• Journal of the Society of Naval Architects of Korea
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• v.60 no.4
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• pp.256-265
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• 2023

This paper describes the results of the development of the submarine Free Running Model (FRM). First, the goal of development was set based on the test conditions and the test environment, and the system was obtained accordingly. The target submarine, Joubert BB2 submarine, was selected with a scale of 18.35 in accordance with the development goal. In order to conduct a submarine FRM test underwater, where communication is impossible, the FRM must operate at least semi-autonomously. For this purpose, an Extended Kalman Filter (EKF) based underwater integrated navigation system and control system using a sailplane and an X-shaped sternplane were designed respectively. In addition, a ballast system was designed to enable the model to float to the water surface in case of an emergency. To verify its propulsion, navigation, and control performance, the FRM tests were conducted in both indoor and outdoor basins. As a result, the relationship between propeller RPM and vehicle speed was derived, and it was confirmed that the navigation and control performance met the target value.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3229-3235
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• 2013

Background: Many breast cancers are caused by certain rare and familial mutations in the high or moderate penetrance genes BRCA1, BRCA2 and CHEK2. The aim of this study was to examine the allele and genotype frequencies of seven mutations in BRCA1, BRCA2 and CHEK2 genes in breast cancer patients and to investigate their isolated and combined associations with breast cancer risk. Methods: We genotyped seven mutations in BRCA1, BRCA2 and CHEK2 genes and then analyzed single variations and haplotype associations in 106 breast cancer patients and 80 healthy controls. Results: We found significant associations in the analyses of CHEK2- 1100delC (p=0.001) and BRCA1-5382insC (p=0.021) mutations in breast cancer patients compared to controls. The highest risk was observed among breast cancer patients carrying both CHEK2-1100delC and BRCA2- Met784Val mutations (OR=0.093; 95%CI 0.021-0.423; p=0.001). We identified one previously undescribed BRCA2 and a CHEK2 four-marker haplotype of A-C-G-C which was overrepresented ($X^2$=7.655; p=0.0057) in the patient group compared to controls. Conclusion: In this study, we identified a previously undescribed BRCA2 and CHEK2 A-C-G-C haplotype in association with the breast cancer in our population. Our results further suggest that the CHEK2-1100delC mutation in combination with BRCA2-Met784Val may lead to an unexpected high risk which needs to be confirmed in larger cohorts in order to better understand their role in the development and prognosis of breast cancer.

• Korean Journal of Microbiology
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• v.37 no.4
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• pp.245-252
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• 2001

Erm proteins, MLS (macrolide-lincosamide-streptogramin B) resistance factor proteins, show high degree of amino acid sequence homology and comprise of a group of structurally homologous N-methyltransferases. On the basis of the recently determined structures of ErmC` and ErmAM, ErmSF was divided into two domains, N-terminal end catalytic domain and C-terminal end substrate binding domain and attempted to overexpress catalytic domain in E. coli using various pET expression systems. Three DNA fragments were used to express the catalytic domain: DNA fragment 1 encoding Met 1 through Glu 186, DNA fragment 2 encoding Arg 60 to Glu 186 and DNA fragment 3 encoding Arg 60 through Arg 240. Among the pET expression vectors used, pET 19b successfully expressed the DNA fragment 3 and pET23b succeeded in expression of DNA fragment 1 and 2. But the overexpressed catalytic domains existed as inclusion body, a insoluble aggregate. To assist the soluble expression of ErmSF catalytic domains, Coexpression of chaperone GroESL or Thioredoxin and lowering the incubation temperature to $22^{\circ}C$ were attempted, as did in the soluble expression of the whole ErmSF protein. Both strategies did not seem to be helpful. Solubilization with guanidine-HCl and renaturation with gradual removal of denaturant and partial digestion of overexpressed whole ErmSF protein (expressed to the level of 126 mg/ι culture as a soluble protein) with proteinase K, nonspecific proteinase are under way.

• The Journal of the Korea Contents Association
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• v.15 no.3
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• pp.192-198
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• 2015

Checked out by the moving vehicle health checks for patients, practitioners, and the increase in radiation dose outside the vehicle, but an investigation into the leakage of radiation can still be negligible. In this study, through experimental results were as follows: Dose that occurs most often where the leak in the right door $1.14{\pm}1.75mR/h$, X-ray generator in terms of proximity to the top $0.65{\pm}1.25mR/h$, X-ray generator and away to the bottom in terms $0.91{\pm}1.25mR/h$, the adjacent rear detector in the upper part $96.98{\pm}158.88mR/h$ dose of the leak appeared in various locations. By measuring position from the rear of the adjacent detector $67.48{\pm}97.03mR/h$ dose had the highest leakage into. Generating device for diagnosis of radiation safety regulations regarding the maximum leakage dose per week, but all met back when it is displayed in the leakage dose Hourly rates do not ignore the leakage radiation dose were measured. Therefore, a mobile health screening in a vehicle outside of the leakage radiation dose to the liver and move on we are not interested twelve barrier leakage radiation dose of defense has a chance to re-evaluate the standards required, and move the vehicle health check using the X-ray increases as the dose per hour, depending on the criteria for choosing the appropriate measures that will require effort.

• Journal of the Korean Society for Railway
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• v.16 no.1
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• pp.32-39
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• 2013

The next generation high-speed train(HEMU-430X) is Korea's first electric multiple unit type, high speed vehicle resulting from a national R&D project. Tests have been conducted on the Kyungbu High Speed Line running at speeds up to 354.64km/h, and analysis of the dynamic behavior of the train was carried out to evaluate its safety. In this study, a simplified method using an accelerometer(the method specified in UIC 518 OR) was chosen to analyze the safety of the train's dynamic behavior. The section chosen for analysis section was ${\pm}10{\sim}20km/h$ with respect to the maximum speed point. In addition, we analyzed the trend of this dynamic behavior with increasing speed by comparing the analyzed values with those of UIC 518 OR. The dynamic behavior results met the limit values of UIC 518 OR and the study indicates that this trend is predicted to continue at speeds above 354km/h.

• Journal of Photoscience
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• v.9 no.2
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• pp.51-54
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• 2002

We propose a novel mechanism (Twist Sharing Mechanism) for the cis-trans photoisomerization of rhodopsin, based on the molecular dynamics (MD) simulation study. New things devised in our simulations are (1) the adoption of Mt. Fuji potentials in the excited state for twisting of the three bonds C9=C10, C11=C12 and C13=14 which are modeled using the detailed ab initio quantum chemical calculations and (2) to use the rhodopsin structure which was resolved recently by the X-ray crystallographic study. As a result, we found the followings: Due to the intramolecular steric hindrance between 20-methyl and 10-H in the retinal chromophore, the C12-C13 and C10-C11 bonds are considerably twisted counterclockwise in rhodopsin, allowing only counterclockwise rotation of the C11 =C12 in the excited state. The movement of 19-methyl in rhodopsin is blocked by the surrounding three amino acids, Thr 118, Met 207 and Tyr 268, prohibiting the rotation of C9=C10. As a result only all-trans form of the chromophore is obtainable as a photoproduct. At the 90$^{\circ}$ twisting of C11=C12 in the course of photoisomerization, twisting energies of the other bonds amount to about 20 kcal/mol. If the transition state for the thermal isomerization is assumed to be similar to this structure, the activation energy for the thermal isomerization around C11=C12'in rhodopsin is elevated by about 20 kcal/mol and the thermal isomerization rate is decelerated by 10$\^$-14/ times than that of the retinal chromophore in solution, protecting photosignal from the thermal noise.

• Magazine of the Korea Concrete Institute
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• v.7 no.3
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• pp.175-186
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• 1995

The determination of the stress intensity factors is investigated by sur-face integral method around the crack tip of the nlass~vc: concrete structure. The surface integral met hod is naturally derived from the standal-ci path integral J. Howevcr. In the J integral method, pressure in the crack-face and body forces can not be considered, while this theory has advantage of ccmsidering many kind of forces, so t.his theory will be useful in investigating more accurate strt:ss states around crack tip. Furthermore. t h~s rrlethod can elerninate unntussary process of using singular elements and fine mesh around crack tip which is used 11; modelling the singularity around crack tip. A computer program for determming $K_I$, $K_{II}$ is tfcvulopcd by applying this theory. $K_I$, $K_{II}$ values usmg X noded isoparametric elements which was proved and variation of the stress intensity factor was investigated by application of darn structures.

• Journal of Korean Foot and Ankle Society
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• v.8 no.1
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• pp.1-6
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• 2004

Purpose: We studied the diagnostic value of ultrasonography to confirm the presence of the syndesmosis injuries in the ankle. Materials and Methods: Pre-operative ultrasonography were taken in 42 cases of ankle fractures to determine injury of syndesmosis between February 2000 and August 2003. Tear of syndesmosis was confirmed when they met the following criteria; widening of distal tibiofibular clear space greater than 7 mm on pre-operative AP X-rays, leakage of contrast dye during intra-operative arthrography, and operative findings revealing syndesmosis rupture. We compared these diagnoses with those made by pre-operative ultrasonography. Results: Syndesmosis injuries were confirmed in 23 cases among the total 42 cases. Ultrasonography revealed syndesmosis tear in 25 cases, with 20 cases corresponding with confirmed tear and 5 cases without tear in confirm. Syndesmoses were found to be intact in 17 cases of ultrasonograph, but 3 cases were actually confirmed tear. In ankle ultrasonography, the sensitivity was 90.9%, the specificity was 75.0%. Conclusion: Preoperative ultrasonography is a non-invasive and useful study to determine the syndesmosis injury in ankle fractures.

• Journal of the Korean Society of School Health
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• v.23 no.1
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• pp.29-40
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• 2010

Purpose: The purposes of this study were: (a) to assess indoor air quality such as $PM_{10}$, $CO_2$ concentrations in child daycare centers, (b) to compare the levels with each standard, and (c) to identify teachers' awareness of indoor air quality in child care centers. Methods: Data were obtained from seventeen child daycare centers and ninety-eight teachers in a district of Seoul, from April 3 to May 12, 2009. Collected data were analyzed by SAS 8.2, and descriptive statistics, $x^2$ test, student t-test, Pearson correlation analysis, and Spearman rank correlation were used. Results: The mean of $PM_{10}$ and $CO_2$ level were $50.3{\mu}g/m^3$ and 792.1ppm. Sixteen child daycare centers (94.2%) met the guidelines of the $PM_{10}$ level, so did thirteen child daycare centers (76.5%) in the $CO_2$ level. $CO_2$ levels were significantly low in child daycare centers using air cleaners than those do not using them (t=-6.03, p<.001). Types of child daycare centers were significantly correlated to the levels of $CO_2$, which public child daycare centers were low in $CO_2$ levels than those of private child daycare centers (t=-2.54, p=.013). There was no significant correlation between teachers' awareness and management attitude of indoor air quality while teachers' awareness of indoor air quality significantly raised the frequency of carpet cleaning. Methods of cleaning routines were significantly correlated with $PM_{10}$, and $CO_2$ levels. Conclusion: The $PM_{10}$ and $CO_2$ concentrations in child daycare centers were satisfactory. Those conditions are affected by general characteristics of child daycare centers and teachers' attitude regarding management of indoor air quality.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.667-670
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• 2005

Ground control points(GCPs) can be extracted from SAR data given precise orbit for DTM generation using optic images and other SAR data. In this study, we extract GCPs from ERS SAR data and SRTM DEM. Although it is very difficult to identify GCPs in ERS SAR image, the geometry of optic image and other SAR data are able to be corrected and more precise DTM can be constructed from stereo optic images. Twenty GCPs were obtained from the ERS SAR data with precise Delft orbit information. After the correction was applied, the mean values of planimetric distance errors of the GCPs were 3.7m, 12.1 and -0.8m with standard deviations of 19.9m, 18.1, and 7.8m in geocentric X, Y, and Z coordinates, respectively. The geometries of SPOT stereo pair were corrected by 13 GCPs, and r.m.s. errors were 405m, 705m and 8.6m in northing, easting and height direction, respectively. And the geometries of RADARS AT stereo pair were corrected by 12 GCPs, and r.m.s. errors were 804m, 7.9m and 6.9m in northing, easting and height direction, respectively. DTMs, through a method of area based matching with pyramid images, were generated by SPOT stereo images and RADARS AT stereo images. Comparison between points of the obtained DTMs and points estimated from a national 1 :5,000 digital map was performed. For DTM by SPOT stereo images, the mean values of distance errors in northing, easting and height direction were respectively -7.6m, 9.6m and -3.1m with standard deviations of 9.1m, 12.0m and 9.1m. For DTM by RADARSAT stereo images, the mean values of distance errors in northing, easting and height direction were respectively -7.6m, 9.6m and -3.1m with standard deviations of 9.1m, 12.0m and 9.1m. These results met the accuracy of DTED level 2