• 환경위생공학
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• 제16권3호
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• pp.80-86
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• 2001

This research was carried out to investigate the effect of microscopic silica matrix coagulation on heavy metals and anion removal in mining wastewater. pH and alkalinity played an important role to coagulate heavy metals such as Al, and Fe and an anion such as ${SO_4}^{2-}$ with silica matrix as well as NaOH. However, the efficiency to form coagulates was much greater in silica matrix-treated wastewater than NaOH-treated one. Fe in wastewater formed coagulation with both silica matrix and NaOH treatments resulting in lowering Fe content in wastewater at above pH 9. For Al removal in wastewater, silica matrix-treated wastewater at above pH 12.3 formed stable coagulate with Al, while NaOH-treated one did not. Alkalinities of 89 and 220 mg/L were required to stabilize silica matrix treated coagulate with Fe and Al, respectively. Reaction time of ten minute was required to provide enough reaction for coagulation between heavy metals and silica matrix. Heavy metals and anion leachates were much lower in coagulate with silica matrix than that with NaOH, which indicates that silica matrix could be used to remove heavy metals efficiently.

• 대한치과보철학회지
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• 제44권5호
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• pp.574-583
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• 2006

Statement of problem : The use of permanent magnetics is increasing in implant dentistry. Purpose : This study is to know the effect of permanent magnetics on bone matrix formation of osteoblasts. Materials and methods : The konus abutment-shaped permanent magnetics were connected to the implant fixture, and placed on the culture plate. The osteoblast-like cell Mc3T3E1 were used for cell culture. As the control group, the implants were connected to titanium healing caps, and cultured in the same conditions of experimental group. After 3. 7, 14 days, cells were cultured, and we measured and compared the amount of collagen type I, osteocalcin, which is bone matrix protein by Western immunoblotting analysis. Results: As a result of Western immunoblotting analysis for estimating the amount of bone extracellular matrix, there was no difference between osteoblast of the experimental group and the control group during 3 and 7day-osteoblast culturing. However when cells were cultured for 14days, the amount of bone extracellular matrix was increased, on the experimental group. Conclusion: From these results, magnetic field of permanent magnetics might have effect on bone formation of osteoblast, especially at initial stage of implant placement. Therefore, their clinical application for implant or bone graft could be possible.

• 대한화장품학회지
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• 제31권2호
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• pp.161-167
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• 2005

잎새버섯(Grifola frondosa HB0071)이 생산하는 세포외 다당체인 GF-glucan이 사람섬유아세포에서 자외선(UVA)조사 시 증가되는 MMP-1 발현에 미치는 영향을 조사하였다. 자외선으로부터 조사된 섬유아세포에 GF-glucan을 처리한 농도에 따라 MMP-1 발현이 억제되었으며, RT-PCR를 이용해 세포내 MMP-1 mRNA 발현 또한 감소하는 것으로 나타났다 즉, 최대 GF-glucan $0.5\%$를 처리했을 때 $54.4\%$의 MMP-1 발현을 억제하였다. 결과적으로, 잎새버섯 HB0071로부터 생산된 GF-glucan은 피부노화와 관련된 extracellular matrix (ECM) 조직에 손상을 주는 MMP-1의 활성을 억제하여 자외선으로부터 손상된 피부의 광노화로부터 보호해주는 것으로 밝혀졌다.

• 한국분말재료학회지
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• 제7권4호
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• pp.218-227
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• 2000

It is well known that the Cu-Cr alloys are very difficult to be made by conventional sintering methods. This difficulty originates both from limited solubility of Cr in the Cu matrix and from limited sintering temperature due to high vapor pressures of Cr and Cu components at the high temperature. Densification of Cu-50%Cr Powder compacts by conventional Powder metallurgy Process has been studied. Three kinds of sintering methods were tested in order to obtain high-density sintered compacts. Completely densified Cu-Cr compacts could be obtained neither by solid state sintering method nor by liquid phase sintering method. Both low degree of shrinkage and evolution of large pores in the Cu matrix during the solid state sintering are attributed to the anchoring effect of large Cr particles, which inhibits homogeneous densification of Cu matrix and induces pore generation in the Cu matrix. In addition, the effect of undiffusible gas coming from the reduction of Cu-oxide and Cr-oxide was observed during liquid phase sintering. A two-step sintering method, solid state sintering followed by liquid phase sintering, was proved to have beneficial effect on the fabrication of high-dendsity Cu-Cr sintered compacts. The sintered compacts have properties similar to those of commercial products.

• 한국주조공학회지
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• 제16권2호
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• pp.109-115
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• 1996

Effect of various austempered structures on fracture characteristics of C/V graphite cast iron has studied. The tensile strength and hardness reached the maximum value of 971.4MPa and HB302 at the austempering temperature of $250^{\circ}C$, respectively. As the austempering temperature increased, the amount of retained austenite increased from 18% to 22, 29%, while $K_{IC}$ values ranged from the value of $65MPa{\cdot}m^{12} to 70MPa{\cdot}m^{1/2}, 66MPa{\cdot}m^{1/2}. This fact that $K_{IC}$ value was not sensitive to the increase of the amount of the retained austenite was that $K_{IC}$ was dependent on the matrix structure in lower bainitic matrix, while dependent on the notch effect from C/V graphite shape in upper bainitic matrix. Fractured surfaces showed a ductile fracture pattern at $300^{\circ}C$. Very large coalescence by C/V graphite and relatively small voids by spheroidal graphite were observed.

• 디지털산업정보학회논문지
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• 제8권4호
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• pp.115-120
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• 2012

In multi-user multi-input multi-output (MU-MIMO) system, zero forcing beamforming (ZFB) is regarded as a realistic solution for transmitting scheme due to its low complexity and simple structure. However, ZFB shows a significant performance degradation when channel matrix has large condition number. In this case, the largest singular value of the channel inversion matrix has a dominant effect on transmit power. In this paper, we propose a perturbation method for reducing an effect of the dominant singular value. In the proposed algorithm, channel inverse matrix is first decomposed by SVD for the transmit signal to be expressed as a combination of singular vectors. Then, the transmit signal is perturbed to reduce the coefficient of the singular vector corresponding to the largest singular value. When a number of transmit antennas is 4, the simulation results of this paper shows that the proposed method shows 8dB performance enhancement at 10-3 uncoded bit error rate (BER) compared with conventional ZFB. Also, the simulation results show that the proposed method provides a comparable performance to Tomlinson-Harashima Precoding (THP) with much lower complexity.

• Journal of the Korean Data and Information Science Society
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• 제21권6호
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• pp.1263-1270
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• 2010

60명의 환자들을 20명씩3개 그룹으로 나누어 각 그룹마다 다른 종류의 식이요법을 실시한 후 1주 간격으로 5주간에 걸쳐서 콜레스테롤 수치에 대한 반복측정 자료를 얻었다. 해당자료를 바탕으로 적합성여부와 유의성 검정을 실시한 결과 등분산 Toeplitz가 다양한 공분산행렬 형태들 중에서 가장 적합한 공분산구조 모형으로 판명되었다. 이 모형에서는 시점들 간의 상관계수는 0.64-0.78로 대체적으로 높은 상관관계들을 보여주고 있으며, 모수인자들의 유의성검정 결과, 시간효과는 대단히 유의하게 나타났으나, 처리 및 처리와 시간과의 교호작용효과는 유의하지 않은 것으로 판명되었다.

• Journal of Pharmaceutical Investigation
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• 제35권6호
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• pp.453-460
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• 2005

4-Aminopyridine (AP) is a potassium channel blocker used in the treatment of neurological disorders such as multiple sclerosis and Alzheimer disease. AP‘s window of therapeutic effect appears to correlate with its plasma halflife (3.5 hours). It demonstrates pH-dependent solubility because of a weakly basic drug. In addition, the resulting release from conventional matrix tablets decreases with increasing pH-milieu of the gastrointestinal tract. The aim of this study is to design sustained release matrix tablet containing AP, overcoming this problem. $Eudragit^{\circledR}$ L 100 (EuL) and sodium alginate were used in an effort to achieve pH independent drug release. The effect of sodium alginate and EuL on drug release from matrix tablet was investigated. The drug release behavior from the different tablets was analyzed by $t_{20%},\;t_{40%},\;t_{60%}$, The exponential diffusion coefficient n, kinetic constant K were calculated according to the Korsmeyer-Peppas equation. The drug release from matrix tablets prepared with sodium alginate was decreased with increasing the content of sodium alginate in pH 7.4 while there is no significant difference in pH 1.2. The exponent n values were determined to be approximately 0.5 and 0.8 respectively, in both pH 1.2 and 7.4. These values indicate diffusion-based anomalous mechanism and erosion-based anomalous mechanism, respectively. The drug release from sodium alginate matrix tablets prepared with solid dispersion of EuL containing drug showed a slow drug release in an acidic medium and a more fast drug release in phosphate medium, compared with sodium alginate matrix tablets prepared with physical mixture. These results may be attributed to the gel forming ability of sodium alginate and pH dependent solubility of EuL. Therefore, sustained-release AP matrix tablets using sodium alginate and EuL were successfully prepared.

• Advances in materials Research
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• 제4권3호
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• pp.165-178
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• 2015

Friction coefficient of epoxy metal matrix composites were investigated. The main objective was to increase the friction coefficient through rubber sole sliding against the epoxy floor coating providing appropriate level of resistance. This was to avoid the excessive movement and slip accidents. Epoxy metal matrix composites were reinforced by different copper wire diameters. The epoxy metal matrix composites were experimentally conducted at different conditions namely dry, water and detergent wetted sliding, were the friction coefficient increased as the number of wires increased. When the wires were closer to the sliding surface, the friction coefficient was found to increase. The friction coefficient was found to increase with the increase of the copper wire diameter in epoxy metal matrix composites. This behavior was attributed to the fact that as the diameter and the number of wires increased, the intensity of the electric field, generated from electric static charge increased causing an adhesion increase between the two sliding surfaces. At water wetted sliding conditions, the effect of changing number of wires on friction coefficient was less than the effect of wire diameter. The presence of water and detergent on the sliding surfaces decreased friction coefficient compared to the dry sliding. When the surfaces were detergent wetted, the friction coefficient values were found to be lower than that observed when sliding in water or dry condition.

• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.363-368
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• 2004

In order to investigate the effect of bovine serum albumin (BSA), as a pore former, on the controlled release of an antibiotic from a biodegradable polymeric device, polycaprolactone (PCL)-cefadroxil matrices were prepared by the solvent casting method. The amount of cefadroxil released from various formulations at $37^{\circ}C$ was measured by HPLC. The duration of antimicrobial activity of matrices against S. aureus was evaluated by measuring the diameters of the inhibition zone. The morphology of the matrices was investigated by scanning electron microscopy (SEM). The release rate and extent of cefadroxil from PCL matrix increased as the loading dose and particle size of BSA/cefadroxil mixture powder increased. Cefadroxil released from the matrix exhibited antibacterial activity for up to 4 days. SEM of the cross-section of matrix showed the typical channel formation after 3 days of release study. Thus, a biodegradable polymeric matrix loaded with antibiotic/BSA mixture can effectively prevent bacterial infection on its surface, thereby bringing about an enhancement of biocompatibility of biomaterials.