• 생명과학회지
• /
• 제17권9호통권89호
• /
• pp.1177-1181
• /
• 2007

칼모둘린은 칼슘과 결합하는 센서로써 다양한 칼모둘린 결합 단백질들과의 상호 작용을 통하여 세포 내에서 여러가지 기능을 조절한다. 진핵 생물들은 많은 종류의 칼모둘린 결합 단백질을 가지고 있기 때문에 이러한 단백질들의 분리와 특성 규명이 중요하다. 이미 여러 가지 방법들을 이용하여 칼모둘린 결합 단백질들이 분리되었고 이미 알려진 단백질의 구조적인 유사성을 토대로 더 많은 단백질들이 예측되었다. 우리는 애기장대에서 칼모둘린 결합 단백질의 분리와 특성 규명을 위해 형광 단백질과 융합된 칼모둘린 과발현 형질 전환체를 제조하여 공촛점 현미경과 Western blot 을 이용하여 과발현 형질 전환체를 선별하였다. 또한 형질 전환체 내의 칼모둘린이 칼모둘린 결합 단백질과 상호 작용함을 pull-down 분석을 통해서 확인하였다. 이러한 결과들을 토대로 칼모둘린 과발현 형질 전환체를 이용하여, 칼모둘린과 상호 작용하는 여러 가지 칼모둘린 결합 단백질들을 분리할 수 있을 것으로 기대된다.

• 한국재료학회:학술대회논문집
• /
• 한국재료학회 2011년도 추계학술발표대회
• /
• pp.3.2-3.2
• /
• 2011

Nanofibers, one of various one-dimensional nanomaterials such as nanorods, nanowires and nanotubes have been successfully synthesized by many groups in recent years and their applications to chemical sensors, catalytic filters and biomedicine, etc. are extensively tested. In particular, there is a possibility that chemical sensors based on oxide nanofibers can overcome the shortcomings of chemical sensors based on single nanowires. In order to prepare oxide nanofibers, the electrospinning method is most widely used. In this work, we synthesized various oxide nanofibers including ZnO, SnO2 and CuO by employing an electrospinning method and various shapes of nanofibers including core-shell nanofibers and hollow nanofibers as well. The response properties of the various nanofibers to oxidizing and reducing gaseous species have been investigated systematically. The normal oxide nanofibers showed high sensitivity and quite fast response time to many gaseous species. Furthermore, derivatives of normal nanofibers including hollow nanofibers, core-shell nanofibers and heterostructured nanofibers display much superior sensing properties. These results hold promise for the practical application of oxide nanofibers to chemical sensors. In addition, the sensing mechanisms operated in the nanofibers will be discussed in detail.

• Design & Manufacturing
• /
• 제8권2호
• /
• pp.12-17
• /
• 2014

Currently, injection molding process is a very useful technique that be applied to many field. And injection molding technology has been commercial based on many studies. However, there is no standard of surface roughness because there are few studies about surface technology of injection product. In addition, when designing the mold, changes of the core surface and the injection conditions are not considered. In this paper, change of surface according to the core and the injection conditions was compared with the surface of the injection product. Accumulation of these technologies will propose direction in mold design, manufacturing and injection molding technology.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2007년도 추계학술대회 논문집 전기기기 및 에너지변환시스템부문
• /
• pp.223-225
• /
• 2007

The contact-less inductive power transformer (IPT) uses principle of electromagnetic induction. Generally, there were many methods to improve the transfer performance of traditional transformer. But, though the principle of IPT is similar to that of general transformer, it is impossible to apply the methods because of large air-gap. Consequently, many linear numerical formulas for analysis of performance and design of traditional transformer cannot be used in development of IPT. The concept of the IPT for vehicle like PRT(Personal Rapid Transit) system is suggested and some suggestions for power collector(core & winding) design of IPT to improve power transfer performance arc presented in this paper. The characteristic of power delivery with these novel methods in design is presented by simulation and examination.

• 정보관리학회지
• /
• 제31권3호
• /
• pp.293-311
• /
• 2014

이 연구에서는 계량정보학적 기법을 사용하여 국내 트위터 관련 연구의 동향을 분석하고자 하였다. 이를 위해 KCI에서 검색된 2009년부터 2014년 4월까지의 트위터 관련 논문 539편에서 제목, 초록, 키워드를 추출하여 분석 자료로 삼았다. 프로파일링 기법을 이용해 트위터 관련 연구가 수행된 학문 분야와 저널을 분석하였고, 동시출현단어 분석을 통해 트위터 관련 연구의 세부 주제 영역을 파악하였다. 그 결과, 국내 트위터 관련 연구는 53개 학문분야에서 다양하게 다루어지고 있으며 핵심 분야는 신문방송학, 경영학, 컴퓨터학 분야로 나타났다. 세부 주제로는 선거를 비롯한 정치 관련 이슈가 가장 많이 다루어졌으며, 기업/구매 관련 이슈도 활발히 연구되었음을 확인할 수 있었다.

• 한국멀티미디어학회논문지
• /
• 제23권2호
• /
• pp.376-382
• /
• 2020

In the 1970s and 1980s, space installations in films became a new approach to film research. Many film directors and theoretical scholars believe that the space setting in films, other than textual stories, is an important core of film narrative research. Early film scholars have proposed that the film space with sensory narrative mode as the core motive force can promote people's in-depth understanding of the film content. Therefore, many researchers have tried to emphasize the importance of space in films through Hitchcock's films, but have not analyzed the elements and techniques of film space performance in detail. Reviewing the Hitchcock's classic crime film, through the space set in the traditional film, we can discover the movie techniques and concepts related to space. Therefore, this study takes Hitchcock's classic crime film as an example, and through analysis of film space expression techniques, attempts to propose factors for film space creation and bring new spatial perception effects to the audience.

• 한국IT서비스학회지
• /
• 제14권4호
• /
• pp.61-80
• /
• 2015

This paper has explored the analyzing and defining the core competencies of IT consultants who carry out IT consulting projects which desperately are needed by companies to survive in business competitions. Many companies have used IT consultants for their IT projects to achieve their project objectives. The problem of this is the results of IT projects carried out by IT consultants from the recognized consulting firms are quite often criticized by many clients who pay high price for hiring IT consultants. The purpose of this paper is that to weight of capability evaluation model for IT consultants. To define the capability model, I conducted the surveys from the IT professionals by the interview and e-mails. The result of this, this paper defines what core skills IT consultants should have to perform well when they carry out the IT projects. There are 6 major skills and 17 sub skills IT consultants should have in succeeding IT projects. 6 major skills are job competence skill, communication skill, business attitude, vocational values, job performance skill, leadership skill and related 17 sub skill are defined. With the capability evaluation model, the managers who are in the charge of incubating and enhancing the capability of IT consultants in the large corporation and also small, medium companies will utilize their companies' strength to get the advantage on the business competition.

• 대한치매학회지
• /
• 제22권1호
• /
• pp.1-15
• /
• 2023

The Seoul Neuropsychological Screening Battery (SNSB) is known as a representative comprehensive neuropsychological evaluation tool in Korea since its first standardization in 2003. It was the main neuropsychological evaluation tool in the Clinical Research Center for Dementia of South Korea, a large-scale multi-center cohort study in Korea that was started in 2005. Since then, it has been widely used by dementia clinicians, and further solidified its status as a representative dementia evaluation tool in Korea. Many research results related to the SNSB have been used as a basis for the diagnosis and evaluation of patients in various clinical settings, especially, in many areas of cognitive assessment, including dementia evaluation. The SNSB version that was updated in 2012 provides psychometrically improved norms and indicators through a model-based standardization procedure based on a theoretical probability distribution in the norm's development. By providing a score for each cognitive domain, it is easier to compare cognitive abilities between domains and to identify changes in cognitive domain functions over time. Through the development of the SNSB-Core, a short form composed of core tests, which also give a composite score was provided. The SNSB is a useful test battery that provides key information on the evaluation of early cognitive decline, analysis of cognitive decline patterns, judging the severity of dementia, and differential diagnosis of dementia. This review will provide a broad understanding of the SNSB by describing the test composition, contents of individual subtests, characteristics of standardization, analysis of the changed standard score, and related studies.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1997년도 춘계학술대회
• /
• pp.374-378
• /
• 1997

Operative procedures such as core drilling with and without fibular bone grafting have been recognized as the treatment methods for osteonecrosis of femoral head(ONFH) by delaying or preventing the collapse of the femoral head. In addition, core drilling with cementation using polymethylmethacrylate (PMMA) has been proposed recently as another surgical method. However, no definite treatment modality has been found yet while operative procedures remain controversial to many clinicians In this study, a finite element method(FEM) was employed to analyze and compare various surgical procedures of ONFH to provide a biomechanical insight. This study was based upon biomechanical findings which suggest stress concentration within the femoral head may facilitate the progression of the necrosis and eventual collapse. For this purpose, five anatomically relevant hip models were constructed in three dimensions : they were (1) intact(Type I), (2) necrotic(Type II), (3) core drilled only(Type III), (4) core drilled with fibular bone graft(Type IV), and (5) core drilled with cementation(Type V). Physiologically relevant loading were simulated. Resulting stresses were calculated. Our results showed that the volumetric percentage subjected to high stress in the necrotic cancellous region was greatest in the core drilled only model(Type III), followed by the necrotic(Type II), the bone graft (Type IV), and the cemented(Type V) models. Von Mises stresses at the tip of the graft(Type IV) was found to be twice more than those of cemented core(Type V) indicating the likelihood of the implant failure. In addition, stresses within the cemented core(Type V) were more evenly distributed and relatively lower than within the fibular bone graft(Type IV). In conclusion, our biomechanical analyses have demonstrated that the bone graft method(Type IV) and the cementation method(Type V) are both superior to the core decompression method(Type III) by reducing the high stress regions within the necrotic cancellous bone. Also it was found that the core region filled with PMMA(Type V) provides far smoother transfer of physiological load without causing the concentration of malignant stresses which may lead to the failure than with the fibular bone graft(Type IV). Therefore, considering the above results along with the degree of difficulties and risk of infection involved with preparation of the fibular bone graft, the cementation method appears to be a promising surgical treatment for the early stage of osteonecrosis of the femoral head.

• Nuclear Engineering and Technology
• /
• 제49권7호
• /
• pp.1537-1546
• /
• 2017

Many thermal-hydraulic tests have been conducted at the Korea Atomic Energy Research Institute for verification of the SMART (System-integrated Modular Advanced ReacTor) design, the standard design approval of which was issued by the Korean regulatory body. In this paper, the contributions of these tests to the standard design approval of SMART are discussed. First, an integral effect test facility named VISTA-ITL (Experimental Verification by Integral Simulation of Transients and Accidents-Integral Test Loop) has been utilized to assess the TASS/SMR-S (Transient and Set-point Simulation/Small and Medium) safety analysis code and confirm its conservatism, to support standard design approval, and to construct a database for the SMART design optimization. In addition, many separate effect tests have been performed. The reactor internal flow test has been conducted using the SCOP (SMART COre flow distribution and Pressure drop test) facility to evaluate the reactor internal flow and pressure distributions. An ECC (Emergency Core Coolant) performance test has been carried out using the SWAT (SMART ECC Water Asymmetric Two-phase choking test) facility to evaluate the safety injection performance and to validate the thermal-hydraulic model used in the safety analysis code. The Freon CHF (Critical Heat Flux) test has been performed using the FTHEL (Freon Thermal Hydraulic Experimental Loop) facility to construct a database from the $5{\times}5$ rod bundle Freon CHF tests and to evaluate the DNBR (Departure from Nucleate Boiling Ratio) model in the safety analysis and core design codes. These test results were used for standard design approval of SMART to verify its design bases, design tools, and analysis methodology.