• 한국기계가공학회지
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• 제15권4호
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• pp.30-39
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• 2016

There have been many cases of deaths from crushing caused by dense crowds. Numerous studies about pedestrian flow have performed various simulations, but the experimental data to prove the simulations are still not enough. In this paper, the evacuation of pedestrians for proving pedestrian flow simulation is observed. Due to the possibility of real casualties, it is difficult to experiment with humans directly. Therefore, ten C57BL/6NCrSIc mice have been used. It is assumed that C57BL/6NCrSIc mice act like humans in panic situations. Electrical Stimulus Experiments on mice are conducted for exits with various angles. ICY software is applied in this paper. As a result, the mice escape fast at a proper angle of 45 to 60 degrees.

• Restorative Dentistry and Endodontics
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• 제27권6호
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• pp.587-599
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• 2002

Extracellular single unit recordings were made from the ventral posteromedial thalamic (VPM) nociceptive neurons to determine mechanoreceptive field (RF) and response properties. A total of 44 VPM thalamic nociceptive neurons were isolated from rats anesthetized with urethane-chloralose. Based on responses to various mechanical stimuli including touch, pressure and pinch applied to the RF, 32 of 44 neurons were classified as nociceptive specific (NS) neuron. The other 12 neurons, classified as wide dynamic range (WDR), showed a graded response to increasingly intense stimuli, with a maximum discharge to noxious pinch. The VPM nociceptive neurons showed various spontaneous activity ranged from 0-6 Hz. They were located throughout the VPM, and had an contralateral RF including mainly intraoral (and perioral) regions. The RF size was relatively small, and very few neurons had a receptive field involving 3 trigeminal divisions. The NS neurons activated only by pressure and pinch stimuli had high mechanical thresholds compared to WDR neurons activated also by touch stimuli. The VPM nociceptive neurons were tested with suprathershold graded mechanical stimuli. Most of 21 NS and 8 WDR neurons showed a progressive increase in number of spikes as mechanical stimulus intensity was increased. In some neurons, the responses reached a peak before the highest intensity was given. Application of 5 mM $CoCl_2{\;}(10{\;}{\mu}\ell)$ solution to the trigeminal subnucleus caudalis did not produce any significant changes in the spontaneous activity, RF size, mechanical threshold, and response to suprathreshold mechanical stimuli of 9 VPM nociceptive neurons tested. 17 of 33 VPM nociceptive neurons responded to noxious heat as well as noxious mechanical stimuli applied to their RF. Application of the mustard oil, a small-fiber excitant and inflammatory irritant, to the right maxillary first molar tooth pulp induced an immediate but short-lasting neuronal discharges upto approximately 4 min in 16 of 42 VPM nociceptive neurons. These results suggest that VPM thalamic nucleus may contribute to the sensory discriminative aspect of orofacial nociception.

• International Journal of Oral Biology
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• 제33권2호
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• pp.51-58
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• 2008

A mutation of UNCL, an inner nuclear membrane RNAbinding protein, has been found to eliminate mechanotransduction in Drosophila. UNCL is expressed in human periodontal tissue including in periodontal ligament (PDL) fibroblasts. However, it is unclear how a mechanical stimulus is translated into cellular responses in PDL fibroblasts. The aim of this study was to evaluate the effect of UNCl on mechanical stress related genes in PDL fibroblasts in response to mechanical stress. The mRNA of TGF-$\beta$, COX-2, and MMP-2 was up-regulated after UNCL inactivation in PDL fibroblasts under the compression force. Under the tensile force, inactivation of UNCL decreased the expression of Biglycan, RANKL, MMP-2, and TIMP-2 mRNAs while it increased the expression of TIMP-1. p38-MAPK was expressed in PDL fibroblasts under compression forces whereas phospho-ERK1/2, p65-NFkB, and c-fos were expressed under tension forces. The expression and phosphorylation of the mechanical stress related genes, kinases, and transcription factors were changed according to the types of stress. Furthermore, most of them were regulated by the inactivation of UNCL. This suggests that UNCL is involved in the regulation of mechanical stress related genes through the signaling pathway in PDL fibroblasts.

• 대한기계학회논문집B
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• 제36권11호
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• pp.1091-1097
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• 2012

최근 현실감을 주는 3D 영화에 진동, 바람과 같이 감각 정보를 추가하여 시각 자극으로 유도되는 운동지각을 향상시키기 위한 시도가 이루어지고 있으나, 추가적인 감각 정보에 의한 운동지각 변화를 정량화하는 연구는 많지 않다. 따라서 본 연구에서는 회전하는 시각 자극과 함께 추가적인 감각 정보를 가하여 그에 따른 운동지각과 이를 정량화하는 것에 대해 연구하였다. 가해진 시각 자극에 대해 피험자의 몸의 기울어짐과 피험자가 느끼는 지표면을 나타내는 체성 감각 막대의 각도를 측정한 결과 추가적인 감각 정보로 인해 운동지각은 증가하는 경향을 보였으며 칼만 필터를 이용하여 구한 시각 정보의 중요도 또한 증가함을 보였다. 따라서 시각 자극과 일치하는 다른 감각 정보는 시각 자극으로 유도되는 운동지각과 시각의 중요도를 증가시키는 경향이 있음을 알 수 있다.

• International Journal of Aeronautical and Space Sciences
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• 제16권3호
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• pp.418-424
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• 2015

The chemical response of energetic materials is analyzed in terms of 1) the thermal decomposition under the thermal stimulus and 2) the reactive flow upon the mechanical impact, both of which give rise to an exothermic thermal runaway or an explosion. The present study aims at building a set of chemical kinetics that can precisely model both thermal and impact initiation of a heavily aluminized cyclotrimethylene-trinitramine (RDX) which contains 35% of aluminum. For a thermal decomposition model, the differential scanning calorimetry (DSC) measurement is used together with the Friedman isoconversional method for defining the frequency factor and activation energy in the form of Arrhenius rate law that are extracted from the evolution of product mass fraction. As for modelling the impact response, a series of unconfined rate stick data are used to construct the size effect curve which represents the relationship between detonation velocity and inverse radius of the sample. For validation of the modeled results, a cook-off test and a pressure chamber test are used to compare the predicted chemical response of the aluminized RDX that is either thermally or mechanically loaded.

• 한국정보통신학회논문지
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• 제25권10호
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• pp.1427-1434
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• 2021

본 연구는 사회성 상호작용 훈련자극에 반응하는 아동의 행동 및 정서적 긴장상태를 연산하는 심리반응 상태 추정 프로세스를 제안한다. 행동 중재에 필요한 훈련자극으로는 공동 주의(Joint attention) 사회성 훈련을 채택하고, 훈련프로토콜은 불연속 개별시도 훈련(DTT: Discrete trial training)기법이 적용된다. 공동 주의 훈련에서 사용자의 집중과 긴장 정도를 확인하기 위해 3가지 훈련자극용 콘텐츠를 구성한 후, 캐릭터 형태의 탁상 로봇을 이용하여 사용자에게 훈련자극을 수행하게 된다. 그런 다음, 비전 기반 헤드 포즈 인식기와 기하학 연산모델로 사용자 응시반응을 추정하고, PPG와 GSR의 생체신호를 심박변이도와 히스토그램 기법으로 신경계 반응을 분석한다. 로봇을 활용한 실험에서 공동 주의에 대한 각 콘텐츠 별 훈련에 사용자의 심리반응을 정량화 할 수 있음을 확인하였다.

• 대한기계학회논문집A
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• 제31권8호
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• pp.817-825
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• 2007

During thirty years, deterministic chaos has moved center stage in many areas of applied mathematics. One important stimulus for this, particularly in the early 1970s, was work on nonlinear aspects of the dynamics of plant and animal populations. There are many situations, at least to a crude first approximation, by a simple first-order difference equation. Past studies have shown that such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behavior, from stable points, to a bifurcating hierarchy of stable cycles, to apparently random fluctuations. But higher-order spectral analyses of such behavior are usually not considered. Higher-order spectra of a signal contain important information that is not present in its power spectrum. So, if we find the spectral pattern and get information from it, it will be able to be used effectively in so many fields. Hence, this paper uses auto bicoherence and bicoherence residue which are sort of bispectrum. Applying these to behavior of logistic difference equation, which is typical chaotic signal, the phenomenon of phase coupling and the appearance of frequency band can be analyzed. Such information means that bispectral analysis is useful to detect nonlinearity of signal.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.711-712
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• 2002

A numerical study of a hemodynamical model for the tumor angiogenesis is carried out. The tumor angiogenesis process is comprised of a sequence of events; secretion of tumor angiogenesis factor(TAF) from the solid tumor, degradation of the basement membrane of nearby blood vessels, migration and proliferation of the endothelial cells. The model takes into account the effect of TAF concentration and endothelial cell density, and their conservation equations are represented as a set of one-dimensional initial boundary value problems. These equations are discretized by using a finite difference method in which the second order schemes both in time and in space are used. The effects of the parameters contained in the model are Investigated extensively through the numerical simulation of the discretized model. The result for the typical case compares very well with the known result.

• 동의신경정신과학회지
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• 제19권2호
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• pp.299-312
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• 2008

Headache is symptom of many people suffered. It caused simply by fatigue, stress, but it also caused by inflammation, mechanical or chemical stimulus, circulation disorder, brain damage. Modern societies develop rapidly by traffic system. But lately it suffering with many traffic problem. Traffic accident is most important of many traffic problem. We experienced a 35 year-old female who complained headache, caused by a traffic accident that happened 22 month ago. We treated the patient by the way of Eo-hyeol (瘀血) type of headache with Herbal medication and Acupuncture. After being treated, the patient show that symptoms(headache, insomnia, anorexia) was improved considerably. This result suggests that oriental medicine treatment has good effect on headache due to traffic accident.

• 한국정밀공학회지
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• 제20권12호
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• pp.198-204
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• 2003

The bone fracture healing is simulated by using one of the complex system rules, named cellular automata method. It is assumed that each cell has property of Bone, Cartilage or Fibrous connective tissue. Nine local rules are adopted to change the property of each cell against the mechanical stimulus, which consists of the strain energy density, and the existence of bone in the surroundings. Two dimensional sheep metatarsal model is considered and the bone fracture healing is simulated. The simulation results agree well with those obtained by using fuzzy logic model and experimental data. The cellular automata method found to be one of the simulation methods to express the bone fracture healing. The cellular automata method is expected to be effective in representing biological phenomenon.