• Title/Summary/Keyword: medical center

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Immunoscintigraphy of Colon Cancers

  • Lee, Bum-Woo;Han, Chang-Soon;Kim, Hak-San;Kim, Chong-Soon;Lee, Bong-Wha;Yoon, Jong-Hyun
    • 대한핵의학회:학술대회논문집
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    • 1987.05a
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    • pp.131.1-131.1
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    • 1987

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Evolution of Radiological Treatment Response Assessments for Cancer Immunotherapy: From iRECIST to Radiomics and Artificial Intelligence

  • Nari Kim;Eun Sung Lee;Sang Eun Won;Mihyun Yang;Amy Junghyun Lee;Youngbin Shin;Yousun Ko;Junhee Pyo;Hyo Jung Park;Kyung Won, Kim
    • Korean Journal of Radiology
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    • v.23 no.11
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    • pp.1089-1101
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    • 2022

  • Immunotherapy has revolutionized and opened a new paradigm for cancer treatment. In the era of immunotherapy and molecular targeted therapy, precision medicine has gained emphasis, and an early response assessment is a key element of this approach. Treatment response assessment for immunotherapy is challenging for radiologists because of the rapid development of immunotherapeutic agents, from immune checkpoint inhibitors to chimeric antigen receptor-T cells, with which many radiologists may not be familiar, and the atypical responses to therapy, such as pseudoprogression and hyperprogression. Therefore, new response assessment methods such as immune response assessment, functional/molecular imaging biomarkers, and artificial intelligence (including radiomics and machine learning approaches) have been developed and investigated. Radiologists should be aware of recent trends in immunotherapy development and new response assessment methods.

  • https://doi.org/10.3348/kjr.2022.0225 인용 PDF

The Effect of Pulsatile Flow on Ultrafiltration In-Vitro Study and Comparison with Roller Pump

  • Lee K.;Jeong J. H.;Mun C. H.;Lee J. C.;Min B. G.
    • Journal of Biomedical Engineering Research
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    • v.26 no.5
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    • pp.337-341
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    • 2005

  • Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.

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