• Journal of Biomedical Engineering Research
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• v.34 no.1
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• pp.40-45
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• 2013

The conventional simulators used the expensive commercial artificial heart with a limited performance, and focused on replicating the heart function. The arterial pressure is the key factor of the cardiovascular disease. The purpose of this study is to develop a simulator focused on the pressure wave. The simulator is composed of a step motor, slider-crank mechanism, piston-cylinder, two check valves, a elastic tube, and two reservoirs. With the changes of design parameters, the functions of the simulator were evaluated. The simulator shows the good agreement of the characteristics of the cardiovascular system.

• The Journal of the Korea Contents Association
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• v.6 no.5
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• pp.9-13
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• 2006

Due to the miniaturization and the network supporting functions of home appliances, there is growing need for mobile environment home network system which provides flexibility, mobility and convenience to users. In this environment, a interactive authentication between mobile devices is important but the related works have no enough convenience to users. This paper proposes a interactive device authentication mechanism using Home Robot and also shows its design and implementation.

• BMB Reports
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• v.51 no.3
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• pp.106-118
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• 2018

How the organ size is adjusted to the proper size during development and how organs know that they reach the original size during regeneration remain long-standing questions. Based on studies using multiple model organisms and approaches for over 20 years, a consensus has been established that the Hippo pathway plays crucial roles in controlling organ size and maintaining tissue homeostasis. Given the significance of these processes, the dysregulation of the Hippo pathway has also implicated various diseases, such as tissue degeneration and cancer. By regulating the downstream transcriptional coactivators YAP and TAZ, the Hippo pathway coordinates cell proliferation and apoptosis in response to a variety of signals including cell contact inhibition, polarity, mechanical sensation and soluble factors. Since the core components and their functions of the Hippo pathway are evolutionarily conserved, this pathway serves as a global regulator of organ size control. Therefore, further investigation of the regulatory mechanisms will provide physiological insights to better understand tissue homeostasis. In this review, the historical developments and current understandings of the regulatory mechanism of Hippo signaling pathway are discussed.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.2
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• pp.13-22
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• 2008

For the accuracy correction of the micro-positioning industrial robot, micro-manipulator has been devised. The compliant mechanisms using piezoelectric actuators is necessary geometrically and structurally to be developed by the optimization approaches. The overall geometric advantage as the mechanical efficiencies of the mechanism are considered as objective functions, which respectively art the ratio of output displacement to input force, and their constraints are the vertical notion of supporting leg and the structural strength of manipulation. In optimizing the compliant mechanical amplifier, the sequential linear programming and an optimality criteria method are used for the geometrical dimensions of compliant bridges and flexure hinges. This paper presents the integrated design process which not only can maximize the mechanism feasibilities but also can ensure the positioning accuracy and sufficient workspace. Experiment and simulation are presented for validating the design process through the comparisons of the kinematical and structural performances.

• Journal of Information Technology Applications and Management
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• v.13 no.4
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• pp.181-195
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• 2006

In recent years, increasing attention has been paid on how to manage a successful relationships between the receiver and provider of the Information Systems(IS) outsourcing services. This study explores the sources of influence for successful outsourcing relationships. Based on the Jaworski's control combination model for marketing, we (1) propose a management combination model of outsourcing relationships where trust is introduced as an intervening variable and outsourcing compleyity as a moderating variable, (2) test this model using a sample of 94 outsourcing projects in 36 organizations that have outsourced there IS functions to external service providers. The results indicated several significant findings. First, the deployment of management mechanism such as contract mechanism and trust building has a significant effect on the outsourcing success through trust only. Second, complexity of outsourcing activities has a moderating effect on relationship management combinations.

• The Transactions of the Korea Information Processing Society
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• v.6 no.3
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• pp.553-561
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• 1999

The facility of schema evolution is necessary in object-oriented database applications. There exist several versions of schema and instances created under different versions of the schema concurrently in the database. This base proposes a mechanism for supporting accessing instances regardless of versions of the schema in schema evolution environments in object oriented databases. There is trade-off between the flexibility of schema modification operations and the system overhead for supporting such schema modifications. Access handling routines are provided to the undefined attributes in each version of the class. Access handling routines are also defined for each pair of semantics rather than defining backdate/update functions for each pair of versions of a class. Thus, this mechanism supports the change of semantics with reduced user and system overhead.

• Journal of Drive and Control
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• v.13 no.2
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• pp.51-58
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• 2016

The present study deals with the issue of clamping force control of an injection molding machine using 2-way cartridge valve based logic circuit. The operating principle for the cartridge valve is described with its construction and static opening behavior. Basic module circuits are designed first and analysed according to the basic functions. Then they are combined with a virtual design model for the clamping mechanism to simulate the control performance of the overall system. The backlash inherent in the mechanism is considered while evaluating the time-delay in the process of clamping force build-up. The effects of a couple of design parameters in backlash, i.e., interval and stiffness have been demonstrated in the time-domain.

• Structural Engineering and Mechanics
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• v.91 no.3
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• pp.291-300
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• 2024

This paper predicts the combined resonance behavior of the truncated conical shells (TCSs) under transverse and parametric coupled excitation. The motion governing equation is formulated in the framework of high-order shear deformation theory, von Kármán theory and Hamilton principle. The displacements and boundary conditions are characterized by a set of displacement shape functions with double Fourier series. Subsequently, the method of varying amplitude (MVA) is utilized to derive the approximate analytical solution of system response of TCSs. A comparative analysis is conducted to verify the accuracy of the current computational method. Additionally, the interaction mechanism of combined resonance, parametric resonance and primary resonance is examined. And the effect of damping coefficient, the external excitation, initial phase, axial motion speed, temperature variation, humidity variation, material properties and semi-vortex angle on the vibration mechanism are analyzed.

• Biomolecules & Therapeutics
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• v.23 no.3
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• pp.233-237
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• 2015

Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Shikonin significantly relaxed fluoride-, thromboxane $A_2$- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, shikonin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and the inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of shikonin on agonist-induced vascular contraction regardless of endothelial function.

• Journal of the Korean Chemical Society
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• v.53 no.4
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• pp.427-431
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• 2009

The thermodynamical mechanism of the extraction of soybean isoflavones from soybean residuals using organic solvent method has been studied. On the basis of experiments, a simple model for determining the distribution coefficients in organic solvent extraction was employed to calculate the thermodynamical functions between $K,\;{\Delta}H^0,\;{\Delta}S^0\;and\;{\Delta}G^0$ in the soybean isoflavones extraction process. The results show that the soybean isoflavones extraction is an endothermic and an entropy-increasing process: the ${\Delta}G^0$ decreases when the temperature arises.