• 동의신경정신과학회지
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• 제15권2호
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• pp.119-139
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• 2004

This research investigates the effect of the Hibiscus syriacus(HSS) on Alzheimer's disease. Specifically, the effects of the HSS extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and reactive oxygen species(ROS); (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. The results were summarized below ; 1. The HSS extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-l cells treated with LPS. 2. The HSS extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The HSS extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the HSS extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The HSS extract suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, $IL-1{\beta}$ and $TNF-{\alpha}$ mRNA, CD68/GFAP, ROS in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The HSS extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. These results suggest that the HSS extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the HSS extract for Alzheimer's disease is suggested for future research.

• 동의신경정신과학회지
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• 제17권1호
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• pp.59-78
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• 2006

Objective : This research investigates the effect of the CMT and SCMT on Alzheimer's disease. Methods : The effects of the CMT and SCMT on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA; (5) the infarction area of the hippocampus in Alzheimer's disease mice induced with CT105 & ${\beta}A$ were investigated Rresults : 1. The CMT and SCMT suppressed the expression of APP, AChE mRNA in PC-12 cells treated with CT-105 2. The CMT and SCMT suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and SCMT group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency 4. The CMT and SCMT suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA in the mice with Alzheimer's disease induced by ${\beta}A$. 5. The CMT and SCMT reduced the infarction area of hippocampus with Alzheimer's disease induced by ${\beta}A$. Conclusions : These results suggest that the CMT and SCMT may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CMT and SCMT for Alzheimer's disease is suggested for future research.

• 한국동물위생학회지
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• 제44권4호
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• pp.247-256
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• 2021

The recombinant lysozyme-HJL34 proteins were expressed and purified using commercial Escherichia (E.) coli expression system. Stx2e⁺ F18⁺ E. coli, Actinobacillus pleuropneumoniae (APP), Streptococcus (S.) suis, and Clostridium (C.) perfringens strains were isolated from pigs. The minimum inhibitory concentrations (MICs) of the recombinant lysozyme-HJP34 proteins were examined by means of the microtiter plate method, according to the NCCLS recommendations. The possibility of its as the alternatives to antibiotics was tested in piglets. The MICs were determined as 75 ㎍/mL, 300 ㎍/mL, 75 ㎍/mL, 35.5 ㎍/m against Stx2e⁺ F18⁺ E. coli, APP, S. suis, C. perfringens, respectively. A total of 25 piglets were divied 5 groups. The piglets in group A~C were fed with commercial feed and those in groups D, E were fed with commercial feedstuff. All piglets in groups B~E were challenged with virulent Stx2e⁺ F18⁺ E. coli, APP, S. suis strains. Groups C and D were treated with antimicrobial from 24 h after challenge. All piglets in group B died within 3 days after challenge. Among 5 piglets in groups C and D piglets, 80% survived after challenge. Among group E piglets, 60% were alive until the end of this study. Therefore, this study indicates that recombinant lysozyme-HJP34 proteins is a suitable possibility as a feed additive for reduction of diseases by bacterial pathogens in piglet feed.

• 한국전자거래학회지
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• 제23권2호
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• pp.1-20
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• 2018

공유 경제의 대표적인 사례 중 하나의 카 쉐어링 서비스는 차량을 공유하여 사용자가 원하는 시간, 장소에서 원하는 만큼 공유하여 사용할 수 있는 서비스를 제공하고 있다. 본 연구에서는 카 쉐어링 서비스의 시스템이 제공하는 기반적 특성인 희소성과, 시스템 품질, 서비스 품질이 사용자의 평가 요소에 영향을 줄 것이라 가정하고 사용자의 평가를 통하여 사용자의 순 편익을 확인하고자 하였다. 분석결과 희소성의 쿠폰과 시간제한은 사용자 평가 요소인 인지된 사회적 지지와 앱 신뢰에 영향을 주었으나 제한 수량은 영향을 주지 않아 카 쉐어링 서비스에서 수량에 대한 제한은 관련 없는 것으로 나타났다. 시스템 품질의 대부분의 변수들이 인지된 사회적 지지와 앱 신뢰에 영향을 주었다. 사용자 평가는 사용자 만족과 추천의도에 영향을 주었다. 사용자가 얻을 수 있는 순 편익으로써 만족감과 조직적 측면에서의 간접적 성과인 추천 의도가 채택되어 순 편익 변수의 역할을 하였다. 공유경제와 관련된 연구는 주로 탐색적 연구에서 국한하는 점으로 비추어 볼 때 본고에서 언급하고 있는 비즈니스 성공 모델의 적용과 사회적 변수 적용 등 실증적으로 분석했다는 점에서 본 연구의 의의가 있다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제49권5호
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• pp.315-320
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• 2000

This paper presents the fabrication and test of a micropump with an electromagnetic actuator and a pair of aluminum flap valves. The actuator consists of a solenoid coil, a permanent magnet and an actuator diaphragm. The actuator diaphragm is fabricated by the spin coating of silicone rubber. The valve are passive ones and are fabricated by micromachining. The deflection of the fabricated actuator diaphragm is measured with a laser vibrometer. The deflection of the actuator diaphragm is proportional to the input current. The measured deflection of the fabricated diaphragm is $400 \mum$,/TEX> when the input is 118 mApp, and the cut-off frequency is 50 Hz. The maximum flow rate of the fabricated micropump with the electromagnetic actuator is about 5$0 \muell/min$ at 5 Hz when the input current and the duty ratio of the square was are 118 mApp and 50%, respectively.

• 한국통신학회논문지
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• 제40권6호
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• pp.1157-1163
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• 2015

본 논문에서는 모바일 상황에서 동작할 수 있는 웹 앱을 이용하여 한글로 영어 발음을 표기할 수 있는 영어단어와 문장 전자사전을 설계하고 개발하였다. 데이터베이스는 영어단어, 한글 발음기호와 그림, 어휘 정의, 음성파일, 문장들을 사용하여 만들었다. 본 영어 학습시스템은 HTML5와 m-Bizmaker 소프트웨어 툴을 사용하여 개발하였다.

• 한국동물위생학회지
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• 제24권4호
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• pp.359-367
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• 2001

A serological survey was performed to establish basic data for the prevalence of antibodies to some major diseases of domesticated boar serum samples from January to December 2000. Sera collected in breeding farms in Gyeongbuk province were tested for Aujeszky's disease virus(ADV), Porcine reproductive and respiratory syndrome virus(PRRSV), Porcine parvovirus(PPV), Japanese encephalitis virus (JEV), Bordetella bronchiseptica(B bronchiseptica), Mycoplasma ; APP), Toxoplasma, and Brucella. There was no antibody to ADV in domesticated boars serum samples detected by Anti-ADV-gpI assay kit. Sero-positive samples to PRRS by IFA were 0.9%(3/330) The HI titers to PPV ranged variously from less than 10 to over 1,280. Two hundred ninety-four out of 330 tested sera showed HI titer of less than 10. In HI test to JEV, 90.3% of the sera (298/330) were below 10. The majority of the serum samples had low prevalence of the antibody B bronchiseptica. ELISA titers to M hyopneumoniae ranged variously from $\leq$ 10 to $\geq$ 1,280. Antibody titers to A pleuropneumoniae type 2(APP2) and type 5(APP5) were 58.2% and 52.7%, respectively, and the tested samples showing ELISA antibody titers of less than 20. There was no significant geographical difference between APP2 and APP5 in this study. In the antibody test of Toxoplasma, 11.5%(38/330) were positive and samples were all negative in sera test of Brucella.

• 한국임상약학회지
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• 제33권1호
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• pp.51-61
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• 2023

Background: Mobile applications (apps) on dietary supplements can increase consumers' access to information. However, it can lead to indiscriminate use of dietary supplements. This study aims to systematically review dietary supplement apps released in English and Korean and evaluate the quality of those apps. Methods: Through the app stores, apps on dietary supplements were systemically searched and examined. Two independent evaluators evaluated the apps and presented a mean score using the Mobile App Rating Scale (MARS). The correlation between MARS scores, user and evaluator ratings, and the number of secondary features of the apps were analyzed. Results: Of the 2,772 dietary supplement apps identified, 17 apps were included according to the selection criteria. The mean MARS score was 3.28 (standard deviation: 0.29) out of 5. Apps had higher scores in aesthetics and functionality dimensions, while engagement and information dimensions had lower scores. There was a positive correlation between the number of app downloads and information among MARS dimensions. The subjective evaluation also correlated with the information dimension. There was a positive correlation between the secondary features of the apps and MARS total score as well as the engagement dimension. Conclusion: The dietary supplement apps need to be managed at a higher level of quality to provide safe and reliable information to consumers. Especially, quality on information and engagement dimensions can be improved. Involvement of healthcare professionals in the app development, management with adequate referencing of information, and use of secondary features for enhanced user engagement can be helpful.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.219.1-219.1
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• 2000

• 한국대기환경학회지
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• 제3권1호
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• pp.65-73
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• 1987

Indoor air pollution problems, in fact, have been neglected due to the unawareness of its seriousness and the lack of accumulated data. Recently, some movement of research and regulations, however, have been made for several indoor air pollutants. In this study, one of the carcinogenic polynuclear aromatic hyrocarbon, Benzo(a) pyrene in indoor airborne particulate, was measured and analyzed to estimate emission strength of BaP from an unvented kerosene heater and to know its level in indoor environment with use of a kerosene heater and a wood-burning fireplace. By the measurement of BaP level in a dark room with air exchange rate of app. 3.0, BaP emission strength of a kerosene heater (11,000Btu/hr) was estimated to be 326.6ng/hr (or 29.7 ng/$10^3$ Btu). With 4-hr operation a day of the kerosene heater in an apartment, the BaP level became 2.97ng/m$^3$ from 0.27ng/m$^3$ of background level. The operation of a wood-burning fireplace app. 2hr a day, on the other hand, increased the BaP level from 0.16ng/m$^3$ of background to 3.53ng/m$^3$. So proper ventilation must be considered seriously when unvented heating facilities are used in indoor environment.