• The Korea Journal of Herbology
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• v.28 no.3
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• pp.25-31
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• 2013

Objectives : To develop a natural antioxidant and anti-hemolytic agents, we investigated the effects of ethanol extracts of Carpesii Fructus and Farfarae Flos. Methods : Aerial parts of Carpesii Fructus and Farfarae Flos were extracted with 80% ethanol. Antioxidant activity of Carpesii Fructus or Farfarae Flos extract was evaluated by employing three different assays, i.e., 1,1-diphenyl-2-picryl hydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-suphonic acid) diammonium (ABTS) scavenging and reducing power activities. Also, anti-hemolytic activity of Carpesii Fructus or Farfarae Flos extract was determined using [2,2'-azobis (2-methylpropionamidine) dihydrochloride (AAPH)]-induced hemolysis, glutathione (GSH) depletion and malondialdehyde (MDA) formation in normal rat red blood cells (RBC) or plasma. Results : The extracts obtained from Carpesii Fructus and Farfarae Flos dose-dependently increased the scavenging activity on DPPH- or ABTS-induced radicals and the reducing power activities. Carpesii Fructus and Farfarae Flos were similar to the scavenging activity and the reducing power of butylated hydroxy anisole effect at high concentration ($1,000{\mu}g/mL$). RBC oxidative hemolysis and plasma MDA formation induced by AAPH were significantly suppressed by the extracts of Carpesii Fructus and Farfarae Flos in a dose-dependent manner. Also, Carpesii Fructus and Farfarae Flos extracts prevented the depletion of cystosolic antioxidant GSH in RBCs. Carpesii Fructus generally had better than the free radical scavenging activity, the reducing power and anti-hemolytic effects of Farfarae Flos. Conclusions : These results suggest that Carpesii Fructus and Farfarae Flos may have value as the potential antioxidant and anti-hemolytic medicinal plant.

• Journal of The Korea Institute of Healthcare Architecture
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• v.18 no.1
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• pp.25-33
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• 2012

As of November 1st 2010, 59% of overall residences in Korea are apartments with 8,185,000 households and when including the multi-unit houses, 71.0% of the overall residences are multifamily houses. The apartments have become the most universal form of residence in Korea and its' relative weight will continuously increase in the future. Meanwhile, Korea has turned into aging society in 2000 and will turn into the super-aged society by 2026 to display the world's fastest speed for aging. Majority of the elderly will spend their declining years in apartments. To understand the residence consciousness and its' properties for unit housing of the elderly residing in apartments, the present study obtained the following results through surveying the 541 nationwide samples. First, the elderly most prefer the mid and high levels(6-9th floors, or 10-15th floors) of apartments. Second, the elderly couples most prefer areas of $85m^2$ while single elderly most prefer $60m^2$. Third, the elderly feel the most inconveniences in bathrooms and showers. Fourth, safety accidents in dwelling of the elderly have no significant correlation with age, gender or their possessed diseases. Fifth, the elderly displayed high satisfaction for their bedrooms. Sixth, there were less tendencies for elderly to feel lack of storage spaces or conduct remodeling. As a result of the analysis, all apartment houses of Korea must support the physical aging of residents and prevent safety accidents in houses to enable Korean aging in place.

• Journal of The Korea Institute of Healthcare Architecture
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• v.18 no.3
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• pp.19-28
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• 2012

The purpose of this research is to suggest design direction about common space of small sized residential units for elderly housing in order to construct desirable residential environment. This research examines spatial composition and the residents' behaviors in three different types of residential units at intervals of five minutes from 9:00 a.m. to 19:00 p.m.; and analyzes the characteristics of spatial use. The following is the result. The using rate of common space is influenced by the atmosphere of residential units more than healthy condition of the elderly; furthermore, the frequency of usage is also increasing highly as mush as forming the lively atmosphere. In order to form the animated residential environment, it is necessary to provide to various activities, such as cooking, eating, watching TV, leisure, hobby, rest, etc; and the space must plan encouraging relationship with other people. Moreover, it is required to consider to each of personal characteristics ingeniously, and manage to programs extending their durability in common space of elderly housing.

• Biomedical Science Letters
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• v.19 no.2
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• pp.147-152
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• 2013

17-${\beta}$-hydroxysteroid dehydrogenase type 1 ($17{\beta}$-HSD type 1) mediates the reaction of $17{\beta}$-estradiol (E2) production from estrone (E1). Inhibitory effects of curcuminoids on $17{\beta}$-HSD type 1 activity were investigated to find a lead compound for treating estrogen-dependent diseases including breast cancer. Among curcuminoids, demethoxycurcumin showed potent inhibitory effect ($IC_{50}=2.7{\mu}M$) on mouse $17{\beta}$-HSD type 1. Curcuminoids also displayed their inhibitory effects on the production of $17{\alpha}$-estradiol which is a carcinogenic metabolite produced by the enzyme. Bisdemethoxycurcumin ($IC_{50}=1.3{\mu}M$) showed potent inhibitory effect on the $17{\alpha}$-estradiol production by chicken $17{\beta}$-HSD type 1. Curcuminoids did not inhibit ERE transcriptional activity with and without E2. Taken together, curcuminoids can be used for treating and preventing E2-dependent diseases via inhibition on $17{\beta}$-HSD type 1 activity.

• Korean Journal of Clinical Laboratory Science
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• v.45 no.1
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• pp.1-4
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• 2013

Vancomycin-resistant enterococci (VRE) have emerged as important healthcare-associated infection since last two decades. ChromID VRE agar (cIDVA) is useful for VRE rectal swab screening. We investigated all VRE were isolated on the cIDVA. A total of 363 rectal swabs of 85 patients to test VRE screening were inoculated into bile-esculin (B-E) broth with $6{\mu}g/mL$ vancomycin. After 24 hours incubation, we subcultured B-E broths were changed to black onto cIDVA. All isolates were identified by the MICROSCAN and VITEK2. The vanA gene and vancomycin minimal inhibition concentration (MIC) were detected by PCR and E-test respectively. 277 E. faecium (84.7%), 16 E. faecalis (4.9%), 25 E. avium (7.6%), 8 E. gallinarum (2.4%) and 1 E. raffinosus (0.3%) were isolated. 10.3% of VRE detected on cIDVA were other than E. faecium and E. faecalis that presented various color from colorless to pale violet. All isolates contained vanA and vancomycin MIC were > $256{\mu}g/mL$. VRE isolates other than E. faecium and E. faecalis should be objective to the contact precautions for healthcare-associated infection control if they possess vanA gene. Due to emerging enterococci carrying vanA such as E. avium, E. gallinarum, and E. raffinosus, VRE surveillance should be expanded to all isolates on chromogenic agar.

• Journal of Preventive Medicine and Public Health
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• v.53 no.3
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• pp.171-174
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• 2020

The coronavirus disease 2019 (COVID-19) pandemic has not only caused significant challenges for health systems all over the globe but also fueled the surge of numerous rumors, hoaxes, and misinformation, regarding the etiology, outcomes, prevention, and cure of the disease. Such spread of misinformation is masking healthy behaviors and promoting erroneous practices that increase the spread of the virus and ultimately result in poor physical and mental health outcomes among individuals. Myriad incidents of mishaps caused by these rumors have been reported globally. To address this issue, the frontline healthcare providers should be equipped with the most recent research findings and accurate information. The mass media, healthcare organization, community-based organizations, and other important stakeholders should build strategic partnerships and launch common platforms for disseminating authentic public health messages. Also, advanced technologies like natural language processing or data mining approaches should be applied in the detection and removal of online content with no scientific basis from all social media platforms. Furthermore, these practices should be controlled with regulatory and law enforcement measures alongside ensuring telemedicine-based services providing accurate information on COVID-19.

• Journal of The Korea Institute of Healthcare Architecture
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• v.7 no.2
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• pp.27-36
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• 2001

This study aims to provide space organization of the Postpartum Care Center and basic data for architectural planning in the reasonable size. Nurturing method of infants at independent Postpartum Care Center combines rooming-in and non rooming-in and space organization is planned accordingly. Types of the existing floor plans are classified as a type centered on maternity protection room, a type of the separate space for multipurpose, a near type to the infants' room. New types of plane are presented as follows a core type concentrate upon nurse room, the infants' room and the same environmental and balanced corridors between the both. When an average capacity of 20 at Postpartum Care Center is planned, proper suitable floor space of Postpartum Care Center is above $753.9m^2$ and $37.69m^2$ per postpartum woman is required. It is indicated that an average floor space per postpartum woman of the reviewed facilities is smaller than one of the Postpartum Care Center in a plan and plane distributed by function too lack in nursing space. Expansion of space for the Postpartum Care Center is generally required, also the enlargement of nursing space is necessary to be harmonized with the management of a medical facilities and those mutual cooperation.

• Journal of The Korea Institute of Healthcare Architecture
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• v.3 no.4
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• pp.59-68
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• 1997

This study is intended to review the Nucleus System of standard hospitals in U.K. The research is focused on the theoretical background, contents of Nucleus System, and the operational problems through the survey of sample hospitals. The contents of research include the development history of standardization, outlines, aimes, advantages, the data of Nucleus system, and the study-visits of sample hospitals. The conclusion could be summarized as follows ; 1) The form of standard hospitals is compact and low-rise the major movements are horizontal. The standard plans of the functional dpartments are unified as cruciform with $15m{\times}15m$ module. 2) The Nulceus System has been developed. The hospitals have 3 stories maximum and courtyards for natural light & ventilation. 3) The advantages of Nucleus System includes reduction of design & construction period, the buildability due to the repetitive construction, and the running cost. And the disadvantages are mentioned as the lack of storage, staff accomodation, pantry, and sanitary facilities. 4) Sample hospitals provide human scale, possibilities of growth & change, and curing environment from art decoration & artificial lake. 5) In case of Korean situation, even the minimum standardization such as hospital design guidelines should be developed in near future.

• Journal of The Korea Institute of Healthcare Architecture
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• v.20 no.1
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• pp.45-55
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• 2014

Purpose: The purpose of this study is to provide data on the basis for architectural planning of floor plan type and spatial composition by analysing standard mental health centers in Seoul. Methods: Data were collected through literature research, field surveys, and expert interviews to 22 standard mental health centers in Seoul. Results: The results of this study could be summarized as follows; Firstly, Mental Health Center is divided into five types according to the location. Location types of mental health center were 'Director type', 'Health center connection type', 'Public facilities connection type', 'Complex center connection type' and 'Commercial Facilities connection type'. Secondly, Depending on the type of management a mental health center is divided into two types. Types are 'Complex type' and 'Independent type'. Average area of 'Complex type' is $192.99m^2$ and 'Independent type' is $266.87m^2$. This difference affects the various spaces. Implications: It is necessary to give and architectural suggestion of mental health center in response to the proposal of the system.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.699-700
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• 2014

The use of Radio Frequency Identification technology (RFID) in medical context enables not only drug identification, but also a rapid and precise identification of patients, physicians, nurses or any other healthcare giver. The combination of RFID tag identification with structured and secured Internet of Things (IoT) solutions enables ubiquitous and easy access to medical related records, while providing control and security to all interactions. This paper defines a basic security architecture, easily deployable on mobile platforms, which would allow to establish and manage a medication prescription service in mobility context making use of electronic Personal Health Records. This security architecture is aimed to be used with a mobile e-health application (m-health) through a simple and intuitive interface, supported by RFID technology. This architecture, able to support secured and authenticated interactions, will enable an easy deployment of m-health applications. The special case of drug administration and ubiquitous medication control system, along with the corresponding Internet of Things context, is presented.