• Tuberculosis and Respiratory Diseases
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• 제68권2호
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• pp.62-66
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• 2010

Background: Extracorporeal membrane oxygenation (ECMO) during severe acute respiratory failure helps to recover the pulmonary function. This study evaluated our experience with veno-venous ECMO in adult patients with acute respiratory failure. Methods: From January 2007 to July 2009, ECMO was used on 54 patients. Of these 54 patients, 7 were placed on veno-venous ECMO for acute respiratory failure. The indications of ECMO were based on the lung dysfunction measured as a $PaO_2/FiO_2$ ratio <100 mm Hg on $FiO_2$ of 1.0, or an arterial blood gas pH <7.25 due to hypercapnia despite the optimal treatment. $EBS^{(R)}$, $Bio-pump^{(R)}$, and Centrifugal Rotaflow $pump^{(R)}$ were used and all cannulations were performed percutaneously via both femoral veins. When the lung function was improved, an attempt was made to wean on ECMO at moderate ventilator settings followed by decannulation. Results: Five of the 7 patients were male and the mean age was $46.3{\pm}18.3$. The causes of acute respiratory failure were 3 cases of pneumonia, 2 near-drownings, 1 pulmonary hemorrhage due to acute hepatic failure and 1 mercury vapor poisoning. The mean support time of ECMO was $17.3{\pm}13.7$ days. Of the 7 patients implanted with ECMO, 5 patients (71%) were weaned off ECMO and 3 patients (43%) survived to hospital discharge after a mean 89.6 hospital days. Conclusion: The early use of ECMO for acute respiratory failure in adults due to any cause is a good therapeutic option for those unresponsive to the optimal conventional treatments.

• 한국환경보건학회지
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• 제34권2호
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• pp.161-169
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• 2008

This study evaluates the protective effects of Korean garlic juice against the toxicity of methyl mercuric chloride (MMC) in relation to fetal ossification in pregnant Fischer 344 rats. This study has as its basis, both theory and data that neutral amino acids in garlic juice have protective effects against mercury poisoning. Pregnant rats were dosed in various combination with 20 mg MMC/kg body wt. and 0.5 or 1.0 garlic juice/kg body wt. on the 7th day of gestation. Fetuses were extracted from the dams on 20th day of gestation, and the fetal bones were stained and measured. The results obtained are as follows: 1. Fetal body weights, body lengths, and head length were significantly decreased by as much as 23.5%, 21.3%, 15.5% respectively in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were almost similar to the controls. 2. The ossification centers were significantly decreased by as much as 35.1% in pelvic phalanges, 53.5% in pectoral phalanges, 74.1% in ternebrae, 76.2% in tail in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $81.2{\sim}88.7%$ and $94.8{\sim}98.9%$ of controls. 3. The ossified pectoral girdles were significantly decreased by as much as 66.6% in clavicle, and in other areas $74.2{\sim}87.4%$ in the 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $81.2{\sim}88.7%$ and $94.8{\sim}98.9%$ of the controls. 4. The ossified pelvic girdles were significantly decreased by as much as 57.1% and 56.1% in two ischium, $67.2{\sim}81.7%$ in metacarpals in the 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $67.0{\sim}85.6%$ and $90.1{\sim}98.7%$ of the controls. 5. The ossified terenebrae were unchanged or significantly decreased; 0.0% in 5th, 54.1% in 1st, 83.9% in 2nd, 75.0% in 3rd, 72.7% in 4th, 79.8% in 6th of 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $29.5{\sim}55.1%$ and $54.5{\sim}84.0%$ of the controls. 6. The ossified ribs were significantly decreased by as much as $8.3{\sim}18.0%$ in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $87.1{\sim}93.5%$ and $96.3{\sim}99.7%$ of the controls. In conclusion, Korean garlic juice significantly protected against the toxicity of MMC in relation to the fetal ossification in pregnant rats.

• 한국식품위생안전성학회지
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• 제22권2호
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• pp.82-87
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• 2007

2006년 1월부터 12월까지 인천관내에 유통 중인 식육부산물을 이용한 복합즉석조리 제품 총 51건을 대상으로 안전성을 검사하였다. 주재료인 식육부산물은 납, 카드뮴, 수은 등 유해중금속 3종의 함량과 발생빈도가 높은 식중독균 9종의 오염여부를 조사하였다. 곱창전골의 주재료인 곱창의 경우는 잔류 ABS도 검사하였다. 복합즉석조리 식품에 포함되어있는 소스류는 대장균군을, 야채류는 잔류농약을 검사하였다. 유해중금속 검사 결과 제품 유형별로 납 $0.073{\sim}0.112ppm$, 카드뮴 $0.006{\sim}0.013ppm$, 수은 $0.746{\sim}0.978ppb$로 조사되어 외국이나 우리나라의 일반식품에 대한 허용기준 보다는 낮은 수준으로 나타났다. 곱창에 대하여 잔류 ABS를 검사한 결과 $0.8ppm{\sim}57.6ppm$(평균 10.3 ppm)이 검출되었다. 식품에 대한 ABS의 허용기준이 정해진 것은 없으나 먹는 물의 허용기준이 0.5ppm인 것과 비교하면 곱창에서 검출되는 ABS의 평균값은 먹는물의 20배를 초과한 수치이다. 식중독균의 오염여부를 조사한 결과 Staphylococcus aureus가 전체 51건 중에서 11건이 분리되어 21.6%의 높은 검출율을 나타냈다. Salmonella spp.는 1건(2.0%)이 검출되었고, Clostridium perfringens는 3건(5.9%)이었다. 제품 유형별로는 곱착전골에 들어있는 곱창 34건 중 12건에서 식중독균이 분리되어 35.3%의 가장 높은 검출율을 보였으며, 부대찌개의 주재료인 햄과 소시지는 25%(2/8), 기타 식육부산물 재료는 20%(1/5)의 검출율을 나타냈다. 선지찌개 중의 선지에서는 식중독균이 검출되지 않았다. 소스류에서 검출된 대장균군은 28.4%(27/95)의 높은 검출율을 보였다. 부재료인 야채류의 잔류농약 검사 결과 총 45건의 시료중 4건에서 농약이 검출되었는데, 클로로타로닐 2.8 ppm, EPN 10.3 ppm, 클로로피리포스 0.4 ppm, 인독사카브 0.7 ppm이었다. 콩나물 33건에서 켑탄과 카벤다짐을 분석한 결과 모두 검출되지 않았다. 연구결과 시판되고 있는 식육부산물을 이용한 복합즉석 조리 식품은 위생상 많은 문제점을 가지고 있었다. 이러한 문제점온 해결하기 위해 현재보다 폭넓고 광범위한 검사가 필요할 것이며, 국민이 안심하고 선택해서 먹을 수 있는 식육부산물을 이용한 복합즉석조리 식품의 생산을 위한 기준과 규격의 보완이 시급한 실정이다.