• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4691-4698
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• 2015

Background: The tumor suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. However, available results for the prognostic value of PTEN expression in patients with cancer remain controversial. Therefore, a meta-analysis of published studies investigating this issue was performed. Materials and Methods: A literature search via PubMed and EMBASE databases was conducted. Statistical analysis was performed by using the STATA 12.0 (STATA Corp., College, TX). Data from eligible studies were extracted and included into the meta-analysis using a random effects model. Results: A total of 3,810 patients from 27 studies were included in the meta-analysis, 22 investigating the relationship between PTEN expression and overall survival (OS) using univariate analysis, and nine with multivariate analysis. The pooled hazard ratio (HR) for OS was 1.64 (95% confidence interval (CI): 1.32-2.05) by univariate analysis and 1.56 (95% CI: 1.20-2.03) by multivariate analysis. In addition, eight papers including two disease-free-survival analyses (DFSs), four relapse-free-survival analyses (RFSs), three progression-free-survival analyses (PFSs) and one metastasis-free-survival analysis (MFS) reported the effect of PTEN on survival. The results showed that loss of PTEN expression was significant correlated with poor prognosis, with a combined HR of 1.74 (95% CI: 1.24-2.44). Furthermore, in the stratified analysis by the year of publication, ethnicity, cancer type, method, cut-off value, median follow-up time and neoadjuvant therapy in which the study was conducted, we found that the ethnicity, cancer type, method, median follow-up time and neoadjuvant therapy are associated with prognosis. Conclusions: Our study shows that negative or loss of expression of PTEN is associated with worse prognosis in patients with cancer. However, adequately designed prospective studies need to be performed for confirmation.

• 한국융합학회논문지
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• 제11권2호
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• pp.361-373
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• 2020

본 연구의 목적은 국내에서 혈액투석환자를 대상으로 적용된 스트레스 중재프로그램을 메타분석하여 스트레스 중재프로그램의 효과를 확인하고, 스트레스 중재 방법의 특성과 경향을 파악하기 위함이다. 분석대상연구는 총 10편으로 MINORS를 사용하여 문헌의 질평가를 실시하였으며, Comprehen sive Meta Analysis Version 3.0 및 Review manager version 5.3을 활용하여 자료를 분석하였다. 연구의 질 평가 점수는 21.2점이었으며, 중재프로그램의 심리적 스트레스에 대한 효과크기는 -.72, 생리적 스트레스 중 코티졸의 효과크기는 -.52로 보통의 효과를 보였다. 하위그룹 분석에서 음악요법, 아로마요법, 투석 중 중재, 개인중재, 1회당 60분 이상의 중재, 총 10~20회기 중재의 효과가 더 컸다. 본 연구 결과를 활용하여 추후 효과적인 스트레스 중재프로그램을 구성할 수 있을 것이며, 추후 혈액투석환자를 대상으로 한 무작위배정 실험연구가 더 필요하다.

• 대한통합의학회지
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• 제5권1호
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• pp.55-66
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• 2017

Purpose : The purpose of this study was to investigate whether mindful meditation programs conducted in ACT(Acceptance &Commitment Therapy) and MBCT(Mindfulness-Based Cognitive Therapy) were effective in changing in depression and anxiety. Methods : In order to achieve this, we have performed meta-analysis of the studies on ACT and MBCT among studies published in the national academic journals, master thesis, and doctoral thesis. Dependent variables were limited to depressive and anxiety symptoms. By using meta analysis method, we retrieved journal articles published in Korea between 2009 and 2015 using keyword searches of electronic databases. Result : The results of the analysis showed that both ACT and MBCT had a significant effect on reducing depressive symptoms (Hedges' g = -0.71, p < 0.01). Both also had a significant effect on reducing anxiety symptoms (Hedges' g = -1.134, p < 0.01). These results imply that both ACT and MBCT interventions can be useful interventions for both depressive and anxiety symptoms. In the case of interventions for depressive symptoms, the college student group showed better results than the adult group. In addition, the ACT program had a stronger effect on reducing depressive symptoms than the MBCT program. In the case of interventions for anxiety symptoms, the mixed gender group showed better results than the female group. Conclusion : The results showed significant differences with regard to the following factors: participant gender, target participants, mindfulness technique availability, session number, and session duration.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 춘계학술대회
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• pp.112-114
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• 2016

데이터 분석은 기존 데이터베이스 관리 도구로부터 데이터를 수집, 저장, 관리, 분석할 수 있는 역량을 말한다. 또한, 대량의 정형 또는 비정형 데이터 집합으로부터 가치를 추출하고 결과를 분석하는 기술을 의미한다. 따라서 메타분석은 여러 실증연구의 정량적인 결과를 통합과 분석을 통해 전체 결과를 조망할 수 있는 기회를 제공하는 통계적 통합 방법이다. 전자상거래 연구에서 인지된 가치의 선행 외부요인들은 연구자에 따라서 다양하게 적용하여 연구되어오고 있다. 본 연구에서는 국내 주요 학회지에 게재된 인지된 가치 관련연구에서 어떠한 요인들을 사용하고 있고 또한 이러한 외부요인들이 인지된 가치 어느 정도의 설명력을 가지는지를 메타분석을 통해 알아보고자 한다. 따라서 연구결과를 바탕으로 학문적 실무적 의의를 논의하고자 한다.

• 한국직업건강간호학회지
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• 제14권1호
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• pp.71-82
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• 2005

Purpose: This study analyzed domestic articles that studied job-stress of nurses using Meta Analysis to evaluate the responses resulted from job-stress and the factors affecting them. Method: To conduct this study, data were collected primarily from database of "richis" and additionally from 8 nursing journals and 5 theses for a degree on job-stress of clinical nurses. Result: As a result of Meta Analysis casual factor of job-stress, the result represented that two reasons; personal factor was the age, occupational factor were ward, duration of employment and position. By the result of analysis of effect of job-stress, satisfaction of the job, exhaustion, health status and immersion of the job were strongly related to job-stress. According to the general solution against job-stress that referred from job-stress related theses, there are several; Imagination Therapy, Assertive Training and Value Clarification Training could bring significant result. Conclusion: This study showed that because job-stress of clinical nurses had nothing to do with personal factors, job-stress management plans for nurses are needed to focus on occupational factors. Also the study suggested that various coping skills that proved to be effective are needed to be used to relieve job-stress and that's responses on nurses.

• 한국문헌정보학회지
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• 제43권4호
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• pp.117-137
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• 2009

본 연구는 도서관의 경제적 가치를 실증적으로 측정한 국내 외 42개의 선행연구들을 수집 정리하고, 상이하게 나타난 투자수익률이나 비용편익비율을 어떻게 해석해야 하는지를 메타분석을 통해서 통계적인 방법으로 파악하고자 한다. 메타분석법은 도서관의 경제적 가치측정 연구들이 제시한 수치를 통계적인 방법으로 분석하여 그 결과를 객관적으로 종합하기 위하여 적용되었다. 선행연구를 토대로 6개의 변인(조사시점, 도서관 유형, 연구방법, 혜택범위, 서비스범위, 1인당 GDP)을 도출하였고, 이들을 대상으로 6개의 가설을 설정하였다. 메타 회귀분석 결과, 혜택의 범위(직접효과, 간접효과) 및 국민 1인당 GDP의 수준에 따라 투자수익률의 일관성 있는 예측이 가능하다는 결과가 나타났다. 본 연구는 도서관의 경제적 가치 분야에서 수행된 국내 최초의 메타분석으로서, 이 분야의 연구에서 도출된 결과를 정책결정에 적용하는 데 도움이 될 것으로 기대된다.

• 대한인간공학회지
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• 제29권6호
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• pp.925-932
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• 2010

Most of the research on three-dimensional interaction field have showed different accuracy in terms of sensing, mode and method. Furthermore, implementation of interaction has been a lack of consistency in application field. Therefore, this study is to suggest research trends of three-dimensional interaction using meta-analysis. Searching relative keyword in database provided with 153 domestic papers and 188 international papers covering three-dimensional interaction. Analytical coding tables determined 18 domestic papers and 28 international papers for analysis. Frequency analysis was carried out on method of action, element, number, accuracy and then verified accuracy by effect size of the meta-analysis. As the results, the effect size of sensor-based was higher than vision-based, but the effect size was extracted to small as 0.02. The effect size of vision-based using hand motion was higher than sensor-based using hand motion. Therefore, implementation of three-dimensional sensor-based interaction and vision-based using hand motions more efficient. This study was significant to comprehensive analysis of three-dimensional motion recognition for interaction and suggest to application directions of three-dimensional interaction.

• 한국콘텐츠학회논문지
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• 제16권1호
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• pp.391-402
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• 2016

본 연구는 유아교사의 교사효능감과 직무만족의 상관관계를 고찰할 수 있는 연구방법인 메타분석(mata-analysis)의 방법으로, 유아교사의 교사효능감과 직무만족 간의 효과크기 및 두 변수의 하위변수 간 효과크기를 살펴보는 것을 연구목적으로 하였다. 이러한 연구목적을 위해 메타분석 전용 프로그램인 CMA(Comprehensive Meta Analysis) 2.0을 분석에 적용하였다. 분석결과, 유아교사의 교사효능감과 직무만족의 관계는 Cohen(1992)의 기준으로 중간 효과크기보다 높게 나타났다. 교사효능감 하위변수 중에서는 개인 교수효능감이 일반 교수효능감보다 직무만족의 관계에서 높은 효과크기를 보였으며, 직무만족의 하위변수 중에서는 직무자체 신념이 교사효능감의 관계에서 효과크기가 가장 높았다. 조절변수인 논문유형에서는 박사 학위논문이 효과크기가 높았으며, 출판연도와 표본 수는 메타회귀분석 결과, 통계적으로 유의하지 않았다. 이상의 분석결과를 기초로 하여 논의와 연구의 한계점을 제시하였다.

• 대한통합의학회지
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• 제9권1호
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• pp.203-217
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• 2021

Purpose: The purpose of this meta-analysis was to examine the high-level evidence of the effects of manual therapy on musculoskeletal diseases. Methods: Domestic databases were searched for studies that conducted clinical trials associated with manual therapy on chronic musculoskeletal diseases. A total of 591 studies published between 2005 and 2018 were identified, with 18 studies satisfying the inclusion data. The studies were classified according to patient, intervention, comparison, and outcome (PICO). The search outcomes were items associated with pain and physical function. The 18 studies included in the study were evaluated by using the R meta-analysis (version 4.0). The quality of 18 randomized control trials was evaluated by using the Cochrane risk of bias (ROB). The effect sizes were computed as the corrected standardized mean difference (SMD). Subgroup and meta-regression analyses were also used. Egger's regression test was carried out in order to analyze the publication bias. Cumulative meta-analysis and sensitivity analysis were also conducted in order to analyze the data error. Results: The following factors showed the large effect size of manual therapy on chronic musculoskeletal diseases: pain (Hedges's g = 2.66; 95% CI = 1.47 ~ 3.85), and physical function (Hedges's g = 2.15; 95% CI: 1.22 ~ 3.08). The subgroup analysis only showed a statistical difference in the type of manual therapy (pain) and outcome (physical function). No statistically significant difference was found in the meta-regression analysis. Publication bias was found in the data, but the results of the trim-and-fill method showed that such bias did not largely affect the obtained data. Furthermore, there were no data errors in the cumulative meta-analysis and sensitivity analysis. Conclusion: This study provides evidence for the effectiveness of manual therapy on chronic musculoskeletal diseases in pain and physical function. Subgroup analysis suggests that only the type of manual therapy for pain and the type of outcome for physical function differed in effect size.

• 한국산업융합학회 논문집
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• 제24권1호
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• pp.31-43
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• 2021

In this study, approximate design optimization using various meta-models was performed for the structural design of active type deck support frame. The active type deck support frame was newly developed to facilitate both transportation and installation of 20,000 ton class offshore plant topside. Structural analysis was carried out using the finite element method to evaluate the strength performance of the active type deck support frame in its initial design stage. In the structural analysis, the strength performances were evaluated for various design load conditions that were regulated in ship classification organization. The approximate optimum design problem based on meta-model was formulated such that thickness sizing variables of main structure members were determined by achieving the minimum weight of the active type deck support frame subject to the strength performance constraints. The meta-models used in the approximate design optimization were response surface method, Kriging model, and Chebyshev orthogonal polynomials. The results from approximate design optimization were compared to actual non-approximate design optimization. The Chebyshev orthogonal polynomials among the meta-models used in the approximate design optimization represented the most pertinent optimum design results for the structure design of the active type deck support frame.