• Radiation Oncology Journal
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• v.6 no.1
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• pp.81-84
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• 1988

Since the entity of postmastectomy lymphangiosarcoma was first reported by Stewart and Treves in 1948, postmastectomy lymphangiosarcoma has become a well recognized, uncommon malignant tumor which occurs in the upper extremity following mastectomy for mammary carcinoma. The postmastectomy lymphangiosarcoma occurred at an average age of 63.9 years and at an average of 10 years and 3 months following mastectomy. The lymphangiosarcoma raised from blood and lymphatic vessel. The histologic appearance has been observed edematous dermiss and dilated lymphatics lining with malignant cells. Most authors recommend radical amputation for treatment, either shoulder disarticulation or forequarter amputation. Other modalities of treatment including radiotherapy were considered as ineffetive. The present report provides a case of the regression of postmastectomy lymphangiosarcoma with chronic lymphedema by external irradiation. Radiation therapy was used as primary therapy. Total tumor dose of 6500 cGy in 9 wks was delivered using 6 MV x-ray and 8 MeV electron.

• Korean Journal of Veterinary Research
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• v.61 no.4
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• pp.32.1-32.4
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• 2021

A 12-year-old neutered male Golden Retriever presented with a progressively enlarging mass in the submandibular region. Histopathological diagnosis confirmed lymphangiosarcoma with metastasis to the liver and spleen. The pleomorphic neoplastic endothelial cells of the tumor grow directly on bundles of dermal collagen, forming numerous clefts and interconnecting channels that are devoid of conspicuous hematic elements. As lymphangiosarcoma is an uncommon malignant neoplasm, the number of previously reported cases and information of the tumor is limited. The present report describes the clinical history and histopathological diagnosis of a progressive lymphangiosarcoma in the submandibular region with metastases in a dog.

• Journal of Veterinary Clinics
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• v.27 no.4
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• pp.488-490
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• 2010

Lymphangiosarcoma was described in a 2-year-old male Miniature Poodle. A 5 cm by 3 cm slightly elevated tan ventral abdominal mass was surgically removed with a wide margin and submitted for diagnosis. The mass has being grown rapidly during the last six months. On histopathology, the mass was composed of anastomosing channels or empty spaces which were free of red blood cells and lined by flat to plump pleomorphic neoplastic cells. The neoplastic channels or spaces were invasive into the surrounding fat and muscle tissues. Mild perivascular lymphocytic infiltration was also noted. Immunohistochemically, the neoplastic cells were positive to vimentin and Factor VIII. Based on histopathology and immunohistochemistry, the tumor was diagnosed as lymphangiosarcoma. Recurrence or metastasis was not noted so far after surgery.

• Journal of Breast Disease
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• v.6 no.2
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• pp.73-78
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• 2018

Primary angiosarcoma of the breast is extremely rare and is observed in 0.0005% to 0.05% of primary breast tumor cases. The diagnosis of this tumor is difficult due to its undefined characteristics. Radiologic findings are often nonspecific and appear completely normal in one-third of patients with primary angiosarcomas. The prognosis is usually poor, and the treatment choices include mastectomy or wide excision. Radiotherapy and chemotherapy produce varying results. We report a patient with primary angiosarcoma of the breast to further our understanding of the characteristics of this tumor and facilitate the correct diagnosis of breast angiosarcoma.

• Journal of Biomedical Engineering Research
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• v.34 no.4
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• pp.170-176
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• 2013

Lymphedema is a phenomenon in which fluid is accumulated inside tissues due to the damaged lymphatic systems. Lymphedema can cause complications such as lymphangitis, infection, changes in skin texture, fibrosis, and lymphangiosarcoma. In this study, a lymphedema screening system based on the elasticity of the skin is proposed to easily quantify lymphedema. The developed probe consists of touch sensors, a load cell and hall-effect sensors to measure the indentation force on the skin and the return time of the skin. The developed system can be used to estimate the change in the elasticity of the skin to quantify lymphedema. The system was tested with a thyroid phantom and gelatin phantoms of different concentrations and the resulting force and the time were recorded. It was found that the increase in the elasticity leads to a higher indentation force and shorter return time. This shows that the developed system can monitor the change in the skin elasticity by measuring the return time and the indentation force. The feasibility of the system in clinical applications will be evaluated in the future study.