• The Plant Pathology Journal
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• 제23권3호
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• pp.174-179
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• 2007

Seedlot disinfection techniques to control mung bean sprout rot caused by Colletoricum acutatum and C. gloeosporioides were evaluated for commercial production scheme. Soaking seedlots in propolis (100 X) and ethanol (20% for 30 min) appeared promising with control values of 85.5 and 80.8 respectively, but still resulted in up to 20% rot incidence. None of the C. acutatum conidia survived through hot water immersion treatment (HWT) for 10 min at temperatures of 55, 60 and $65^{\circ}C$, whereas the effective range of the dry heat treatment (DHT) was $60-65^{\circ}C$. Tolerance of mung bean seedlot, as estimated by hypocotyl elongation and root growth, was lower for HWT than for DHT. Germination and growth of sprouts were excellent over the range of $55-65^{\circ}C\;at\;5^{\circ}C$ intervals, except for HWT at $65^{\circ}C$ for 5 min. At this marginal condition, heat damage appeared so that approximately 2% of seeds failed to sprout to normal germling and retarded sprouts were less than 5% with coarse wrinkled hypocotyls. These results suggested that DHT would be more feasible to disinfect mung bean seedlots for commercial sprout production. Heat treatment at above ranges was highly effective in eliminating the epiphytic bacterial strains associated with marketed sprout rot samples. HWT of seedlot at 55 and $60^{\circ}C$ for 5 min resulted in successful control of mung bean sprout rot incidence with marketable sprout quality. DHT at 60 and $65^{\circ}C$ for 30 min also gave good results through the small-scale sprouting system. Therefore, we optimized DHT scheme at 60 and $65^{\circ}C$ for 30 min, considering the practical value of seedlot disinfection with high precision and accuracy. This was further proved to be a feasible and reliable method against anthracnose incidence and those bacterial strains associated with marketed sprout rot samples as well, through factory scale mung bean sprout production system.

• 재무관리연구
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• 제26권3호
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• pp.139-169
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• 2009

본 연구는 새로운 VaR 추정모형으로 수정 VaR(modified VaR)을 소개하고, 수정 VaR의 예측성과를 역사적 시뮬레이션 모형이나 Riskmetrics 등 전통적인 모형들과 비교하였다. 수정 VaR은 분산뿐만 아니라 왜도, 첨도를 VaR 계산에 고려함으로써 금융자산분포의 비대칭성과 꼬리가 굵은 성질이 위험측정치에 반영될 수 있는 장점이 있다. 수정 VaR은 6개국의 주가지수 수익률을 이용한 표본외 예측성과검증에서 다른 모형들에 비해 가장 우수한 예측성과를 보였다. VaR 예측의 독립성검증에서는 Riskmetrics와 GARCH 모형이 우수한 것으로 나타났으나 수정 VaR에 대해 서도 독립성이 기각되지 않았다. 특정한 표본을 이용한 예측성과분석에서 나타날 수 있는 data snooping 문제를 해결하기 위해 skew t 분포를 이용한 시뮬레이션분석을 시도하였는데, 시뮬레이션 검증결과에서도 수정 VaR이 가장 양호한 예측성과를 보였다. 포트폴리오 VaR에 대한 표본외 예측성과에서도 수정 VaR은 단일변량모형이나 다변량 정규분포모형에 비해 우수한 성과를 보였다. 다변량 수정 VaR은 포트폴리오 구성자산 간의 선형상관관계뿐 아니라 공왜도(coskewness)와 공첨도(cokurtosis)를 통한 비선형 상호의존관계도 고려할 수 있다는 점에서 포트폴리오 위험에 대한 우수한 예측성과는 당연한 결과라고 할 수 있다. 6개국 주가지수로 구성된 포트폴리오의 VaR을 component VaR로 분할한 실증분석에서는 포트폴리오 VaR의 분할결과가 적극적인 위험관리와 포트폴리오 최적화를 위한 자산재배분에 효과적으로 활용될 수 있음을 확인하였다.

• Investigative Magnetic Resonance Imaging
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• 제23권1호
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• pp.46-54
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• 2019

Purpose: The aim of this study was to evaluate the diagnostic performance of a computer-aided detection (CAD) system used with automated breast ultrasonography (ABUS) for suspicious lesions detected on breast MRI, and CAD-false lesions. Materials and Methods: We included a total of 40 patients diagnosed with breast cancer who underwent ABUS (ACUSON S2000) to evaluate multiple suspicious lesions found on MRI. We used CAD ($QVCAD^{TM}$) in all the ABUS examinations. We evaluated the diagnostic accuracy of CAD and analyzed the characteristics of CAD-detected lesions and the factors underlying false-positive and false-negative cases. We also analyzed false-positive lesions with CAD on ABUS. Results: Of a total of 122 suspicious lesions detected on MRI in 40 patients, we excluded 51 daughter nodules near the main breast cancer within the same quadrant and included 71 lesions. We also analyzed 23 false-positive lesions using CAD with ABUS. The sensitivity, specificity, positive predictive value, and negative predictive value of CAD (for 94 lesions) with ABUS were 75.5%, 44.4%, 59.7%, and 62.5%, respectively. CAD facilitated the detection of 81.4% (35/43) of the invasive ductal cancer and 84.9% (28/33) of the invasive ductal cancer that showed a mass (excluding non-mass). CAD also revealed 90.3% (28/31) of the invasive ductal cancers measuring larger than 1 cm (excluding non-mass and those less than 1 cm). The mean sizes of the true-positive versus false-negative mass lesions were $2.08{\pm}0.85cm$ versus $1.6{\pm}1.28cm$ (P < 0.05). False-positive lesions included sclerosing adenosis and usual ductal hyperplasia. In a total of 23 false cases of CAD, the most common (18/23) cause was marginal or subareolar shadowing, followed by three simple cysts, a hematoma, and a skin wart. Conclusion: CAD with ABUS showed promising sensitivity for the detection of invasive ductal cancer showing masses larger than 1 cm on MRI.

• 대한치과기공학회지
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• 제45권2호
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• pp.31-38
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• 2023

Purpose: This in vitro study aimed to compare the trueness of 3-unit fixed dental provisional prostheses (FDPs) fabricated by three different additive manufacturing and subtractive manufacturing procedures. Methods: A reference model with a maxillary left second premolar and the second molar prepped and the first molar missing was scanned for the fabrication of 3-unit FDPs. An anatomically shaped 3-unit FDP was designed on computer-aided design software. 10 FDPs were fabricated by subtractive (MI group) and additive manufacturing (stereolithography: SL group, digital light processing: DL group, liquid crystal displays: LC group) methods, respectively (N=40). All FDPs were scanned and exported to the standard triangulated language file. A three-dimensional analysis program measured the discrepancy of the internal, margin, and pontic base area. As for the comparison among manufacturing procedures, the Kruskal-Wallis test and the Mann-Whitney test with Bonferroni correction were evaluated statistically. Results: Regarding the internal area, the root mean square (RMS) value of the 3-unit FDPs was the lowest in the MI group (31.79±6.39 ㎛) and the highest in the SL group (69.34±29.88 ㎛; p=0.001). In the marginal area, those of the 3-unit FDPs were the lowest in the LC group (25.39±4.36 ㎛) and the highest in the SL group (48.94±18.98 ㎛; p=0.001). In the pontic base area, those of the 3-unit FDPs were the lowest in the LC group (8.72±2.74 ㎛) and the highest in the DL group (20.75±2.03 ㎛; p=0.001). Conclusion: A statistically significant difference was observed in the RMS mean values of all the groups. However, in comparison to the subtractive manufacturing method, all measurement areas of 3-unit FDPs fabricated by three different additive manufacturing methods are within a clinically acceptable range.

• 한국환경생태학회지
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• 제32권6호
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• pp.686-697
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• 2018

오늘날 원격탐지기술의 발달로 인해, 산림지역과 같이 피복 분류작업이 난해한 지역을 비롯한 광범위한 지역에서의 세밀한 변화탐지를 위한 고해상도 위성영상 취득이 가능해졌다. 하지만, 고해상도 영상에 대한 시계열분석의 과정에서 많은 양의 지상 관측 데이터가 요구된다. 본 연구에서는 토지피복도를 지상 관측데이터로 활용한 위성영상 분류 방법의 가능성을 시험하였다. 연구대상지는 강원도 원주시이며, 산림지역과 시가화지역이 공존하는 공간이다. 연구 자료는 2015년 3월에 촬영된 KOMPSAT-3A 영상과 2017년도 토지피복도를 이용하여 분류를 시도하였다. 서포트벡터머신(SVM)과 랜덤포레스트(RF)의 두 가지 상이한 화소기반 분류기법을 적용하여 대상지에 대한 피복분류의 분류정확도를 비교 분석하였으며, SVM 분석의 경우 다수 분석(Majority analysis)을 후속 진행하였다. 분석대상은 산림식생만 포함한 지역과 연구대상지 전지역으로 구분하였고, 대상 면적이 협소한 습지는 분석과정에서 제외하였다. 분류 결과는 오차 행렬의 전체 정확도가 두 가지 분류대상에 대해 RF 기법이 SVM 기법보다 더 나은 것으로 나타났다. 산림지역만을 대상으로 한 경우, RF 기법이 SVM 기법에 비해 18.3% 높은 값을 나타낸 반면, 전체지역을 대상으로 한 경우는 둘 사이의 간격이 5.5%로 줄어들었다. SVM 기법에 다수 분석 (Majority analysis)을 추가로 실시한 경우, 1% 정도의 정확도 향상이 나타났다. RF 기법은 산림지역의 활엽수를 분석해 내는데 상당히 효과적이었지만, 다른 대상에 대해서는 SVM 기법이 더 나은 결과를 나타내었다. 본 연구는 고해상도 단일시기 영상에 대한 화소 기반의 분류기법을 시험한 것으로, 추후 시계열분석 및 객체기반 분류기법의 추가적인 적용으로 향상된 정확도와 신뢰도를 얻을 수 있을 것으로 판단된다. 이 연구의 방법론은 시공간적으로 고해상도 분석결과를 제공함으로써, 대면적의 토지계획에 유용할 것으로 기대된다.

• 대한두경부종양학회지
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• 제14권2호
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• pp.156-163
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• 1998

Background & Objectives: Frameless fractionated stereotactic radiotherapy(FFSRT) is a modification of stereotactic radiosurgery(SRS) with radiobiologic advantage of fractionation without losing mechanical accuracy of SRS. Local recurrence of head and neck cancer at or near skull base benefit from reirradiation. Main barrier to successful palliation is dose limitation secondary to normal tissue tolerance. We try to evaluate the efficacy and safety of FFSRT as a new modality of reirradaton in these challenging patients. Materials & Methods: Seven patients with recurrent head & neck cancer involving at or near skull base received FFSRT from September 1995 to November 1997. Six patients with nasopharyngeal cancer had received induction chemotherapy and curative radiation therapy. One patient with maxillary sinus cancer had received total maxillectomy and postoperative radiation therapy as a initial treatment. Follow-up ranged from 11 to 32 months with median of 24 months. Three of 7 patients received hyperfractionated radiation therapy(1.1-1.2Gy/fraction, bid, total 19.8-24Gy) just before FFSRT. All patients received FFSRT(3-5Gy/fraction, total 15-30Gy/5-10fractions). Chemotherapy(cis-platin $100mg/m^2$) were given concurrently with FFSRT in four patients. Second course of FFSRT were given in 4 patients with progression or recurrence after initial FFSRT. Because IF(irregularity factor; ratio of surface area of target to the surface area of sphere with same volume as a target) is too big to use conventional stereotactic RT using multiple arc method for protection of radiation damage to critical normal tissue, all patients received FFSRT with conformal method using irregular static ports. Results: Five of 7 patients showed complete remission in follow-up CT &/or MRI. Three of these five patients who developed marginal, in-field, and out-field recurrences, respectively. Another one of complete responders has been dead of G-I bleeding without evidence of local recurrence. One partial responder who showed progressive disease 15 months after initial FFSRT has received additional FFSRT, and then he is well-being with symptomatic improvement. One minmal responder who showed progression of locoregional disease 9 months after $1^{st}$ FFSRT has received 2nd FFSRT, and then he is alive with stable disease. Five of 7 case had showed direct invasion to skull base and had complaint headache and various symptoms of cranial nerve involvement. Four of these five case showed improvement of neurologic symptoms after FFSRT. No significant neurologic complicaltion related to FFSRT was observed during follow-up periods. Tumor volumes were ranged from 3.9 to 50.7 cc and surface area ranged from 16.1 to $114.9cm^2$. IF ranged from 1.21 to 1.74. The average ratio of volume of prescription isodose shell to target volume was 1.02 that indicated the improvement of target coverage and dose distribution with FFSRT with conformal method compared to target coverage with FFSRT with multiple arc method. Conclusion: Our initial experience suggests that FFSRT with conformal method was relatively effective and safe modality in the treatment of recurrent head and neck cancer involving at or near skull base. Treatment benefit included good palliation of symptoms and reasonable radiographic response. However, more experience and additional follow-up are needed to better assess its ultimate role in treating these challenging patients.