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Drug Release from Xyloglucan Beads Coated with Eudragit for Oral Drug Delivery

  • Yoo Mi Kyong;Choi Hoo Kyun;Kim Tae Hee;Choi Yun Jaie;Akaike Toshihiro;Shirakawa Mayumi;Cho Chong Su
    • Archives of Pharmacal Research
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    • v.28 no.6
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    • pp.736-742
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    • 2005
  • Xyloglucan (XG), which exhibits thermal sol to gel transition, non-toxicity, and low gelation concentration, is of interest in the development of sustained release carriers for drug delivery. Drug-loaded XG beads were prepared by extruding dropwise a dispersion of indomethacin in aqueous XG solution (2 wt.-$\%$) through a syringe into corn oil. Enteric coating of XG bead was performed using Eudragit L 100 to improve the stability of XG bead in gastrointestinal (GI) track and to achieve gastroresistant drug release. Release behavior of indomethacin from XG beads in vitro was investigated as a function of loading content of drug, pH of release medium, and concentration of coating agent. Adhesive force of XG was also measured using the tensile test. Uniform-sized spherical beads with particle diameters ranging from 692 $\pm$ 30 to 819 $\pm$ 50 $\mu$m were obtained. The effect of drug content on the release of indomethacin from XG beads depended on the medium pH. Release of indomethacin from XG beads was retarded by coating with Eudragit and increased rapidly with the change in medium pH from 1.2 to 7.4. Adhesive force of XG was stronger than that of Carbopol 943 P, a well-known commercial mucoadhesive polymer, in wet state. Results indicate the enteric-coated XG beads may be suitable as a carrier for oral drug delivery of irritant drug in the stomach.

The Detection of Yellow Sand Using MTSAT-1R Infrared bands

  • Ha, Jong-Sung;Kim, Jae-Hwan;Lee, Hyun-Jin
    • Proceedings of the KSRS Conference
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    • v.1
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    • pp.236-238
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    • 2006
  • An algorithm for detection of yellow sand aerosols has been developed with infrared bands from Moderate Resolution Imaging Spectroradiometer (MODIS) and Multi-functional Transport Satellite-1 Replacement (MTSAT-1R) data. The algorithm is the hybrid algorithm that has used two methods combined together. The first method used the differential absorption in brightness temperature difference between $11{\mu}m$ and $12{\mu}m$ (BTD1). The radiation at 11 ${\mu}m$ is absorbed more than at 12 ${\mu}m$ when yellow sand is loaded in the atmosphere, whereas it will be the other way around when cloud is present. The second method uses the brightness temperature difference between $3.7{\mu}m$ and $11{\mu}m$ (BTD2). The technique would be most sensitive to dust loading during the day when the BTD2 is enhanced by reflection of $3.7{\mu}m$ solar radiation. We have applied the three methods to MTSAT-1R for derivation of the yellow sand dust and in conjunction with the Principle Component Analysis (PCA), a form of eigenvector statistical analysis. As produced Principle Component Image (PCI) through the PCA is the correlation between BTD1 and BTD2, errors of about 10% that have a low correlation are eliminated for aerosol detection. For the region of aerosol detection, aerosol index (AI) is produced to the scale of BTD1 and BTD2 values over land and ocean respectively. AI shows better results for yellow sand detection in comparison with the results from individual method. The comparison between AI and OMI aerosol index (AI) shows remarkable good correlations during daytime and relatively good correlations over the land.

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A study on the correlation between non-point source pollutants from the forest of Juam basin and algae bloom in the Juam lake. (주암호유역 산림기원 비점오염원물질과 주암호에 서식하는 조류번식간의 상관성 규명)

  • Kim, Nam-Jong;Shin, Dae-Yewn
    • Journal of environmental and Sanitary engineering
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    • v.21 no.4 s.62
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    • pp.39-48
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    • 2006
  • In Juam basin, the ratio of non-point pollution source among pollutant loading of basin was significantly high, since the utilization level of land was high. In addition, the most pollutants were not treated and flowed out. In this study, the correlation between non-point source pollutants from the forest area and increasing algae was investigated. 1. Chl-a concentration flowed out to runoff from forest area and stream water was low as $0.1{\sim}20.3{\mu}g/{\ell}$ and $0.1{\sim}9.3{\mu}g/{\ell}$, respectively, and chl-a concentration ($0.1{\sim}28.5{\mu}g/{\ell}$) of branch stream was higher $5{\sim}7$ times than that of runoff from forest area. 2. In correlation between runoff from forest area and Juam lake water, annual chl-a concentration of area front Juam dam was higher twice than forest area. 3. In runoff from forest area within Juam basin, flagellate, green, diatom and blue algae occupied $33.0{\sim}41.7%$, $22.2{\sim}30.8%$, $17.3{\sim}22.5%$ and $13.7{\sim}17.6%$, respectively. 4. In runoff from forest area, both green and diatom algae were maintained constantly irrespectively of season, and flagellate algae dominated since August. 5. In characteristics by forest tree types, four types algae were inhabited in mixed forest, and flagellate algae were higher in conifer and broadleaf forest than in other area. And green algae in herbaceous forest were higher than other area.

Wave energy conversion utilizing vertical motion of water in the array of water chambers aligned in the direction of wave propagation

  • Hadano, Kesayoshi;Lee, Ki Yeol;Moon, Byung Young
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.9 no.3
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    • pp.239-245
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    • 2017
  • As a new technical approach, wave energy converter by using vertical motion of water in the multiple water chambers were developed to realize actual wave power generation as eco-environmental renewable energy. And practical use of wave energy converter was actually to require the following conditions: (1) setting up of the relevant device and its application to wave power generation in case that severe wave loading is avoided; (2) workability in installation and maintenance operations; (3) high energy conversion potential; and (4) low cost. In this system, neither the wall(s) of the chambers nor the energy conversion device(s) are exposed to the impulsive load due to water wave. Also since this system is profitable when set along the jetty or along a long floating body, installation and maintenance are done without difficulty and the cost is reduced. In this paper, we describe the system which consists of a float, a shaft connected with another shaft, a rack and pinion arrangement, a ratchet mechanism, and rotary type generator(s). Then, we present the dynamics model for evaluating the output electric power, and the results of numerical calculation including the effect of the phase shift of up/down motion of the water in the array of water chambers aligned along the direction of wave propagation.

APPLICATION AND EVALUATION OF THE GLEAMS MODEL TO A CATTLE GRAZING PASTURE FIELD IN NORTH ALABAMA

  • Kang, M. S.;P. prem, P.-Prem;Yoo, K. H.;Im, Sang-Jun
    • Water Engineering Research
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    • v.5 no.2
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    • pp.55-68
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    • 2004
  • The GLEAMS (Groundwater Loading Effects of Agricultural Management System, version 3.0) water quality model was used to predict hydrology and water quality and to evaluate the effects of soil types from a cattle-grazed pasture field of Bermuda-Rye grass rotation with poultry litter application as a fertilizer in North Alabama. The model was applied and evaluated by using four years (1999-2002) of field-measured data to compare the simulated results for the 2.71- ha Summerford watershed. $R^2$ values between observed and simulated runoff, sediment yields, TN, and TP were 0.91, 0.86, 0.95, and 0.69, respectively. EI (Efficiency Index) of these parameters were 0.86, 0.67, 0.70, and 0.48, respectively. The statistical parameters indicated that GLEAMS provided a reasonable estimation of the runoff, sediment yield, and nutrient losses at the studied watershed. The soil infiltration rates were compared with the rainfall events. Only high intensity rainfall events generated runoff from the watershed. The measured and predicted infiltration rates were higher during dry soil conditions than wet soil conditions. The ratio of runoff to precipitation was ranging from 2.2% to 8.8% with average of 4.3%. This shows that the project site had high infiltration and evapotranspiration which generated the low runoff. The ratio of runoff to precipitation according to soil types by the GLEAMS model appeared that Sa (Sequatchie fine sandy loam) soil type was higher and Wc (Waynesboro fine sandy loam, severely eroded rolling phase) soil type relatively lower than the weighted average of the soil types in the watershed. The model under-predicted runoff, sediment yields, TN, and TP in Wb (Waynesboro fine sandy loam, eroded undulating phase) and Wc soil types. General tendency of the predicted data was similar for all soil types. The model predicted the highest runoff in Sa soil type by 105% of the weighted average and the lowest runoff in Wc soil type by 87% of the weighted average

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THE HISTOLOGIC STUDY OF THE GRAFTED hBMP-I FOR IMMEDIATE IMPLANT FIXATION (발치 후 즉시 임플란트 식립시 이식된 hBMP-I의 조직학적 고찰)

  • Lee, Eun-Young;Kim, Kyoung-Won;Choi, Hee-Won;Um, In-Woong;Chung, Ho-Yong
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.30 no.4
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    • pp.316-322
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    • 2004
  • A low molecular weight component named bone morphogenetic protein(BMP) chemically isolated from the organic matrix of bone, induce postfetal connective tissue cells surrounding small blood vessels to differentiate into cartilage and bone. The end product of BMP is a spherical ossicle of lamella bone filled with red bone marrow for the functional loading. This is a important point that the graft material is embedded the defect site during the implant surgery. Because present knowledge of the relationship between BMP and bone regeneration arises mainly from studies of induced bone formation in heterotopic sites, it would be helpful to determine whether BMP plays any part in the process of bone healing. The BMPs have been shown to play crucial roles in normal skeletal development as well as bone healing and are able to activate transcription of genes involved in cellular migration, proliferation, and differentiation. The delivery of BMP on matrices has been efficacious in the treatment of defect bone in implant surgery. The purpose of the histologic study was to evaluate the effect of DLB(demineralized lyophilized bone) coated with purified human BMP(hBMP-I) in immediate implant surgery with bony defect to obtain the functional structure of implant asap. The ability of a graft of hBMP-I to accelerate bony defect repair provides a rationale for its use in immediate implant surgery that have large bone defect in edentulous area.

A Study on the Sulfur-Resistant Catalysts for Water Gas Shift Reaction II. Effect of Alkali Metal Salt on the Activity of CoMo Catalyst (황에 저항성을 가지는 수성가스 전환반응 촉매의 연구 II. CoMo 촉매의 활성에 미치는 알칼리 금속염의 영향)

  • Kim, Joon Hee;Lee, Ho In
    • Journal of the Korean Chemical Society
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    • v.42 no.6
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    • pp.696-702
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    • 1998
  • The effect of alkali metal salt on the activity of Co-Mo catalyst which has high resistance to sulfur poisoning for water gas shift reaction(WGSR) was studied. Two groups of catalysts were prepared to investigate the effects of anion and cation in alkali metal salts. For K-doped catalysts made with various potassium salts having different anion, the catalytic activity was explained to depend mainly on the BET surface area. Among the catalysts prepared by various nitrates of alkali metal as precursor, the Li-doped catalyst showed the best activity, and the others did not make significant differences giving relatively low activities. And the change of BET surface area by varying the loading of alkali metal showed a similar trend to that of activity. In this case, the activity was dependent on both BET surface area and the ratio of $Mo^{6+}$ with a tetrahedral coordination symmetry to $Mo^{6+}$ with an octahedral one, $Mo^6+[T]/Mo^{6+}[O]$ value.

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Mode identifiability of a cable-stayed bridge based on a Bayesian method

  • Zhang, Feng-Liang;Ni, Yi-Qing;Ni, Yan-Chun
    • Smart Structures and Systems
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    • v.17 no.3
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    • pp.471-489
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    • 2016
  • Modal identification based on ambient vibration data has attracted extensive attention in the past few decades. Since the excitation for ambient vibration tests is mainly from the environmental effects such as wind and traffic loading and no artificial excitation is applied, the signal to noise (s/n) ratio of the data acquired plays an important role in mode identifiability. Under ambient vibration conditions, certain modes may not be identifiable due to a low s/n ratio. This paper presents a study on the mode identifiability of an instrumented cable-stayed bridge with the use of acceleration response data measured by a long-term structural health monitoring system. A recently developed fast Bayesian FFT method is utilized to perform output-only modal identification. In addition to identifying the most probable values (MPVs) of modal parameters, the associated posterior uncertainties can be obtained by this method. Likewise, the power spectral density of modal force can be identified, and thus it is possible to obtain the modal s/n ratio. This provides an efficient way to investigate the mode identifiability. Three groups of data are utilized in this study: the first one is 10 data sets including six collected under normal wind conditions and four collected during typhoons; the second one is three data sets with wind speeds of about 7.5 m/s; and the third one is some blind data. The first two groups of data are used to perform ambient modal identification and help to estimate a critical value of the s/n ratio above which the deficient mode is identifiable, while the third group of data is used to perform verification. A couple of fundamental modes are identified, including the ones in the vertical and transverse directions respectively and coupled in both directions. The uncertainty and s/n ratio of the deficient mode are investigated and discussed. A critical value of the modal s/n ratio is suggested to evaluate the mode identifiability of the deficient mode. The work presented in this paper could provide a base for the vibration-based condition assessment in future.

Design of the 1.5kVA Class Wireless Power Transfer Device for Battery Charging of Integrated Power Control System in MSAP (군 이동기지국시스템(MSAP) 통합전원제어장치 배터리 충전용 1.5kVA급 무선전력전송기기의 설계)

  • Kim, Jin-Sung;Kim, Byung-Jun;Park, Hyeon-Jeong;Seo, Min-Sung
    • The Journal of the Korea institute of electronic communication sciences
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    • v.15 no.3
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    • pp.413-420
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    • 2020
  • The Tactical Information and Communication Network system provides real-time multimedia services such as voice and data by utilizing the Mobile Subscriber Access Point. At this time, an external transmission path is constructed through the Low Capacity Trunk Radio and the High Capacity Trunk Radio system. The communication devices of each wireless transmission system are mounted on a tactical vehicle and a secondary battery is used to prevent a power interruption when the supply power to the tactical vehicle is transferred to the integrated power control device. In this paper, the basic design of the Wireless Power Transfer device for charging the battery of the integrated power control system of the mobile base station system using the Loading Distribution Method and checking the number of primary windings and the core material selection by the air gap through the Finite Elements Method.

Acrylamide Polymerization on ceramic Powders(I) : The Process Control of Si2N4 Gelcasting by Polymerization of Acrylamicde (세라믹분체 표면에서 아크릴아마이드 중합(제1보) : 아마이드 고분자중합에 의한 질화규소 겔캐스팅 공정제어)

  • 류병환;김은영;이재도
    • Journal of the Korean Ceramic Society
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    • v.36 no.2
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    • pp.178-185
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    • 1999
  • For the process control of silicon nitride gelcasting, the composition effect of acryamide system on the viscosity of slip and mechanical property of gelcast green body were investigated. The slip was prepared by ball milling of silicon nitride suspension prepared with acrylamide monomer and polyelectrolyte dispersant after premixing them by attritor. The slip mixed with initiator was vacuum deaired and cast into molds, and then polymerized. The consolidated green body was obtained by drying the gelated slip. The viscosity measument and the diametral compression test was done to evaluate the rheological behaviro of slip and mechanical property of gelcast body, respectively. Experimental results showed that the high solid loading of silicon nitride slip was obtained up to 46 vol% with a low viscosity. The mechanical property of gelcast body mainly increased with increasing the concentration of monomer. The gelcast body was machinable above the ∼3 MPa of tensile strength. The relative density of pressured-sintered body was 98.5% at 1760$^{\circ}C$, 3 h.

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