• 대한치매학회지
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• 제22권3호
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• pp.100-108
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• 2023

Background and Purpose: The efficacy and safety of GV1001 have been demonstrated in patients with moderate-to-severe Alzheimer's disease (AD). In this study, we aimed to further demonstrate the effectiveness of GV1001 using subscales of the Severe Impairment Battery (SIB), which is a validated measure to assess cognitive function in patients with moderate-to-severe AD. Methods: We performed a post hoc analysis of data from a 6 month, multicenter, phase 2, randomized, double-blind, placebo-controlled trial with GV1001 (ClinicalTrials.gov, NCT03184467). Patients were randomized to receive either GV1001 or a placebo for 24 weeks. In the current study, nine subscales of SIB-social interaction, memory, orientation, language, attention, praxis, visuospatial ability, construction, and orientation to name-were compared between the treatment (GV1001 1.12 mg) and placebo groups at weeks 12 and 24. The safety endpoints for these patients were also determined based on adverse events. Results: In addition to the considerable beneficial effect of GV1001 on the SIB total score, GV1001 1.12 mg showed the most significant effect on language function at 24 weeks compared to placebo in both the full analysis set (FAS) and per-protocol set (PPS) (p=0.017 and p=0.011, respectively). The rate of adverse events did not differ significantly between the 2 groups. Conclusions: Patients with moderate-to-severe AD receiving GV1001 had greater language benefits than those receiving placebo, as measured using the SIB language subscale.

• Journal of Chest Surgery
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• 제48권5호
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• pp.345-350
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• 2015

Background: Conventional stripping is considered to be the standard procedure for great saphenous vein (GSV) varicosities, but many other alternative treatments such as cryostripping, endovenous laser therapy (EVLT), radiofrequency ablation, and ultrasound-guided foam sclerotherapy have been developed. Among them, both cryostripping and laser therapy have been reported to be less traumatic, with lower rates of complications and recurrences when compared to conventional stripping. To compare the efficacy of these treatments, we have analyzed and compared the mid-term clinical outcomes of cryostripping and EVLT. Methods: Patients diagnosed with varicose veins of the GSV and treated with cryostripping or laser therapy between September 2008 and April 2013 were enrolled in this study. Duplex ultrasonography was used for the diagnosis and evaluation of varicosity and reflux, and the clinical-etiology-anatomy-pathophysiology classification was used to measure the clinical severity. The symptoms, Venous Clinical Severity Score (VCSS), recurrence rates, and complication rates of the cryostripping and laser therapy groups were analyzed and compared. Results: A total of 68 patients were enrolled in this study. 32 patients were treated with cryostripping, and 36 patients were treated with laser therapy. The median follow-up period was 29.6 months. Recurrence was noted in three patients from the cryostripping group and in two patients from the EVLT group. There was no difference in the VCSS score, operative time, duration of hospital stay, and complication rate between the cryostripping group and the EVLT group. Conclusion: The mid-term clinical outcomes of cryostripping were not inferior to those of EVLT. Further, considering its cost-effectiveness, cryostripping seems to be a safe and feasible method for the treatment of varicose veins.

• 동의신경정신과학회지
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• 제16권2호
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• pp.13-24
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• 2005

Background and Objectives : Acupuncture as a therapeutic intervention is widely used for the treatment of many functional disorders such as substance abuse and mental dysfunction. Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug addiction. Yet, there are still many unanswered questions about the basic mechanism of acupuncture. Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and raised the possibility that both of these effects may be linked to the same or closely overlapping the mesolimbic dopamine systems. Neiguan (PC6) point on the pericardium channel which is associated with the brain and its mental function, has been used to treat mental, psychosomatic disorders and gastroenterological disorders. The present study was designed to investigate the effect of acupuncture on repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and to measure the effect of acupuncture on Fos-like immunoreactivity. Methods : Male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5 mg/kg, s.c.). Acupuncture was applied at bilateral Neiguan (PC6) points for 1 min after the morphine challenge. Results showed that acupuncture at the specific acupoint PC6, but not at control points (tail and HE8) significantly decreased Fos-like immunoreactivity induced by a systemic morphine challenge or a single s.c. morphine injection in the morphine-repeated animals. Results and Conclusions : These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts. Moreover, in a more general sense these results suggest that acupuncture can be used as a therapeutic intervention for correcting reversible malfunction of the body by direction of brain pathway and thus acupuncture can contribute to the biochemical balance in the central nervous system by regulating neurotransmitters.

• Journal of Acupuncture Research
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• 제33권1호
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• pp.103-116
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• 2016

Objectives : This study was performed to assess the effectiveness of conservative Korean traditional medical treatment on lumbar intervertebral disc herniation in 12 adolescents. Methods : Data were collected from adolescent patients diagnosed with lumbar intervertebral herniation by MRI, hospitalized at Jaseng Korean Medicine Hospital from January 1, 2014 to December 31, 2015. A total of 12 patients were included in the study. Patients were treated by acupuncture, pharmacopuncture, electroacupuncture, herbal medicine, chuna manual therapy, physical therapy during hospitalization period. To measure treatment outcomes, a verbal numerical rating scale (VNRS), Oswestry disability index (ODI), range of motion (ROM), Straight leg raising test (SLR), and EQ-5D were used. Results : The average age of the participants was $16.05{\pm}1.62$. The average of duration of symptom was $19.25{\pm}26.83(weeks)$ and the average length of hospitalization was $23.8{\pm}16.4(days)$. 2 patients (17 %) suffered from only lumbar pain, while 10 patients (83 %) suffered from lumbar and leg pain. No participant suffered from only leg pain. 8 patients (67 %) were diagnosed with disc herniation in one segment, and 4 patients (33 %) were diagnosed with disc herniation in multiple segments. A total of 17 disc segments (28 %) were herniated. The most herniated lumbar level was L4-5. 3 segments were diagnosed with bulging (17 %), 6 with protrusion (35 %), and 8 with extrusion (47 %). Extrusion was the most frequent herniated type. After treatment, the average VNRS of lumbar pain significantly decreased from $5.58{\pm}1.62$ to $2.91{\pm}1.56$ (p<0.001) and the average VNRS of leg pain significantly decreased from $5.16{\pm}2.51$ to $3.08{\pm}1.8$ (p<0.001). ODI significantly decreased from $48.87{\pm}18.72$ to $28.57{\pm}15.05$ (p<0.05), and EQ-5D significantly increased $0.58{\pm}0.31$ to $0.80{\pm}0.12$ (p<0.05). Range of flexion significantly improved from $61.25{\pm}32.62$ to $68.33{\pm}26.22$ (p<0.05). Conclusion : Conservative Korean Traditional Medical Treatment may be effective in the treatment of lumbar intervertebral disc herniation in adolescence. However, more case reports and clinical research are needed.

• 항공우주정책ㆍ법학회지
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• 제29권1호
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• pp.97-126
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• 2014

October 4, 1957 the Soviet Sputnik 1 was launched into space the first time in the history of mankind. After launching, the realm of humankind was expanded to space. Today all countries of the world wage a fierce competition in order to utilize space for various purposes. World powers of space such as United States, Russia, China, and Japan, put reconnaissance satellites and ocean surveillance satellites into orbit, being able to easily see equipment and troops movement on earth. Each country makes efforts to occupy space assets through the militarization of space and expand national interests. Recently private companies or individuals involved in commercial space activities are becoming more prevalent. Thus, in addition to space activities for military purposes, commercial space activities become widespread. Individuals and private companies as well as nations are also involved in space activities. Outer space is not the monopoly of space powers such as the United States and Russia. The whole human race can benefit from free access to space, being the common heritage of mankind. In particular, outer space becomes an indispensable element of military activities and human life. Many countries are now entering space development, putting a lot of budget into new development programs. Republic of Korea also built the Narodo Space Center, starting its space development with budget and manpower. We have to find out ways to use space not only for military purposes but also for commercial space activities that can contribute to the national economy. In addition, through the joint efforts of the international community, we have to make efforts for preservation and peaceful use of space. Various issues relating to space activities and research should be studies in order to contribute to the progress of humanity. Those issues include the definition of outer space, space debris reduction and environmental conservation issues, non-bind measure cooperation - European International Code of Conduct, space law and national legislation related empowerment issues, arms control measures in space, and restrictions on the use of nuclear fuel. We also need to be involved in the discussion of those issues as one of responsible space countries. In addition, we try to find out regional cooperation schemes such as the ESA in the Europe actively. Currently in the Northeast Asia, cooperation bodies led by Japan and China respectively, are operated in the confrontational way. To avoid such confrontation, a new cooperative body needs to be established for cooperation on space exploration and information. The system to allow the exchange of satellite information for early warning of natural disasters needs to be built as well. In addition, efforts to enhance the effectiveness of the relevant international treaties on space, and fill in the blanks in international space laws should be made at the same time. To this end, we have to do a leading role in the establishment of standards such as non-binding measures (resolution) - Code of Conduct, being discussed in the UN and other organizations, and compliance with those standards. Courses in aerospace should be requires in law schools and educational institutes, and professional manpower need to be nurtured. In addition, the space-related technology and policy needs to be jointly studied among the private, public, and military groups, and the cross exchange among them should be encouraged.

• 한국의학물리학회지:의학물리
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• 제28권4호
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• pp.190-196
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• 2017

For the $ViewRay^{(R)}$ system (ViewRay Inc., Cleveland, OH, USA) which is representative of magnetic resonance (MR) guided radiotherapy machine, it is important to evaluate effectiveness of AAPM's TG-51 protocol and the effect of the magnetic field on absolute dosimetry. In order to measure the absolute dose, MR-compatible chamber and water phantom system manufactured in this study were used. The materials of the water phantom system were plastic of polymethyl methacrylate (PMMA) and non-ferrous materials. Due to the inherent feature of the $ViewRay^{(R)}$, all Co-60 sources are not located at gantry angle of $0^{\circ}$ while being located at gantry angle of $90^{\circ}$. For this reason, absolute dosimetry was performed based on the measurements in solid water phantom (SWP) and water which determine the SWP to water correction factor. For evaluation of output constancy with gantry angle, measurements were made with ionization chamber inserted in cylindrical water-equivalent phantom. For measured doses in water, the values of dose deviation according to a reference dose of 200 cGy for Head 1, Head 2 and Head 3 were -0.27%, -0.45% and -0.22%, respectively. For measured doses in SWP, the values of dose deviation according to a reference dose of 200 cGy for Head 1, Head 2 and Head 3 were -1.91%, -2.07% and -1.84%, respectively. All values of dose measured in SWP tended to be less than those measured in water by -1.63%. With the reference gantry angles of $0^{\circ}$ and $90^{\circ}$, the maximum values of deviation for Head 1, Head 2 and Head 3 were 0.48%, 1.06% and 0.40%, respectively. The measurement agreement is within the range of results obtainable for conventional treatment machines. The low strength of the magnetic field does not affect dose measurements. Using the SWP to water correction factor, absolute doses for $ViewRay^{(R)}$ system can be measured.

• 유통과학연구
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• 제13권11호
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• pp.69-77
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• 2015

Purpose - Economic status at an early stage of life after one's retirement is often determined by the long-term sacrifice of one's earlier consumption tendencies. In general, the first and foremost way to secure income after retirement is through annuity savings. People sign up for personal annuity savings in order to guarantee a stable economic life upon retirement, and such actions may be heavily influenced by self-efficacy. Confidence in current economic activity is a source of rational decision-making. Inability to achieve self-control can lead to reckless spending and the eventual hindering of proper investment for the future. This paper examines how self-efficacy and self-control affect the intention and action of enrolling in an annuity savings plan in relation to one's level of financial literacy. Research design, data, and methodology - To analyze the proposed model, this study investigates financial consumers over the age of 20. The data were collected from 511 respondents and analyzed with SPSS 21.0 and AMOS 21.0. First, for the one-dimensional test and to measure the convergent validity of each structure, we use the scale purification process. The results of the test and the confirmatory factor analysis ensure the focus of the validity of the single dimension for each structure. In addition, the validity of the measurement was guaranteed from the results of correlation analysis. Results - First, self-efficacy and self-control have positive effects on the purchasing intention of the personal annuity savings plan. Second, purchasing intention positively affects purchasing behavior. Lastly, self-control has a positive effect on purchasing intention among the low financial literacy group, whereas self-efficacy does not have this effect in the high financial literacy one. Conclusions - The time of product benefit is different with age. The younger group would be granted the savings after several decades once they enroll, whereas the older group would wait for a relatively shorter period of time. Therefore, further research should be conducted in order to verify such a difference. However, this study has value through its confirmation that the roles of self-efficacy and self-control play a part in leading to the enrollment in annuity savings plans and by verifying different effects based on levels of financial literacy. Such results suggest a number of implications in a real life setting. First, banks need to put greater emphasis on the stability of annuity savings in general. Second, customers with relatively low levels of financial literacy are able to control their finances through annuity savings, but find self-efficacy difficult due to a lack of financial understanding. Therefore, such customers should be approached from an invest-effectiveness comparison method. Third, customers with high financial literacy tend to put more value in rational economic decision-making and behavior than in self-efficacy. Therefore, such customers should be approached by promoting the reliability of annuity savings and the excellence of the specific bank's annuity savings plan in comparison to those of other financial institutions.

• 대한교통학회지
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• 제21권5호
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• pp.31-40
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• 2003

우리나라의 비신호교차로의 유형은 양방향정지식과 무통제식으로 분류될 수 있다. 무통제식은 국내외에서도 용량이나 서비스수준 분석에 관한 연구가 거의 전무하다. 본 연구에서는 이러한 유형의 무통제 교차로의 서비스 수준을 분석할 수 있는 방법론을 개발하는 것을 목표로 하였다. 우선 무통제 교차로의 서비스수준을 평가할 수 있는 효과척도 선정을 위한 분석을 수행하였다. 교통량, 상충횟수, 교차로 통행시간(지체) 등을 분석한 결과, 상충횟수과 교통량이 선형의 관계를 가지고 있는 것으로 나타나 이 2가지를 효과척도로 선정하였다. 서비스수준 E와 F의 경계가 되는 교통량(용량)은 1985 USHCM의 전방향정지식 교차로의 용량을 참고로 2000대/시로 하였으며 이때 상충횟수는 300회가 된다. 그리고 서비스수준별 상충횟수와 교통량을 용량상태를 기준으로 비례적으로 배분하였다. 교차로 총교통량으로 서비스수준을 결정할 때. 방향별 교통량비가 상충횟수에 영향을 주는 것으로 분석되어 방향별 교통량비에 대한 서비스 교통량을 보정하는 방법을 제안하였다.

• 서비스연구
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• 제8권1호
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• pp.103-122
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• 2018

본 연구의 목적은 금융마케팅 서비스에서 투자자들이 미흡하게 느끼는 ELS 상품이 실제로 획득할 수 있는 수익률이 얼마나 되는지를 분석하여 ELS에 대한 투자효과를 규명함으로써 ELS 투자방향을 제시하는데 있다. 연구방법은 스텝다운형 ELS를 대상으로 2001년 1월부터 2017년 8월까지 200개월 동안 만기 3년의 조기상환조건 달성확률, 만기상환조건 달성확률, 조기상환추정수익률, 만기상환추정수익률을 산출하였다. 분석결과는 조기상환조건 100% 달성확률은 74.5%이었으며, 조기상환조건 95%는 달성확률이 83.0%, 90%는 89.5%, 85%는 92.5%, 80%는 96.5%, 75%는 97.5% 이었다. 가장 낮은 75% 경우에 만기까지 보유할 확률은 2.5%인 것으로 분석되어 조기상환조건이 달성될 확률이 높았다. 만기도래했을 때 주가상승률이 만기상환조건 65% 이내에 있을 확률은 98.5%이었으며, 만기상환조건 60%, 58%, 57%, 55%, 50%, 45%는 달성확률이 100% 이었다. 만기상환조건 65%는 원금손실 리스크가 1.5%정도 있는 것으로 분석되어서 만기에 약정된 수익률을 달성할 확률이 높았다. ELS 투자의 유의방안으로는 만기상환조건의 비율이 낮은 상품을 선택하고, 조기상환조건 비율이 높은 상품을 선택해야 하며, 주가지수가 박스권 형성이 예상 될 때 투자하는 것이 유리하다.

• 디자인학연구
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• 제11권2호
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• pp.71-81
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• 1998

도시의 옥외광고물은 직, 간접적으로 그 도시의 주체성 확립과, 가로경관을 형성하는데 가장 기본적인 요소로 인식되고 있다. 옥외광고물은 단순히 상업적 수단에 의해 출발하였지만 최근 들어서는 급속한 경제발전과 다양화된 사회구조 속에서 수많은 업종이 탄생하며, 그에 따라 광고물의 절대적인 종류와 양의 팽창을 가져오게 하였다. 이러한 양적 팽창은 새로운 도시환경 문제로 대두되게 되었으며 옥외광고물의 보다 더 효율적인 관리와 세련되고 합리적인 디자인이 필요하게 되었다. 따라서 본 연구를 통하여 가로경관이 향상될 수 있는 방향을 설정해 보고자 한다. 따라서 본 연구에서는 도시의 가로경관(Street Scenes of City), 옥외광고물(Outdoor Advertising Signs)의 개념과 특성 및 옥외광고물의 영향 등을 알아본 후 현황분석 에서는 현재 우리 나라 옥외광고물법과 외국 옥외광고물법의 특징을 조사 비교하여 보며 또한 도시경관에서 옥외광고물이 어떤 영향을 미치는지에 대한 조사를 실시하여 그 문제점을 도출한 후 옥외광고물의 디자인 관리정책 방향을 다음과 같이 제시하고자 한다. (1)도시의 환경 적, 경관 적 문제해결을 위하여 옥외광고물의 지역별 차별화 유도, (2)비현실적 광고물법은 변화하는 옥외광고물에 대응하기 위하여 개정이 필요함. (3)관리행정상의 문제는 옥외광고물 행정의 효율화를 통하여 해결해야 한다. (4)광고 제작업체의 문제는 장, 단기 계획으로 유도한다. (5)광고주 및 광고제작 업자의 경관의식과 공동의식 함양을 위하여 경관오염 징수 제를 실시하여야 한다. 이렇게 커다란 정책의 방향을 제시하여 도시경관의 향상과 지역 차별화를 유도하여 보다 더 아름다운 도시경관을 이루고자한다.