• 대한의생명과학회지
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• 제5권1호
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• pp.27-40
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• 1999

본 연구는 MarA와 함께 MarB가 AcrAB efflux pump를 목표로 하는지 여부, 그리고 항생제의 균체외 배출기능에 대하여 어떤 조절 작용이 있는지를 항생제 내성검사를 통하여 살펴보았다. 본 연구 결과는 MarB가 MarA와 함께 AcrAB/TolC efflux pump의 항생제 배출기 능을 억제적으로 조절한다는 것을 간접적으로 보여 주었으며, 한편 이미 알려진 대로 MarA는 acrRAB operon의 발현을 전사 수준에 서 positive regulation하므로, MarB는 AcrAB efflux pump의 기능을 억제적으로 조절한다는 것을 암시하고 있다. 그리고 MarA와 함께 MarB단백질의 작용 목표는 AcrAB efflux pump임을 간접적으로 보여주고 있다. 또한 MarB는 MarA와 함께 대장균의 다른 efflux system(들)의 항생제 배출기능에 대해서도 억제적으로 조절할 가능성이 높은 것으로 나타났다.

• 대한방사선기술학회지:방사선기술과학
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• 제41권5호
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• pp.413-419
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• 2018

Magnetic Resonance Imaging for patients with metallic implant has poor image quality, and signal loss and artifacts including distortion can occur. The purpose of this study is to carry out a comparative evaluation on high receive bandwidth(hiBW), O-MAR, O-MAR XD to reduce artifacts in knee implant. To take MRI, 3.0T scanner and dual-source radiofrequency transmission were used. O-MAR XD technique's strong option showed a significant difference (p<0.001) with O-MAR XD technique's weak option, O-MAR and hiBW excluding the medium option. O-MAR XD's medium option had a significant difference (p<0.01) with O-MAR XD's weak, O-MAR and hiBW. O-MAR XD technique's weak option had a significant difference (p<0.01) with O-MAR XD's strong and medium options, O-MAR and hiBW. O-MAR technique had a significant difference (p<0.001) with strong, medium, weak options of O-MAR XD technique except for hiBW. HiBW had a significant difference (p<0.001) with strong, medium and weak options of O-MAR XD technique except for O-MAR. The results showed that O-MAR XD technique was more useful for MRI scan for patients with knee replacement surgery than traditional techniques such as hiBW or O-MAR, and susceptibility artifacts decreased more when O-MAR XD technique's strong or medium option was applied. Based on the results above, it is considered that it will be possible to acquire images whose susceptibility artifacts were highly decreased by using O-MAR XD technique's strong or medium option when conducting MRI for artificial knee joint and it will be helpful for checking and monitoring patients with knee joint replacement.

• 대한의생명과학회지
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• 제10권2호
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• pp.153-161
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• 2004

Antibiotic resistance is often associated with the production of inner membrane proteins (for example, AcrAB/TolC efflux pump) that are capable to extrude antibiotics, detergents, dyes and organic solvents. In order to evaluate the unknown MarB function of Escherichia coli, especially focused on the function of OmpF porin, several mutants were construted by T4GT7 transduction. MarA plays a major roles in mar (multiple antibiotic resistance) phenotype with AcrAB/TolC efflux pump in E. coli K-12. Futhermore, MarA decreases OmpF porin expression via micF antisense RNA. Expression of acrAB is increased in strains containing mutation in marR, and in those carrying multicopy plasmid expressing marA. MarB protein of E. coli K-12 showed its activity at OmpF porin & TolC protein as target molecule. Some paper reported MarB positively regulates OmpF function. MarA shows mar phenotype, and MarB along with MarA show decreased MIC through OmpF function. By this experiment, MarB could decrease MIC through the OmpF porin & TolC protein as target.

• 대한지역사회영양학회지
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• 제4권1호
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• pp.46-56
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• 1999

A deep understanding of the dietary patterns and nutrient intake is important for assessment of possilbe nutritional risk and for establishing nutrition improvement strategies. This study was conducted toexamine the dietary characteristics of a nutritionally poor elderly group compared to the middle-and highly-nourished group. Elderly participant was recruited from local elderly centers in Suwon city in 1998. Trained dietitians interviewed 119 elderly(35 males, 84 females) aged 60 years and over for collecting dietary data(24-hour recall) and related variables. Male and female subjects were grouped into high, middle, and low according to the mean nutrient adequancy ratio(MAR) tertiles. An analysisof the percentage of RDA(Recommended Daily Allowances of Korea) for each of the 10 nutrients showed that the male low-MAR group consumed below the RDA in all kinds of nutrients, and the female low-MAR group consumed nutrients below the RDA except vitamin C. An evaluation of nutrient density by Index of Nutritonal Quality(INQ) also showed a similar tendency. Thus, the INQ level of the male low-MAR group was significantly lower than the middle-or high-MAR group, especially in protein, vitamin A, thiamin, riboflavin, and phosphorus(p<0.05). Moreover, INQ level of female low-MAR group was significantly lower than that of the high group(p<0.05) in all nutrients. The female low-MAR group's daily food intake were also lower than those of the high-MARgroup in gains, fish, fruits, oil and beverages. The energy distribution from carbohydrates, fats and proteins showed that the male low-MAR group had significantly higher carbohydrate and lower fat proportions compared to each gender high-MAR group, respectively. The male and female low-MAR group had low scores about eating all side dishes. These findings indicate that a moderate increase of the meat/egg/fishes intake was needed by the male low-MAR group for improving nutrition adequacy, and an overall increase of the food quantity and quality was desired for the female low-MAR group. These data could be used for planning a community elderly nutrition program and establishing strategies for tailored guidelines for the individuals.

• 한국방사선학회논문지
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• 제16권2호
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• pp.131-139
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• 2022

본 연구는 척추경 나사못(Pedicle screw)을 돼지 흉추에 삽입하여 일반적인 CT검사(Non MAR)와 인공물을 줄이기 위한 금속성 인공물 감소기법(Metallic Artifact Reduction for Orthopedic Implants, O-MAR)으로 얻어진 흉추 Axial영상을 4개의 알고리즘(Standard, Soft, Bone, Detail)에 재구성하였다. 이에 얻은 영상을 image J 프로그램을 이용하여 신호대잡음비(Signal Noise Ratio, SNR)와 대조도대잡음비(Contrast to Noise Ratio, CNR)를 주어진 식에 의거하여 측정값을 구하고 흉추 척추경 나사못 삽입술 CT검사에 맞는 관전압과 알고리즘을 알아보고자 하였다. 결과적으로 Non MAR 사용한 경우에는 80, 100, 120, 140 kVp에서 soft 알고리즘이 SNR, CNR이 가장 높게 나타났다. 반면에 MAR를 사용한 경우 80 kVp에서는 Standard 알고리즘이 가장 높게 나타났고 100 kVp에서는 Standard, Soft 알고리즘이 비슷한 값으로 높게 나타났다. 120 kVp에서는 Soft, Standard 알고리즘이 비슷한 값으로 나타났고 140 kVp에서는 Soft 알고리즘에서 SNR, CNR이 가장 높게 나타났다. 따라서 Non MAR와 MAR를 비교했을 경우 MAR를 사용한다고 하더라도 관전압 변화에 따라 모든 알고리즘에서 SNR과 CNR이 증가하는 것은 아니었다. 본 연구는 이후 척추경 나사못 CT검사 영상 평가에 도움이 되는 기초자료로써 선택적인 관전압과 알고리즘 사용으로 영상의 질을 더 높일 수 있는 계기가 될 것으로 사료된다.

• Imaging Science in Dentistry
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• 제51권1호
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• pp.55-62
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• 2021

Purpose: This study evaluated the influence of a metal artifact reduction (MAR) tool in a cone-beam computed tomography (CBCT) device on the diagnosis of vertical root fractures (VRFs) in teeth with different root filling materials. Materials and Methods: Forty-five extracted human premolars were classified into three subgroups; 1) no filling; 2) gutta-percha; and 3) metallic post. CBCT images were acquired using an Orthopantomograph 300 unit with and without a MAR tool. Subsequently, the same teeth were fractured, and new CBCT scans were obtained with and without MAR. Two oral radiologists evaluated the images regarding the presence or absence of VRF. Receiver operating characteristic (ROC) curves and diagnostic tests were performed. Results: The overall area under the curve values were 0.695 for CBCT with MAR and 0.789 for CBCT without MAR. The MAR tool negatively influenced the overall diagnosis of VRFs in all tested subgroups, with lower accuracy (0.45-0.72), sensitivity (0.6-0.67), and specificity (0.23-0.8) than were found for the images without MAR. In the latter group, the accuracy, sensitivity, and specificity values were 0.68-0.77, 0.67-083, and 0.53-087, respectively. However, no significant difference was found between images with and without MAR for the no filling and gutta-percha subgroups (P>0.05). In the metallic post subgroup, CBCT showed a significant difference according to MAR use (P<0.05). Conclusion: The OP 300 MAR tool negatively influenced the detection of VRFs in teeth with no root canal filling, gutta-percha, or metallic posts. Teeth with metallic posts suffered the most from the negative impact of MAR.

• 한국방사선학회논문지
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• 제15권3호
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• pp.273-279
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• 2021

전산화단층촬영 검사 시 인체 내에 삽입되어 있는 금속물질은 금속주위에 있는 인체조직이나 뼈와 큰 밀도차이가 있어 인공물을 발생시킨다. 이 실험을 통해 Single source Dual energy CT에서 Dual energy검사 및 MAR 알고리즘의 특성을 비교분석하여 임상적으로 적용방법에 대한 기초자료를 제시하려 한다. MAR 알고리즘을 적용하거나 Dual Energy를 이용하여 검사하였을 때 금속 인공물이 감소하였는데 MAR알고리즘을 적용한 영상은 세부적인 부분을 왜곡시키는 단점이 있다. Dual Energy로 검사한 영상은 MAR알고리즘을 적용한 영상보다 세부적인 부분까지 구현해 낼 수 있다는 장점이 있으나 재구성에 소요되는 시간이 길며 피폭선량이 MAR알고리즘을 적용한 영상보다 약 4배 가량 높았다. 수술 후 Follow up 및 금속물질의 위치를 파악하기 위해서는 MAR알고리즘을 적용하여 영상을 획득하는 것이 검사적 측면에서 유용하며 미세 병변 확인 및 수술계획을 세우거나 진단적인 측면에서 검사를 시행하였을 때는 Dual Energy로 검사하는 것이 더 유용하다.

• Imaging Science in Dentistry
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• 제51권1호
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• pp.1-7
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• 2021

Purpose: The aim of this study was to assess artifacts generated in cone-beam computed tomography (CBCT) of 3 types of dental implants using 3 metal artifact reduction (MAR) algorithm conditions (pre-acquisition MAR, post-acquisition MAR, and no MAR), and 2 peak kilovoltage (kVp) settings. Materials and Methods: Titanium-zirconium, titanium, and zirconium alloy implants were placed in a dry mandible. CBCT images were acquired using 84 and 90 kVp and at normal resolution for all 3 MAR conditions. The images were analyzed using ImageJ software (National Institutes of Health, Bethesda, MD) to calculate the intensity of artifacts for each combination of material and settings. A 3-factor analysis of variance model with up to 3-way interactions was used to determine whether there was a statistically significant difference in the mean intensity of artifacts associated with each factor. Results: The analysis of all 3 MAR conditions showed that using no MAR resulted in substantially more severe artifacts than either of the 2 MAR algorithms for the 3 implant materials; however, there were no significant differences between pre- and post-acquisition MAR. The 90 kVp setting generated less intense artifacts on average than the 84 kVp setting. The titanium-zirconium alloy generated significantly less intense artifacts than zirconium. Titanium generated artifacts at an intermediate level relative to the other 2 implant materials, but was not statistically significantly different from either. Conclusion: This in vitro study suggests that artifacts can be minimized by using a titanium-zirconium alloy at the 90 kVp setting, with either MAR setting.

• 대한방사선치료학회지
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• 제29권2호
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• pp.9-17
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• 2017

목 적: 방사선치료에서 CT number에 의해 나타나는 조직의 묘사 및 전자밀도는 CT(Computed Tomography)기반의 전산화치료계획 정확성을 보장하는데 중요한 역할을 한다. 하지만 체내의 금속 이식물은 CT number의 정확성을 감소시킬 뿐 아니라 조직 묘사에 대한 불확실성을 나타내기 때문에 임상에서는 metal artifact를 감소시킬 수 있는 알고리즘이 개발되었다. 이에 본 연구에서는 본원에서 사용하고 있는 GE사의 SMART MAR의 CT number 정확도를 평가하고 방사선치료에서의 유용성에 대해 평가하고자 한다. 대상 및 방법: 영상평가를 위해 CIRS ED phantom을 이용하여 6개 조직의 rod를 삽입하여 동일한 체적의 ROI를 형성 후 original 영상을 획득하고 의료용 티타늄 rod를 삽입하여 non-SMART MAR 영상과 SMART MAR영상을 획득하여 CT number와 SD값을 비교하였다. Metal artifact로 인해 CT number 변화에 따른 선량변화 확인을 위해 전산화계획시스템 Epclipse를 사용하여 CIRS ED phantom CT 영상에 PTV를 형성하여 original 영상을 획득하고 편측 티타늄 삽입, 양측 티타늄 삽입 영상을 획득하여 non-SMART MAR와 SMART MAR영상에 동일한 치료계획을 수립하여 PTV가 받는 평균처방선량, HI(Homogeneity Index), CI(Conformity Index)를 비교, 분석하였다. 흡수선량 측정은 원통형 아크릴 팬텀과 0.125 cc ionchamber, electrometer를 이용하여 선량변환상수(cCy/nC)를 계산하고 CIRS phantom을 이용하여 편측, 양측 티타늄 rod를 삽입한 영상으로 non-SMART MAR와 SMART MAR 영상을 획득하여 동일한 지점에서의 흡수선량을 측정하여 전산화치료계획상의 point dose와 비교하였다. 결 과: 영상평가 결과 CT number는 non-SMART MAR영상보다 SMART MAR 영상이 original영상에 더 유사한 값이 나왔고 SD값은 SMART MAR영상에서 더 감소되었다. 선량평가 결과 평균처방선량과 HI 및 CI 값은 SMART MAR 영상보다 non-SMART MAR 영상이 original 영상에 더 근접한 결과가 나왔지만 통계적으로 유의하지 않았다. 흡수선량 측정결과 치료계획상의 point dose와 실제 흡수선량과의 차이가 non-SMART MAR의 영상에서는 각각 2.69, 3.63 %의 차이가 있었지만 SMART MAR영상에서는 0.56, 0.68 %로 감소하였다. 결 론: 금속 이식물을 삽입한 환자의 CT 영상에 SMART MAR를 적용했을 때 CT number 정확성 상승 및 SD 감소로 영상의 질이 향상되므로 종양과 정상조직의 윤곽도 생성 및 선량계산 시 유용할 것으로 사료된다.

• Imaging Science in Dentistry
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• 제50권1호
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• pp.23-30
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• 2020

Purpose: This study was conducted to assess the effectiveness of a metal artifact reduction (MAR) algorithm activated at different times during cone-beam computed tomography (CBCT) acquisition on the magnitude of artifacts generated by a zirconium implant. Materials and Methods: Volumes were obtained with and without a zirconium implant in a human mandible, using the OP300 Maxio unit. Three modes were tested: without MAR, with MAR activated after acquisition, and with MAR activated before acquisition. Artifacts were assessed in terms of the standard deviation (SD) of gray values and the contrast-to-noise ratio (CNR) in 6 regions of interest with different distances (10 to 35 mm, from the nearest to the farthest) and angulations(70° to 135°) from the implant region. Results: In the acquisitions without MAR, the regions closer to the implant(10 and 15mm) had a higher SD and lower CNR than the farther regions. When MAR was activated (before or after), SD values did not differ among the regions (P>0.05). The region closest to the implant presented a significantly lower CNR in the acquisitions without MAR than when MAR was activated after the acquisition; however, activating MAR before the acquisition did not yield significant differences from either of the other conditions. Conclusion: Both modes of MAR activation were effective in decreasing the magnitude of CBCT artifacts, especially when the effects of the artifacts were more noticeable.