• Journal of Korean Institute of Industrial Engineers
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• v.30 no.4
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• pp.285-293
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• 2004

In this study, a machine grouping problem for the formation of manufacturing cells is considered. We constructed the problem as minimizing manufacturing leadtime consisting of parts' processing, moving, and waiting time. Specifically, the main objective of the defined problem is established as minimizing inter-cell traffic in order to minimize the part's moving time. In addition, to reduce the waiting time of parts, the load balance among cells is implicitly included as constraints. Since this problem is well known as NP-complete and cannot be solved in polynomial time, a genetic algorithm is implemented to obtain solutions. Also, a local optimization algorithm is applied in order to improve the solution by the genetic algorithm. Several experiments show that the suggested algorithms guarantee near optimal solutions in a few seconds.

• Molecules and Cells
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• v.45 no.5
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• pp.284-290
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• 2022

Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. Although many pharmaceutical companies are gradually developing exosome therapeutics, numerous hurdles remain regarding manufacture of clinical-grade exosomes for therapeutic use. In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinical-grade exosomes. However, owing to the lack of consensus regarding the guidelines for manufacturing therapeutic exosomes, close communication between regulators and companies is required for the successful development of exosome therapeutics. This review shares the challenges and perspectives regarding the manufacture and quality control of clinical grade exosomes.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.373-376
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• 2001

In this paper to cope with the reduction of products life-cycle as the variety of products along with the various demands of consumers, a virtual simulator is developed to make the changeover of manufacturing line efficient to embody a virtual simulation similar to a real manufacturing line. The developed virtual simulator can design a layout of a factory and make the time scheduling. Every factory has one simulator so that one product can be manufactured in the factories to use them as virtual factories. We suggest a scheme that heightens the ability to the diversity of manufacturing models by making the information of manufacturing lines and products models to be shared. The developed system embodies a virtual manufacturing line on the simulation using various manipulators and work cells as manufacturing components. we develop a virtual simulator system on Window 98/NT environment of Microsoft, operating system using of the greater part of PC user. Window program have a merit making GUI environment that programmer can use without the expert knowledge about hardware. A suer with the simulator can utilize an interface that makes one to manage the separate task process for each manufacturing module, change operator components and work cells, and easily teach tasks of each task module.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.1263-1266
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• 1997

In a fault-tolerant modern manufacturing systms characterized by the configuration, in which automated redundant machines prone to unexpected failures are interconnected with other complex subsystems such as AGV's, robots, computer control systems to produce complete parts, faulures together with repairs and reconfigurations should be considered as the three basic events to be modeled for computing the performance of manufacturing systems. In this papre, transient analysis is applied to modular cell manufacturing systems form a performability viewpoint whose modeling adantage is that various performanc e measures can be evaluated compositely in the context of application. The hypothertical modular cells are modeled firstly with hybrid decomposition method and availability measures as special cases of performability are computed and comments on performabililty modeling analysis are mentioned.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.390-396
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• 2002

This study is concerned with the strict machine-cell and part-family grouping (MCPFG) in cellular manufacturing system design. Most of MCPFG methodologies often suffer from improper assignment of machines and parts in which exceptional machine has more common operations with machines in a cell other than its own cell and exceptional part has more operations through machines in a cell other than the cell corresponding to its own family. This results in the loss of similarity in part design or common setup of machines and the benefits from the conversion of job shop manufacturing into cellular manufacturing are lost. In this study, a two-phase methodology is proposed to find the machine-cells and part families under the strict constraints in which all machines and parts are assigned to its most proper cells and families. Test results with moderately medium-sized ill-structured MCPFG problems available from the literature show the substantial efficiency of the proposed approach.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.50
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• pp.45-54
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• 1999

Cellular manufacturing(CM) is a manufacturing philosophy and strategy for improving both productivity and flexibility. Cell formation(CF), the first and key problem faced in designing an effective CM system, is a process whereby parts with similar design features or processing requirements are grouped into part families, and the corresponding machines into machine cells. In this paper, a sophisticated fuzzy mixed-integer programming model is proposed to simultaneously form manufacturing cells and minimize the total costs of dealing with exceptional elements. Also, we will proposed a new method to solve the cell formation problem in the fuzzy environment.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.1
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• pp.24-35
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• 2013

A cell formation approach based on cluster analysis is developed for the configuration of manufacturing cells. Cell formation, which is to group machines and parts into machine cells and the associated part families, is implemented to add the flexibility and efficiency to manufacturing systems. In order to develop an efficient clustering procedure, this paper proposes a cluster analysis-based approach developed by incorporating and modifying two cluster analysis methods, a hierarchical clustering and a non-hierarchical clustering method. The objective of the proposed approach is to minimize intercellular movements and maximize the machine utilization within clusters. The proposed approach is tested on the cell formation problems and is compared with other well-known methodologies available in the literature. The result shows that the proposed approach is efficient enough to yield a good quality solution no matter what the difficulty of data sets is, ill or well-structured.

• International Journal of Precision Engineering and Manufacturing
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• v.1 no.1
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• pp.84-90
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• 2000

The importance of Virtual Manufacturing System is increasing in the area of developing new manufacturing processes, implementing automated workcells, designing plant facility layouts and workplace ergonomics. Virtual manufacturing system is a computer system that can generate the same information about manufacturing system structure, states, and behaviors as is observed in a real manufacturing. In this research, a virtual manufacturing system for flexible manufacturing cells (VFMC), (which is a useful tool for building Computer Integrated Manufacturing (CIM), has been developed using object-oriented paradigm, and implemented with software QUEST/IGRIP. Three object models used in the system are the product model, the facility model, and the process model. The concrete behaviors of a flexible manufacturing cell are re[presented by the task-oriented description diagram, TIC. An example simulation is executed to evaluate applicability of the developed models, and to prove the potential value of virtual manufacturing paradigm.

• International Journal of Stem Cells
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• v.17 no.2
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• pp.102-112
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• 2024

An organoid is a self-organized three-dimensional structure derived from stem cells that mimics the structure, cell composition, and functional characteristics of specific organs and tissues and is used for evaluating the safety and effectiveness of drugs and the toxicity of industrial chemicals. Organoid technology is a new methodology that could replace testing on animals testing and accelerate development of precision and regenerative medicine. However, large variations in production can occur between laboratories with low reproducibility of the production process and no internationally agreed standards for quality evaluation factors at endpoints. To overcome these barriers that hinder the regulatory acceptance and commercialization of organoids, Korea established the Organoid Standards Initiative in September 2023 with various stakeholders, including industry, academia, regulatory agencies, and standard development experts, through public and private partnerships. This developed general guidelines for organoid manufacturing and quality evaluation and for quality evaluation guidelines for organoid-specific manufacturing for the liver, intestines, and heart through extensive evidence analysis and consensus among experts. This report is based on the common standard guideline v1.0, which is a general organoid manufacturing and quality evaluation to promote the practical use of organoids. This guideline does not focus on specific organoids or specific contexts of use but provides guidance to organoid makers and users on materials, procedures, and essential quality assessment methods at end points that are essential for organoid production applicable at the current technology level.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1995.04a
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• pp.122-129
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• 1995

This paper presents a similarity coefficient based approach to the problem of machine-part grouping for cellular manufacturing. The method uses relevant production data such as part type, production volume, routing sequence to make machine cells and part families for cell formation. A new similarity coefficient using weighted factors is introduced and an algorithm for formation of machine cells and part families is developed. A comparative study of two similarity coefficients - Gupta and seifoddini's method and proposed method - is conducted. A software program using TURBO C has been developed to verify the implementation.