• Journal of Radiation Protection and Research
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• 제32권1호
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• pp.15-20
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• 2007

An empirical formula fur the neutron dose equivalent at the maze entrance of medical accelerator treatment rooms was derived on the basis of a Monte Carlo simulation. The simulated neutron dose equivalents around the Varian medical accelerator by the MCNPX code were employed. Two cases of target rotational planes were considered: parallel and perpendicular to maze walls. Most of the maximum neutron dose equivalents at the doorway were found when the target rotational planes were parallel to maze walls and the beams were directed to the inner maze entrances. The neutron dose equivalents at the outer maze entrances were calculated for about 698 medical accelerator facilities which were generated from the geometry configurations of running treatment rooms, based on such gantry rotation that produces the maximum neutron dose at the doorway. The results calculated with the empirical formula in this study were compared with those calculated by the Kersey method for 7 operating facilities. It was found that the maximum disagreement between the calculation of this study and that of the Kersey method was a factor of 8.54 with the value calculated by the Kersey method exceeding that of this study. It was concluded that the kersey method estimated the neutron dose equivalent at the doorway computed by MCNPX more conservatively than this study technique.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 추계학술대회
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• pp.340-342
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• 2015

윈도우 시스템은 90년대 이후로 지속적으로 사용되어진 개인용 컴퓨터의 운영체제로 그래픽 사용자 인터페이스와 멀티프로세싱 기능 등을 제공한다. 최근 배포되어지는 8.1 버전은 기존의 윈도우 시스템과 비교하여 다양한 특징을 가지고 있지만 윈도우 스토어는 네트워크를 이용하여 설치할 수 있는 다양한 응용 프로그램을 제공한다. 그러나 현재 윈도우 스토어에는 게임을 위한 응용 프로그램은 거의 제공되지 않고 있다. 이 논문에서는 사용자가 간편하게 설치하여 실행시킬 수 있는 미로탈출 앱을 설계한다. 제안한 앱은 저용량으로 윈도우 스토어에서 다운로드해서 사용자가 직관적으로 미로탈출 게임을 할 수 있도록 한다. 이를 위하여 HTML5와 자바스크립트를 이용하여 개발한다.

• Toxicological Research
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• 제16권2호
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• pp.117-124
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• 2000

The objective of this experiment is to investigate neurobehavioral and developmental effects of fumonisin B1 (FB1) after prenatal FB1 administration in rats. FB1 (0.8 or 1.6 mg/kg) was orally exposed to pregnant rats during gestational days 13 to 20, whereas the vehicle alone was administered to control group. Maternal and offspring body weights, physical landmarks of incisor eruption, eye opening, testes descending and vaginal opening, open field activity, running wheel activity, and complex maze performance were included as endpoints for developmental and neurobehavioral measurement. Maternal body weights were not signfficantly altered after FB1 exposure. Percentage of maternal weight gain difference between control and 1.6 mg/kg FBI groups was about 4%. Pre- and post-weanling weight of offsprings after prenatal exposure to FB1 was not signfficantly changed, suggesting that FB1 at 0.8 or 1.6 kg/kg doses may not cross the placenta. Significant gender difference in running wheel activity on postnatal days 57 to 63 and complex maze performance on postnatal days 75 to 78 was observed.

• 생명과학회지
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• 제17권11호
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• pp.1464-1471
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• 2007

당뇨병은 만성적 대사질환으로 말초뿐만 아니라 중추신경계에서도 다양한 합병증을 유발시키는 것으로 알려져 있다. 특히, 당뇨환자는 인지기능의 손상으로 인해 치매 유병율이 높은 것으로 보고되고 있다. 규칙적인 운동은 당뇨병의 이차 합병증을 예방하기 위한 치료적 방법으로 흔히 권장된다. 이에 본 연구는 당뇨흰쥐를 대상으로 트레드밀 운동이 기억력과 해마 BDNF 발현에 미치는 효과를 조사하였다. SD계열 흰쥐를 실험동물로 하여 STZ (50 mg/kg) 투여로 유발시킨 당뇨흰쥐를 8주간 주 5회 30분씩 트레드밀에서 달리도록 하였다. 운동프로그램 종료 후, Morris water maze로 기억력을 측정하고, 해마조직을 적출하여 Western으로 brain-derived neurotrophic factor (BDNF) 발현을 정량화하였다. 본 연구결과 8주간의 당뇨는 선행연구과 유사하게 기억력 손상과 함께 해마 조직의 BDNF 발현을 유의하게 감소시키는 것으로 나타났다. 하지만 트레드밀 운동은 당뇨흰쥐에서 기억력과 해마 BDNF 발현을 유의하게 향상시키는 것으로 나타났다. 이러한 결과는 당뇨동물에서 운동이 해마 BDNF 발현의 증가를 통해 인지기능의 손상을 완화시킬 수 있음을 보여주는 것이다.

• 한국정보처리학회논문지
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• 제3권1호
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• pp.43-54
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• 1996

이 논문은 새로운 휴리스틱 탐색(heuristic search)방법을 이용하여, 수평 및 수 직선으로 이루어진 방해 물들이 놓인 가운데 수평 및 수직선으로 구성된 최단 거리 (rectilinear shortestpath)와 꺾이는회수가 가장 적은최소 꺾임경로(link metric shortest path) 및 이 둘을 혼합시킨 혼합형 최단 경로를 구하는 알고리즘을 서술 하고 있다. 최단 경로를 구하는 방법으로 미로 찾기형 알고리즘(maze-running algorithms)과 선형 탐색 알고리즘(line-search algorithms)의 장점만을 이용한 GMD 알고리즘(Guided Minimum Detour algorithm)을 제안하고 있으며 이를 더욱 효율 적으 로 개선한 LGMD 알고리즘 (Line-by-Line Guided Minimum Detour algorithmm)을 개발 하였다. 이들 GMD와 LGMD 알고리즘은 기존의 최단 경로를 내포하고 있는 conection group를 이용하지 않고서도 휴리스틱을 사용한 guided A 탐색(guided A* search)을 이용하여 최적의 최단 경로를 구할 수 있는 장점이 있으며 시간과 메모리 면에서 효 율을 극대화하였다. 이들 GMD와 LGMD 알고리즘은 각각 O(m＋eloge＋NlogN)와 O(eloge＋ NlogN)의 시간과 O(e＋N)의 메모리를 사용한다. 여기서 m은 탐색에 사용된 지선 (line segment)들의 수이다. 또한 LGMD는 최소 꺾임 경로(link metric shortest path)와 최단 경로와 최소의 꺾임을 조합한 혼합형 최단 경로를 구하는 데에도 적용될 수 있는 확장성을 가지고 있다.

• Biomolecules & Therapeutics
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• 제14권2호
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• pp.83-89
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• 2006

The main aim of this study was to characterize the pharmacological profile of flavonoids utilizing behavioral tests and to investigate how the psychopharmacological activities of wogonin, baicalein and oroxylin A are different. Wogonin, baicalein and oroxylin A were intraperitoneally injected as dosages of 2.5, 5, 10 and 20 mg/kg. In the locomotor activity, Rota-rod test, and elevated plus-maze tests, the behavioral parameters were analyzed by automatic systems. Thiopental induced sleeping time was measured. Water extract of S. baicalensis didn't exhibit sedative effect. Wogonin and bacalein exhibited anxiolytic activity although it was less potent than buspirone. Wogonin and baicalein decreased locomotor activity at a dose of 10 mg/kg. Wogonin also shortened significantly running time on the rota-rod at doses of 5 and 10 mg/kg. Wogonin and baicalein enhanced sleeping at doses of 5 and 10 mg/kg. These results indicate that wogonin produce anxiolysis with sedation and so did bacalein with mild sedation. On the contrary, oroxylin A enhanced running activity on the rotarod and did't depress locomotor activity. Oroxylin A significantly hindered sleeping rather than helped it at doses of 5 and 10 mg/kg. Oroxylin A didn't produce anxiolysis and instead, produce awakening effect. This study demonstrates that wogonin and bacalein exhibited anxiolytic activity with mild sedation, but oroxylin A didn't produce anxiolysis and instead, produce awakening effect. This result indicates that anxiolytic effect without sedation induced by Scutellaria baicalensis is produced by combination of flavonoids.

• 운동영양학회지
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• 제23권3호
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• pp.13-21
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• 2019

[Purpose] Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis. [Methods] Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Protein levels were assessed using western blot analysis and newborn cells were detected using 5-bromo-2'-deoxyuridine (BrdU). [Results] Three weeks of treadmill running ameliorated the behavioral depression caused by 14 days of continuous restraint stress. The exercise regimen enhanced BrdU-labeled cells and class III β-tubulin levels in the hippocampal dentate gyrus, as well as those of thioredoxin-1 (TRX-1) and synaptosomal β2-adrenergic receptors (β2-AR) under stress. In vitro experiments involving treatment with recombinant human TRX-1 (rhTRX-1) augmented the levels of phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2), nuclear β-catenin, and proliferating cell nuclear antigens, which were previously inhibited by U0216 and FH535 (inhibitors of ERK1/2 and β-catenin/T cell factor-mediated transcription, respectively). The hippocampal neurogenesis elicited by a 7-day exercise regimen was abolished by a selective inhibitor of β2-AR, butoxamine. [Conclusion] These results suggest that TRX-1-mediated hippocampal neurogenesis by β2-AR function is a potential mechanism underlying the psychotropic effect of exercise.