• 제목/요약/키워드: main agent of research

검색결과 242건 처리시간 0.025초

Properties of Bubble used in Concrete ac cording to Change in Manufacturing Condition

  • Byoungil Kim
    • Architectural research
    • /
    • 제26권1호
    • /
    • pp.13-20
    • /
    • 2024
  • This study is a research investigation into the properties of bubbles that affect the characteristics of foamed concrete during its production. The study examined the properties of bubbles based on the manufacturing conditions. To investigate these properties, the selected experimental factors included bead size, the length/diameter ratio of the bubble-generating tube, and compressed air. The experimental design used a design of experiments, and the test results were analyzed using analysis of variance. The foaming agent used to generate bubbles was AES (Alcohol Ethoxy Sulfate), and the method employed for bubble manufacture was the pre-foaming method. In the test results, a significant factor affecting the foaming rate of bubbles was the bead size; the highest foaming rate was observed when using 2mm beads. Bead size also primarily influenced the volume change of the aqueous solution, while other factors did not affect the foaming rate and volume change. None of the factors affected the change in bubble size, but compressed air was considered the main factor affecting bubble size and its change. The foaming rate and volume change of the aqueous solution showed a high correlation with each other. Spherical bubbles in the early stage eventually transformed into angular bubbles. Moreover, over time, it was observed that the bubble size increased.

Inhibitory Effect of Panax notoginseng and Berberine on LPS-induced iNOS, COX-2 and Prostaglandin E2

  • Lee, Boo-Young;Moon, Jin-Young;Kim, Cherl-Ho;Park, Won-Hwan
    • 동의생리병리학회지
    • /
    • 제20권5호
    • /
    • pp.1327-1333
    • /
    • 2006
  • Many traditional herbal remedies exhibit several beneficial effects including anti-inflammation. Panax notoginseng Buck F.H. Chen. is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Korean and Chinese medicine. The pharrnacokinetic profiles of the main P. notoginseng are still not accurately investigated. The exact mechanism of the anti-inflammatory action of P. notoginseng, however, has not been determined. In the present study, we examined the effect of P. notoginseng on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, and inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW264.7 macrophages. The results indicated that P. notoginseng concentration-dependently inhibited LPS-induced NO production. Furthermore, P. notoginseng inhibited the expression of LPS-induced iNOS and COX-2 proteins without an appreciable cytotoxic effect on RAW264.7 cells. Berberine also inhibited LPS-induced iNOS protein as potently as P. notoginseng. This was consistent with the findings that P. notoginseng and also berberine inhibited prostaglandin E2 synthesis induced by LPS.

Genetic Variation of Strawberry Fusarium Wilt Pathogen Population in Korea

  • Cho, Gyeongjun;Kwak, Youn-Sig
    • Mycobiology
    • /
    • 제50권1호
    • /
    • pp.79-85
    • /
    • 2022
  • Strawberries are a popular economic crop, and one of the major plantations and exporting countries is Korea in the world. The Fusarium oxysporum species complex (FOSC) is a soil-borne pathogen with genetic diversity, resulting in wilt disease in various crops. In Korea, strawberries wilt disease was first reported in the 1980s due to the infection of FOSC, causing significant economic damage every year. The causal agent, F. oxysporum f. sp. fragariae, is a soil-borne pathogen with a characteristic of FOSC that is difficult to control chemically and mutates easily. This study obtained genetic polymorphism information that was based on AFLP, of F. oxysporum f. sp. fragariae 91 strains, which were isolated from strawberry cultivation sites in Gyeongsangnam-do and Chungcheongnam-do, and compared strains information, which was the isolated location, host variety, response to chemical fungicide, and antagonistic bacteria, and mycelium phenotype. As a result, AFLP phylogeny found that two groups were mainly present, and group B was present at a high frequency in Gyeongsangnam-do. Group B proved less sensitive to tebuconazole than group A through Student's t-test. In addition, the fractions pattern of AFLP was calculated by comparing the strain information using PCA and PERMANOVA, and the main criteria were separated localization and strawberry varieties (PERMANOVA; p< 0.05). And tebuconazole was different with weak confidence (PERMANOVA; p< 0.10). This study suggests that the F. oxysporum f. sp. fragariae should be continuously monitored and managed, including group B, which is less chemically effective.

미국 노스다코타주 농업연구와 농촌지도의 특징과 한국의 농촌지도사업에 주는 시사점 (Characteristics of North Dakota State University Extension Service in USA)

  • 박덕병;고햄 개리
    • 농촌지도와개발
    • /
    • 제8권1호
    • /
    • pp.73-83
    • /
    • 2001
  • North Dakota State University (NDSU) Extension Service's purpose was to create a learning partnership that helped adults and youth enhance their lives and communities. NDSU Extension Service has maintained a strong blend of county, regional and state staff to support their program delivery. Experiment Station and Extension Service were integrated both in their job duties and at the administrative level. While researchers at the campus and center carried out both research and outreach activities with producers, Extension staff both at county and center carried out some research activities as well as outreach activities. The strong county-based Extension network was the main avenue for program delivery. Extension agents also provide programs on a multi-country basis. Program planning includes county advisory councils, multi-county advisory councils, support groups, and commodity groups, such as farmers and business people. Planning was used to shape their long-range plan of work along with adjustments to their annual activities. Funding of the NDSU Extension Service has been a blend of federal, state, and county dollars. In the past few years, grant dollars and agency partnerships have increased. Local input into extension programs, combined with support and funding from state and federal partners, enabled the extension service to truly meet the needs of people.

  • PDF

Effect of Combined Exposure to EDTA and Zinc Pyrithione on Pyrithione Absorption in Rats

  • Jung, Dong Sik;Jung, Guk Hwa;Lee, Eun Ho;Park, Hye Ran;Kim, Ju Hwan;Kim, Kyu-Bong;Kim, Hak Rim;Kim, Hyung Gun
    • Toxicological Research
    • /
    • 제35권2호
    • /
    • pp.155-160
    • /
    • 2019
  • Zinc pyrithione (ZnPT) is a coordination complex of zinc and has been used widely as an anti-dandruff agent in shampoos. Many shampoos contain both ZnPT and EDTA, a chelating agent speculated to increase ZnPT absorption, thereby raising concerns about neurotoxicity. Here, we investigated the effect of EDTA on ZnPT absorption by direct comparison of ZnPT and pyrithione (PT) concentrations in shampoo formulations, and by pharmacokinetic analysis of ZnPT, PT, and 2-methanesulfonylpyridine (MSP), the main ZnPT metabolite, in rat plasma or urine following exposure to shampoo containing ZnPT alone or a combination of ZnPT and EDTA. Approximately 17.3% of ZnPT was converted to PT by the addition of EDTA in the shampoo formulation. Plasma ZnPT and PT concentrations were not measured up to 24 hr after treatment with shampoo containing 1% ZnPT or 1% ZnPT + 2% EDTA in all rats. However, PT amount in 24-hr urine sample, MSP concentration in plasma, and MSP amount in 24-hr urine sample were approximately 4-, 2.6-, and 2.7-fold higher, respectively, in the 1% ZnPT + 2% EDTA shampoo group than in the 1% ZnPT shampoo group. As confirmed by the formulation analysis and in vivo pharmacokinetic analysis, the exposure of ZnPT could be increased by the absorption of PT due to partial dissociation of ZnPT into PT.

Characterizations of High Early-Strength Type Shrinkage Reducing Cement and Calcium Sulfo-aluminate by Using Industrial Wastes

  • Lee, Keon-Ho;Nam, Seong-Young;Min, Seung-Eui;Lee, Hyoung-Woo;Han, Choon;Ahn, Ji-Whan
    • 한국세라믹학회지
    • /
    • 제53권2호
    • /
    • pp.215-221
    • /
    • 2016
  • In this study, the utilization of the by-products of various industries was examined using raw materials of CSA high-functional cement such as coal bottom ash, red mud, phosphate gypsum, etc. Technology to improve energy efficiency and reduce $CO_2$ was developed as part of the manufacturing process; this technology included lower temperature sintering ($150{\sim}200^{\circ}C$) than is used in the OPC cement manufacturing process, replacement of CSA cement with the main raw material bauxite, and a determination of the optimum mix condition. In order to develop CSA cement, a manufacturing system was established in the Danyang plant of the HANIL Cement Co. Ltd., in Korea. About 4,200 tons of low purity expansion agent CSA cement (about 16%) and about 850 tons of the lime-based expansion agent dead burned lime (about 8%) were produced at a rate of 60 tons per hour at the HANIL Cement rotary kiln. To improve the OPC cement properties, samples of 10%, 13%, and 16% of CSA cement were mixed with the OPC cement and the compressive strength and length variation rate of the green cement were examined. When green cement was mixed with each ratio of CSA cement and OPC cement, the compressive strength was improved by about 30% and the expansibility of the green cement was also improved. When green cement was mixed with 16% of CSA cement, the compressive strength was excellent compared with that of OPC cement. Therefore, this study indicates the possibility of a practical use of low-cost CSA cement employing industrial wastes only.

자심활혈탕(滋腎活血湯)이 전신성홍반성낭창(全身性紅斑性狼蒼) 동물모델에 미치는 영향(影響) (Effect of Jasinwhalhyul-tang on MRL/MpJ-Ipr/Ipr Mouse Model with Systemic Lupus Erythematosus)

  • 최훈섭;조충식;김철중
    • 대한한의학회지
    • /
    • 제29권1호
    • /
    • pp.67-84
    • /
    • 2008
  • Objective : The main purpose of this study was to evaluate the effect of Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) on MRL/MpJ-Ipr/Ipr mouse model with systemic lupus erythematosus. Methods: The effect of JWT on MRL/MpJ-Ipr/Ipr mice that have autoimmune disease similar to SLE in humans was evaluated after JWT per oral in the present study. Mice were administered with Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) (80 or 400mg/kg) or distilled water for control group from experimental week 10 for 22 weeks. Results : The amount of erythematosus skin lesion and proteinuria were significantly decreased. The size and weight of cervical lymph nodes and spleen were significantly reduced. The ratio between activated $CD3^+CD69^+$ T-cells and undifferentiated $CD3^+CD4^-CD8^-$ T-cells in lymph nodes, spleen and kidney was effectively reduced. The gene expression of TGF-$\beta$ in spleen and kidney was increased. The amount of anti-dsDNA IgG in blood was decreased. The gene expression of TGF-$\beta$ in normal mouse spleen cells was increased depending on concentration by treatment of with T cell stimulating agent. In the histological examination of skin and kidney, the amount of infiltration of immune cells involved in the inflammatory response was decreased. Conclusions : According to the above results, JWT should be considered as an applicable therapeutic agent to SLE in clinical practice. Further research is required to investigate other efficacies of JWT on SLE.

  • PDF

UCP 600 해상운송서류(海上運送書類) 규정(規定)의 주요(主要) 개정사항(改正事項)에 관한 연구(硏究) (A Study on The Revision of UCP600 concerning the Sea Transport Documents)

  • 박세운
    • 무역상무연구
    • /
    • 제35권
    • /
    • pp.71-98
    • /
    • 2007
  • UCP 600 approved at the Banking Commission Meeting of ICC at the end of October, 2006 comes into effect from July 1, 2007. The main revision of the UCP 600 concerning the sea transport document are as follows. First, if the bill of lading contains an on-board-notation, with the date of shipment, the date stated in the on-board-notation will be deemed the date of shipment. Secondly, phrases "on its face" and "otherwise authenticated" should be eliminated. Thirdly, when an agent signs for or signs on behalf of the master, there is no longer a need for the name of master to be quoted. Fourthly, the terminology "loading on-board or shipped on a named vessel" is changed to "shipped on-board a named vessel." Fifthly, phrases "the rejection of the documents transported only by sail" is removed. Finally, new rule in UCP is the signing of a charter party bill of lading by the charterer or a named agent on behalf of the charterer. My assessment of the revision in UCP 600 is as follows: Because a freight forwarder transport document is a weaker form than a liner bill of lading as collateral, banks may need a secure measure as to protect themselves from such a weak collateral effect. we recognize that Such a weak collateral effect stemmed from the elimination of rules in UCP 500 article 30, and the admission of transport documents issued by the freight forwarder as long as any one besides carrier, shipper, and charterer satisfies the requirements of transport document clauses in UCP 600. Finally, I hope the Commentary on UCP 600 will serve to explain the ambiguities remaining in the new rules.

  • PDF

노년여성의 브래지어 구매의사결정 관련행동에 관한 연구 (A Study on the Behavior Related to Brassieres Purchasing Decision Making of Elderly Women)

  • 박은미
    • 대한가정학회지
    • /
    • 제35권2호
    • /
    • pp.65-79
    • /
    • 1997
  • This research is intended for 418 elderly women who reside in Seoul and the National Capital region. the survey and analysis are on the practical behavior related to purchasing decision making of brassieres for elderly women. The purpose of the survey and analysis is to induce contented and rational purchase activity for elderly women; also, to supply the fundamental sources which can support accomplishing scientific and systematic marketing activity to foundation manufacturing business. The main results of this study are as follows; 1. The elderly women tend to decide on purchase of the brassiere subjectively alone than rely on the informants and to listen to sales women's advice more. The younger, more educated and higher income of family, the elderly women tend more to depend on their own subjective sense than others' recommendations and rely on such mass media as TV and magazines for information source. 2) The elderly women tend to purchase their brassieres personally. In particular, the younger, more educated and higher income they tend more to choose their brassieres alone rather than with others. 3) The companions for elderly women's purchase were their daughter, daughter-in-law and friends. The younger, more educated and higher income, they tend more to accompany friends. The older, less educated and lower income, they tend more to be accompanied by their daughter or daughter-in-lay. 4) The elderly women are aware of the trademarks for brassieres. Although most of them know about their brassiere size, the majority of them tend to purchase their brassieres without trying on them. the older, less educated and lower income, they are less aware of trademarks and their brassiere size, and thus are less influential in their purchasing decision making. 5) The places of purchasing on which elderly women rely most for their brassiere are department stores, agent and markets. Other places are private haberdashery's, discount and pension shop. The department stores are most used by the less younger, more educated and higher income, while the markets are most often visited by those older, less educated and lower income, while the markets are most often visited by those older, less educated and lower income. The agent are favored by the medium class old people between two extremes.

  • PDF

The Antioxidative Effect of Eclipta prostrata L. Extract on Cultured NIH3T3 Fibroblasts Injured by Manganese-Induced Cytotoxicity

  • Lee, Sang-Hee;Jung, In-Ju;Jang, Hyesook
    • 대한의생명과학회지
    • /
    • 제24권4호
    • /
    • pp.357-364
    • /
    • 2018
  • Manganese (Mn) is used as main materials in various chemical processes of industry, but it suggested that Mn brings about its toxicant by fume or dust through respiratory system and skin barrier. Mn toxicant induces the loss of mental health and life quality by cerebrovascular and skin diseases. Nevertheless, it lefts much unknown on the mechanism and the effectively therapeutic methods about Mn toxicant. Therefore, this study was evaluated the cytotoxicity induced by manganese dioxide ($MnO_2$) in cultured NIH3T3 fibroblasts, and also, the correlation between $MnO_2$-induced cytotoxicity and oxidative stress was examined. While, the effect of Eclipta prostrata L. (EP) extract belong to Compositae was assessed against $MnO_2$-induced cytotoxicity in the view of antioxidative effect for searching the natural resources mitigating or preventing the $MnO_2$-induced cytotoxicity. In this study, $MnO_2$-induced cytotoxicity was revealed as mid-toxic by Borenfreud and Puerner's toxic criteria, and catalase (CAT), an antioxidant prevented $MnO_2$-induced cytotoxicity by the remarkable increase of cell viability in these cultures. While, in the protective effect of EP extract on $MnO_2$-induced cytotoxicity, EP extract effectively prevented the cytotoxicity induced by $MnO_2$ via antioxidative effects such as xanthine oxidase (XO) inhibitory ability and DPPH-radical scavenging ability. From the above results, EP extract showed the effective prevention against $MnO_2$-induced cytotoxicity correlated with oxidative stress by antioxidative effects. Conclusively, this study may be useful to research or development the alternatively therapeutic agent from natural resources like EP extract for the treatment of diseases resulted in oxidative stress.