• Biotechnology and Bioprocess Engineering:BBE
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• v.8 no.3
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• pp.192-198
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• 2003

BiP, immunoglobulin binding protein, is an ER homologue of Hsp70. However, unlit other Hsp70 proteins, regulatory protein(s) for BiP has not been identified. Here, we demo strafed the presence of potential regulatory proteins for BiP using a pull -down assay. Since BiP can bind any unfolded protein, only the ATPase domain of BiP was used for the pull -down assay in order to minimize nonspecific binding. The ATPase domain was cloned to produce recombinant protein, which was then conjugated to CNBr-activated agarose. The structural conformation and ATP hydrolysis activity of the recombinant ATPase domain were similar to those of the native protein, light proteins from metabolically labeled mouse plasmacytoma cells specifically bound to the recombinant ATPase protein. The binding of these proteins was inhibited by excess amounts of free ATPase protein, and was dependent on the presence of ATP. These proteins were eluted by ADP. Of these proteins, Grp170 and BiP where identified. while the other were not identified as known ER proteins, from Western blot analyses. The presence of the ATPase-binding proteins for BiP was first demonstrated in this study, and our data suggest similar regulatory machinery for BiP may exist in the ER, as found in prokaryotes and other cellular compartments.

• Earthquakes and Structures
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• v.9 no.5
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• pp.957-981
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• 2015

Earthquakes occur as a cluster in many regions around the world where complex fault systems exist. The repeated shaking usually induces accumulative damage to affected structures. Damage accumulation in structural systems increases their level of degradation in stiffness and also reduces their strength. Many existing analytical tools of modeling RC structures lack the salient damage features that account for stiffness and strength degradation resulting from repeated earthquake loading. Therefore, these tools are inadequate to study the response of structures in regions prone to multiple earthquakes hazard. The objective of this paper is twofold: (a) develop a tool that contains appropriate damage features for the numerical analysis of RC structures subjected to more than one earthquake; and (b) conduct a parametric study that investigates the effects of multiple earthquakes on the response of RC moment resisting frame systems. For this purpose, macroscopic constitutive models of concrete and steel materials that contain the aforementioned damage features and are capable of accurately capturing materials degrading behavior, are selected and implemented into fiber-based finite element software. Furthermore, finite element models that utilize the implemented concrete and steel stress-strain hysteresis are developed. The models are then subjected to selected sets of earthquake sequences. The results presented in this study clearly indicate that the response of degrading structural systems is appreciably influenced by strong-motion sequences in a manner that cannot be predicted from simple analysis. It also confirms that the effects of multiple earthquakes on earthquake safety can be very considerable.

• Korean Institute of Interior Design Journal
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• v.23 no.2
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• pp.51-61
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• 2014

Aesthetics of use for modern people can be regarded as being weighted toward universal and rational function since it has focused on an 'automation and efficiency' and 'smartness' in terms of technological and human engineering position. Thus, aesthetics of use as an individual agent has remained in minimal level. This study attempts to seek conceptual model of design regarding the behavior of users from the systematization of critical theories about the usability. To do that, 'HERTZAIN TALES' written by Anthony Dune and the concept and system of Droog Design have been used as a core standard. In line with the various experiments by artist groups such as Fluxus, Memphis group and the work of product semantics, and inherent characteristics of Droog design, which has surfaced from the 1990s, concepts that has mentioned in the Hertzain tales have been organized into main texts. By overcoming cognitive bias inherent in the material culture and by overcoming an existing usability based on immateriality and dialectic solution, the autonomy of critical design and instrumentality of Droog design have been systemized. By interpreting the design aspect of 12 pieces that have been submitted to the RE;MIND section, the core of this study, it has been confirmed that conceptual and critical design's aesthetics of use From the interpretation of the design aspect of 12 pieces that have been submitted to the RE;MIND section, the core of this study, it has been confirmed that conceptual and critical design's aesthetics of use has established the autonomy and independence of the behavior of users, created functional articulation of materials and secured new conceptual model and thus, could be an effective methodical clue for creating an emergent design.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.5 s.51
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• pp.11-23
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• 2006

This paper evaluates the seismic response of multi-span prestressed concrete girder bridges typically found in the New Madrid Seismic Zone region of the central United States. Using detailed nonlinear analytical models and synthetic ground motion records for Memphis, TN, nonlinear response history analyses are performed for two levels of ground motion: 10% probability of exceedance (PE) in 50 years, and 2% probability of exceedance (PE) in 50 years. The results show that the bridge performance is very good fur the 10% PE in 50 years ground motion level. However, the performance for the 2% PE in 50 years ground motion is not so good because it results in highly inelastic behavior of the bridge. Impact between decks results in large ductility demands on the columns, and failure of the bearings that support the girders. It is found that making the superstructure continuous, which is commonly performed for reducing dead load moments and maintenance requirements, results in significant improvement in the seismic response of prestressed concrete girder bridges.

• Advances in concrete construction
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• v.2 no.3
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• pp.177-192
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• 2014

One of the main applications of FRP composites is confining concrete columns. Hence identifying the cyclic and monotonic stress-strain behavior of confined concrete columns and the parameters influencing this behavior is inevitable. Two significant parameters affecting the stress-strain behavior are aspect ratio and corner radius. The present study aims to scrutinize the effects of corner radius and aspect ratio on different aspects of stress-strain behavior of FRP confined concrete specimens (rectangular, square and circular). Hence 44 FRP confined concrete specimens were tested and the results of the tests were investigated. The findings indicated that for specimens with different aspect ratios, the relationship between the ultimate stress and the corner radius is linear and the variations of the ultimate stress versus the corner radius decreases as a result of an increase in aspect ratio. It was also observed that increase of the corner radius results in increase of the compressive strength and ultimate axial strain and increase of the aspect ratio causes an increase of the ultimate axial strain but a decrease of the compressive strength. Investigation of the ultimate condition showed that the FRP hoop rupture strain is smaller in comparison with the one obtained from the tensile coupon test and also the ultimate axial strain and confined concrete strength are smaller when a prism is under monotonic loading. Other important results of this study were, an increase in the axial strain during the early stage of unloading paths and increase of the confining effect of FRP jacket with the increase and decrease of the corner radius and aspect ratio respectively, a decrease in the slope of reloading branches with cycle repetitions and the independence of this trend from the variations of the aspect ratio and corner radius and also quadric relationship between the number of each cycle and the plastic strain of the same cycle as well as the independence of this relationship from the aspect ratio and corner radius.

• Journal of Korean Neurosurgical Society
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• v.30 no.4
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• pp.493-500
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• 2001

Objective : Anterior cervical locking plates are the devices for achieving anterior cervical spinal fusion. This study was conducted to evaluate the locking plate system regarding its long-term advantages and disadvantages in the view of interbody fusion rate, hardware-related failures, vertebral change close to the fusion segment and postoperative complications. Method : Eight-six patients, operated from Jan., 1996 to Jun. 1998, were followed-up for more than two years. All of the cases were fused with iliac bone graft and ORION locking plate(Sofamor Danek USA, Inc., Memphis, TN) fixation. The patients were discharged or transferred to rehabilitation department 2-7 days after operation. A comprehensive evaluation of the interbody fusion state, instrument failure, vertebral change and postoperative complications were made by direct interview and cervical flexion-extension lateral plain films. Results : There were 55 male and 31 female with a mean age of 45 years(18-75 years). The mean follow-up period was 29 months(24-43 months). Various disorders that were operated were 40 cervical discs, 6 cervical stenosis including OPLL, 2 infections, and 38 traumas. Fusion level was single in 59 cases, two levels of each disc space in 15 cases, and two levels after one corpectomy in 12 cases. There was no instrument failure. Pseudoarthrosis was observed in two cases(2%) without radiological instability. The other patients(98%) showed complete cervical fusion with stable instrument. Mild settling of interbody graft with upward migration of screws was found in 12 cases(14%). Anterior bony growth at the upper segment was found in 5 cases(6%). Postoperative foreign body sensation or dysphagia was observed in 12 cases(4%), and disappeared within one month in 7 cases and within six months in 4 cases. One patient complained for more than six months and required reoperation to remove paraesophageal granulation tissue. Conclusion : The results show that Orion cervical locking plate has some disadvantages of upward migration of screws, anterior bony growth at the upper segment, or possibility of esophageal compression even though it has advantages of high interbody fusion rate or low instrument failure. Author believe that anterior cervical locking plate in the future should be thinner, and should have short end from the screw hole, and movable screw with adequate stability.

• Korean Journal of Health Education and Promotion
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• v.31 no.4
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• pp.63-72
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• 2014

Objectives: The current study reviews the implementation and evaluation of the Chronic Disease Self-Management Program (CDSMP) in the United States (U.S.) to illustrate the program's potential contribution to improving health among Korean adults with chronic conditions while saving healthcare costs. Methods: This study examines existing literature on the history, theoretical background, essential elements, and delivery outcomes of CDSMP with special focus on the successes and challenges to be faced in the implementation of CDSMP to Koreans with chronic conditions. Results: CDSMP is designed to empower people with chronic conditions to develop skills necessary for medical, social role, and emotional management of chronic conditions. Recent studies show the utility of CDSMP in achieving the Triple Aim health reform goals (i.e., better care, better health, better value). Lessons learned from the U.S. experience emphasize the importance of establishing evidence-based studies, collaborating with community partners, and diversifying funding sources to make CDSMP more sustainable. Conclusion: The current study demonstrates the replicability of CDSMP and potential for expansion in Korea. More concerted efforts among academia, government, and communities are needed to deliver CDSMP to Korean adults and identify its effectiveness within the Korean context in terms of meeting the Triple Aim goals of better care, better health, and better value.

• The Journal of Society for e-Business Studies
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• v.17 no.2
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• pp.165-187
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• 2012

Improvements on the incumbent R&D project management structure and performance evaluation criteria in the telecommunication and broadcasting area have been called for. There have been attempts to develop alternative R&D project performance evaluation criteria. In an attempt to develop an alternative measure, this study integrates two different perspectives on R&D projects and various criteria currently being used by many foreign and domestic institutes. As a result, we have developed an alternative R&D project performance evaluation instrument. Then, we have applied the instrument to Korean cases in order to validate it. The new R&D project performance evaluation criteria can contribute to an improvement on the management of R&D projects in the telecommunication and broadcasting area.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.437-446
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• 2016

This paper is to research on the characteristics of the recipient furniture design that requires changes reflected in the contemporary socio-cultural factors in the convergence culture, as represented by the digital and IT. The purpose of this study is, as specific methods therefore, to research in both perspectives the design of the after industrial revolution of functionalism and the case of the Memphis group which is expressed the appearance of diverse social atmosphere of the 20th century. Based on this, it will illuminate the appearance of the furniture designs recipient requires changes in universal modern society of values of complex convergence. To reveal that sociocultural factors that accept values of society are important in predicting the future of furniture design is the object of this study. It recognizes that a key element of modern furniture design will be based on a broad and deep study.

• Culinary science and hospitality research
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• v.21 no.5
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• pp.192-203
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• 2015

Internal marketing has been considered as a way of achieving higher service quality and customer satisfaction in the service industry. However, the definitions and implementation of internal marketing varies by researcher. Therefore, the purpose of this study was to explore an explanatory internal marketing mix that can be utilized in the foodservice industry. Using a web-based survey method, a total of 405 usable samples were collected and used in the data analysis. Five internal marketing components (i.e., vision, development, reward, employee motivation, and internal communication) were adopted from previous literature, and the results indicated significant impacts of the internal marketing mix on employee job satisfaction.