many countries including Korea, and it has led to improvements in the neurological outcomes of patients with GA1. In this review, the clinical symptoms, natural histories, and outcomes before and after the introduction of NBS in patients are discussed.

• 농촌의학ㆍ지역보건
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• 제36권4호
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• pp.264-279
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• 2011

이 연구는 서울시 1개 보건소를 대상으로 대사증후군 관리프로그램 등록자의 등록 당시와 6개월 후의 생활습관 및 대사증후군 위험인자의 변화를 비교 분석함으로써 대사증후군 관리사업의 효과를 평가하는 것을 목적으로 하였다. 최종 분석대상자는 처음 사업을 시작한 2009년 6월부터 2010년 8월까지 서울시 1개 보건소에 등록하고, 6개월 후 재방문하여 설문과 재검사를 마친 430명 중 자료에 결측치가 없는 381명이었다. 연구 자료는 이들이 보건소에서 등록 관리 받으면서 작성한 설문지와 검사기록을 통해 수집되었다. 최종 분석대상자를 관리유형에 따라 분류하면 적극적 상담군이 110명(28.9%), 동기부여 상담군 A가 133명(35.0%), 동기부여 상담군 B가 138명(36.2%) 이었다. 연구결과는 다음과 같다. 첫째, 등록자의 생활습관의 변화는 적극적 상담군에서 신체활동이 유의하게 증가되었다. 식습관은 0.7점 증가하였으며, 음주, 흡연은 감소하였으나 통계적으로 유의하지 않았다. 동기부여 상담군 A에서는 중등도 신체활동과 흡연, 음주에서 통계적으로 유의한 변화가 있었으나 식습관은 거의 변화가 없었다. 동기부여 상담군 B에서는 신체활동이 통계적으로 유의하게 감소하였으며, 식습관은 변화가 없었고, 음주, 흡연은 감소하였으나 통계적으로 유의하지 않았다. 둘째, 대사증후군 위험인자 변화는 적극적 상담군에서 수축기 혈압, 이완기 혈압, TG는 통계적으로 유의하게 감소하였으며(P<0.05), (P<0.01), (P<0.01), HDL-C는 증가하였으나 통계적으로 유의하지 않았고 허리둘레, 식전혈당은 오히려 증가하였으나 통계적으로 유의하지 않았다. 동기부여 상담군 A는 허리둘레, 수축기 혈압, 이완기 혈압, 중성지방은 감소하였고, HDL-C 또한 증가하였으나 통계적으로 모두 유의하지 않았으며, 식전혈당은 오히려 증가하였다. 동기부여 상담군 B는 TG만 통계적으로 유의하게 감소하였고, HDL-C는 증가하였으나 통계적으로 유의하지 않았다. 수축기 혈압, 이완기 혈압은 낮아졌으나 식전혈당, 허리 둘레는 오히려 통계적으로 유의하게 증가하였다. 셋째, 주관적 건강상태는 관리군(적극적 상담군, 동기부여 상담군 A, 동기부여 상담군 B) 모두에서 통계적으로 유의하게 긍정적으로 변화하였다. 넷째, 대사증후군 등록자의 6개월 후 재검율은 전체 19.0%이며, 적극적 상담군 29.4%, 동기부여 상담군 A는 19.0%, 동기부여 상담군 B는 14.5%로 나타났다. 등록경로별로 보면 직접 방문하여 대사증후군 관리사업에 등록된 경우가 이동검진이나 건강검진을 통해 등록한 경우보다 높았다. 등록 관리 6개월간 월1회 방문하게 하여 적극적으로 관리서비스를 제공한 적극적 상담군에서 생활습관 및 위험인자들의 변화가 있었으며, 동기부여 상담군에서는 변화가 미미하였다. 즉 제공된 관리서비스의 양과 질에 따라 생활습관과 대사증후군 위험인자 변화에는 차이가 있었다. 하지만 전체적으로는 보건소 대사증후군 관리 사업은 사업목표 달성을 위해 보다 더 효과적인 사업전략 개발이 필요하다 하겠다.