• Clinical and Experimental Pediatrics
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• v.56 no.12
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• pp.505-513
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• 2013

Because the prevalence of allergic diseases has significantly increased in recent years, understanding the causes and mechanisms of these disorders is of high importance, and intense investigations are ongoing. Current knowledge pinpoints immune tolerance mechanisms as indispensable for healthy immune response to allergens in daily life. It is evident that development and maintenance of allergen-specific T cell tolerance is of vital importance for a healthy immune response to allergens. Such tolerance can be gained spontaneously by dose-dependent exposures to allergens in nature or by allergen-specific immunotherapy. Allergen-specific immunotherapy induces regulatory T cells with the capacity to secrete interleukin-10 and transforming growth factor-${\beta}$, limits activation of effector cells of allergic inflammation (such as mast cells and basophils), and switches antibody isotype from IgE to the noninflammatory type IgG4. Although allergen-specific immunotherapy is the only method of tolerance induction in allergic individuals, several factors, such as long duration of treatment, compliance problems, and life-threatening side effects, have limited widespread applicability of this immunomodulatory treatment. To overcome these limitations, current research focuses on the introduction of allergens in more efficient and safer ways. Defining the endotypes and phenotypes of allergic diseases might provide the ability to select ideal patients, and novel biomarkers might ensure new custom-tailored therapy modalities.

• Journal of Radiation Protection and Research
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• v.10 no.1
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• pp.41-49
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• 1985

Neutron Streaming analysis in 1300 MWe pressurized water reactor cavity was performed. In this calculation, the discrete ordinates transport codes, ANISN and DOT 3.5, and the Monte Carlo code, TRIPOLI-02 were used with the coupling code, DOTTRI. In this study IBM 3033 type computer was used. The calculated neutron fluxes and dose rates were compared with the measured data in a 900MWe pressurized water reactor cavity to show a good agreement, although some deviations in the results for each energy group were noticed. These results will be applied in the radiation shielding design of high capacity nuclear power reactors and, to the means of radiation protection in case of the reactor maintenance and the access of the reactor cavity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1159-1162
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• 2004

We studied on the production of the ceramic by the mineral-Oriental medicine and the property of the clean active water depositting on the ceramic stone. The results are as follows: We properly mixed of maifanshi, mica, ochre, and added to a small amount cinnabar, and therefore formed the ceramic stone. By the plasticity process and the irradiating magnetic force recovered the disappeared a part of constitutent elements. The recovered effects were become higher the freshness, maintenance, deodoriztion, clean water. As well as having the ability on capture of the notoxious heavy metal on human. The ceramic powder were mixed proper dose maifanshi, mica. And the powder had ionization, absorption, adhesion by the plasticity process and magnetic force. The clean active water of depositting on the ceramic stone during 24hours were observed significant the content of micro element, dissolved oxygen, abstraction on Herbs.

• Korean Journal of Veterinary Service
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• v.31 no.4
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• pp.457-463
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• 2008

The sex steroid hormone estradiol-$17{\beta}(E_2)$ mediate their biological effects on development, differentiation and maintenance of reproductive tract and other target tissue through gene regulation by nuclear steroid receptors. Although the importance of $E_2$ in many physiological process has been reported, but little is known about the effects of $E_2$ on primary cultured chicken hepatocyte. therefore, in the present study, we have examined the effect of $E_2$ on cell proliferation and it's related signal cascades. $E_2$ increase $[^3H]$-thymidine incorporation in time-(${\leq}8hr$) and dose-($10^{-10}M$)dependent manner and treatment of $E_2$ increased the phosphorylation of p44/43 MAPKs(p44/42 mitogen-activated protein kinase) and JNK(c-Jun N-terminal kinase) in a time dependent manner. In addition, PD98059(p44/42 blocker, $10^{-5}M$), SP600125(JNK blocker, $10^{-6}M$) blocked the estrogen-induced increase in $[^3H]$-thymidine incorporation. In conclusion, $E_2$ stimulates the proliferation of primary cultured chicken hepatocytes and this action is mediated by p44/42 MAPKs and JNK signal transduction pathway.

• Clinical and Experimental Pediatrics
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• v.49 no.6
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• pp.696-699
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• 2006

Tolosa-Hunt syndrome is a rare disease in children characterized by dull, persistent pain around the affected eye and ophthalmoplegia caused by granulomatous inflammation in the cavernous sinus, superior orbital fissure, or orbit. Although spontaneous remission can occur, corticosteroids frequently have a dramatic response; however, recurrence can transpire after complete remission. We report an 11-year-old girl with Tolosa-Hunt syndrome who responded to corticosteroid promptly, without complications, but suffered three recurrences of headache and retro-orbital pain and required maintenance on a low dose of steroid.

• Korean Journal of Biological Psychiatry
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• v.23 no.2
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• pp.48-56
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• 2016

Alzheimer's disease (AD) is a neurodegenerative disorder in which neuronal loss causes cognitive decline and other neuropsychiatric problems. It can be diagnosed based on history, examination, and appropriate objective assessments, using standard criteria such as the Diagnostic and Statistical Manual of Mental Disorders or the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Brain imaging and biomarkers are making progress in the differential diagnoses among the different disorders. The cholinesterase inhibitors, donepezil, rivastigmine and galantamine and N-methyl-D-aspartate receptors antagonist memantine are approved by the US Food and Drug Administration for AD. Recently some acetylcholinesterase inhibitors gained approval for the treatment of severe AD and became available in a higher dose formulation or a patch formulation. Optimal care in AD is multifactorial and it should include early diagnosis and multidisciplinary care with pharmacological and nonpharmacological interventions including exercise interventions, cognitive interventions and maintenance of social networks.

• The Journal of the Korean Society for Microbiology
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• v.21 no.3
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• pp.331-336
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• 1986

A microbiological study for the isolation and characterization of Leptospira interrogans was performed in an attempt to define the characteristics of Leptospirosis in Korea. The results are summerised as follows. Thirty-five cultures were isolated from 11 patients with leptospirosis and 24 wild rodents captured in Paju area. The isolation rate of Leptospira from wild rodents reached 23.1%. All 35 cultures were identified as Leptospira interrogans by their characteristic morphology and motility in dark field microscopy, pathogenecity in Guinea pig and sensitivity to 8-Azaguanine. Cultures formed diffuse subsurface colonies with hazy margin and were catalase, peroxidase and oxdase positive. The fifty percent lethal dose of isolate HM 4 in Guinea pig was $8.9{\times}10^4$ org. Mouse passage method was sucecssfully applied in maintenance of fresh isolates without any loss of their original virulency.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.2307-2310
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• 2005

A pressurizer is one of the major safety related equipment of nuclear power plants. In order to inspect and maintain the internal structures of a pressurizer, jumpers have to enter the pressurizer, in spite of the high dose exposure. Therefore, a tele-operated robotic manipulator has been developed, which consists of four parts with 2DOFs arms, a gripper, base frame, and control console. The task of this robotic manipulator is to extract the damaged electric heaters and inspect the internal structure of the pressurizer. The gripper hanging from the manipulator approaches the heaters and extracts the damaged heater by using a self-locking mechanism. In order to investigate the structural stability of the robotic manipulator, a stress analysis has been performed by using the ANSYS code. The results of this paper include the position control and vibration control of robotic gripper and the development of processing visual information for a vision sensor.

• Journal of Radiation Protection and Research
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• v.11 no.1
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• pp.65-69
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• 1986

An asymmetry in dose profile of a $^{60}Co$ teletherapy unit was found by means of water-phantom measurement. The reason of that trouble was confirmed to be the abnormal 'ON' position of the source, which is resulted from the high friction between contiguous surfaces of the spring for driving the source to 'OFF' position. Lubrication in the spring improved the mobility a little, but was not a radical repair. The radical repair was to replace the old spring by new one. Periodic maintenance for source driving system and periodic measurement of field symmetry are required for prevention of abnormal 'ON' position of $^{60}Co$ source.

• Journal of Environmental Science International
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• v.20 no.6
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• pp.767-773
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• 2011

The objectives of this research are to investigate the proper coagulation conditions which are a type and doses of coagulants, mixing conditions (velocity gradients and mixing times), pH and so on through Jar-test, to evaluate the flux variations, permeate, backwashing according to characteristics of pretreatment of the wastewater by means of MF membranes for river maintenance water reuse. The effluent water from B-city K-sewage treatment plant are used for this research. Turbidity and suspended solids(SS) are 14.2 NTU and 10.4 mg/L respectively. This condition causes fouling for membrane process. The flux decline could be reduced when coagulation pretreatment was carried out. Optimal coagulations PAC which are commonly used in the sewage treatment plant was observed in this research. The results indicate that an optimal coagulation dose and pH are 80 ppm and pH of 7 respectively, but coagulation efficiency was lower at strong acid or strong base. Results showed that continuous and steady operations in membrane separation process by means of the effective removal of organic matter and turbidity with coagulation pretreatment of sewage secondary effluent were achieved.