• Radiation Oncology Journal
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• 제37권3호
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• pp.215-223
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• 2019

Purpose: To determine prognostic significance of lymphovascular invasion (LVI) in prostate cancer patients who underwent adjuvant or salvage postoperative radiotherapy (PORT) after radical prostatectomy (RP) Materials and Methods: A total of 168 patients with prostate cancer received PORT after RP, with a follow-up of ≥12 months. Biochemical failure after PORT was defined as prostate-specific antigen (PSA) ≥0.2 ng/mL after PORT or initiation of androgen deprivation therapy (ADT) for increasing PSA levels regardless of the value. We analyzed the clinical outcomes including survivals, failure patterns, and prognostic factors affecting the outcomes. Results: In total, 120 patients (71.4%) received salvage PORT after PSA levels were >0.2 ng/mL or owing to clinical failure. The 5-year biochemical failure-free survival (BCFFS), clinical failure-free survival (CFFS), distant metastasis-free survival (DMFS), overall survival, and cause-specific survival rates were 78.3%, 94.3%, 95.0%, 95.8%, and 97.3%, respectively, during a follow-up range of 12-157 months (median: 64 months) after PORT. On multivariate analysis, PSA level of ≤1.0 ng/mL at the time of receiving PORT predicted favorable BCFFS, CFFS, and DMFS. LVI predicted worse CFFS (p = 0.004) and DMFS (p = 0.015). Concurrent and/or adjuvant ADT resulted in favorable prognosis for BCFFS (p < 0.001) and CFFS (p = 0.017). Conclusion: For patients with adverse pathologic findings, PORT should be initiated as early as possible after continence recovery after RP. Even after administering PORT, LVI was an unfavorable predictive factor, and further intensive adjuvant therapy should be considered for these patients.

• 한국방사선학회논문지
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• 제12권2호
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• pp.233-243
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• 2018

본 연구는 치과병원에 내원 환자를 대상으로 방사선 검사 시 방사선피폭 인지도에 대한 관련요인을 분석하여 방사선피폭 인식의 변화를 위한 교육 자료를 만드는데 기초자료를 제공하기 위해 시도하였다. 방사선 장치 중 가장 방사선 피폭을 가장 많이 받는 검사에 대해서는 전체 65.5%로 CT가 가장 높았으며, 방사선 검사 시 피폭에 가장 민감한 부위에 대해서는 생식선 56.1% 가장 많았고, 방사선에 대한 정보 파악은 전체 26.3%가 TV나 신문을 통해 습득하는 것이 가장 많았다. 방사선 인식도, 방사선 유해성, 방사선 검사 시 심리상태, 방사선 피폭방지, 방사선 필요성에 대해서는 성 별간 남자가 더 높게 나타났으며, 통계학적으로는 유의한 차이가 있었다. 본 연구를 통해서 환자들로 하여금 방사선피폭에 대하여 올바르게 인식을 할 수 있도록 교육프로그램의 개발이 시급하며, 방사선사들에게는 환자의 피폭선량을 경감을 위한 세심한 배려가 필요하다고 하겠다. 또한 환자들은 방사선에 대해서 올바르게 인식하는 것이 촬영 시 불안감과 방사선피폭을 줄일 수 있을 것이다.

• Radiation Oncology Journal
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• 제11권2호
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• pp.321-330
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• 1993

Purpose: A retrospective analysis was performed to evaluate the incidence of radiation induced lung damage after the radiation therapy for the patients with carcinoma of the lung. Method and Materials: Sixty-six patients with lung cancer (squamous cell carcinoma 27, adenocarcinoma 14, large cell carcinoma 2, small cell carcinoma 13, unknown 10) were treated with definitive, postoperative or palliative radiation therapy with or without chemotherapy between July 1987 and December 1991. There were 50 males and 16 females with median age of 63 years (range: 33~80 years). Total lung doses ranged from 500 to 6,660 cGy (median 3960 cGy) given in 2 to 38 fractions (median 20) over a range or 2 to 150 days (median in days) using 6 MV or 15 MV linear accelerator. To represent different fractionation schedules of equivalent biological effect, the estimated single dose (ED) model, $ED=D{\dot}N^{-0.377}{\dot}T^{-0.058}$ was used in which D was the lung dose in cGy, N was the number of fractions, and T was the overall treatment time in days. The range of ED was 370 to 1357. The endpoint was a visible increase in lung density within the irradiated volume on chest X-ray as observed independently by three diagnostic radiologists. Patients were grouped according to ED, treatment duration, treatment modality and age, and the percent incidence of pulmonary damage for each group was determined. Result: In 40 of 66 patients, radiation induced change was seen on chest radiographs between 11 days and 314 days after initiation of radiation therapy. The incidence of radiation pneumonitis was increased according to increased ED, which was statistically significant (p=0.001). Roentgenographic changes consistent with radiation pneumonitis were seen in $100\%$ of patients receiving radiotherapy after lobectomy or pneumonectomy, which was not statistically significant. In 32 patients who also received chemotherapy, there was no difference in the incidence of radiation induced change between the group with radiation alone and the group with radiation and chemotherapy, among the sequence of chemotherapy No correlation was seen between incidence of radiation pneumonitis and age or sex. Conclusions: The occurrence of radiation pneumonitis varies. The incidence of radiation pneumonitis depends on radiation total dose, nature of fractionation, duration of therapy, and modifying factors such as lobectomy or pneumonectomy.

• 한국방사선학회논문지
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• 제9권6호
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• pp.381-392
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• 2015

본 연구는 1차 의료기관 내원 환자를 대상으로 진단용 방사선 검사 시 방사선피폭 인식에 대한 관련요인을 분석하여 방사선피폭 인식의 변화를 위한 교육 자료를 만드는데 기초자료를 제공하기 위해 시도하였다. 방사선 장치 중 가장 방사선 피폭을 가장 많이 받는 검사에 대해서는 전체 66.7%로 CT가 가장 높았으며, 방사선 검사 시 피폭에 가장 민감한 부위에 대해서는 생식선 56.2% 가장 많았고, 방사선에 대한 정보 파악은 전체 25.9%가 TV나 신문을 통해 습득하는 것이 가장 많았다. 방사선 인식도, 방사선 유해성, 방사선 검사 시 심리상태, 방사선 피폭방지, 방사선 필요성에 대해서는 성 별간 남자가 더 높게 나타났으며, 통계학적으로는 유의한 차이가 있었다. 본 연구를 통해서 환자들로 하여금 방사선피폭에 대하여 올바르게 인식을 할 수 있도록 교육프로그램의 개발이 시급하며, 방사선사들에게는 환자의 피폭선량을 경감을 위한 세심한 배려가 필요하다고 하겠다. 또한 환자들은 방사선에 대해서 올바르게 인식하는 것이 촬영 시 불안감과 방사선피폭을 줄일 수 있을 것이다.

• 대한두경부종양학회지
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• 제34권1호
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• pp.9-13
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• 2018

Background/Objectives: Brain metastasis (BM) is a rare form of distant metastasis with papillary thyroid cancer (PTC). Patients with BM of PTC carry a poor prognosis. The aim of this study was to contribute to the understanding of this disease by analyzing patients with BM of PTC. Materials & Methods: Between March 2003 and December 2013, the patient database was conducted to identify thyroid cancer patients treated. Among the 22,758 thyroid cancer patients, 14 (0.06 %) were identified to have metastasis to the brain during follow-up. The medical records of 14 patients with BM were retrospectively reviewed, focusing on the following: patient characteristics, synchronous or previous distant metastasis, treatments including whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS) and surgery, and characteristics on radiologic findings, time interval between first diagnosis of primary thyroid cancer and BM and survival after BM. Results: The mean age at initial diagnosis and BM were $50.9{\pm}15.8years$ and $61.3{\pm}12.7years$. The mean duration between initial diagnosis and BM was $10.4{\pm}7.9years$. Patients were treated with varied combinations of surgery, SRS and WBRT except 4 patients who had refused treatment. The median overall survival (OS) time after BM diagnosis was 10 months (range 1 - 19). Patients receiving treatment (WBRT and/or surgery, SRS) had a significant longer median OS of 16.5 months in comparison to 3.5 months for those treated without treatment. (p = 0.005) Conclusion: Patients who received aggressive treatment had a longer OS than those with only supportive care. Treatment such as surgery, SRS and WBRT should be considered in patients with BM.

• 한국산업정보학회논문지
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• 제24권6호
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• pp.43-53
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• 2019

최근 몇 년간 실내 환경에서 발생하는 대기 위험 물질에 관한 피해사례가 많이 있었으며, 이에 대해 빠른 대처를 하지 못하여 큰 피해가 발생하곤 했다. 이에 관해 본 시스템은 대기 위험 물질 농도 안전 수치 초과시 사용자의 Mobile에 Push Message로 전송하는 시스템을 구축하고자 한다. 본 시스템은 아두이노(Arduino), 라즈베리 파이(Raspberry PI)와 같은 IoT System으로 데이터를 추출하고 Cloud Computing System에 구현된 MongoDB, MySQL을 통하여 Database를 구축하였다. 해당 Database는 NodeJS를 이용한 Application Server를 통해 데이터를 가져오며, Application에 전송하여 시각화하였다. 또한, IoT System에서 위험 상황에 관한 신호를 받으면 Google FCM 라이브러리를 이용하여 Push Message를 보낸다. Mobile Application은 Android Web View를 이용하여 개발하며, Web View에 들어갈 Page는 HTML5 (HTML, Javascript CSS)를 이용하여 개발한다. 본 시스템의 Application을 통하여 사용자가 실내 대기 위험 물질을 실시간 모니터링하며, 위험 상황 시 사용자의 Mobile에 실내/외 검출 위치와 농도에 대한 실시간 정보를 Push Message로 전송하여 사용자의 빠른 대처에 도움이 될 것이라 기대할 수 있다.

• Imaging Science in Dentistry
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• 제50권3호
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• pp.227-236
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• 2020

Purpose: Image artifacts caused by patient motion cause problems in cone-beam computed tomography (CBCT) because they lead to distortion of the 3-dimensional reconstruction. This prospective study was performed to quantify patient movement during CBCT acquisition and its influence on image quality. Materials and Methods: In total, 412 patients receiving CBCT imaging were equipped with a wireless head sensor system that detected inertial, gyroscopic, and magnetometric movements with 6 dimensions of freedom. The type and amplitude of movements during CBCT acquisition were evaluated and image quality was rated in 7 different anatomical regions of interest. For continuous variables, significance was calculated using the Student t-test. A linear regression model was applied to identify associations of the type and extent of motion with image quality scores. Kappa statistics were used to assess intra- and inter-rater agreement. Chi-square testing was used to analyze the impact of age and sex on head movement. Results: All CBCT images were acquired in a 10-month period. In 24% of the investigations, movement was recorded (acceleration: >0.10 [m/s²]; angular velocity: >0.018 [°/s]). In all examined regions of interest, head motion during CBCT acquisition resulted in significant impairment of image quality (P<0.001). Movement in the horizontal and vertical axes was most relevant for image quality (R²>0.7). Conclusion: Relevant head motions during CBCT imaging were frequently detected, leading to image quality loss and potentially impairing diagnosis and therapy planning. The presented data illustrate the need for digital correction algorithms and hardware to minimize motion artefacts in CBCT imaging.

• 대한영양사협회학술지
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• 제12권2호
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• pp.172-184
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• 2006

This study was aimed to provide safety management guidance by evaluating the microbial quality of cooked dried-seafoods in school foodservice operations. Nineteen seafood items were collected from six elementary schools, those were dried-anchovy, dried-seaweed and dried-fish, which were classified as cooking process. The temperatures at receiving and after cooking were measured and the analyses of cooking processes and microbial quality were performed. The temperatures of all foods after cooking were higher than the temperature limit of $74\^circC$. The number of total aerobic bacteria and S. aureus in dried-anchovy over the limit of $10^5$ and even the level of S. aureus was found to be unsatisfactory. The count of total aerobic bacteria was 2.1x$10^8$ CFU/g and the number of total aerobic bacteria after cooking was over the limit in one school. The level of E. coli (3.1x$10^3$ CFU/g) was over the limit at one school and the number of S. aureus (1.2×$10^4$ CFU/g) was considered as unacceptable. Dried- tangle and green laver were contaminated with total aerobic bacteria showing the over the limit. The numbers of total aerobic bacteria in dried- filefish, pollack and squid were 4.3x$10^6$, 3.4x$10^6$-3.9x$10^7$ and 4.6x$10^5$-4.1x$10^7$ CFU/g, respectively, which were in acceptable or unsatisfactory level. The E. coli in dried- filefish and pollack were over the limit. The total aerobic bacteria levels, 4.6x$10^5$-1.5x$10^6$ CFU/g in dried-pollack and 8.0x$10^5$-2.2x$10^7$ CFU/g in dried-squid, were over the limit after cooking except dried-filefish. The E. coli levels, 4.3x$10^3$ CFU/g in dried-filefish and 2.5x$10^2$ CFU/g in dried-pollack, were over the limit of $10^2$ CFU/g. The numbers of Enterobacteriaceae were either acceptable (3.3x$10^3$ CFU/g) or unsatisfactory (1.6x$10^4$ CFU/g) level in dried-pollack. S. aureus was unsatisfactory level (6.5x$10^4$ CFU/g) in dried-filefish while unacceptable in dried-pollack both before and after cooking. Unacceptable levels of S. aureus, 2.4x$10^4$ and 1.3x$10^5$ CFU/g were found from two schools, respectively. These results suggest that the contamination of raw materials and the seasonings added after cooking should be controlled to manage the microbial safety of cooked dried-seafoods.

• Radiation Oncology Journal
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• 제16권3호
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• pp.347-350
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• 1998

목적 : 본 연구는 계획된 방사선치료의 과정 도중에 방사선치료를 완료하지 못하는 환자들의 빈도를 조사하고 그 이유를 분석하고자 하였다. 대상 및 방법 :삼성서울병원 치료방사선과에서 방사선치료를 받은 환자 중에서 1996년 4월부터 1997년 5월까지 방사선치료를 시행 받은 1,100명의 환자들을 대상으로 하였다. 대상 환자들 중에서 최초 계획 방사선량의 95$\%$ 이하를 받은 경우를 불완전 방사선치료로 정의하여 그 빈도와 이유를 조사하였다. 결과 : 불완전 방사선치료의 빈도는 1,100명 중 128명으로 12$\%$였다. 불완전 방사선치료 환자들의 운동수행능력은 전체 환자들에 비하여 불량하였으며, 방사선치료의 목적은 고식적 목적이 많았다. 불완전 방사선치료의 가장 흔한 이유는 환자의 거부였으며 이는 주로 환자의 방사선치료에 대한 불신과 경제적 부담 때문이었다. 결론 : 불완전 방사선치료의 빈도를 줄이기 위해서는 방사선치료의 임상적 적응 여부는 물론 환자의 사회 경제적인 여건을 잘 고려하여 방사선치료의 대상 환자를 선정하는 것이 요망되며 이는 특히 고식적 방사선치료의 경우에 더욱 중요하다고 할 수 있겠다.

• 중소기업융합학회논문지
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• 제3권2호
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• pp.27-32
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• 2013

무선 신체 영역 네트워크 (WBAN)는 블루투스 활성화 장치 및 PDA와 같은 작고 가벼운 무선 시스템의 출현에 의해 가능하게 되었다. 안테나는 WBAN 시스템의 필수적인 부분입니다 및 기술적 요구 사항과 물리적 제약 여러 가지에, 자신의 디자인 및 배치의 주의 깊은 고려가 필요하다. 의류의 일부는 건강 관리 응용 프로그램에서 추적 및 네비게이션 등의 통신 기능을 제공하기 위해 본 논문은 착용할 수 있는 안테나의 디자인을 제안하고 있다. 착용할 수 있는 안테나의 기판은 착용할 수 있도록 하기 위해서 경량, 낮은 유지 보수, 눈에 거슬리지 않는 작은 크기로 만들도록 섬유 재료로 만든다 본 논문은 안테나 디자인 WBAN 요구 사항을 만족 하는지 확인하기 위해 섬유/기판의 유형을 포함하여 착용할 수 있는 안테나에 대한 다른 매개 변수의 영향을 조사한다. 안테나의특성 및 동작은 무선 표준 기술 및 시스템 요구 사항에 의해 설정된 사양을 준수 할 필요가 있다. 이것은 다양한 유닛의 송신 및 수신 주파수 대역을 적절하게 선택될 필요가 있다는 것을 의미한다. 인체에 노출 될 수 있는 힘의 레벨에 제한이 있기 때문에, 안테나 등의 RF 시스템의 구성 요소는 이러한 제한을 충족하도록 설계 되어야한다. 직접 전력 전송에 영향을 미치는 안테나 이득, 안전 지침 내에 전력 레벨을 보장하는 중요한 매개 변수이고 설계에 가장 중요하다. WBAN 안테나 및 장치와 인체 사이의 전자기 상호 작용은 또한 탐색 할 것이다.