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BIOLOGICAL STUDIES IN CHILD AND ADOLESCENT DEPRESSION (소아 ${\cdot}$ 청소년 우울장애의 생물학적 연구)

  • Cho, Soo-Churl
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.5 no.1
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    • pp.28-35
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    • 1994
  • Research on biological aspects on adult depression has been subjected to more than 25 years of systematic research, while biologic investigations regarding childhood and adolescent depression are only now being initiated. Although no unifying, explanatory theory of the biologic etiology of childhood depression emerges from the results of studies reviewed above, the findings do support that biological factors may be involved in the genesis of childhood depression. The research reviewed in this paper suggests that age and pubertal factors have major effects in most biological markers of depression. Some of these markers, like sleep EEG and neuroendocrine markers should be broken down by decades during adult life span. Thus, although adult data are very valuable points of departure for biological research on child and adolescent depression, it is very hard to transfer the adult data to prepubertal children and adolescents, ignoring the biological changes that take place in growth and development, pubety and aging. A great deal of work in basic developmental neuroscience remains to be done. It will be crucial for further advances in this field to determine the normal patterns of neurotransmitter interaction in this age group and to study children at high risk for depression. It will be also crucial to use primate models of depressive illness in order to be able to answer the many queations that cannot be investigated in humans for ethical issues. Conclusively, much closer collaboration between developmental and neurobiological and behavioral studies in primates and in humans will be essential for further development.

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Software development for the visualization of brain fiber tract by using 24-bit color coding in diffusion tensor image

  • Oh, Jung-Su;Song, In-Chan;Ik hwan Cho;Kim, Jong-Hyo;Chang, Kee-Hyun;Park, Kwang-Suk
    • Proceedings of the KSMRM Conference
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    • 2002.11a
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    • pp.133-133
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    • 2002
  • Purpose: The purpose of paper is to implement software to visualize brain fiber tract using a 24-bit color coding scheme and to test its feasibility. Materials and Methods: MR imaging was performed on GE 1.5 T Signa scanner. For diffusion tensor image, we used a single shot spin-echo EPI sequence with 7 non-colinear pulsed-field gradient directions: (x, y, z):(1,1,0),(-1,1,0),(1,0,1),(-1,0,1),(0,1,1),(0,1,-1) and without diffusion gradient. B-factor was 500 sec/$\textrm{mm}^2$. Acquisition parameters are as follows: TUTE=10000ms/99ms, FOV=240mm, matrix=128${\times}$128, slice thickness/gap=6mm/0mm, total slice number=30. Subjects consisted of 10 normal young volunteers (age:21∼26 yrs, 5 men, 5 women). All DTI images were smoothed with Gaussian kernel with the FWHM of 2 pixels. Color coding schemes for visualization of directional information was as follows. HSV(Hue, Saturation, Value) color system is appropriate for assigning RGB(Red, Green, and Blue) value for every different directions because of its volumetric directional expression. Each of HSV are assigned due to (r,$\theta$,${\Phi}$) in spherical coordinate. HSV calculated by this way can be transformed into RGB color system by general HSV to RGB conversion formula. Symmetry schemes: It is natural to code the antipodal direction to be same color(antipodal symmetry). So even with no symmetry scheme, the antipodal symmetry must be included. With no symmetry scheme, we can assign every different colors for every different orientation.(H =${\Phi}$, S=2$\theta$/$\pi$, V=λw, where λw is anisotropy). But that may assign very discontinuous color even between adjacent yokels. On the other hand, Full symmetry or absolute value scheme includes symmetry for 180$^{\circ}$ rotation about xy-plane of color coordinate (rotational symmetry) and for both hemisphere (mirror symmetry). In absolute value scheme, each of RGB value can be expressed as follows. R=λw|Vx|, G=λw|Vy|, B=λw|Vz|, where (Vx, Vy, Vz) is eigenvector corresponding to the largest eigenvalue of diffusion tensor. With applying full symmetry or absolute value scheme, we can get more continuous color coding at the expense of coding same color for symmetric direction. For better visualization of fiber tract directions, Gamma and brightness correction had done. All of these implementations were done on the IDL 5.4 platform.

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Serotype and antimicrobial susceptibility of Salmonella spp. isolated from pigs and cattle (소와 돼지유래 Salmonella속 균의 혈청형 및 약제감수성)

  • Lee, Woo-Won;Jung, Byeong-Yeal;Lee, Gang-Rok;Lee, Dong-Soo;Kim, Yong-Hwan
    • Korean Journal of Veterinary Service
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    • v.32 no.1
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    • pp.49-59
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    • 2009
  • At the present study, it was aimed to explore the states of antimicrobial resistant Salmonella spp. isolates from 3,850 pigs (2,732 ileocecocolic lymphnodes and 1,118 cecal contents) and 1,764 cattle (965 cecal lymphnodes and 799 cecal contents) slaughtered in Busan province from December 2000 to November 2001. Among 5,614 samples, 457 of Salmonella spp. were isolated from pig lymphnodes (13.5%), pig cecal contents (4.4%), cattle lymphnodes (3.5%) and cattle cecal contents (0.5%). Salmonella spp. were showed different isolation ratio, that was 10.8% in summer, 9.0% in autumn, 8.4% in spring and 5.0% in winter. As a result of serotyping, B group (65.4%) were identified as the most common in pigs and cattle, in order of $C_1$ (14.0%), $D_1$ (5.5%), $C_2$ (4.2%), $E_1$ (4.2%) and L (3.5%). 34 serotypes were found, among them, Salmonella Typhimurium (S. Typhimurium) (21.0%) was the most common serotype from pigs and cattle. The major serotypes were in order of S. Derby (15.3%), S. Schwarzengrund (14.7%), S. Typhimurium var Copenhagen (9.2%), S. Mbandaka (5.7%), S. Enteritidis (5.5%) and S. Ruiru (3.5%). The most common serotype was S. Typhimurium in pigs, and S. Ruiru in cattle. S. Ruiru was firstly isolated from pigs and cattle in Korea. In antimicrobial susceptibility test, all the isolates were demonstrated susceptibility to norfloxacin and ofloxacin. But the isolates were showed resistance other antibiotics in order of doxycycline (68.3%), tetracycline (67.8%), penicillin (54.5%) and streptomycin (52.5%). S. Typhimurium were exhibited resistance to ampicillin (34.8%), chloramphenicol (36.2%), streptomycin (94.9%), sulfamethoxazole/trimethoprim (34.8%) and tetracycline (97.8%). There were 53 strains (38.4%) which had multi drug resistant (MDR) isolates, resistant to more than 6 antimicrobial agents. The most common resistance patterns of MDR isolates were ampicillin, chloramphenicol, carbenicillin, doxycycline, nalidixic acid, penicillin, streptomycin, sulfamethoxazole/trimethoprim and tetracycline (ACCbDNaPSSuT).

Variation of Protein Content and Amino Acid Composition in Perilla Germplasm (들깨 유전자원의 단백질함량과 아미노산조성)

  • Lee, Jung-Il;Bang, Jin-Ki;Lee, Bong-Ho;Kim, Kwnag-Ho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.35 no.5
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    • pp.449-463
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    • 1990
  • To obtain the basic informations on quality improvement, seed protein and amino acid composition were analyzed in 460 strains of perilla germplasm. Among the tested strains, total protein content ranged from 17.9% to 28.1 % with the 23.6% of varietal means. Form the experiment, Namji, Sandong, and Eunjin were selected as high protein strains of which content was as high as 28.1%. In protein content, collected strains from Jeonnam province showed highest, and was not significantly different by maturity, but this characteristics showed differences by seed coat color and 1,000 seed weight. The significantly negative correlation was observed between protein content and seed setting ratio. However it was observed that significant and high positive correlation between protein and oil content. A calibration for an Infra-Alyzer 450 using log reflectance readings at 2208, 1982, 1940 and 1722nm could be used without adjustment for the measurment of the protein content in perilla with a standard deviation of differences against micro-kjeldahl of 0.27%. The amino acid composition of perilla was similar to the other oilseed crops, and showed a relatively high lysine and methionine content. Further, amino acid composition of perilla seed was exellently characterized with bal ance and higher than FAO recommendation. Major amino acids were indentified as a glutamic acid and arginine in perilla seed protein.

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Factors Influencing the Satisfaction of In-School Clinical Practice Due to COVID-19 (COVID-19로 인한 교내 임상실습 영향요인)

  • Seung-Ju Kang;Chung-Sin Shim
    • Journal of Industrial Convergence
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    • v.20 no.12
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    • pp.245-250
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    • 2022
  • This study aims to identify the factors that affect the satisfaction of practice among nursing students who participated after replacing it with on-campus practice in a situation where practice was not possible due to COVID-19. Data were collected from 144 nursing students who participated in the clinical practice alternative campus practice conducted from September 13 to December 3, 2021 at a university located in G province. Data analysis was analyzed by ANOVA, Pearson's correlation coefficient, and hierarchical multiple regression analysis. The subject's satisfaction with practice is a general characteristic, self-efficacy (r=.540, p=.000), self-leadership (r=.553, p=.000), and critical thinking ability (r=.382, p=.000). , there was a significant correlation between major satisfaction (r= .248, p=.003). Variables that affect the clinical performance of the subjects were self-efficacy 20.4% (𝛽=.266, p=.047), self-leadership 51.2% (𝛽=.271, p=.047), and satisfaction with practice The explanatory power of the variables was 33.8%. Therefore, it is necessary to develop and apply a curriculum that can increase self-leadership and self-efficacy in order to increase the satisfaction of nursing students' practice.

The Analysis of Vegetation-Environment Relationships of the Coniferous Forests in Subalpine Districts of Mt. Chiri by TWINSPAN and CCA (TWINSPAN 및 CCA에 의한 지리산(智異山) 아고산대(亞高山帶) 침엽수림군집(針葉樹林群集)과 환경(環境)의 상관관계(相關關係) 분석(分析))

  • Lee, Soo Won;Lee, Kang Young;Song, Ho Kyung
    • Journal of Korean Society of Forest Science
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    • v.86 no.3
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    • pp.279-287
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    • 1997
  • This study was carried out to identify the analysis of vegetation-environment relationships of the coniferous forests in subalpine districts of Mt. Chiri by two-way indicaton species analysis(TWINSPAN) and CCA. The results are summarized as follows; The subalpine coniferous forest in Mt. Chin was classified Abies koreana community group by the TWINSPAN method. The Abies koreana community group was classified Abies koreana-Pinus densiflora, Abies koreana-Quercus mongolicd and Abies koreana-Picea jezoensis. The Abies koreana-Quercus mongolica community classified into two subcommunities, typical and Pinus koraiensis subcommunity. The Abies koreana-Picea jezoensis community classified into three subcommunities such as typical, Taxus cuspidate and Cornus controversa subcommunity. The subalpine conifers commnities in Mt. Chiri could be classified into six vegetation units, which consisted of three vegetation communities and five subcommunities. The relationship between vegetation community and influencing environmental factors was analyzed by using the CCA ordination method. It was found that altitude, concentrations of $Ca^{++}$ and $Mg^{++}$ in soil were, major environmental variables, which influence the distribution of vegetation community in the first axis, and $Ca^{++}$ and altitude in the second axis. In the relations of communities and environmental factors by CCA, the optimal ecological habitats of Abies koreana-Pinus densiflora community could be located at low elevations, in which $Ca^{++}$ and $Mg^{++}$ are rich. Abies koreana-Quercus mongolica community prefers the sites in mid-elevation zone, in which $Ca^{++}$ and $Mg^{++}$ are medium level in soil. The optimum site for Abies koreana-Pinus koraiensis community and Abies koreana-Taxus cuspidata community could be high elevations in which $Ca^{++}$ and $Mg^{++}$ are poor. Abies koreana-Cornus controversa community is found in the site at low elevations where $Ca^{++}$ and $Mg^{++}$ are medium.

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Characteristics of Soil Erosion on the Forest Fired Sites by Using Rainfall Simulator (인공강우장치를 이용한 산불발생지의 토양침식 특성에 관한 연구)

  • Lee, Heon Ho;Joo, Jae Duk
    • Journal of Korean Society of Forest Science
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    • v.95 no.6
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    • pp.649-656
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    • 2006
  • The purpose of study is to measure soil erosion quantity for elapsed four years from the fire on forest fired sites of Dong-gu, Daegu. This study was conducted to investigate the characteristics of soil erosion by fire occurrence influencing on the soil erosion were. Also analysis result follows that the relations between soil erosion quantity and rainfall intensity, the slope and elapsed year. The results analysed were as follows: 1. Soil erosion by year of occurrence of forest fire was increased 1.9 to 5.7 times as rainfall intensity was increased by 30 m/hr, and 1.4 to 14.2% as degree of slope was increased by $10^{\circ}$. 2. In the first year of forest fire occurrence, soil erosion was fairly heavy for 10 minutes of initial rainfall of which rainfall intensity was 80 m/hr and degree of slope was $30^{\circ}$. The amount of soil erosion was gradually reduced as elapsed time. From two years after fire, the amount of soil erosion by rainfall intensity and degree of slope was nearly constant. 3. The amount of soil erosion by rainfall intensity and slope in accordance with elapsed time after fire was reduced 28.9 to 94.1% in three years after occurrence of forest fire as compared to the first year of fire. Soil erosion was fairly heavy by rainfall intensity and slope in the first year of fire, but it was gradually reduced from two years after fire. 4. In the analysis on influences of each factors on the amount of soil erosion on forest fired sites, the amount of soil erosion was significant differences in major impacts of each rainfall intensity, degree of slope and elapsed year after fire and interaction of rainfall intensity${\times}$degree of slope and rainfall intensity${\times}$elapsed year after fire, but no differences were observed in interaction of degree of slope${\times}$elapsed year after fire and rainfall intensity${\times}$degree of slope${\times}$elapsed year after fire. Rainfall intensity was the most affecting factor on the amount of soil erosion and followed by degree of slope and elapsed year after fire. 5. For correlation between soil erosion and affecting three factors, soil erosion showed significant positive relation with rainfall intensity and degree of slope at I % level, and significant negative relation with elapsed year after fire at 1 % level. 6. As a result of regression of affecting three factors on soil erosion. rainfall intensity was most significant impact factor in explaining the amount of soil erosion on forest fired sites, followed by degree of slope and elapsed year after forest fire. 7. The formula for estimating soil erosion using rainfall intensity, degree of slope and elapsed year after forest fire occurrence was made. S.E = 0.092R.I + 0.211D.S - 0.942E.Y(S.E : Soil erosion, R.I : Rainfall intensity, D.S : Degree of slope, E.Y : Elapsed year after forest fire occurrence)

Monitoring of Toxicants Affecting Metamorphosis of Silkworm in Mulberry Leaves (뽕잎 및 대기 중 누에영향물질 모니터링 및 독성조사)

  • Park, Kyung-Hun;Park, Yeon-Ki;Lee, Hee-Dong;Park, Byung-Jun;Joo, Jin-Bok;Sohn, Bong-Hee;Kang, Pil-Don;Kim, Mi-Ja;Seong, Su-Il
    • Journal of Sericultural and Entomological Science
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    • v.46 no.2
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    • pp.58-64
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    • 2004
  • The current study was performed to clarify the pupation disorder symptoms in silkworm which herbicide, molinate has been regarded as a causal origin. Molinate residues in mulberry leaves was monitored in major rearing area of silkworm; Yeacheon, Sangju and Namwon. Detected range of the molinate in mulberry leaves was 0.002 to 0.013 mg/kg and detection frequency was 30.0 to 81.8%. Molinate concentration in the air of mulberry tree growing area was $0.004\;{\mu}g/m^3$. Water diluted solution of molinate at the concentration of 1, 10, 100 mg/l gave no abnormal symptoms in silkworm irrespective of spraying to silkworm or spiking to diet. Exposing the silkworm to the air containing 250, 2,500, and $10,000\;{\mu}g/m^3$ also revealed no abnormal symptom. These results illustrated that the abnormal growth of silkworm encountered in the field was not caused by pesticide contamination.

Development of Pitch Pine Glued Laminated Timber for Structural Use -Improvement of Bending Capacity of Pitch Pine Glulam by Using Domestic Larch Laminars- (리기다소나무의 구조용 집성재 이용기술 개발 -낙엽송 층재와의 혼합 구성을 통한 집성재의 휨성능 향상-)

  • Kim, Kwang-Mo;Shim, Kug-Bo;Park, Joo-Saeng;Kim, Wun-Sub;Lim, Jin-Ah;Yeo, Hwanmyeong
    • Journal of the Korean Wood Science and Technology
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    • v.35 no.6
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    • pp.13-22
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    • 2007
  • This study was carried out to scrutinize possibility of manufacturing pitch pine (Pinus rigida) glued laminated timber in order to add values of pitch pine trees. Also, it was investigated to improve bending performance of pitch pine glulam. Pitch pine was imported as one of major plantation species in Korean peninsula. Machine stress rated grades of pitch pine lumber mostly ranged between E7 and E9. which grades were more or less inferior to producing high quality glulam. However, the adhesive properties between pitch pine and pitch pine, and between pitch pine and Japanese larch (Larix kaempferi Carr.), such as shear bond strength, wood failure rate and de-lamination rate of bonded layer submerged in cold and boiling water, were higher than Korean Standard criteria. These properties are essential for manufacturing glulam with single species or multiple species. The modulus of rupture (MOR) of pitch pine glulam exceeded the criterion of Korean Standard for glulam strength grade but modulus of elasticity (MOE) was lower than the criterion. On the other hand, the bending performances (MOR and MOE) were improved 20 percent by mixing with Japanese larch laminar. It is effective to arrange higher quality Japanese larch laminar at the outer layer of glulam for improving bending performances. In conclusion, it is possible to use low quality pitch pine as laminar of structural glulam for adding values of pitch pine.

Breeding of a Mid Maturing Watermelon Cultivar, 'Hangyeol' with Resistance to Anthracnose Race 3 (수박 탄저병 Race 3 저항성 중생종 수박 '한결' 육성)

  • Huh, Yun-Chan;Hong, Kue-Hyon;Ko, Ho-Cheol;Park, Kyoung-Sub;Park, Dong-Kum;Lee, Joong-Sup;Cho, Myeoung-Cheoul;Lee, Sok-Young;Ko, Kwan-Dal;Lee, Woo-Moon
    • Korean Journal of Breeding Science
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    • v.42 no.6
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    • pp.695-698
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    • 2010
  • The incidence of Anthracnose causing severe damage to the foliage and fruit in watermelon has increased in some major watermelon producing areas in Korea. To develop anthracnose resistant line, 'AU-Producer' having resistant gene to anthracnose was selected from germplasm and crossed with high quality line '920533'. Following the initial cross, backrossing and disease screening were performed to select resistant lines that produced high yields with excellent quality fruit. As a results of these procedure, a mid maturing watermelon line, 'Hangyeol' with resistance to anthracnose (Colletotrichum orbiculare) race 1 and 3 was developed at the National Institute of Horticultural and Herbal Science, Rural Development Administration (RDA). It has red flesh and commonly produces fruit with clear stripes on skin between 5.3 to 10.1 kg. Average soluble solid contents are ranged from 9.8 to 11.8$^{\circ}$Bx. The yield and quality of 'Hangyeol' is comparable to or better than those harvested from the popular commercial cultivars. The achievement of this experiment could contribute to provide the resistant parents in an anthracnose resistance breeding program in watermelon.