• 대한한방부인과학회지
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• 제34권4호
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• pp.78-96
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• 2021

Objectives: It is a statistical study to examine the data of CaPSPI (Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification), developed for diagnosis of menopause disorders and to record the status of treatment of it. Methods: From November 1, 2020 to June 19, 2021, 36 cases of data of 33 respondents of the CaPSPI were analyzed. For the use of the basic data of the clinical menopausal disorder, we investigated frequency of menopausal symptoms and the difference between them depending on the period of menopause, and the presentation of usage prescriptions. And the diagnostic results for three kinds' diagnosis [for examination (D1), for treatment (D2), by doctors (D3)] were compared. The diagnostic consistency of D1 and D3 and the statistical significance between DT and disease elements (證素) was investigated. Results: 1. Hot flush was the highest in the symptom survey of the menopause that the subjects complained of, followed by insomnia. There was no significant difference in symptom expression according to menopausal period. 2. The diagnostic consistency of D1 and D2 showed significant diagnostic consistency only in liver depression, and the diagnostic consistency of D1 and D3 showed significant consistency in liver depression and Dual Deficiency of Heart and Spleen. 3. D3' diagnosis and disease elements had statistical significance for cases of P<0.1 was found to be related to the theory of oriental medicine. Conclusions: It is needed to continue to accumulate diagnosis and treatment results through CaPSPI in the future to strengthen the basis for patten identification and treatment of menopause disorders.

• 대한영양사협회학술지
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• 제27권1호
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• pp.1-14
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• 2021

This study aimed to investigate the relationship between meal regularity (i.e. breakfast intake and meal-times), and the risk of metabolic syndrome (MetS) among generally healthy Korean single-person household adults (≤60 years, n=594) based on the Seventh Korean National Health Examination and Nutrition Survey (KNHANES) (2016~2018). Among men (n=325), the breakfast intake frequency was not significantly associated with the pervalence of MetS. However, men consuming a regular meal at least once a day showed a lower prevalence of MetS compared to those whose meals were irregular. These patterns remained after adjusting for age, smoking and drinking habits, individual income, education level, exercise, and total calorie intake. An association between meal regularity and MetS risk was observed in post-menopausal women (n=84), but not in pre-menopausal women (n=185). More specifically post-menopausal women with irregular breakfast eating habits or eating no breakfast at all showed a significantly higher risk of MetS than those eating breakfast regularly after the adjustment. The analysis revealed an odds ratio (OR) of 8.46, confidence intervals (CIs): 1.149~62.199, P<0.05 in irregular breakfast eaters, and an OR of 13.377, CIs: 1.665~107.511, P<0.05, in those who ate no breakfast. Furthermore, post-menopausal women who had irregular meals daily showed a higher risk of MetS than those consuming one or more regular meals/day after the adjustment (OR: 16.888, CIs: 1.258~226.655, P<0.05). In conclusion, the results from this study may be used for formulating optimal dietary guidelines for the prevention and the management of MetS in adults in single-person households.

• 대한한방내과학회지
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• 제40권1호
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• pp.154-163
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• 2019

Objective: We report on the administration progression and adverse event of Er-Xian decoction for menopausal hot flushes. A hot flush is a rapid and intense heat-dissipation reaction that involves considerable sweating, enlargement of the peripheral blood vessels, and internal body heat. Er-Xian decoction is a prescription for treating menopausal hot flush symptoms in postmenopausal women. We report administration progression and adverse event of Er-Xian decoction for menopausal hot flush. Methods: We used the Menopause Rating Scale and Menopause-Specific Quality of Life questionnaire to evaluate the progression of hot flushes, and we conducted a literature review to determine the effective dosage of Er-Xian decoction. Result: In all cases, Facial hot flushes and evaluation variables were improved by the administration of EXD. However, in Case 1, a rise of liver function indexes which may be related to EXD administration was observed. Conclusion: Considering that menopausal flushing usually lasts for several years, The resluts are meaningful that the short-term administration of EXD led to improvement of symptoms. In order to further use EXD in the future, it will be necessary to conduct follow-up studies on the subject of safety verification, such as repeated dose toxicity studies.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.322-326
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• 1998

In order to evaluate menopausal syndrome objectively, examinations were performed as follows: 1) Simplified Menopausal Index (SMI Koyama) and QOL questionnaire (Nagata) were examined subjectively. 2) Urine 17-KS-5 (S Nishikaze), 17-OHCS (OH) were examined objectively. 3) A mobile telemedical device with EKG and KSG was lent to Patients. The subjects were 48 menopausal patients who visited our university hospital as outpatients. According to the results of 5, OH, the subjects were divided into 4 Groups; Group I is high S & high OH, Group ll low S & low OH, Group 111 is low S & high OH, Group tl is high S & low OH. Group IH was the largest (64.6%), Group of was none. The subjects showed significantly lower QOL condition and higher score of SMI. In the QOL, questionnaire items of fixation to physical status (psychogenic reaction), sleep (insomnia), pain(chronic pain) were in common. In SMI, functional vascular symptoms were the largest number. On treatment, Group I was considered to have no need for supplementary agents, but anti-Oketsu agents was prescribed. For Group ll and in some supplementary agents such as red ginseng were prescribed, because they showed low 5. In conclusion, all the groups showed a sign- nificant improvement of QOL and SMI. Group I showed a decrease of OH, Group ll showed an increase of 5, Group In showed an increase of S and SIOH and a decrease of OH. These phenomena were considered prohomeostatic. In QOL, the items of chronic pain, insomnia and appetite were improved. In SMI, chillness, dyspnea, palpitation, pain and fatigability were improved. In mobile tole-medical device, abnormal findings were found in 88.2% of patients. General sdaptation syndrome (Selye, H.) is considered to adjust human life. Menopause is the transit period to exhausted stage in it. So its symptoms vary from person to person. In conclusion, 5 and OH are useful both for classification of menopausal syndrome and for determining treatments according to the classification

• 비만대사연구학술지
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• 제2권2호
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• pp.54-63
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• 2023

Estrogen is crucial in regulating food intake, energy expenditure, glucose metabolism, and lipid metabolism. During menopause, the decline in estrogen levels predisposes women to weight gain, abdominal obesity, insulin resistance, type 2 diabetes, hypertension, and cardiovascular disease (CVD). Menopausal hormone therapy (MHT) prevents weight gain, improves lipid metabolism by lowering low-density lipoprotein cholesterol while raising high-density lipoprotein cholesterol, and delays the onset of type 2 diabetes in menopausal women. The effect of MHT on CVD in menopausal women remains controversial. The Women's Health Initiative study was terminated prematurely after it revealed that hormone administration increased the risk of myocardial infarction, stroke, and thromboembolism. However, some studies have found that MHT had no effect or decreased the risk of CVD. The inconsistent results were likely due to multiple factors, including the timing of hormone therapy initiation, duration of therapy, type and dosage, and presence or absence of CVD risk factors at the start of treatment. Despite its benefits in terms of managing weight gain and reducing the risk of type 2 diabetes, dyslipidemia, and CVD associated with obesity, it is not recommended as the primary therapy for weight loss or diabetes prevention. MHT is primarily indicated for postmenopausal women, who are likely to benefit from its potential to prevent weight gain and improve lipid metabolism.

• 여성건강간호학회지
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• 제22권4호
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• pp.275-286
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• 2016

Purpose: This study explored influencing factors on quality of life (QoL) above middle-aged women in relation to demographic factors, health-related factors, menopausal status, metabolic syndrome (MS) and its risk factors. Methods: This study was secondary data analysis from the Sixth Korea National Health and Nutrition Examination Survey 2013~2015 that utilized a complex, multi-stage probability sample design. Study sample of 2,310 was inclusive of (28.8%) of women who were over 40. To evaluate the factors that would influence an impaired quality of life, $x^2$ test, GLM, and logistic regression analysis were done. Results: Level of quality of life was lower in women with late post-menopause(over 10 years since menopause) than women with pre-menopause. Factors influencing impaired QoL were as follows: graduated middle school and elementary school or less (OR=2.43, 4.42, respectively, p<.05), no job (OR=1.92, p<.001), stress (OR=1.92, p=.001), depression (OR=1.93, p=.001), insufficient sleep (OR=1.64, p=.003), late post-menopause (OR=2.61, p=.044) and over 85cm of waist circumference (OR=1.76, p=.01). Conclusion: These results suggest that late post-menopause may be an independent factor influencing an impaired QoL. To promote post-menopausal womens' health, a nursing strategy is required to teach women how to manage levels of stress, depression, insufficient sleep, and abdominal obesity through health education, nutritional counselling, and physical activity program.

• 대한한의학원전학회지
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• 제26권4호
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• pp.267-280
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• 2013

Objective : One of the unique syndromes in Asian traditional medicine named 'heat entering the blood chamber(熱入血室, HEBC)' first appeared in Shanghanlun(傷寒論) and Jinguiyaolue(金匱要略) written by Zhangzhongjing(張仲景) who is the most famous doctor in ancient China. Method : Through comparison between Huangdineijing(黃帝內經), Shanghanlun(傷寒論), Jinguiyaolue(金匱要略) and other medical texts, the correct meaning, causes and mechanisms of HEBC can be analysed and organized to suggest new view of HEBC in modern society. Result : This syndrome is usually occurred in women during catching cold and menstruation, accompanying alternation of chillness and fever, pseudo-malaria, delirium, raveled chest(結胸), uterine hemorrhage, etc. The main sign of this syndrome, delirium belongs to the category of liver disease and fever in Huangdineijing(黃帝內經) which is a document more early published than Shanghanlun. Although there are still many other comprehensions about what blood chamber is, it could be the same as uterus according to Huangdineijing, it is relevant to the control of menstruation and emotions, and the function of liver and thoroughfare vessel(衝脈). Conclusion : HEBC is a syndrome exclusive to women, caused by their unique physical and psychological characteristics. It's beginning can be found in Huangdineijing, and by Shanghanlun and Jinguiyaolue, its concept as a single disease pattern becomes established. In other words, HEBC is a complex disease related to menstruation and its related hormonal dysfunctions, closely related to PMS, menopausal syndrome of today. Physical symptoms accompanied by psychological anxiety and fear is characteristic of this condition. Therefore gynecological approaches as well as socio-cultural issues related to women in modern society must be adopted when dealing with HEBC.

• 정신신체의학
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• 제4권1호
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• pp.109-119
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• 1996

최근 호르몬 대치요법으로 갱년기 증상들만 없어질 뿐 아니라 심장질환, 골다공증 등의 예방은 물론이고 젊음의 유지 및 삶의 질이 높아지자 산부인과 의사는 물론이고 정신과 의사들도 갱년기 증상에 대해서 다시 더 많은 관심을 갖게 되었다. 그리하여 저자는 일반 정신과 의사들이 갱년기 증상을 이해하는데 도움을 주기 위하여 갱년기 증상중 정신과와 관련이 있는 열성홍조와 갱년기 우울증을 중심으로 다음과 같은 몇 가지 점을 문헌고찰을 통하여 재검토하였다. 갱년기 및 폐경기의 정의. 갱년기의 생리(난소의 노화, 주간 율동의 변화, 초일주기 율동의 변화, 시신경교차 상부핵의 일주기 율동의 변화), 혈관운동성 홍조(정의와 병태생리, 원인, 진단, 치료), 갱년기 우울증(정의, 원인, 치료) 등을 재고찰하여 보았다.

• 근관절건강학회지
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• 제30권3호
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• pp.179-188
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• 2023

Purpose: This study was conducted to investigate the prevalence and related factors of metabolic syndrome in postmenopausal adult women in South Korea. Methods: Data of 678 postmenopausal adult women aged 19 to 64 were collected from the Eighth Korea National Health and Nutrition Examination Survey in 2021 and analyzed by a complex sampling design using SPSS 20.1. Results: The prevalence of metabolic syndrome in postmenopausal adult women was 25.8%. The prevalence was 1.93 times (confidence interval [CI]=1.15~3.25, p=.014) higher for high school graduates, 2.55 times (CI=1.33~4.91, p=.005) higher for middle school graduates, and 2.90 times (CI=1.36~6.15, p=.006) higher for elementary school graduates, compared to college graduates. It was found that artificial menopausal women had 2.74 times (CI=1.18~6.38, p=.020) higher prevalence than natural menopausal women. In addition, women who perceived their health as bad were 1.90 times (CI=1.14~3.16, p=.014) higher than women who perceived their health as good, and women who did not muscle exercise more than twice a week had 1.87 times (CI=1.05~3.34, p=.034) higher prevalence than women who did muscle exercise. Conclusion: Therefore, in order to effectively prevent and manage metabolic syndrome in postmenopausal adult women, a focus must be placed on vulnerable groups to manage these factors.

• 대한한방부인과학회지
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• 제24권4호
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• pp.114-125
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• 2011

Objectives: To understand relations general characteristics, lifestyle habits including smoking, alcohol habit, exercise, eating habit and menopausal symptoms measurement indicators during treatment for hot flush in menopausal women. Methods: The participants were 159 women (45~60 yr) who were not currently on hormone therapy, and had reached hot flash scores of 10 or higher. The evaluating indexes of this trial are hot flush score, hot flush visual analogue scale(VAS), Hot flush consistence time, sweating visual analogue scale(VAS), Menopause Rating Scale(MRS), Menopause-specific quality of life questionnaire(MENQOL), Kupperman's Index. Results: 1. When the participants divided according to body mass index(BMI), overweight group showed a high score in all indicators. Therefore, obesity can aggravate the symptoms of menopause. 2. When the participants divided according to drinking habits, Hot flush consistence time of non-alcohol group showed a statistically significant difference. However, the sample size is uneven. Additional studies will be needed. 3. When the participants divided according to eating habits, Hot flush consistence time of regular group showed a statistically significant difference. However, the sample size uneven. Additional studies will be needed. 4. When the participants was divided depending on whether exercise, non-exercise group showed a high score in all indicators. Thus, exercise will be able to improve menopausal symptoms. Conclusions: Improvement of obesity and exercise will be able to improve menopausal symptoms.