Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

THE HISTOLOGIC STUDY OF THE GRAFTED hBMP-I FOR IMMEDIATE IMPLANT FIXATION

발치 후 즉시 임플란트 식립시 이식된 hBMP-I의 조직학적 고찰

  • Lee, Eun-Young (Dept. of Oral & Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Kim, Kyoung-Won (Dept. of Oral & Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Choi, Hee-Won (Dept. of Oral & Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Um, In-Woong (Korea Tissue Bank) ;
  • Chung, Ho-Yong (In-Dental Clinic)
  • 이은영 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 김경원 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 최희원 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 엄인웅 (한국조직은행) ;
  • 정호용 (인치과크리닉)
  • Published : 2004.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

A low molecular weight component named bone morphogenetic protein(BMP) chemically isolated from the organic matrix of bone, induce postfetal connective tissue cells surrounding small blood vessels to differentiate into cartilage and bone. The end product of BMP is a spherical ossicle of lamella bone filled with red bone marrow for the functional loading. This is a important point that the graft material is embedded the defect site during the implant surgery. Because present knowledge of the relationship between BMP and bone regeneration arises mainly from studies of induced bone formation in heterotopic sites, it would be helpful to determine whether BMP plays any part in the process of bone healing. The BMPs have been shown to play crucial roles in normal skeletal development as well as bone healing and are able to activate transcription of genes involved in cellular migration, proliferation, and differentiation. The delivery of BMP on matrices has been efficacious in the treatment of defect bone in implant surgery. The purpose of the histologic study was to evaluate the effect of DLB(demineralized lyophilized bone) coated with purified human BMP(hBMP-I) in immediate implant surgery with bony defect to obtain the functional structure of implant asap. The ability of a graft of hBMP-I to accelerate bony defect repair provides a rationale for its use in immediate implant surgery that have large bone defect in edentulous area.

Keywords

References

  1. Heiple KG, Chase SW, Hernon CH: A comparative study of the healing process following different types of bone transplantation. J Bone Joint Surgery 1963;45A:1593-1616
  2. 이은영: The effect of purified human BMP with DLB(hBMP-I) on osseointegration of immediate titanium implants: cases report. JKMPR 2003;25(2):176-185
  3. Branemark P: Osseointegration and its experimental background. J Prosthet Dent 1983;50:399
  4. Caplan AI: Mesenchymal stem cells. J Orthop Res 1991;9:641-650 https://doi.org/10.1002/jor.1100090504
  5. Aronow MA, Gerstenfeld LC, Owen TA: Factors that promote progressive development of the osteoblast phenotype in cultured rat calvaria cells. J Cell Physiol 1990;143:213-221 https://doi.org/10.1002/jcp.1041430203
  6. Boden SD, Hair G, Titus L: Glucocortico-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6. Endocrinology 1997;138:2820-2828 https://doi.org/10.1210/en.138.7.2820
  7. Boden SD, Sumner DR: Biologic factors affecting spinal fusion and bone regeneration. Spine 1995;20(Suppl 24):102S-112S https://doi.org/10.1097/00007632-199512151-00006
  8. Kim SS, Denis F, Lonstein JE: Factors affecting fusion rate in spondylolisthesis. Spine 1990;15:979-984 https://doi.org/10.1097/00007632-199009000-00026
  9. Subach BR, Haid RW, Rodts GE and Kaiser MG: Bone morphogenetic protein in spinal fusion: overview and clinical update. Neurosurg Focus 2001;10(4):Article 3
  10. Burchart H: The biology of bone graft repair. Clin Orthop 1983; 174:28-42
  11. Khalid A. Al Ruhaimi. Bone Graft Substitutes: A Comparative Qualitative Histologic Review of current Osteoconductive Grafting Materials. The International J of Oral Maxillofac Implants 2001;16(1):105-113
  12. 이은영, 엄인웅, 이종호: hBMP-I의 골유도능에 관한 실험적 연구. Dental Prosessional Implantologist 2002;12(6):55-60
  13. Urist MR, Huo YK, Brownell AG: Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc Natl Acad Sci USA 1984;81:371
  14. Einhorn TA, Majeska RJ, Mohaideen A, Kagel EM, Bouxsein ML, Turek TJ, Wozney JM. A single percutaneous injection of recombinent human bone morphogenetic protein-2 accelerates fracture repair JBJS 2003;85-A(8):1425-1434
  15. BMP-2 Evaluation in surgery for tibial trauma(BESTT) study group. Govender S, Csimma C, Genabt HK: Recombinent human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective controlled, randomized study of four hundreds fifty patients. J Bone Joint Surg Am. 2002;84:2123-34
  16. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierry G, Muschler GF, et al: Osteogenic protein-1(bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 2001; 83:Suppl 1(Pt 2):S151-158
  17. Boyne PJ, Marx RE, Nevins M, Triplett G, Lazaro E, Lilly LC, et al: A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 1997;17:11-25
  18. 엄인웅: The effect of hBMP-I on osseointegration of tiatnium implant. Dental Prosessional Implantologist 2002;6:55-61
  19. Wang xiang: The effect of bone morphogenetic protein on oxeointegration of Titanium Impants. J Oral Maxillofac Surg 1993;51:647-651 https://doi.org/10.1016/S0278-2391(10)80264-2
  20. Urist MR, Sato K, Brownell AG: Human bone morphogenic protein(hBMP). Proc Soc Exp Biol Med 1983;173(2):194-199 https://doi.org/10.3181/00379727-173-41630
  21. Einhorn TA: Clinical application of recombinent human BMPs: early experience and future development. JBJS 2003;85-A(3),82-88
  22. Bessho K: Purification and characterization of bone morphogenetic protein(BMP). Mie Med J 1990;40:61
  23. Bessho K, Tagawa T, Murata M: Purification of bone morphogenetic protein derived from bovine bone matrix. Biochem Biophys Res Commun 1989;165:595
  24. Gao TJ, Lindholm TS, Marttinen A: Composite of bone morphogenetic protein type IV collagen, coral-derived hydroxyapatite and tricalcium phosphate ceramics. In Press kd
  25. 임창준: 동종 골 이식을 이용한 구강악안면 재건. 대악성회지 1997;19(3):217-231
  26. Brugnami F, Then PR, Moroi G: Histologic evaluation of human extraction sockets treated with demineralized freeze-dried bone allograft(DFDBA) and cell occlusive membrane. J Periodontol 1996;67:821
  27. Urist MR: A bone morphogenetic system in residual bone matrix in the mouse. Clin Orthop 1973;9:210