• Archives of Pharmacal Research
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• v.26 no.12
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• pp.1096-1101
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• 2003

To enhance the liver targeting and reduce the side effects of 5-fluorouracil (5-Fu), it was acylated by stearyl chloride to obtain .$\b{N}_{\b{1}}$stearyl-5-Fu (5-FuS). The chemical structure of the prodrug was confirmed by Nuclear Magnetic Resonance and Infrared Spectrometry. 5-FuS was incorporated into solid lipid nanoparticles (SLN), which were prepared by the physical agglomeration method. The mean diameter of 5-FuS-SLN was 240.19 nm and the drug loading was 20.53%. The release characteristics in vitro of 5-FuS-SLN were fitted to the first-order pharmacokinetic model. Compared with 5-Fu injection, a study on the distribution of 5-FuS-SLN in mice showed that 5-FuS-SLN could double 5-Fu concentration in mice livers. The main pharmacokinetic parameters of 5-FuS-SLN in rabbits is shown as follows: $V_d$=0.04336L/kg, $T_{1/2} \beta$=1.2834h, CL=0.1632 L/h. In conclusion, 5-FuS-SLN has significant liver targeting properties. The employment of a prodrug to enhance drug liposoluble properties and the preparation method presented in this paper, seem to be an alternative strategy to the traditional colloidal delivery system.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.691-706
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• 2008

ATP(Automatic Train Protection) system in railway signaling system is the important one grasping the position and velocity of a train. The wayside transmitter of ATP system is installed between rails. In concrete slab track, the signal current using wayside transmitter of ATP system is influenced by reinforcing bars. The magnetic coupling between reinforcing bars and wayside transmitter of ATP system as a filter makes an input current distorted. So, it makes an alternating current signal with a desirable size not transmit to on-board system of a train. Way to decrease the distortion of an input current signal frequency is to avoid maximum induction current frequency. And the induction phenomenon between reinforcing bars insulated and wayside transmitter of ATP system does not occur. In this paper, we represent the model about wayside transmitter of ATP system and reinforcing bars on the concrete slab tracks, and calculated the parameters demanded for the model. Also, we demonstrated it through the Maxwell program. Furthermore, we calculated impedance on wayside transmitter used in KVB system and ERTMS/ETCS system which are a kind of ATP system, frequency response of induction current, using the Matlab, and demonstrated the validity of it, using the PSpice program.

• Korean Journal of Optics and Photonics
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• v.6 no.4
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• pp.352-358
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• 1995

Measurements of the Faraday rotation and magnetization of terbium-doped Hoya FR5 glass and cerium-doped Hoya FR4 glass have been made as a function of temperature T in the range 4.2 K -10 K and of magnetic field H of up to 80 kG at the $Ar^+$ laser wavelength of 514.5nm. The saturations of magnetization and Faraday rotation above H/T> $5kG.K^{-1}$ can be analyzed by the quantum theory of paramagnetism. Calculated parameters show that the large Verdet constant of $Ce^{3+}$ glass is due to the effective $4f\rightarrow5d$ electric dipole transition effect and that of $Tb^{3+}$ glass is due to the magnetization effect.effect.

• Journal of Magnetics
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• v.16 no.2
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• pp.108-113
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• 2011

The electron spin resonance lineshape (ESRLS) function for the electron spin resonance linewidth (ESRLW) of $Cr^{3+}$ (S = 3/2) in ferroelectric lithium niobate single crystals doped with 0.05 wt% of Cr, is obtained by using the projection operator technique (POT), developed by Argyres and Sigel. The ESRLS function is calculated to be axially symmetric about the c - axis and analyzed by using the spin Hamiltonian $H_{SP}={\mu}_B(B{\cdot}{^\leftrightarrow_{g}}{\cdot}S)+S{\cdot}{^\leftrightarrow_{D}}{\cdot}S$ with the parameters g = 1.972 and D = $0.395\;cm^{-1}$. In the ca plane, the linewidths show a strong angular dependence, whereas in the ab plane, they are independent of the angle. This result implies that the resonance center has an axial symmetry along the c - axis. Further, from the temperature dependence of the linewidths that is shown, it can be seen that the linewidths increase as the temperature increases, at a frequency of v = 9.27GHz. This result implies that the scattering effect increases with increasing temperature. Thus, the POT is considered to be more convenient to explain the scattering mechanism as in the case of other optical resonant systems.

• Transactions of Materials Processing
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• v.23 no.7
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• pp.431-438
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• 2014

For electromagnetic forming(EMF) the most important feature is a forming coil which creates the electromagnetic force(Lorentz force), using current density and a magnetic field. Most previous papers have concentrated on the final configuration of the blank or the efficiency of EMF process. Studies focused on the design parameters affected by the forming coil performance have not been conducted. In order to design a suitable forming coil for an object, the current study uses LS-DYNA EM-Module to not only optimize the coil but also to examine the effect of coil performance. By this method a suitable forming coil was made and tested to determine whether or not good formability was achieved in a free bulge test Numerical analysis was also used. The workpiece was Al 1100-O with a thickness of 1.27mm and the coil was made from copper CW004A, which has good electrical conductivity and is suitable for electrical components.

• Kyungpook Mathematical Journal
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• v.47 no.4
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• pp.455-471
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• 2007

The magnetohydrodynamic axisymmetric instability of a streaming gas jet surrounded by bounded fluid with non-uniform field has been developed. The problem is formulated, solved and the boundary conditions are applied across the interfaces. The eigenvalue relation is derived and discussed analytically and the results are confirmed numerically. Some reported works are recovered as limiting cases from the present general results. The streaming has a destabilizing effect for all short and long wavelengths. The capillary force is stabilizing for short wavelengths but it is destabilizing for long wavelengths. The axial magnetic fields interior the gas and fluid media are stabilizing. The transverse field is destabilizing for all wavelengths. The radii ratio of the gas and fluid cylinders plays an important role for stabilizing the model and made it more realistic one than the full liquid jet or/and the ordinary hollow jet. The numerical analysis clarify the stable and unstable domains based on different values of the various parameters of the problem.

• Proceedings of the KIEE Conference
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• 1994.07b
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• pp.1603-1605
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• 1994

Recently, Gas Circuit Breakers are rapidly replacing Vacuum Circuit Breakers in the medium voltage switchgear. This is due to the improved performance of - GCB in interrupting capability, price, weight, size etc., while the countermeasure to suppress the switching surges of VCB has not been satisfactory. Intensive research works on the GCB have been conducted in the world widely since 1980. Nowadays it is well known that the thermal expansion type GCB can provide- better performance than puffer type in the distribution power system. KERI has conducted researches in the GCB rated at 25.8kV 25kA with Jinkwang Co. using the thermal expantion principle since 1993. In this paper, the calculated results of electric and magnetic fields for the model GCB are presented and analyzed. The effect of permanent magnet used to improve the interruption capabilty at the low current level is also investigated. The design parameters for the interrupter inspected through the short-circuit tests conducted at high power laboratory of KERI.

• Proceedings of the KIEE Conference
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• 1997.07a
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• pp.47-50
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• 1997

The FEM(Finite Element Method) can be used to analysis SRM(Switched Reluctance Motor) as it can account for the salient pole geometry of the stator and rotor and the nonlinear properties of the magnetic materials. However, FEM requirers a lot of computer memory and computing time because, the kind of SRM drivers is verity and the switching strategies are various for one SRM driver. In this paper we proposed the method of analysis of a SRM which results are similar to FEM and has very short computing time. The Inductance and torque for each phase current at each rotor position are calculated by using two-dimensional nonlinear FEM analysis. Using the look-up table of inductance and torque and the voltage equations of SRM we obtained the phase current and torque. To verify proposed algorithm, 3 phase 6/4 SRM is analysed and found a good agreement with FEM results. And computing time is about 1/1600 of the FEM analysis.

• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.26.2-26.2
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• 2009

The Solar and Space Weather Research Group (SOS) in Korea Astronomy and Space Science Institute (KASI) is constructing the Space Weather Prediction Center since 2007. As a part of the project, we are developing automatic real-time system of the global 3-D magnetohydrodynamics (MHD) simulation. The MHD simulation model of earth's magnetosphere is designed as modified leap-frog scheme by T. Ogino, and it was parallelized by using message passing interface (MPI). Our work focuses on the automatic processing about simulation of 3-D MHD model and visualization of the simulation results. We used PC cluster to compute, and virtual reality modeling language (VRML) file format to visualize the MHD simulation. The system can show the variation of earth's magnetosphere by the solar wind in quasi real time. For data assimilation we used four parameters from ACE data; density, pressure, velocity of solar wind, and z component of interplanetary magnetic field (IMF). In this paper, we performed some initial tests and made a animation. The automatic real-time system will be valuable tool to understand the configuration of the solar-terrestrial environment for space weather research.

• Proceedings of the KIEE Conference
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• 1998.07a
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• pp.104-106
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• 1998

For the development of the 0.7 MJ small-sized superconducting magnetic energy storage (${\mu}$SMES) device, quench currents of a kA class superconducting cable were tested for various winding tensions because a dry superconducting coil is usually quenched by an abrupt heat pulse due to strand motions. The test coil similar to parameters of the optimally designed 0.7 MJ ${\mu}$SMES except a stored energy and a size was fabricated based on the test results of the kA class superconducting cable and tested. These experimental results show that the highly prestressed test coil has an excellent DC performance in spite of a dry type coil but its quench current is much degraded even at the low field ramping rate of about 0.4 T/s.