• The Korea Journal of Herbology
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• v.28 no.2
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• pp.67-73
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• 2013

Objective : Lithospermum Erythrorhizon (LE) has been used as an anti-bacterial and anti-inflammatory agent. However, it is unclear that LE aqueous extract could show the anti-inflammatory effects in RAW 264.7cells. The purpose of this study was to investigate the anti-inflammatory effect of aqueous extract from LE on lipopolysaccharide (LPS) - induced inflammatory response. Methods : To measure out the cytotoxicity of LE, we performed the MTT assay. To evaluate the anti-inflammatory effects of LE, we examined the inflammatory mediators such as nitric oxide (NO), prostaglandin E2 ($PGE_2$) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-${\alpha}$, interleukin, (IL)-$1{\beta}$ and (IL)-6) on RAW 264.7 cells. We also examined molecular mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor-B (NF-${\kappa}B$) activation by western blot. Results : Aqueous Extract from LE itself did not have any cytotoxic effect in RAW 264.7 cells. Aqueous extract from LE inhibited LPS-induced productions of inflammatory mediators such as NO, $PGE_2$, and pro-inflammatory cytokines including TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 in RAW 264.7cells. In addition, LE inhibited the phosphorylation of p38 kinases (p38), c-Jun $NH_2$-terminal kinase (JNK), and NF-${\kappa}B$ activation in RAW 264.7 cells. Conclusion : LE down-regulated LPS-induced production of inflammatory mediators through the inhibition of p38, JNK and NF-${\kappa}B$ activation. Taken together, these results could provide the evidence for the anti-inflammatory effects of LE. Therefore, LE may be a novel target in the management of inflammation and help to support a potential strategy for prevention and therapy of inflammatory diseases.

• Journal of Wetlands Research
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• v.25 no.1
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• pp.64-73
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• 2023

Before 2022, there was a lot of confusion in the process of planning and implementing the projects for ecological restoration of the stream due to dualization the principal agent of stream management. Because the Ministry of Environment took charge of the project in 2022, securing the health of aquatic ecosystem of stream became an essential factor in the project. Therefore, in this study, the streams that require the project for ecological restoration was selected in Han River estuary, where it is essential to secure the health of the stream aquatic ecosystem as blackish water zone and Ramsar wetland are located. Physical, chemical, spatial/humanistic, health of aquatic ecosystems evaluation indexes were calculated based on the detailed facts and figures of the project for ecological restoration of the stream in the beginning. Ranking, re-scaling, z-score, and t-score normalization methods were applied to the calculated evaluation index, and the values were compared and analyzed. After that, the entropy weight method was applied to each evaluation index. Through this process, the streams(Mokgamcheon, Anyangcheon etc.) that require the project for ecological restoration were selected for the purpose of securing the health of the aquatic ecosystem in Han River estuary. The result of this study can be used as basic research data in the process of selecting the priority determination of the projects for ecological restoration of the stream.

• Journal of Korea Entertainment Industry Association
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• v.13 no.2
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• pp.13-25
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• 2019

This study conducted individual in-depth interviews of tourists from Taiwan, Hong Kong and Thailand who visited Daegu. According to the analysis, Taiwan's target audience conducted an interview at the Chimac Festival in July 2018 at Duryu Park and was a university student as an individual female tourist. She got the information through SNS. The accommodation was guest house and medium and low cost hotel. The main tourist attractions included Seomun Market Night Market, Eworld and Dongseongno. The meals were Anjirang Gopchang and Galbijim in Dongin-dong. Next, the Hong Kong tourist interview was held in May 2018 at the Kwandeung Festival in Duryu Park, and was an individual tourist as a man. Lastly, an interview with a Thai tourist was held in April 2018 at the Donghwa Temple Cherry Blossom Festival in Palgongsan Mountain, and he purchased a travel agent product as a man. Participants of the tour in Daegu were interested in unusual experiences such as beauty, wedding, theme parks, and restaurants that are unique to Korea. What was disappointing was that there were not enough shopping facilities, such as duty free shops, and that the table in the restaurant was inconvenient, and that there were not enough signboards by language for foreigners.

• Journal of Broadcast Engineering
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• v.28 no.3
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• pp.293-301
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• 2023

Unstandardized medical data collection and management are still being conducted manually, and studies are being conducted to classify CT data using deep learning to solve this problem. However, most studies are developing models based only on the axial plane, which is a basic CT slice. Because CT images depict only human structures unlike general images, reconstructing CT scans alone can provide richer physical features. This study seeks to find ways to achieve higher performance through various methods of converting CT scan to 2D as well as axial planes. The training used 1042 CT scans from five body parts and collected 179 test sets and 448 with external datasets for model evaluation. To develop a deep learning model, we used InceptionResNetV2 pre-trained with ImageNet as a backbone and re-trained the entire layer of the model. As a result of the experiment, the reconstruction data model achieved 99.33% in body part classification, 1.12% higher than the axial model, and the axial model was higher only in brain and neck in contrast classification. In conclusion, it was possible to achieve more accurate performance when learning with data that shows better anatomical features than when trained with axial slice alone.

• Tuberculosis and Respiratory Diseases
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• v.86 no.2
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• pp.82-93
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• 2023

Tuberculosis (TB) is a significant public health concern. Globally, TB is among the top 10 and the leading cause of death due to a single infectious agent. Providing standard anti-TB therapy for at least 6 months is recommended as one of the crucial strategies to control the TB epidemic. However, the long duration of TB treatment raised the issue of non-adherence. Non-adherence to TB therapy could negatively affect clinical and public health outcomes. Thus, directly observed therapy (DOT) has been introduced as a standard strategy to improve anti-TB medication adherence. Nonetheless, the DOT approach has been criticized due to inconvenience, stigma, reduced economic productivity, and reduced quality of life, which ultimately could complicate adherence issues. Apart from that, its effectiveness in improving anti-TB adherence is debatable. Therefore, digital technology could be an essential tool to enhance the implementation of DOT. Incorporating the health belief model (HBM) into digital technology can further increase its effectiveness in changing behavior and improving medication adherence. This article aimed to review the latest evidence regarding TB medication non-adherence, its associated factors, DOT's efficacy and its alternatives, and the use of digital technology and HBM in improving medication adherence. This paper used the narrative review methodology to analyze related articles to address the study objectives. Conventional DOT has several disadvantages in TB management. Integrating HBM in digital technology development is potentially effective in improving medication adherence. Digital technology provides an opportunity to improve medication adherence to overcome various issues related to DOT implementation.

• 한국노년학
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• v.39 no.4
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• pp.741-762
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• 2019

The purpose of this study is to identify the Nutrition Quotient for Elderly(NQ-E) of the elderly living in the community and to investigate the characteristics of living conditions affecting the nutritional status of the elderly. The subjects of the survey were 1,970 elderly single elderly households aged 65 and over in the nationwide through convenience sampling method. A survey cooperative system was established with Comprehensive Support Center for Elderly Living Alone, and the 25 social welfare institutions. 385 Life Managers for Elderly Living Alone participated as a survey agent. As a result, NQ-E was 51.14 points, which is the lowest level in the NQ-E, and the explanatory power was 20.1% in multiple regression analysis. Significant variables were age, sex, subjective health status, low number of medication, non-smoker, non-alcoholic, satisfactory economic status, academic status, and the interaction with family and neighbors. Based on this result, this study explains that comprehensive measures of nutritional management for the elderly living alone needs to be sought.

• Korean Journal of Culture and Social Issue
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• v.9 no.spc
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• pp.35-55
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• 2003

The purpose of this study is to review the previous studies on the safety problems in Korea and to propose a psychological total safety system model. The model consisted of four agents; the government as the safety management agent, the suppliers of safety goods and services, consumer of safety goods and services, and civil movement institutions for safety. It was emphasized that the culture specific social representations of safety and accident have emerged in the course of rapid industrialization process in Korea during last 30 years. We delineated the social representations of the Korean people on safety and accident according to the model. A psychological analysis of drinking and driving behavior was performed as an application of the model. It was emphasized that safety psychologists have to develope and to apply the knowledge and the information from human engineering psychology and applied social psychology on safety and accidents.

• Information Systems Review
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• v.19 no.4
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• pp.135-156
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• 2017

An intelligent personal assistant (IPA) is a software agent that assists people to perform basic tasks or services for an individual by commonly providing information via natural language. In spite of the versatile capabilities of the IPA to answer a user's simple information-based queries, such as the weather and driving directions, the actual usage rates for IPA services are limited to date. In this research, to evaluate the factors affecting the intention to use IPA, we develop an empirical model based on technology acceptance model, innovation diffusion theory, and IS success model. Afterward, we collect 203 questionnaires from actual users of IPAs. Finally, the structural equation model validates the causal relationship between the constructs of the model. Consequently, the innovation characteristics of IPA drawn from innovation diffusion theory, namely, relative advantage, compatibility, observability, all exerted a positive influence on perceived usefulness. Furthermore, information quality, a quality characteristic of IPA obtained from DeLone and McLean's IS success model, presented a positive effect on perceived usefulness and perceived ease of use. Finally, the perceived intelligence of IPA displayed a positive influence on perceived usefulness and ease of use. This characteristic was also a major factor that can increase the intention to use the IPA. Given these research findings, this study is significant for identifying factors that may influence the intention to use the IPA by providing strategic guidelines to relevant business operators and establishing an integrated model.

• Journal of Food Hygiene and Safety
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• v.39 no.3
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• pp.181-190
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• 2024

Bovine mastitis-associated Escherichia coli (BMEC) is considered the main causative agent of significant financial losses in the dairy industry worldwide, as it alters both the quantity and quality of milk produced and increases the rate of culling. This creates a variety of challenges for researchers, veterinarians, and farmers in understanding and determining the most effective therapies and diagnostic techniques. Subclinical mastitis is particularly concerning, as infected bovines exhibit no obvious symptoms and continue to secrete apparently normal milk over an extended period, allowing the causative pathogen, E. coli, to spread within the herd. For effective prevention, understanding the pathogenesis of mastitis through three stages invasion, infection, and inflammation is essential. To date, no clear correlation has been found between virulence factors and pathogenicity contributing to the clinical severity of BMEC. Multidrug-resistant E. coli and the evolution of novel resistance mechanisms have become concerns owing to the extensive use of antibiotics to treat mastitis. Therefore, it is vital to explore alternative controls to enhance the efficacy of BMEC treatment. Over the past 30 years, various genetic typing techniques have been used to examine the subspecies-level epidemiology of bovine mastitis. These studies have advanced our understanding of the origin, transmission pathway, population structure, and evolutionary relatedness of BMEC strains. In this review we provide an overview of BMEC, including insights into its etiology, genetic relationship, pathogenesis, and management of the disease, as well as new therapy options.

• Journal of Korean Society of Archives and Records Management
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• v.4 no.2
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• pp.23-39
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• 2004

The Bolshevik Revolution of 1917 resulted not only in the establishment of the Socialist regime, but also in the critical changes in the Russian archival system. The Soviet government issued "Decree On the Reorganization and Centralization of Archival Affairs in the Russian Socialist Federated Soviet Republic", which prepared the ground for the archival administration in USSR. After having been revised and supplemented in the 1920's, the decree, signed by V. I. Lenin, was changed into "The Decree on the Archival Administration of Russian Soviet Federated Socialist Republic", by which the Bolshevik government was able not only to develop the conception of the State Archival Fond with the Single Archival Fond, but also to enlarge the archival collection. Besides, it was remarkable that the archival decree of 1929 provided the justification for actual developments of the archival institution. And from the practical point of view, the decree improved the archival affairs by means of the defining of the conservation period. It was at the beginning of the Stalin's period that the decree of 1929 was issued. Therefore, it may be said that the decree was one of the proofs as well as the agricultural collectivization and the industrialization that Stalin gained the overall control of the Soviet government. It was confirmed when the Second Conference of Soviet Archivists was held from 25 May to 1 June in 1929. After this meeting, M. N. Pokrovskii, who was the director of the Archival Administration in the course of the 1920's, lost the influence over the Soviet archival organizations, which meant that the autonomy of the Soviet archivists was reduced in a great degree. The Central Archival Administration of the Bolshevik regime experienced the analogous changes. It was changed into the Central Archival Agent in 1929 when the Stalinist system became strengthened. At the same time, it was significant that the Central Archival Administration of USSR was established. However, the Soviet archival affairs became under the direct control of the N. K. V. D. in the period of the Great Purge.