• Journal of Preventive Medicine and Public Health
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• 제34권3호
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• pp.262-268
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• 2001

Objectives : To integrate the results of studies which assess an association between blood lead and blood pressure. Methods : We surveyed the existing literature using a MEDLINE search with blood lead and blood pressure as key words, including reports published from January 1980 to December 2000. The criteria for quality evaluation were as follows: 1) the study subjects must have been workers exposed to lead, and 2) both blood pressure and blood lead must have been measured and presented with sufficient details so as to estimate or calculate the size of the association as a continuous variable. Among the 129 articles retrieved, 13 studies were selected for quantitative meta-analysis. Before the integration of each regression coefficient for the association between blood pressure and blood lead, a homogeneity test was conducted. Results : As the homogeneity of studies was rejected in a fixed effect model, we used the results in a random effect model. Our quantitative meta-analysis yielded weighted regression coefficients of blood lead associated with systolic blood pressure and diastolic blood pressure results of 0.0047 (95% confidence interval [CI]: -0.0061, 0.0155) and 0.0004 (95% CI: -0.0031, 0.0039), respectively. Conclusions : The published evidence suggested that there may be a weak positive association between blood lead and blood pressure, but the association is not significant.

• Nutrition Research and Practice
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• 제17권1호
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• pp.62-72
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• 2023

BACKGROUND/OBJECTIVES: Many studies have revealed an association between fat mass and the obesity-related gene (FTO) and obesity. On the other hand, no meta-analysis was conducted with data from only Koreans. Therefore, this study performed a meta-analysis using Korean data to provide evidence for the association between FTO single nucleotide polymorphisms (SNPs) and the risk of obesity among Korean adults. SUBJECT/METHODS: Meta-analysis was finally conducted with data extracted from seven datasets of four studies performed on Korean adults after the screening passed. Five kinds of FTO SNPs (rs9939609, rs7193144, rs9940128, rs8050136, and rs9926289) were included, and the relationship between FTO SNPs and body mass index (BMI) was investigated using linear regression with an additive model adjusted for covariants, such as age, sex, and area. RESULTS: The minor alleles of FTO SNPs were associated with increased BMI (odds ratio [OR], 1.31; 95% confidence interval [CI], 1.21-1.42). In sub-group analysis, FTO rs9939609 T>A was significantly associated with BMI (OR, 1.23; 95% CI, 1.06-1.42). The other FTO SNPs together were significantly associated with BMI (OR, 1.37; 95% CI, 1.25-1.49). The publication bias was not observed based on Egger's test. CONCLUSIONS: This meta-analysis showed that minor alleles in the FTO SNPs were significantly associated with an increased BMI among Korean adults. This meta-analysis is the first to demonstrate that minor alleles in the FTO SNPs contribute significantly to the increased risk of obesity among Korean adults using data from a Korean population.

• 기술혁신연구
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• 제19권3호
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• pp.141-174
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• 2011

이 논문은 정부보조금이 민간연구개발투자를 보완하는지 또는 대체하는지에 대한 선행연구문헌의 다양한 연구결과를 통합하여 최종결과와 연관된 구조적 요인이 무엇인지 메타분석 기법을 활용하여 분석하고자 하였다. 분석을 위해 선행연구결과에 대한 문헌의 다양한 특성을 자료의 분석기간, 자료의 수, 자료구조, 자료수준, 분석대상국가, 모형의 동태적 특성, 분석방법 등으로 변수화 하여 로짓분석을 하였다. 분석결과를 살펴보면 실증연구에 대한 선행연구문헌의 연구결과를 세부결과에 따라 구분한 경우는 자료의 수와 자료의 구조에 관련된 변수가 통계적으로 유의한 것으로 나타났다. 그리고 단일문헌의 결과를 평균적인 결과에 따라 통합하여 분석한 경우는 자료의 수준 및 분석대상국가가 연구결과에 통계적으로 유의한 것으로 나타났다. 정부보조금이 기업의 연구개발투자결정에 미치는 영향에 대한 기존 선행 메타분석과 비교하여 2000년 이후 최근까지의 자료를 추가하고 연구특성으로 다양한 분석방법을 변수화하여 포함하여 메타분석을 실시하였다는 점에서 의의를 지닌다. 또한 국내에서는 최초의 사례로 정부보조금이 민간연구개발투자에 미치는 영향에 대하여 다양한 해외 실증연구사례의 참조가 가능할 것으로 생각된다.

• The Korean Journal of Pain
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• 제30권4호
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• pp.250-257
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• 2017

Vitamin D is a cofactor responsible for autoimmune disorders. There is no agreement in the studies investigating the association between vitamin D and fibromyalgia. This study aims to combine the conflicting results of the primary studies which compared these patients with control groups regarding the serum concentration of vitamin D. This meta-analysis has been designed based on PRISMA guidelines. Relevant keywords were searched in PubMed, Science direct, Scopus, Cochrane, and Google scholar and primary studies were selected. After screening the eligible studies according to inclusion/exclusion criteria, we investigated the risk of bias in the selected studies and also the heterogeneity between the primary results using Cochrane (Q) and I-squared ($I^2$) indices. The primary results were combined using inverse variance method and Cohen statistics as well as a random effects model. Publication bias was assessed using Egger test. Sensitivity analysis was applied to investigate the influence of each primary study on the final result of the meta-analysis. Suspected factors in the heterogeneity were assessed using meta-regression models. We entered 12 eligible studies in the meta-analysis including 851 cases compared with 862 controls. The standardized mean difference of Vitamin D between the two groups was -0.56 (95% confidence interval: -1.05, -0.08). Our meta-analysis showed that vitamin D serum levels of patients with fibromyalgia was significantly lower than that of control group.

• 자원ㆍ환경경제연구
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• 제16권1호
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• pp.65-98
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• 2007

본 연구의 목적은 국내에서 수행된 습지가치추정 선행연구를 대상으로 메타회귀분석을 실시하여, 습지가치에 영향을 미치는 인자들을 규명하고 정책적 시사점을 도출하며, 국내 자연환경 가치추정 분야에 메타회귀분석의 적용 가능성을 검토하는 데 있다. 메타회귀분석은 기존에 축적되어 있는 연구로부터의 정보를 희귀분석을 사용하여 종합하는 기법으로써, 선행연구에서 관찰되는 가치추정치를 종속변수로 연구의 특성, 예를 들면, 대상지의 특성, 추정기법, 모집단의 인구 사회학적 특성 등을 설명변수로 설정하여 분석한다. 이야기체 문헌검토와 비교할 때 메타회귀분석의 가장 큰 장점은 연구자의 자의적 판단을 피하고 통계적 신뢰성에 기반을 둔 객관적인 결론을 도출할 수 있다는 점이다. 실증분석 결과 우리나라의 경우 단위면적당 습지가치는 어떤 습지기능을 대상으로 하였는지보다는 어떤 가치추정기법을 사용했는지에 따라 더 큰 영향을 받는 것으로 나타났다. 또한 습지면적과 습지가치는 유의한 음의 상관관계를 보임으로써 생태학적 원칙보다는 경제학적 원칙이 적용되고 있음을 확인할 수 있었으며, 이러한 점은 습지보호 및 관리정책에 시사하는 바가 크다. 본 연구의 사례분석을 통해 메타회귀분석은 선행연구 결과를 종합하고 관련정책 수립시 유용한 정보를 제공할 수 있는 분석의 틀로써 충분한 활용 가능성을 갖고 있는 것으로 판단된다. 그러나 본 연구는 메타분석의 활용 가능성뿐만 아니라 한계 및 불확실성의 존재를 확인하는 계기도 되었다. 메타회귀분석의 유효성과 신뢰성을 높이기 위해서는 지속적인 관련연구의 DB 구축, 개별연구의 질 향상을 위한 노력, 추정모델의 개선을 위한 연구 등이 병행해서 이루어져야 할 것으로 생각된다.

• 농촌계획
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• 제29권4호
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• pp.191-200
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• 2023

This study aims to estimate the value of environmental services that could be generated by seawater flowing in the Geumgang Estuary by using meta-regression for benefit transfer. The environmental services that can be generated by seawater flowing are assumed to be improved water quality, increased biodiversity, and enhanced water-friendly effect. The analysis was conducted using 122 data from 28 studies from EVIS. The results show that households in the neighborhood where seawater is distributed are willing to pay about KRW 46,918, KRW 7,752, and KRW 7,859 per year for improved water quality, increased biodiversity, and enhanced water-friendly, respectively. The WTP of the national households other than neighboring households was found to be KRW 19,401, KRW 3,206, and KRW 3,250 for the three environmental services, respectively. The WTP for water quality improvement is higher than that for biodiversity increase and water-friendly effect increase, which may be due to the fact that water quality improvement is an environmental service that is close to the use value. In addition, neighboring households have a higher WTP than national households because neighboring households are more likely to evaluate the benefits of seawater flowing as a use value, while national households are more likely to evaluate it as a non-use value.

• Nutrition Research and Practice
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• 제4권5호
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• pp.375-382
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• 2010

The precise effects of protein intake on fractional synthesis rate (FSR) of muscle protein are still under debate. The sample size of these studies was small and the conclusions in young and elderly subjects were inconsistent. To assess the effect of dietary protein intake on the FSR level, we conducted a meta-analysis of controlled protein intake trials. Random-effects models were used to calculate the weighted mean differences (WMDs). Ten studies were included and effects of short-term protein intake were evaluated. In an overall pooled estimate, protein intake significantly increased the FSR (20 trials, 368 participants; WMD: 0.025%/h; 95%CI: 0.019-0.031; P < 0.0001). Meta-regression analysis suggested that the protein dose was positively related to the effect size (regression coefficient = 0.108%/h; 95%CI: 0.035, 0.182; P = 0.009). A subgroup analysis indicated that protein intake significantly increased FSR when the protein dose was ${\leq}$ 0.80 g/kg BW (16 trials, 308 participants; WMD: 0.027%/h; 95%CI: 0.019-0.031; P < 0.0001), but did not affect FSR when the protein dose was > 0.80 g/kg BW (4 trials, 60 participants; WMD: 0.016%/h; 95%CI: 0.004-0.029; P = 0.98). In conclusion, this study is the first integrated results showing that a short-term protein intake is effective at improving the FSR of muscle protein in the healthy elderly as well as young subjects. This beneficial effect seems to be dose-dependent when the dose levels of protein range from 0.08 to 0.80 g/kg BW.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5161-5166
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• 2014

Our aim was to access the association between recreational physical activity (RPA) and risk of ovarian cancer (OC). The studies were retrieved from the PubMed and Embase databases up to February 20th, 2014. Risk ratios (OR) and 95% confidence intervals (CI) were used to estimate effect sizes. Random-effects or fixed-effects models were used to pool the data. The trim and fill method was applied for sensitivity analysis. Begg's rank correlation test and Egger's regression asymmetry test were employed to assess the publication bias. A total of 6 studies (435398 participants including 2983 OC patients) were included in this meta-analysis. The overall estimate indicated that there was weakly inverse association between RPA and OC risk (RR=0.90, 95%CI: 0.72-1.12, p=0.335). Meanwhile, for prospective cohort studies, a result consistent with the overall estimate was obtained (RR=1.12, 95% CI: 0.88-1.42, p=0.356). However, for case control studies, the pooled estimate of RR was 0.76 (95%CI: 0.64-0.90, p=0.002), indicating a clear significant association between RPA and OC risk. In addition, the sensitivity analysis indicated a significant link between RPA and risk of OC after removing Lahmann's study (RR=0.80, 95% CI: 0.68-0.93, p=0.004). No significant publication bias was found (Begg's test: p=1.00; Egger's test: p=0.817). In conclusion, our meta-analysis indicated a weakly inverse relationship between RPA and the occurrence of OC.

• 한국융합학회논문지
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• 제7권5호
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• pp.145-153
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• 2016

이 연구는 메타분석을 활용하여 현재 다양한 영역에서 실시되고 있는 수용전념치료 프로그램의 효과에 대해 종합적으로 평가하였다. 메타분석은 통계적인 방법을 활용하여 개입의 크기와 방향을 제시한다. 이를 통해 개입에 대한 종합적 분석이 가능하다. 논문의 선정기준을 통해 총 43편의 연구물을 분석 대상으로 선정하였다. 선정된 33편의 연구물에서 183개의 효과크기를 종합하여 전체효과크기, 하위집단별 효과크기, 메타회귀분석 결과를 제시하였다. 그 결과 수용전념치료 프로그램의 전체 효과크기는 0.704로 나타났다. 이는 중간 이상의 효과크기를 의미한다. 수용전념치료의 효과 영역에 따라 효과크기를 비교한 결과, 정의적 영역, 인지적 영역, 행동적 영역 순으로 효과크기를 나타냈다. 참가자의 특성에 따른 효과크기를 비교한 결과 첫째, 성별에 따른 분석결과, 혼성 집단, 여성 집단, 남성 집단 순으로 효과크기를 나타냈다. 둘째 연령에 따른 분석 결과 일반성인, 대학생(대학원생), 청소년 순이었다. 이러한 연구 결과를 바탕으로 후속연구와 향후 프로그램 운영에 대한 시사점을 논의하였다.

• 대한수의학회지
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• 제44권4호
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• pp.669-676
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• 2004

To evaluate the diagnostic accuracy of two commercial ELISA tests (Allied- and CSL-ELISA) for the diagnosis of Mycobacterium paratuberculosis in cattle, Meta-analysis using English language papers published during 1990-2001 was performed. Diagnostic odds ratios (DOR) were analyzed using regression analysis together with summary receiver operating characteristic (ROC) curves. The difference in diagnostic performance between the two ELISA systems was evaluated by using linear regression. Publication bias was assessed by funnel plot and linear regression. The pooled sensitivity and specificity were 44% (95% CI, 38 to 51) and 98% (95% CI, 96 to 99) for the random-effect model. The DOR between studies was heterogeneous. The area under the fitted ROC curve (AUC) was 0.72 for the unweighted and 0.77 for the weighted model. Maximum joint sensitivity and specificity for the unweighted and weighted model from their summary ROC curve were 70% and 75%, respectively. Based on the fitted model, at a specificity of 95%, sensitivity was estimated to be 52% for the unweighted and 57% for the weighted model. From the final multivariable model study characteristic, the country was the only significant variable with an explained component variance of 13.3%. There were no significant differences in discriminatory power, sensitivity, and specificity between the two ELISA tests. The overall diagnostic accuracy of two commercial ELISA tests was moderate, as judged by the AUC, maximum joint sensitivity and specificity, and estimates from the fitted model and clinical usefulness of the tests for screening program is limited because of low sensitivity and heterogeneous of DOR. It is, therefore, recommended to use ELISA tests as a parallel testing with other diagnostic tests together to increase test sensitivity in the screening program.