• 동의신경정신과학회지
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• 제17권2호
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• pp.91-122
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• 2006

Objective : This research investigates the effect of the Jangwon-Dan,(JWD) on Alzheimer's disease. Method : The effects of the JWN extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, and $TNF-{\alpha}$ mRNA, (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. Result : 1. The JWN extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and CD68/GFAP, in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the JWN extract for Alzheimer's disease is suggested for future research.

• 동의신경정신과학회지
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• 제16권1호
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• pp.97-117
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• 2005

This research investigates the effect of the Chaenomelis fructus(CMF) on Alzheimer's disease. Specifically, the effects of the CMF extract on (1) >$IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior of AD mice with ${\beta}A$; (5) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and ROS; (6) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. The results were summarized as follows; 1. The CMF extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The CMF extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The CMF extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. A significant inhibitory effect on the memory deficit was shown on the CMF extract group of the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The CMF extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ protein, mRNA, $TNF-{\alpha}$ mRNA, CD68/GFAP, and ROS in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The CMF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer’s disease induced by ${\beta}A$. These results suggest that the CMF extract may be effective for the treatment of Alzheimer’s disease. Investigation into the clinical use of the CMF extract for Alzheimer's disease is suggested for future research.

• 동의생리병리학회지
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• 제17권4호
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• pp.1037-1049
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• 2003

Numerous lines of evidence indicate that some of the neurotoxicity associated with Alzheimer's disease (AD) is due to proteolytic fragments of the amyloid precursor protein (APP). Most research has focused on the amyloid 6 (M). However, the possible role of other cleaved products of APP is less clear. Lately It has been reported that a recombinant carboxy-terminal 105 amino acid fragment (CT105) of APP induced strong nonselective inward currents in Xenopus oocyte. In a brain with Alzheimer's disease (AD), to investigate the roles of carboxyl-terminal fragment (CT105) of amyloid precursor protein (APP) in apoptosis processes possibly linked to neurodegeneration associated with AD, we examined the effects of the CT of APP with 105 amino acid residues (CT105) on the alteration of apoptosis triggers in neubroblastoma cells. We have investigated whether Radix Polygalae and Rhizoma Acori Graminei mixture extract (RP+RAG) inhibits CT105-induced apoptosis of neuroblastoma cells. We found that RP+RAG inhibits CT105-induced apoptosis in SK-N-SH cells. Treatment of the cells with RP+RAG inhibited CT105-induced DNA fragmentation and Tunel assay of nuclear chromatin and inhibited the caspase-3 expression in SK-N-SH cells. As the result of this study, In RP+RAG group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of neuroblastoma cells by CT105 expression is promoted. These results indicate that RP+RAG possess strong inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of neuroblastoma cells by CT105 expression

• 한국콘텐츠학회논문지
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• 제19권5호
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• pp.249-258
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• 2019

현재는 스마트 홈 사업에 대한 사람들의 관심이 증가하고 있다. 따라서 스마트 홈 시스템에 대하여 연구가 중요해지고 있다. 스마트 홈 시스템에서 중요한 구성 부분인 스마트 홈 앱은 지속적으로 관심을 위해서는 사용성을 고려한 평가지표 개발이 중요하다. 이에 본 논문은 스마트 홈 앱을 대상으로 스마트 홈 앱 디자인의 사용성 평가지표 개발하고자 하는데 있다. 본 연구를 위하여 델파이 기법을 이용하여 3차에 걸쳐 조사를 실시하였다. 1차 조사에서는 문헌고찰을 통해 도출된 평가 영역에 대한 전문가들의 의견을 수렴하고 내용타당도 비율(CVR) 값을 분석하여 적절한 영역 8개를 선정하였다. 1차 조사 결과를 바탕으로 국내외 선행연구와 사용자 인터뷰 조사를 통해 총 38개 평가 항목을 수집하였다. 수집된 38개 평가 항목은 2, 3차에서 평균(M), 표준편차(SD), 내용타당도 비율(CVR), 합의도(H), 수렴도(QD) 등을 분석하고 최종 8개 영역 하위에 포함된 27개 항목을 선정되었다. 본 연구 결과는 스마트 홈 앱 디자인의 사용성 평가 시 가이드라인으로 활용될 수 있다.

• Nutrition Research and Practice
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• 제17권6호
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• pp.1238-1254
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• 2023

BACKGROUND/OBJECTIVES: Weight loss via a mobile application (App) or a paper-based diary (Paper) may confer favorable metabolic and anthropometric changes. SUBJECTS/METHODS: A randomized parallel trial was conducted among 57 adults whose body mass indices (BMIs) were 25 kg/m² or greater. Participants randomly assigned to either the App group (n = 30) or the Paper group (n = 27) were advised to record their foods and supplements through App or Paper during the 12-week intervention period. Relative changes of anthropometries and biomarker levels were compared between the 2 intervention groups. Untargeted metabolic profiling was identified to discriminate metabolic profiles. RESULTS: Out of the 57 participants, 54 participants completed the trial. Changes in body weight and BMI were not significantly different between the 2 groups (P = 0.11). However, body fat and low-density lipoprotein (LDL)-cholesterol levels increased in the App group but decreased in the Paper group, and the difference was statistically significant (P = 0.03 for body fat and 0.02 for LDL-cholesterol). In the metabolomics analysis, decreases in methylglyoxal and (S)-malate in pyruvate metabolism and phosphatidylcholine (lecithin) in linoleic acid metabolism from pre- to post-intervention were observed in the Paper group. CONCLUSIONS: In the 12-week randomized parallel trial of weight loss through a App or a Paper, we found no significant difference in change in BMI or weight between the App and Paper groups, but improvement in body fatness and LDL-cholesterol levels only in the Paper group under the circumstances with minimal contact by dietitians or health care providers.

• 한국전자통신학회논문지
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• 제11권5호
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• pp.499-504
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• 2016

본 서비스는 스마트폰 앱을 통해서 그리고 아시아 문화전당에서 외국인의 언어로 방송내용을 들을 수 있는 목적을 가진다. 본 논문은 비콘의 신호로 외국인을 인식하는 방법을 설명하고 IoT 게이트웨이는 AllJoyn 프로토콜 접속 기능을 사용하여 선택된 외국인 언어로 음성서비스를 제공한다. IoT 서비스 플랫폼은 외국인의 인식자 관련 등록 받아들여서, 모든 장치들로 메시지들을 보내고, 그것들은 모든 IoT 게이트웨이들이고, IoT 게이트웨이는 외국인의 스마트폰 앱에 연결되어서 방송내용들을 들을 수 있다. 만일 외국인이 비콘의 관리 거리를 벗어난다면, 음성 앱 서비스는 해제된다.

• 한국공간구조학회논문집
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• 제17권1호
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• pp.93-100
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• 2017

With increasing number construction of high-rise building which has about 40 to 60 floors there have been many kinds of problem which related with usage from vibration. To predict response acceleration, it is important to assess correct natural frequency. However, due to the noise of MEMS sensor, it is difficult to measure dynamic characteristic such as natural frequency when measuring ambient vibration using MEMS sensor within cell phone. Therefore, a comparative analysis on vibration measuring applications was performed after measuring ambient vibration of 2 skyscrappers which have height between 133.5~244.3m that are located in Seoul and Observation tower using I-jishin APP with noise reduction function of MEMS sensor in order to verify the effectiveness of low noise type vibration measurement APP.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2015년도 춘계학술발표대회
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• pp.534-536
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• 2015

소프트웨어 산업의 발전에 따라 개발 수요의 충족 및 개발 효율성의 증대를 위해 다양한 개발 방법론과 개발 지원 도구들이 등장해 왔다. 그러나 데이터베이스 응용 소프트웨어(Database Application Software, DB-App)의 개발이 활발함에도 불구하고, 해당 분야 개발의 효율을 도모하는 방안에 관한 연구는 미비한 실정이다. DB-App의 소스 코드(Source code)에는 쿼리(Query)문이 빈번하게 사용되지만 작성 과정에서 오류가 발생하기가 쉽고 관리에 대한 어려움이 있다. 이는 개발 효율을 저하시켜 비용을 증가시키는 요인이 된다. 본 논문에서는 다양한 데이터베이스와 프로그래밍 언어로 개발되는 DB-App 개발을 지원하기 위한 방법을 기술하였으며, 사용자의 설정에 따라 쿼리문을 포함한 소스 코드를 생성하는 도구를 설계하였다.

• 한국멀티미디어학회논문지
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• 제18권8호
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• pp.968-979
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• 2015

In this paper, we study a vibration bell App which shows waiting sequence numbers by utilizing smartphones to solve an inconveniently long waiting time from ordering to getting foods in restaurants and coffee shops. Unlike existing independently developed hardware and software, the vibration bell App is developed to manage and integrate customer management service, POS service in shops, and group shop management services. The functions of the vibration bell App include two-way communications based on NFC- issuing waiting sequence numbers and electronic coupon, showing event information, and transferring user information. Furthermore, the user's personal information is minimized by recognizing the pre-existing information of the user's smartphone. Replacing the shop's vibration bell system with the vibration bell APP, the shops can reduce the cost of construction and maintenance by up to 1/10, compared to the cost of for existing vibration bell systems. Moreover, the customer's preference and current sales trend can be easily figured out. Thus, it will have a great effect on the future marketing strategies.

• Educational Technology International
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• 제23권2호
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• pp.183-205
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• 2022

Mental status examination is an important stage in the assessment process because it serves as the foundation for establishing nursing diagnosis and intervention. Until now many students still feel difficult to understand the terms in the assessment of mental status. Interactive Mobile Learning in one of the media that is currently being developed. The use of this media will provide more in-depth learning opportunities, and students can practice their skills in carrying out practicals because of the mobility principle possessed by smartphones. The purpose of this study was to develop a smartphone-based app and evaluate the app's effectiveness by measuring nursing students' knowledge of mental status examination. Design: A randomized trial with a pre-and post-test design was conducted at a university in Indonesia. A total of seventy junior nursing students participated in this study. The intervention group received a smartphone-based app, and the control group received one-time lecture-based learning. We offered the experimental group the app and information about how to use it, and we encouraged them to use it. The control group received classroom instruction. Results: The intervention group scored significantly higher than the control group on knowledge score (t = 19.40, p = 0.000) and satisfaction with the learning method (t = 0.640, p = 0.021) Conclusion: These findings suggest that smartphonebased education could be an effective method in nursing education for teaching mental status examinations.