• Journal of Nutrition and Health
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• 제43권4호
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• pp.357-366
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• 2010

There has been no genome-wide association study (GWAS) for macronutrient intake as a quantitative trait. To explore genetic loci associated with total calorie and macronutrient intake, genome-wide association data of autosomal single nucleotide polymorphisms (SNPs) from Korean adults were analyzed. We conducted a GWAS in 3,690 men and women aged 40 to 60 years from an urban population-based cohort. At the baseline examination (June 18, 2001 through January 29, 2003), DNA samples of the study subjects were collected and analyzed for genotyping. The information of average daily consumption of total calorie, carbohydrate, protein, and fat was obtained from a semi-quantitative food frequency questionnaire and transformed by natural logarithm for analyses after adjustment of calorie intake. Using multivariate linear regression analysis adjusted for age, sex, and height, we tested for 352,021 SNPs and found weak associations, which do not reach genome-wide association significance, with calorie and macronutrient intake. However, a number of SNPs were found to have potential associations with macronutrient intake; in particular, signals in SORBS1 and those in PRKCB1 were likely associated with carbohydrate and fat intake, respectively. We observed an inverse association between the minor allele of the SNPs in these genes and the amount of consumption of carbohydrate or fat. Our GWAS identified loci and minor alleles weakly associated with macronutrient intake. Because SORBS1 and PRKCB1 are reportedly associated with the metabolism of glucose and lipid as well as with obesity-related diseases, further investigations on biological and functional roles of polymorphism of these genes in the relation to macronutrient intake are warranted.

• 대한지역사회영양학회지
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• 제3권2호
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• pp.210-217
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• 1998

The purpose of this study was to examine changes in energy and macronutrient intakes during the premenstrual(days -10-1) and postmenstrual(days 5-14) phases. Thirty-two college female students recorded their food consumption and dietary patterns over 5 weeks from September 8 to October 12, 1997. Mean daily energy and macronutrient intakes and the percentage of energy intake from protein and carbohydrate were relatively consistent over the two menstrual cycle phases, but the energy intake from fat increased 1%(P<0.05)during the postmenstrual phase. Two different dietary patterns were identified by the shifts in energy intake between postmenstrual and premenstrual phases. Seventy five percent of subjects revealed a consistent pattern with the results of previous studies investigating food intake over the menstrual cycle, in which the premenstrual phase is associated with an increment in energy, carbohydrate, and protein intake. In contrast, energy, protein, and fat intakes increased during the postmenstrual phase in 25% of the subjects. We conclude that cyclical fluctuations in energy and macronutrient intakes occur in both postmenstrual and premenstrual dietary pattern groups across the two menstrual phased with the opposite directions.

• Journal of Nutrition and Health
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• 제33권8호
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• pp.794-801
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• 2000

The purpose of this study is to determine the effects of the aerobic exercise type on macronutrient self-selection. Male Sprague-Dawley rats were placed on a macronutrient self-selection diet for 4 weeks. For this purpose, mixed feeds were prescribed for the rats while they were forced to swim and run for 4 weeks. Animals were either swimming exercise or treadmill running exercised at 20m/min(60min/day). Cumulative daily energy and macronutrient intake were determined during this period. The running exercise group gained weight much more than the control group, while the swimming exercise group lost weight less than the control group. Such findings suggests that the former group took more feed. On the other hand, the dietary efficiency of the control group was higher, which implies that no physical exercise would result in a higher dietary efficiency. And there was significant difference of total dietary and calorie intakes among the three groups, Although insignificant in statistical means, it was found that the running group took feed most, which is attributable to the homeostasis requiring the supplementation of the calorie lost by exercise. Also, the running exercise group took the protein and carbohydrate most. while the control group took fat most. The decrease of fat intake by the running exercise group suggests the possibility that the in-body enzymes should adapt themselves to the changing in-body condition caused by the endurance exercise. In contrast, it is conceived that the more intake of the carbohydrate may be attributable to the need of supplementing the nutrient lost by the endurance exercise. As discussed above, the endurance exercise group took carbohydrate and protein and less fat than control group. In particular, it was found that the amount of feed intakes was affected much by types, intensity and duration of the exercises. All in all, such findings would apply to human beings. Now can increase the intakes of carbohydrate and decrease the intake of fat through an effective running exercise program and thereby, change our dietary patterns to the benefit of our body and simultaneously, prevent and adult\\`s diseases by decreasing the in % body fat level.(Korean J Nutrition 33(8) : 794-801, 2000)

• 대한지역사회영양학회지
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• 제16권3호
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• pp.315-323
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• 2011

There are a few studies that reported the association of sleep duration with calorie intake and energy expenditure. Using cross-sectional data from a population-based prospective study, we evaluated the association of sleep duration with indicators of obesity including body mass index and waist circumference, calorie intake and its proportion of macronutrients, and physical activity. The study subjects were 4,226 male and female adults, who were aged 40 to 69 years and were free of diagnosed cardiovascular disease, diabetes mellitus, and dyslipidemia at baseline. Robust regression analysis was used to analyze associations. The study found that sleep duration is inversely associated with waist circumference, calorie intake, and percent of calories from fat intake and is positively associated with percent of calories from carbohydrate intake and physical activity. The inverse association between sleep duration and waist circumference was stronger among men than among women. The inverse association between sleep duration and calorie intake was stronger among women than among men and such association was also stronger among obese persons than those with a normal body mass index. The positive association between sleep duration and physical activity was strongly demonstrated regardless of sex or obesity. Physical activity is positively associated with sleep duration independent of potential confounding factors including age, sex, income, occupation, marital status, education, smoking status, waist circumference, calorie and macronutrient intake, and alcohol intake.

• Nutrition Research and Practice
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• 제10권5호
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• pp.524-529
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• 2016

BACKGROUND/OBJECTIVES: Use of smaller plates to control food intake is a commonly recommended strategy for restricting energy intake, despite conflicting results. Therefore, the aim of this study was to examine whether or not three different sizes of plates influence energy intake during a multi-itemed buffet meal in normal weight women. SUBJECTS/METHODS: This was a cross-over study conducted on 37 female participants aged 19-25 years with normal BMI levels. Participants were recruited from Hacettepe University and the surrounding community. On experimental days, participants ate a standard breakfast and were then randomly assigned to eat lunch using a small (19 cm), medium (23 cm), or large (28 cm) diameter plate. Visual analogue scale (VAS) scores on sensory and satiety outcomes were measured for all meals. Energy and macronutrient intakes during lunch were recorded. RESULTS: There was no evidence that use of a smaller plate size reduced energy or specific macronutrient intake during the free choice lunch meal. Multiple visits to the serving table were not associated with energy or macronutrient intake. Plate size did not affect VAS scores during the test days. CONCLUSIONS: Plate size did not influence energy intake, meal composition, or palatability in normal weight women during a multi-itemed open buffet lunch. Studies in natural settings at the population level are needed to clarify current outcomes.

• Journal of Nutrition and Health
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• 제32권6호
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• pp.746-755
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• 1999

This study was to investigate the eating behavior and the anthropometric and biochemical correlates of dietary restraint in femals university from 14 to 20 September 1997, including a Korean Thanksgiving day (16 September). The daily energy intakes and macronutrient compositions were analyzed by means of 7-day dietary records. The most important variable correlated with dietary restraint was hip girth. When dividing the subjects into restrained and unrestrained groups by the basis of a median spit on the hip girth, the restrained group had a about 400kcal less than the unrestrained group in 16 September. Differences were also found with respect to macronutrient composition. The restrained group showed a significant lower fat portion of the energy intake in 16 September and a higher fat portion in 20 September than the unrestrained group. It means that the restrained eaters reduced their fat intake in the Korean Thanksgiving day. However, they can't keep the cognitive control in the 4-day after the holiday.

• 대한지역사회영양학회지
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• 제1권3호
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• pp.366-375
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• 1996

The effect of carbohydrates, fat and protein consumption on the blood pressure of adolescents was investigated from the cross sectional data. The two major areas of inquiry were : 1)measuring the variation of blood pressure at various levels of macronutient intake. 2)measuring the relative importance between the factor of nutrient intake and physical growth. A total of 726 students(341 boys and 385 girls) in the first grade of middle school in Kangwha country were studied for their dietary consumption and physical growth as well as blood pressure. Multiple regression analysis was used as the analytical method to identify the relative importance between the factors. Besides the macronutrient consumption, other nutrients such as vitamin and mineral intakes were included in the regression model. The results showed a variation of blood pressure by macronutrient intake level was in consistant both in blood pressure and by gender. Systolic and diastolic blood pressure decreased with increasing protein intake for girls(p<0.05). However, it was not observed in the case of boys. The systolic blood pressure of boys showed a tendency to decrease with fat intake increase, while their diastolic blood pressure showed the opposite trend. Results of the regression analysis showed that physical growth was a more influential factor than nutrition on blood pressure for both sexes. This could imply that the dietary hypertension factors observed in adults may not be operative generally in a population with normotensive blood pressure during growth.

• Journal of Nutrition and Health
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• 제44권2호
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• pp.119-130
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• 2011

한국인의 대사증후군 관련 식사요인 중 다량 영양소의 섭취 양상을 파악하고 역학적 특성을 파악하기 위해 2007~2008 국민건강영양조사 자료를 분석하였다. 한국인의 다량 영양소 섭취 양상은 성별, 연령대별, 건강 상태별로 달랐으나 전체적으로 탄수화물 섭취가 높은 편이고 지방의 섭취가 낮은 편이었다. 특히 60대 이상에서 당뇨병이나 고혈압 진단을 받았거나 대사증후군을 가지고 있는 사람들은 다른 그룹에 비해 탄수화물 에너지비가 더욱 높고 지방 섭취는 더욱 낮았으며 지방 급원 음식도 달랐다. 따라서 향후 대사증후군 및 기타 만성 질환의 예방과 관리를 위해서는 한국인의 성별, 연령대별, 건강상태별로 식생활의 특성을 파악하고 이를 토대로 적절한 영양 정책과 사업을 실시하여야 할 것이다.

• 대한지역사회영양학회지
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• 제20권6호
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• pp.468-478
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• 2015

Objectives: The objective of this study was to evaluate the thermic effects, the macronutrient oxidation rates and the satiety of medium-chain triglycerides (MCT). Methods: The thermic effects of two meals containing MCT or long-chain triglycerides (LCT) were compared in ten healthy men (mean age $24.4{\pm}2.9years$). Energy content of the meal was 30% of resting metabolic rate of each subject. Metabolic rate and macronutrient oxidation rate were measured before the meals and for 6 hours after the meals by indirect calorimetry. Satiety was estimated by using visual analogue scales (VAS) at 8 times (before the meal and for 6 hours after meal). Results: Total thermic effect of MCT meal (42.8 kcal, 8.0% of energy intake) was significantly higher than that (26.8 kcal, 5.1% of energy intake) of the LCT meal. Mean postprandial oxygen consumption was also significantly different between the two types of meals (MCT meal: $0.29{\pm}0.35L/min$, LCT meal: $0.28{\pm}0.27L/min$). There were no significant differences in total postprandial carbohydrate and fat oxidation rates between the two meals. However, from 30 to 120 minutes after consumption of meals, the fat oxidation rate of MCT meal was significantly higher than that of the LCT meal. Comparison of satiety values (hunger, fullness and appetite) between the two meals showed that MCT meal maintained satiety for a longer time than the LCT meal. Conclusions: This study showed the possibility that long-term substitution of MCT for LCT would produce weight loss if energy intake remained constant.

• Journal of Preventive Medicine and Public Health
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• 제40권1호
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• pp.45-50
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• 2007

Objectives : The aim of this study was to investigate the relationship between the contributions of macronutrients to the total energy intakes and Body Mass Indices (BMI, $kg/m^2$) of Korean women. Methods : We used dietary records data from 115 healthy Korean women, ages 20 and over, who completed four 3-day dietary records between February 2003 and March 2004. For the calculation of nutrients we used a dietary assessment program developed by the Korean Nutritional Society. Macronutrient intakes were estimated by averaging individual total daily intakes in four 3-day dietary records. Subjects were categorized into three Body Mass Index (BMI) groups : underweight (BMI < 20), normal (20 $\leq$ BMI < 25), and overweight (BMI $\geq$ 25) group. Results : The total energy intakes were not different among the three BMI groups. Similarly, other macronutrient intakes such as protein, fat, carbohydrate, vegetable protein, animal protein, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids were not different. From the multivariate nutrient density model, substituting polyunsaturated fatty acid for carbohydrate was positively associated with BMI in women aged 20 to 49 ($\beta=2.31$, p<0.01). In women aged 50 and over, substituting animal protein for carbohydrate was positively associated with BMI ($\beta=0.549$, p=0.04). Conclusions : No single macronutrient was associated with BMI when all subjects were combined. However, when stratified by age, polyunsaturated fatty acid intake in younger women, and animal protein intake in older women, were positively associated with BMI. In the future, we recommend a larger study to confirm these results.