• 한국환경생태학회지
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• 제12권3호
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• pp.212-223
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• 1998

여천공단 주변 산림지역의 식물군집구조를 밝히고 13년간 변화를 파악하기 위하여 300$m^2$ 조사구를 27개소 설정하였다. DCA ordination분석 결과 곰솔군집, 곰솔-참나무류군집, 곰솔-사스레피나무군집, 소나무-곰솔군집, 소나무군집으로 나누어졌다. 5개 군집의 천이경향을 살펴보면 곰솔-참나무류군집, 소나무-곰솔군집은 졸참나무, 상수리나무를 중심으로한 참나무류군집으로 변화될 것이며, 곰솔군집, 곰솔-사스레피나무군집, 소나무군집은 현상태를 유지할 것으로 판단되었다. 5개 군집의 토양산도는 pH 4.38~4.61로 산성토양이었으며, 유기물함량, 치환성양이온(C $a^{++}$, $Mg^{++}$, $K^{+}$)함량은 전국토양의 평균치보다 낮은 상태로 불량하였다. 13년간의 식물군집구조와 토양특성변화를 살펴보면 종수, Shannon의 종다양도, 최대종다양도에 있어 1983년보다 1996년이 높아졌으며, 토양특성도 동일한 경향이었다.

• 정보화연구
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• 제10권2호
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• pp.273-281
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• 2013

스마트워크의 유형은 모바일 기기등을 이용하여 현장에서 업무를 수행하는 모바일오피스, 자택에서 본사 통신망에 접속하여 업무를 수행하는 재택근무, 자택인근 원격사무실에서 근무하는 스마트워크센터근무와 같은 형태를 의미하며 기존 사무실개념에 비하여 공간과 시간의 벽을 극복할 수 있도록 도와준다. 본 논문에서는 엘리베이터 산업의 에프터서비스 산업문야에서 모바일 오피스 시스템을 개발하는 과정을 설명하는데 개발된 시스템은 A/S Work이라 명명 하였다. 개발된 A/S Work 시스템은 M 엘리베이터사의 에프터서비스에 활용되어 기존시스템과 비교하면 다음과 같은 장점을 가진다. 1) 고객별 작업전후 사진관리 2) 현장에서의 고객만족도조사 3) 작업일지관리 앱 4) 작업자 근태관리 5) 그룹 SMS 기능.

• 한국정보통신학회논문지
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• 제19권8호
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• pp.1845-1852
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• 2015

바코드 시스템과 전자태그(RFID)부터 저 전력 블루투스 기술을 활용한 비콘(Beacon)까지 진료 및 검사 단계를 자동화하고 스마트 기기와 연계된 진료 정보를 이용하는 등 정보기술과 보건‧의료 분야의 용합이 널리 확산되고 있다. 본 논문에서는 환자에게 혈액을 수혈하는 과정에서 다른 혈액형이 수혈되는 사고를 예방하기 위해 안전한 수혈관리를 위한 모바일 헬스케어 시스템을 설계하고 구현하였다. 환자 팔찌, 채혈 용기, 혈액백 및 의료진 신분증의 바코드에 저장된 정보를 스마트 기기로 인식하여 환자의 정보와 매칭시켜 안전하고 효율적인 수혈이 가능하도록 구현하였다. 본 논문에서 제안하여 구현한 수혈관리 모바일 헬스케어 시스템을 종합병원의 수혈 과정에 적용한 결과, 안전하고 효율적인 수혈이 가능하여 수혈 과정에서 발생하는 사고의 예방이 가능한 것으로 확인되었다.

• 약학회지
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• 제55권1호
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• pp.39-44
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• 2011

Many reports indicate that $18{\beta}$-glycyrrhetinic acid ($18{\beta}$-GA) from Glycyrrhizae Radix has anti-inflammatory and immunoregulatory activities, whereas reports regarding anticancer activity of the compound are few. In present study, we investigated antitumor effect of $18{\beta}$-GA on tumor caused by A549 cancer cell in mice. Data resulting from the cytotoxicity assay showed that $18{\beta}$-GA caused killing of A549 cells. $LD_{50}$ values of $18{\beta}$-GA were app. 180 ${\mu}M$ and 80 ${\mu}M$, corresponding to 48 hr- and 72 hr-treatments, displaying that the killing activity was more effective as the $18{\beta}$-GA treatment was prolonged. Based on these data, antitumor effect of $18{\beta}$-GA was tested in nude mice. For induction of the tumor, A549 ($3{\times}10^6$ cells/mouse) was injected subcutaneously into the lateral abdomen of nude mice (Balb/c nu/nu). To determine the antitumor effect, nude mice with tumor were given $18{\beta}$-GA (1 mg/200 ${\mu}l$/mouse) intraperitoneally every three days for four times. Tumor-sizes were measured with a caliper for a period of 24 days. Results showed that the $18{\beta}$-GA treatment reduced the tumor-sizes (P<0.05) as compared with negative control nude mice that received diluent (DPBS). The reduction degree was greater than reduction degree by doxorubicin (60 ${\mu}g$/mouse), and the pattern of reduction was almost sustained during the entire period of the observation. In conclusion, our studies demonstrate that $18{\beta}$-GA has antitumor activity to the A549 cancer cell-caused tumor.

• 대한화학회지
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• 제35권4호
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• pp.374-378
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• 1991

pH 7.8의 인산 완충용액에서 Bilirubin의 전기화학적인 환원거동을 직류 폴라로그래피, 시차 펄스폴라로그래피, 순환 전압전류법 및 정전위 전기량법으로 조사하였다. 직류 폴라로그램에서 반파전위가 -1.32V와 -1.51V vs. Ag/AgCl인 2개의 환원파를 확인하였고, 각 환원파의 전류유형은 제1환원파는 확산지배적인 전류였으며 제2환원파는 반응성전류가 약간 포함된 확산전류였다. 그리고 각 환원단계는 모두 비가역적이었다. 또한 Bilirubin의 농도가 3.4 ${\times}$ 10$^{-4}$M 이하일 때 나타나는 전방파가 흡착에 의한 전류임을 확인하였다. 환원반응에 관여하는 전자수는 제1단계에서는 2개였으며, 제2단계에서는 1개였다.

• PNF and Movement
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• 제13권1호
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• pp.39-46
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• 2015

Purpose: The accelerometer is a tool for evaluating walking by the displacement of the center of mass (COM) in the body. Recently, smartphones have added an accelerometer app, and it can be used to evaluate outcomemanures in rehabilitation. The purpose of this study was to investigate the COM in the bodies of normal persons and stroke patients using this smartphone application while walking. Methods: Twenty normal persons and twenty-two stroke patients were recruited and had their COM measured using G-walk and the smartphone application, SMAP, during 10 m walking. Subjects repeated the 10 m of walking 3 times, and we used the SMAP, Accelerometer Monitor ver. 1.5.0, to evaluate COM during the walk. To measure the displacement of COM, we used the difference in value between the maximal angle and the minimum anterior-posterior (AP), mediolateral (ML), and rotational angles during the walk. Results: For the normal persons, there was significant correlation between the AP and AP of SMAP, and was also a significant correlation between rotational angle and the ML of SMAP. In the stroke patients, there was significant correlation between AP and ML, and the rotational angle of SMAP. Conclusion: Our research results suggest that if the SMAP system is reinforced in the case of patients who have a greater displacement of COM, it may be used as an evaluation tool during walking.

• 비만대사연구학술지
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• 제1권2호
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• pp.74-77
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• 2022

Treatment of obesity includes diet therapy, exercise therapy, cognitive behavioral therapy, drug therapy, and bariatric surgery. Most obese patients lose weight by combining diet, exercise, cognitive behavioral therapy or medication. But, in some cases, only one of these treatments is preferred. A 56-year-old male patient had a body mass index (BMI) of 33.1 kg/m² and a waist circumference of 108 cm. He had been treated for hypertension; diabetes and dyslipidemia were diagnosed but not treated. However, at the initial visit to treat obesity, he was diagnosed with type 2 diabetes mellitus and dyslipidemia again. So he decided to treat these two diseases with drugs first and modify his lifestyle. He started walking more than 20,000 steps every day and then he really walked about 15,000 steps every day during 5 months, although diet calorie or alcohol drinking amount was not significantly decreased. After about 6 months, the patient's weight decreased by 10.1 kg, the BMI decreased by 4.1 kg/m², the waist circumference decreased by 10 cm, the glycated hemoglobin (HbA1c) decreased by 4.59%, the visceral fat area decreased by 115 cm², and the subcutaneous fat decreased by 38 cm². As a result of body composition analysis, muscle mass increased by 1.2 kg, and the percentage of body fat decreased by 10.4%. The walking exercise does not have any space restrictions and has high accessibility by using a mobile phone app. Therefore, considering the patient's situation, it would be better to treat obese patients by first recommending walking exercises and increasing the number of steps to lose weight and improve the comorbidities.

• Journal of Pharmaceutical Investigation
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• 제38권3호
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• pp.191-197
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• 2008

The purpose of the present study was to examine the pharmacokinetics and lymphatic delivery of the oligopeptide, a model peptide of X antigen epitope peptides, after the intramuscular administration of the peptide-bearing liposomes in rats. $^{14}C$-labelled peptide was used as a tracer to analyze the peptide levels in plasma, bile, urine, tissue homogenates, and lymph nodes (superior cervical nodes, brachial nodes and superior mesenteric nodes). Model peptide rapidly disappeared from the plasma by 30 min (${\alpha}$ phase) after i.v. administration, which was followed by the late disappearance. The apparent plasma half-lives ($t_{1/2({\alpha}),app}$) of the peptide at the ${\alpha}$ phase when administered at a dose of 0.2-1.0 mg/kg were about 5 min. The maximum plasma concentration ($C_{max}$) was $1.52\;{\mu}g/mL$, after the i.m. administration of the peptide at a dose of 1.0 mg/kg. The bioavailability, which was calculated from the time zero to last quantitative time, of the i.m. administered peptide was over 60%. Of the various tissues tested, the peptide was mainly distributed in the kidney after the i.m. administration. The peptide levels in the kidney 3 hr after the i.m. administration were higher than those of maximum plasma concentration ($C_{max}$). The cumulative amounts of the peptide found in the urine 72 hr after the administration of 1.0 mg/kg were 2-folder higher than those in the bile, suggesting that the peptide is mostly excreted in the urine. Moreover, the concentrations of the peptide in the lymph nodes were as high as that of the plasma and the tissues. In conclusion, the peptide concentration in the lymph nodes was maintained by 24 hr after the i.m. administration of the peptide-bearing liposomes.

• 한국농공학회논문집
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• 제54권3호
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• pp.1-9
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• 2012

As topographic characteristics of Korea where 64 % of the national land area is forest and only 17 % is being used as farmland, remediation of farmland contaminated by heavy metals is a considerably important issue. In this study, as an alternative of practically and effectively remediating farmland which was abandoned as its crop plants exceeded maximum residue limit of heavy metals due to mining impact, applicability of stabilization method was examined through the pilot-scale field experiment. Three plots ($L{\times}W{\times}D=3m{\times}2m{\times}0.3m$) were installed at the selected farmland and in plot 1, only soil of the selected farmland was applied, in pilot 2, soil of the selected farmland plus 3 % limestone (w/w) was applied and in pilot 3, soil of the selected farmland plus 3 % limestone was applied and then uncontaminated soil was covered thereon (0.3 m). After that, seeds of radish, Korean cabbage and soybean of which characteristics of edible portions are different were sowed on each plot and cultivated. Afterwards, at a proper harvesting time (app. 80 days later), crop plants and soil were collected and phytoavailability (0.11 M HOAc extractable) of heavy metals in soil and accumulated concentration of heavy metal in edible portion of crop plants were examined. As a result, it was revealed that phytoavailability of heavy metals in soil added with limestone (plot 2) was clearly reduced compared with plot 1 (untreated) and owing to this treatment, accumulated concentration of heavy metals in edible portion of crops was also clearly reduced compared with plot 1. While radish cultivated in plot 1 had exceeded maximum residue limit of agricultural products, in particular, plot 2 using limestone had shown concentration lower than maximum residue limit and this plot had shown little difference with 3 plot where crop was cultivated in uncontaminated soil cover. Therefore, it was considered that for abandoned farmland like the selected farmland, reducing mobility and phytoavailability of heavy metals and reducing crop uptake through stabilization method would be an effective and practical alternative for producing safe agricultural products on a sustained basis.

• 한국식품과학회지
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• 제53권3호
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• pp.278-289
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• 2021

본 연구는 인지기능 개선에 도움이 되는 천연기능성소재를 선발하기 위해 체계적 문헌고찰을 실시하였다. 2020년 10월 06일 기준 문헌검색을 통해 16,184건을 수집하였고 선택 및 배제 기준에 따라 총 27건의 문헌을 선별하였다. 27건 중 ω-3 지방산 관련 논문 12건, 비타민 B군 관련 논문 8건, 비타민 D와 E 관련 논문 각각 1건이었으며, 안세린/카르노신, 베테인, 카페인, 크로뮴, 피소스티그민 관련 논문이 각각 1건이었다. 각 문헌의 비뚤림 위험 평가를 진행한 결과 ω-3 지방산 관련 논문 2건, 비타민 B군 관련 논문 1건, 베테인, 카페인, 피소스티그민 관련 논문의 비뚤림 위험이 '높음'으로 평가되었고, 비뚤림 위험이 높다고 평가된 6건의 논문들을 제외하고 근거수준평가 및 결과분석을 시행하였다. ω-3 지방산 관련 논문은 6-24개월동안 DHA 0.48-2.2 g, EPA 203-720 mg의 용량을 함께 또는 따로 중재하여 총 1,031명의 대상자 중 437명의 유의적인 효과를 확인하였다. 경도인지장애 환자를 대상으로 진행된 ω-3 지방산 논문에서는 인지기능영역(공간력, 기억력, 회상력, 언어력)과 인지기능 관련 바이오마커(Aβ-42, APP mRNA)를 개선시키는 등 치매개선에 긍정적인 효과를 나타냈다. 그러나 치매 환자를 대상으로 한 ω-3 지방산 연구에서는 인지기능평가에 대한 개선효과를 확인하기 어려웠다. 비타민 B 관련 논문은 6 또는 24개월 동안 엽산 400-800 ㎍, 비타민 B₁₂ 25-500 ㎍, 비타민 B₆ 20 mg의 용량을 함께 또는 따로 중재하여 총 1,180명의 대상자 중 530명에서 유의적인 효과를 확인하였다. 비타민 B군의 섭취는 치매 위험성과 관련된 혈중 호모시스테인 농도를 감소시켰으며, 혈중 ω-3 지방산의 농도와 높은 상관관계를 나타내는 것을 확인할 수 있었다. 그 외에 비타민 D와 E는 인지기능관련 바이오마커(Aβ-42, APP mRNA, PS1 mRNA)를 감소시키고 인지기능평가(WAIS-RC, ADAS-cog) 개선효과를 나타냈으며 안세린/카르노신은 치매척도검사를 개선하였고 크로뮴 섭취는 기억력 부분의 인지기능영역을 유의적으로 개선하였다. 그러나 ω-3 지방산과 비타민 B를 제외한 연구들은 선별된 문헌의 개수가 제한적이며, 개선 효과를 판단할 근거가 부족하였다. 중재 기간 및 용량에 따라 결과를 종합하면, ω-3 지방산은 6개월 이상 DHA 0.48-2.2 g, EPA 203-720 mg의 용량을 복합 또는 DHA 단독으로 중재했을 경우 인지기능 개선 효과를 확인할 수 있었으며, 엽산 400-800 ㎍, 비타민 B₁₂ 25-500 ㎍, 비타민 B₆ 20 mg의 용량을 복합 또는 엽산을 단독으로 6개월 이상 중재할 경우 혈중 호모시스테인 농도 감소와 인지능력개선을 확인할 수 있었다.