• Asian Pacific Journal of Cancer Prevention
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• 제17권sup1호
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• pp.37-42
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• 2016

Studies have shown that smoking is a learnt behavior, often initiated during adolescence. This paper aims to describe tobacco-related knowledge, attitude and associations among school adolescents aged 13-15 with exposure to anti-smoking information. Using data from the Global Youth Tobacco Survey (GYTS) in Viet Nam, 2014, knowledge was measured through 4 questions about tobacco use, and attitude was assessed through 3 questions on personal, social and environmental aspects. Students giving most anti-tobacco responses to all questions were considered as having correct knowledge or appropriate attitude or both. Access to anti-smoking information was determined by exposure to any media messages on tobacco control during the past 30 days and teaching in school about the danger of tobacco use during the past 12 months. A substantial percentage of students thought that being near others who smoke might be harmful to them and smoking is harmful to health (89.4% and 89.6% respectively). However, only 46.4% reported that it is definitely difficult to quit smoking and 66.9% thought that smoking for only 1 or 2 years, once stopped, is harmful to health. Slightly more than half of the respondents reported appropriate attitude that young smokers have fewer friends than others and smoking makes them less attractive and less comfortable at social events. Noticing anti-smoking messages in the media together with having lessons in school about the dangers of tobacco substantially increased the likelihood of having correct knowledge, appropriate attitude and both. Despite relatively high awareness about smoking harms, effective educational communication is still highly needed to improve the level of comprehensive knowledge and an appropriate attitude regarding tobacco use.

• 한국환경보건학회지
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• 제40권2호
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• pp.114-126
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• 2014

Objectives: We aimed to develop a measurement method of five metabolites of trichloroethylene (TCE) in a concurrent biological sample, e.g., trichloroacetic acid (TCA), dichloroacetic acid (DCA), S-(1,2-dichlorovinyl) glutathione (DCVG), S-(1,2-dichlorovinyl)-L-cysteine (DCVC), and N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine (NAcDCVC) and to validate the method before application to pharmacokinetic study. Methods: TCE metabolites were simultaneously analyzed using high performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS) with as little as 50 ${\mu}L$ of serum and urine. DCA, TCA and NAcDCVC were extracted with diethyl ether, while DCVC and DCVG were extracted by solid phase extraction. This method was validated according to the guidelines for bioanalytical method validation of the Korean National Institute of Toxicological Research. Then, we determined the five metabolites in five strains of mice at 24 hr after exposure to 1 g TCE /kg body weight. Results: The limits of detection for the five metabolites in biological samples ranged from 0.001 to 0.076 nmol/mL, which is comparable to or better than those previously reported. Most calibration curves showed good linearity ($R^2=0.99$), and between-batch variation was less than 20% expressing acceptable robustness and reproducibility. Using this method, we found TCA and DCA were detected in all test mice at 24 hr after the oral administration while NAcDCVC and DCVC were detected in some strains, which showed strain-dependent metabolism of TCE. Conclusions: The present method could provide robust and accurate measurements of major key metabolites of TCE in biological media, which allowed concurrent analysis of TCE metabolism for limited amounts of biospecimens.

• 생태와환경
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• 제39권2호통권116호
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• pp.209-218
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• 2006

두 종의 초식성 동물플랑크톤(Daphnia magna. Moina macrocopa)의 직접노출 밀도차(0, 4, 8개체)와 동물플랑크톤 배양여과액(ZCMF) 농도차(0, 25, 50%)에 따른, 두남조 Microcystis aeruginosa와 Planktothrix agardhii의 생체량과 세포내 microcystin(MC)을 1일 간격으로 측정하였고, 직접노출실험의 경우 동물플랑크톤 생존륜을 1일 간격으로 관찰하였다. 동물플랑크톤 직접노출 실험 결과, 두 균주에서 세포내 MC함량이 증가하였으며 (rm-ANOVA: P< 0.039), P. agardhii균주에서는 4개체 처리군(ZT1)보다 8개체 처리군(ZT2)에서 통계적으로 유의한 수준으로 높은 세포내 MC값이 관찰되었다(Tukey test. P<0.082).세포내 MC가 최고값을 보인 3일 또는 4일째에, 처리군들은 대조군에 비하여 통계적으로 유의한 차이를 보였다(One-way ANOVA, P< 0.021). ZCMF에 노출시킨 M. aeruginosa균주에서 세포내 MC함량이 통계적으로 유의한 수준으로 차이가 있었다(rm-ANOVA: P< 0.004), 실험기간동안 세포내 MC값은 M. aeruginosa균주에서 25%처리군 보다 50%처리군에서 통계적으로 유의한 수준으로 높게 나타났다(Tukey test, Plt; 0.025). 본연구결과, 세포내 MC량은 초식성 동물플랑크톤의 직접노출 밀도차와 분비화학물질(infochemical)농도차에 의존하여 증가 혹은 변화될수 있는 가능성이 있는 것으로 나타났으며, 부영양호에서 독성 남조 번성 조절시, 이러한 가능성을 고려하여 생물조절이 이루어져야 할 것으로 보인다.

• Clinical and Experimental Reproductive Medicine
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• 제1권1호
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• pp.1-14
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• 1974

Data from this study support the View that the following factors are not sufficiently important in Korea to invalidate the relationships observed between age of marriage and fertility: (1) Premarital pregnancy and common law marriage, (2) shortening of birth intervals in late marriages, (3) adverse effects of very eary marriage in reproductive capacity, and (4) postponement of first pregnancy among early marriages. Thirteen variables which were considered to be potential predictors of fertility were studied to determine their influence on three indices of fertility. Age of marriage and family planning praetice are the strongest predictors and account for about 10% and 7% of the total variance, respectively. Seven other factors each account for an intermediate amount of variability; these are ideal number of children, rural versus urban study area, education, aspiration for daughter, index of exposure to mass media, economic index of respondent's home at survey, and residence before marriage. The remaining variables have no consistently significant relationship to fertility. Most of the relationships appear to be stable and consistent over time; others appear to be changing. The latter group include those variables which are associated with modernization indices of family planning practice, mass media exposure. and aspiration for daughters. Thus, the index of family planning practice is of limited significance for the $40{\sim}49$ age group but is the most important variable for the $20{\sim}29$ year women. The relationship is a direct one for the two age groups between 30 and 49 years which suggests that these groups already had high fertility when family planning services became available and that this high fertility then became an inducement to acccept contraception. The pattern of relationship is not yet clear for the $20{\sim}29$ year group. Similar interactions are observed for the other indices of modernity and are discussed. The thirteen variables together can account for a maximum of about 40% of the variance in the number of live births in the age group $30{\sim}39$, and for lesser amounts of variance in other age and fertility groupings.

• 고전문학과교육
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• 제15호
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• pp.329-353
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• 2008

Tasan Jeong Yak-yong is great scholar, who makes a synthesis of Sil-hak[實學, Practical Science of Korea], reformer of society, and a poet in the Joseon Dynasty. He expressed contradiction and conflict of those days by intellectual language, and reperceived basic ideology of the Joseon society. Also he theorized dissatisfaction of the people about those days and its system as form of religion. We can divide Tasan's life into two times. The first part is his ages 16~39 in the period of Jeong-jo(1777~1800). The second part is in the period of Sun-jo(1801~1834). In this period, he was exiled into Gang-jin for 17 years. After banishment, he lived a quiet life for the rest of his life in his hometown. His allegoric poetry were written in this second period. The special feature of allegoric poetry is strong satire. An allegory would be that is 'king's ear', which the barber has sight, or the barber's voice, which has divulged king's secret among the bamboos. Otherwise it would be that is the sound 'king's ear is donkey's ear' in the bamboos. This sound is divulging of the true donkey's ear. It doesn't travel to audiences, but travels trough wind in the bamboos. The narration exists just as story that barber can't stand to keep silence about king's secret. There are exposure of true and critical motive as allegoric expression. Tasan's allegoric poetry stand on the basis of his love for the people. Also there reveals his thought deeply with an enormous amount of reading and self-communion. Moreover there are his warm mind with his sharp insight in which captures alive lives as allegoric materials. Most of allegoric poetry satirize actuality of those days to make an excuse for external distinguishing marks of animals and plants. However Tasan's poetry are different from them. After he grasped serious problems from his contemporary actuality, and then choosed allegoric media to express correctly. Because he grasped the special features of lives after minute observation, he could exposure controversial point of the actual. His sharp insight was not limited to allegoric media. He noticed his period and the current of his society sensitively. It made his allegoric poetry as important materials to make us to know the condition of the people in the Joseon Dynasty. Tasan's allegoric poetry is inherited by Baek Seok[白石, 1912~1995] as regular juvenile literature. Baek Seok's juvenile stories are the results of expansion and transition for Tasan's allegoric poetry. Allegoric poetry was the shout of barber to prosecute about social irregularities and contradiction, and the sound of the bamboos to travel moaning of the people in the past. Now allegoric poetry create new emotion to make us to speculate ourselves with our surrounding. This changes are caused by special feature of allegoric poetry as a form to reflect our general lives.

• 생명과학회지
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• 제12권6호
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• pp.812-820
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• 2002

이 연구는 주변의 김치들을 수거하여 젖산에 내성을 가진 Leuconostoc mesenteroides을 선택배지를 이용하여 분리하고, 지방산 조성을 분석하여 동정한 결과, Leuconostoc mesenteroides LM3균주로 동정했다. 이어서 그의 성장패턴을 관찰하고, 유도기와 지수성장기에서 젖산을 첨가한 결과 성장저해가 일어났음을 확인했으며, 젖산의 최종농도가 0.4%이상인 배지에서는 성장속도가 느려짐을 알았다. 그리고 정지기시작단계에서 고농도의 젖산을 단시간 처리하였을 때, 대조균주가 생존하지 못하는 4%농도에서도 Leuconostoc mesenteroides LM3군주가 생존하는 것을 확인하여 산에 대한 내성이 뛰어남을 알 수 있었다. 이에 trehalose 농도의 변화, 그리고 trehalase와 ATPase 활성을 측정하였고, 이를 통해 젖산에 의한 세포내의 변화를 관찰하였다. 그 결과, 각 성장시기별로 0.6% 젖산을 첨가했을 때 Leuconostoc mesenteroides LM3균주가 trehalose 축적률이 높아졌으나 trehalase활성엔 큰 변화가 없었다. ATPase 활성은 감소하는 경향을 보였으나 시기별 활성은 일정하였고, 세포내 pH를 측정한 결과 Leuconostoc mesenteroides LM3균주는 pH 6으로 일정하게 유지되었다.

• 방송공학회논문지
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• 제22권6호
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• pp.702-712
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• 2017

본 논문에서는 신호 구조에 가중치 맵으로써 Laplacian을 이용한 언샤프 마스킹과 평균 밝기에 가중치 맵으로써 영상의 평균 밝기를 이용한 감마 변환 알고리듬을 제안하고자 한다. 패치를 기반으로 한 기존의 가중치 맵은 신호 구조 및 평균 밝기 영역에서 영상 내 밝기 값이 한쪽으로 치우쳐 세부 정보가 손실되는 단점이 있다. 본 논문에서는 패치 단위의 언샤프 마스킹을 이용하여 세부정보를 향상시켰고, 전역적 및 지역적 영상의 평균 밝기 값을 이용하여 감마 변환된 값을 선형 결합한 기법을 제안한다. 제안하는 알고리듬은 영상 내 윤곽선과 같은 세부 정보를 보존시키고 빛의 밝기 조절을 통해 주관적 화질을 향상시켰다. 실험 결과를 통해 기존 알고리듬에 비해 제안한 알고리듬이 우수한 성능을 나타내는 것을 확인하였다.

• Environmental Analysis Health and Toxicology
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• 제30권
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• pp.7.1-7.7
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• 2015

Objectives The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity profiling of graphene family nanano-materials (GFNs) in alternative in vitro and in vivo toxicity testing models. Methods The GFNs used in this study are graphene nanoplatelets ([GNPs]-pristine, carboxylate [COOH] and amide [$NH_2$]) and graphene oxides (single layer [SLGO] and few layers [FLGO]). The human bronchial epithelial cells (Beas2B cells) as in vitro system and the nematode Caenorhabditis elegans as in vivo system were used to profile the toxicity response of GFNs. Cytotoxicity assays, colony formation assay for cellular toxicity and reproduction potentiality in C. elegans were used as end points to evaluate the GFNs' toxicity. Results In general, GNPs exhibited higher toxicity than GOs in Beas2B cells, and among the GNPs the order of toxicity was pristine > $NH_2$ > COOH. Although the order of toxicity of the GNPs was maintained in C. elegans reproductive toxicity, but GOs were found to be more toxic in the worms than GNPs. In both systems, SLGO exhibited profoundly greater dose dependency than FLGO. The possible reason of their differential toxicity lay in their distinctive physicochemical characteristics and agglomeration behavior in the exposure media. Conclusions The present study revealed that the toxicity of GFNs is dependent on the graphene nanomaterial's physical forms, surface functionalizations, number of layers, dose, time of exposure and obviously, on the alternative model systems used for toxicity assessment.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제15권12호
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• pp.983-987
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• 2009

유아들의 언어습득에 있어서 중요한 점 하나는 학습자에 대한 언어환경의 노출이다. 유아가 접하는 언어환경은 부모와 같은 인간뿐만 아니라 각종 미디어와 같은 인공적 환경도 포함되며, 유아는 이러한 방대한 언어환경을 탐색하면서 언어를 학습한다. 본 연구는 대용량의 언어 데이터 노출이 영향을 미치는 유아언어학습을 유연하고 적절하게 모사하는 인지적 기제에 따른 기계학습 방식을 제안한다. 유아의 초기 언어학습은 문장수준의 학습과 생성 같은 행동들이 수반되는데, 이는 언어 코퍼스에 대한 노출만으로 모사가 가능하다. 모사의 핵심은 언어 하이퍼망 구조를 가진 기억기반 학습모델이다. 언어 하이퍼망은 언어구성 요소들 간의 상위차원 관계 표상을 가능케 함으로써 새로운 데이터 스트림에 대해 유사구조의 적용과 이용을 도모하여 발달적이고 점진적인 학습을 모사한다. 본 연구에서는 11 개의 유아용 비디오로부터 추출한 문장 32744개를 언어 하이퍼망을 통한 점진적 학습을 수행하여 문장을 생성해 유아의 점진적, 발달적 학습을 모사하였다.

• 한국항행학회논문지
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• 제15권3호
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• pp.378-385
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• 2011

본 논문은 개인용 컴퓨터에서 발생할 수 있는 프라이버시 영상 및 음성 정보 수집의 기술적 문제를 지적하고 이에 대응하기 위한 방안을 제시한다. 개인용 컴퓨터와 노트북의 사용이 보편화되면서 주변 기기들의 보급 또한 늘어나고 있으며 특히 카메라와 마이크의 경우 개인 프라이버시에 대한 침해가 일어날 수 있어 각별한 주의가 필요하다. 현재 카메라의 경우 사용 여부를 표시하기 위해 점멸등이 장착되어 있으나 그렇지 않은 경우가 대부분이며, 마이크의 경우에는 사용 여부를 표시하기 위한 수단이 전혀 준비되어 있지 않다. 이러한 허점은 장치 사용에는 아무런 문제가 되지 않으나, 사용자가 인지하지 못하는 시점에 악의적인 공격자에 의해 장치가 동작하여 영상이나 음성 같은 정보가 노출되어 개인 프라이버시의 침해를 일으킬 수 있다. 따라서 본 논문은 이를 대응하기 위하여 개인용 컴퓨터에 연결된 카메라와 마이크에 대한 접근을 시도하는 경우 이를 감지하여 사용자에게 통보하기 위한 방안을 제시하고 실제의 도청감시 소프트웨어 및 대응 소프트웨어를 구현하여 실험하였다. 제안한 방안을 실제 환경에 적용하면 프라이버시 노출문제를 효과적으로 해결할 수 있을 것으로 사료된다.