• Journal of Environmental Health Sciences
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• v.23 no.3
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• pp.50-55
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• 1997

1992년부터 1995년까지 약 4개년 동안 전남 지역에서 사육하고 있는 가축의 유병률을 조사한 결과, 유방염으로 의심이 되는 젖소 970두 중에서 180두(18.6%)가 유방염에 이환되었으며, 돼지 2,400두 중에서 84두(3.5%)가 설사증에 이환되었고, 닭 1,010수중에서 9수(0.9%)가 설사증에 이환되었다. 대장균의 분리율을 조사한결과, 유방염에 이환되어 있는 젖소 180두중 37두(20.6%)에서 대장균이 분리되었으며, 설사증에 이환되어 있는 돼지 84두중 51두(60.7%)에서 대장균이 분리되었고, 설사증에 이환되어 있는 닭 9수중 5수(55.6%)에서 대장균이 분리되었다. Acriflavine을 이용하여 대장균의 S-R변이를 조사한 결과, S-R변이는 mercuric chloride, cysteine, caffeine, glucose, nicotine 등의 순으로 나타났는데, 이중 mercuric chloride가 가장 감수성이 높았다. 대장균의 항균요법제에 대한 감수성은 naxcel, linsmycin, cephalexin, gentamycin등이 높은 감수성을 나타내었는데, S-R변이 후에는 감수성이 일반적으로 저하되는 경향이었다.

• Journal of Pharmaceutical Investigation
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• v.8 no.3
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• pp.1-10
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• 1978

The purpose of this paper was to investigate the bioavailability of sulfadimethoxine in pathological rats and rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows: The absorption of sulfadimethoxine was decreased in rats damaged liver and kidney as compared with that of normal rats. Especially, absorption of sulfadimethoxine in rats damaged liver was more decreased than that of rats damaged kidney. Blood level of sulfadimethoxine administered orally was mostly decreased significantly in rabbits damaged kidney and liver, and in rabbits severely damaged kidney the blood level of sulfadimethoxine was not significant at 4 to 6 hours. Urinary clearance of sulfadimethoxine in rabbits severely damaged kidney was inhibited at 5 to 6 hours. but in rabbit damaged liver. Hepatic clearance of sulfadimethoxine was accelerated in rabbits damaged kidney but in rabbits damaged liver. Protein binding percentage of sulfadimethoxine was not affected by the various concentration of carbon tetrachloride and mercuric chloride respectively.

• Journal of Pharmaceutical Investigation
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• v.9 no.2
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• pp.1-10
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• 1979

The purpose of this paper was to investigate the bioavailability of oxytetracycline in pathological rats and rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows: The blood level of oxytetracycline administered orally was mostly decreased significantly in rabbits damaged kidney and liver, and in rabbits severely damaged kidney, the blood level of oxytetracycline was not significant at 4 to 6 hours. Urinary clearance of oxytetracycline in rabbits severely damaged kidney was inhibited at 5 to 6 hours but in rabbits damaged liver. Hepatic clearance of oxytetracycline was accelerated in rabbits damaged kidney but in rabbits damaged liver. AUC of oxytetracycline orally administered in rabbits damaged liver and kidney was largely decreased. The absorption of oxytetracycline was decreased in rats damaged liver and kidney as compared with that of normal rats. Especially, absorption of oxytetracycline in rats damaged liver was more decreased than that of rats damaged kidney. The absorption of oxytetracycline was inhibited by combinated administration of carbon tetrachloride and mercuric chloride.

• The Korean Journal of Zoology
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• v.37 no.3
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• pp.428-438
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• 1994

HgC12의 투여량에 따른 8일 계배의 대뇌 신경세포 분화에 미치는 영향을 규명하기 위하여 신경세포의 미세구조 변화를 전자현미경을 이용하여 관찰하였으며, 또한 탈수소효소의 활성도 및 ATP의 변화 상을 분석한 결과는 다음과 같다. 대뇌 신경세포의 미세구조의 변화는 0.1mg과 0.5mg 투여 군에서는 핵막이 약간 불규칙하게 관찰되지만 조면소포체와 Golgi복합체가 발달되고 rnltochondria가 다수 관찰되었다 그러나 1.Omg 투여군에서는 조면소포체와 Golgi복합체의 발달이 미약하였으며. 2.Omg 투여군에서는 핵막이 파괴되고 2중막이 분리되었으며, Golgi복합체의 발달이 매우 미약하였다. 탈수소효소 촬성도는 수은의 투여량이 증가할수록 감소하는 현상을 보였는데 LDH의 활성도는 1.Omg투여군이 약간 감소하였고, 2 Omg 투여 군에서는 69n로 크게 감소 현상을 보였다. MDH활성도는 2.Omg투여 군에서 82%로 활성이 감소하는 것으로 나타났다 한편 SDH활성도는 1.Omg투여 군에서 80%. 2.Omg투여군에서는 65%로 활성이 크게 감소하였다. ATP의 변화는 1.Omg투여군 이하에서는 정상군과 유의한 변화는 없으나 2.Omg투여군에서는 크게 증가하는 것으로 나타났다.

• YAKHAK HOEJI
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• v.22 no.4
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• pp.226-232
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• 1978

It was to investigate the absorption, excretion, protein binding of ampicillin in the pathological animals pretreated with carbon tetrachloride and mercuric chloride. The absorption of ampicillin was not affected in rats with damaged liver and kidney as compared with that of normal rats. The blood level of ampicillin after oral administration was increased significantly in rabbits with damaged kidney and liver. The blood level of ampicillin in rabbit with damaged kidney was more increased than that in rabbits with damaged liver. In severly damaged rabbits, it was more increased than that of mildly damaged rabbits. Urinary excretion of ampicillin in pathological animals was more inhibited than that of ampicillin in normals. Hepatic excretion of ampicillin was accelerated in rabbits with damaged kidney. However, in rabbits with damaged liver, it was inhibited as compared with that in normals. Protein binding of ampicillin was slightly enhanced by the various concentration of carbon tetrachloride and mercuric chloride, respectively. The results suggest that the increase of blood level of ampicillin in pathological animals was due to the inhibition of renal excretion.

• Toxicological Research
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• v.9 no.2
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• pp.159-166
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• 1993

The treatmene of V79 cells with diethyl maleate (DEM) led to decrease in glutathione (GSH) level as increasing DEM concentration. Mercuric chloride, treated for 6 hrs with 2ng/ml, affected the GSH metabolizing enzymes glutathione S-transferase (GST) and glutathione peroxidase (GSP), dropping their activities to 60% and 75%, respectively, though not so much in GSH level(80%). However, the toxic effects of mercuric chloride on those enzymes and GSH level were both amplified when the Hg2+ treatment was combined with the preceding DEM treatment.

• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1726-1728
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• 2010

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.385.1-385.1
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• 2002

Cordyceps has been used as a tonic for replenishing vital function in Chinese traditional medicines. As an attempt to obtain fundamental data for the kidney function, MeOH Ex. and its hexane. ethyl acetate, butanol and water fractions of cultivated Cordyceps pruinosa on mercuric chloride induced renal failure rats were investigated. Urin volume. blood parameters(urea nitrogen. uric acid. creatinine) and urinary electrolytes content (natrium. potassium. chloride) were determined. MeOH extract and butanol fraction showed diuretic effect. (omitted)

• Biomedical Science Letters
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• v.14 no.3
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• pp.187-192
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• 2008

To clerify the protective effect of omega-3 of polyunsaturated fatty acid docosahexaenoic acid (DHA) on the cytotoxicity induced by organic mercury in cultured NIH3T3 fibroblasts. The measurement of cell viability on ogranic mercury wad done by XTT assay after NIH3T3 fibroblasts were cultured with various concentrations of methyl mercuric chloride (MMC). And also, the effect of DHA on the MMC-mediated cytotoxicity was examined by cell viability, and antioxidant effect of DHA was also assessed by superoxide dismutase (SOD)-like activity and the lipid peroxidation activity in cultured NIH3T3 fibroblasts. In this study, MMC decreased cell viability and $XTT_{50}$ value was determined at $50{\mu}M$ of MMC in these culture. In the effect of DHA against the cytotoxicity induced by MMC, DHA significantly increased the cell viability damaged by MMC in cultured NIH3T3 fibroblasts. And also, DHA showed the antioxidant effect by showing the increase of SOD-like activity and the decrease of lipid peroxidation activity. From these results, it is suggested that organic mercury such as MMC has highly toxic effect on cultured NIH3T3 fibroblasts, and also, omega-3 of polyunsaturated fatty acid, DHA showed the protection on MMC-induced cytotoxicity and antioxidant effect.

• The Korean Journal of Food And Nutrition
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• v.10 no.2
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• pp.166-173
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• 1997

1993년부터 1995년까지 약 3개년 동안 우리 나라에서 사육하고 있는 가축의 유병율을 조사한 결과, 닭 16,200수 중에서 54수(0.3%)가 괴사성 장염에 이환 되었으며 새끼돼지 620두 중에서 9두(13.8%)가 장독혈증에 이환 되었다. C. perfringens의 분리율을 조사한 결과, 괴사성 장염에 이환 되어있는 닭 54수 중 7수(13.0%)에서 본균이 분리되었으며 장독혈증에 이환 되어있는 새끼돼지 66두 중 14두(21.2%)에서 본균이 분리되었고 장독혈증에 이환 되어있는 소 9두 중 3두(33.3%)에서 본균이 분리되었다. Acriflavine을 이용하여 C. perfringens의 S-R변이를 조사한 결과, S-R변이는 mercuric chloride, nicotine, caffeine, cysteine, glucose 등의 순으로 나타났는데, 이중 mercuric chloride가 가장 감수성이 높았다. C. perfringens의 항균요법제에 대한 감수성은 cepalothin, penicillin, erythromycin, amikacin 등이 높은 감수성을 나타내었는데, S-R변이 후에는 감수성이 일반적으로 저하되는 경향이었다. 중화시험법을 이용하여 C. perfringens의 독소형을 분류한 결과, cd 24균주 중 22균주(91.7%)는 A형이었으며 2균주(8.3%)는 C형이었다.