• BMB Reports
• /
• 제56권8호
• /
• pp.426-438
• /
• 2023

Muscle wasting in end-stage renal disease (ESRD) is an escalating issue due to the increasing global prevalence of ESRD and its significant clinical impact, including a close association with elevated mortality risk. The phenomenon of muscle wasting in ESRD, which exceeds the rate of muscle loss observed in the normal aging process, arises from multifactorial processes. This review paper aims to provide a comprehensive understanding of muscle wasting in ESRD, covering its epidemiology, underlying molecular mechanisms, and current and emerging therapeutic interventions. It delves into the assessment techniques for muscle mass and function, before exploring the intricate metabolic and molecular pathways that lead to muscle atrophy in ESRD patients. We further discuss various strategies to mitigate muscle wasting, including nutritional, pharmacological, exercise, and physical modalities intervention. This review seeks to provide a solid foundation for future research in this area, fostering a deeper understanding of muscle wasting in ESRD, and paving the way for the development of novel strategies to improve patient outcomes.

• 대한토목학회논문집
• /
• 제8권1호
• /
• pp.69-75
• /
• 1988

활성 슬러지 하수처리장의 주요 Process Control Variables인 Sludge age와 Sludge recycle올 고려하여 폐슬러지의 유량 ($Q_w$)을 효과적으로 결정하기 위한 두가지의 식이 개발되었다. 아울러 반송 슬러지의 일부를 폐슬러지로 배출할 경우에는 우선 순환비 (R)를, 포기조내의 활성슬러지의 일부를 폐슬러지로 배출할 경우에는 2차침전지의 슬러지 침전효율($S_f$)을 정확히 측정하여 개발된 식을 이용하면 폐슬러지의 유량을 용이하게 산정할 수 있다는 사실이 Sensitivity analysis의 결과로 밝혀졌다.

• Ocean and Polar Research
• /
• 제24권4호
• /
• pp.483-490
• /
• 2002

Detailed investigations on both submarine and subaerial volcaniclastic deposits around Dokdo were carried out to identify geomorphologic characteristics, stratigraphy, and associated depositional processes of Dokdo caldera. Dokdo volcano has a gently sloping summit (about 11km in diameter) and relatively steep slope (basal diameter is about 20-25 km) rising above sea level at about 2,270m. We found ragged, elliptical-form of Dokdo caldera with a diameter of about 2km estimated by Chirp (3-11 kHz) sub-bottom profile data and side scan sonar data for the central summit area of Dokdo volcano. We interpreted that the volcaniclastic deposits of Dokdo unconformably consist of the Seodo (west islet) and the Dongdo(east islet) formations based on internal structure, constituent mineral composition, and bedding morphology. The Seodo Formation mainly consisted of massive or inversely graded trachytic breccias (Unit S-I), overlain by fine-grained tuff (Unit S-II), which is probably supplied by mass-wasting processes resulting from Dokdo caldera collapse. The Dongdo Formation consists of alternated units of stratified lapilli tuff and inversely graded basaltic breccia (Unit D-I, Unit D-III, and Unit D-V), and massive to undulatory-bedded basaltic tuff breccias (Unit D-II and Unit D-IV) formed by a repetitive pyroclastic surge and reworking processes. Although, two islets of Dokdo are geographically near each other, they have different formations reflecting their different depositional processes and eruptive stages.

• 한국해양학회지:바다
• /
• 제7권3호
• /
• pp.148-156
• /
• 2002

서해 남부 함평만에서 해안선의 지형 특성과 해안절벽의 침식과정을 조사하기 위해 야외관찰과 정밀 측량을 실시하였다. 함평만 해안선은 급경사면 그리고 불안정한 토양층이나 연약한 풍화암층으로 이루어진 높이 l0m미만의 해안절벽(sea-cliff)들로 대부분 구성되며, 매우 활발한 침식을 받고있다. 톱날모양의 해안선 형태, 해빈 표면에 노출된 잔류풍화기반암 및 "Island Stack"등 독특한 해안선 지형 특성들이 활발한 해안침식 증거들로 나타난다. 함평만에서의 해안선 후퇴는 해안절벽 기저부의 침식 사태(landslide or mass wasting), 테일러스(talus)형성 그리고 테일러스의 침식(소멸)의 순차적 과정이 반복되어 나타난 결과로 해석된다. 본 연구에서 테일러스가 여름철에 침식.제거되는 현상은 정상적인 해양조건에서 일어나는 계절적 해수면 상승에 의한 것으로 판단된다. 이는 겨울철 폭풍과 함께 해안 침식의 또 다른 중요 요인으로 제시된다.요인으로 제시된다.