• Journal of Plant Biotechnology
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• 제36권4호
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• pp.309-319
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• 2009

Transgenic plant cell cultures for the production of biopharmaceuticals including monoclonal antibodies, recombinant proteins have been regarded as an alternative platform in addition to traditional microbial fermentation and mammalian cell cultures. Plant-made pharmaceuticals (PMPs) have several advantages such as safety, cost-effectiveness, scalability and possibility of complex post-translational modifications. Increasing demand for the quantity and diversity of pharmaceutical proteins may accelerate the industrialization of PMP technology. Up to date, there is no plant-made recombinant protein approved by USFDA (Food and Drug Administration) for human therapeutic uses due to the technological bottlenecks of low expression level and slight differences in glycosylation. Regarding expression levels, it is possible to improve the productivity by using stronger promoter and optimizing culture processes. In terms of glycosylation, humanization has been attempted in many ways to reduce immune responses and to enhance the efficacy as well as stability. In this review article, all these respects of transgenic plant cell cultures were summarized. In addition, we also discuss the general characteristics of plant cell suspension cultures related with bioreactor design and operation to achieve high productivity in large scale which could be a key to successful commercialization of PMPs.

• International Journal of Automotive Technology
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• 제3권1호
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• pp.1-8
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• 2002

There is Increasing world-wide interest in diesel particulate filters (DPF) because of their proven effectiveness in reducing exhaust smoke and particulate emissions. Fine particulates have been linked to human health . DPF use requires a means to secure the bum-out of the accumulated soot, a process called regeneration. If this is not achieved, the engine cannot continue to operate. A number of techniques are available, but most are complex, expensive or have a high electrical demand. The use of fuel additives to catalyse soot bum-out potentially solves the problem of securing regeneration reliably and at low cost. Work on organo-metallic fuel additives has shown that certain metals combine to glove exceptional regeneration performance. Best performance was achieved with a combination of iron and strontium based compounds. Tests were carried out un a bed engine and on road vehicles, which demonstrated effective and reliable regeneration from a tow dose fuel additive, using a single passive DPF. No control valves, flow diverters. heaters or other devices were employed to assist regeneration. Independent particle size measurements showed that there were no harmful side effects from the use of the iron-strontium fuel additive.

• 경영정보학연구
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• 제6권2호
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• pp.161-179
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• 2004

본 연구는 중소형 e-Learning시스템의 개발을 위한 실질적 경험을 제시하는 데 목적이 있다. 제안된 시스템은 교수자로 하여금 전문적인 컴퓨팅 관련 기술의 도움없이 인터페이스를 정의하고, 컨텐츠를 조직화하며, 문제의 출제 및 자동 채점이 가능하도록 설계되었다. 본 연구는 e-Learning의 도입을 어렵게 느끼거나, 학교당국의 정책적 결정에 의해서 수용하겠다는 교육현장의 교수자가 타인의 도움없이 본인 스스로 구현할 수 있는 방안을 제시한다. 또한, 교수-학습자 간의 상호작용이 가능하고 개인적으로 운영할 수 있는 저비용, 고효율의 e-Learning기반 사이트를 실질적으로 구현하고 운영할 수 있는 방안을 제안한다.

• 한국표면공학회지
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• 제41권1호
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• pp.33-37
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• 2008

Polycarbonate has a high transmittance to light, low specific gravity, flexibility and cost-effectiveness that extends the application field of the polymer to bio-engineering, optics, electronic parts, etc. Moreover, electro plating of metallic film on PC could endow the parts the electromagnetic interference shielding capability. However, poor adhesion of copper on PC limited the wide usage in the industry. In this work, a composite(PC/ABS) and MmSH(Momentary mold Surface Heating) injection process were used to improve the plating characteristics; plating thickness, gloss and adhesion. Also plasma treatment and chemical treatment were employed for improving adhesion. Plating characteristics on PC/ABS were better than those on PC due to the anchoring effect of butadiene. MmSH injection process could ameliorate the gloss and coating adhesion. Also plating thickness and adhesion of PC and PC/ABS were increased by plasma treatment.

• 제어로봇시스템학회논문지
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• 제16권7호
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• pp.632-638
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• 2010

This paper presents an optimum tire force distribution method for 6WD/6WS(6-Wheel-Drive and 6-Wheel-Steering) electric vehicles. Using an independent steering and driving system, the performance of 6WD/6WS vehicles can be improved, as, for example, with respect to their maneuverability under low speed and their stability at high speed. Therefore, there should be a control strategy for finding the optimum tire forces that satisfy the driver's command and minimize energy consumption. From the driver's commands (steering angle and accelerator/brake pedal stroke), the desired yaw moment, the desired lateral force, and the desired longitudinal force were obtained. These three values were distributed to each wheel as the torque and the steering angle, based on the optimum tire force distribution method. The optimum tire force distribution method finds the longitudinal/lateral tire forces of each wheel that minimize the cost function, which is the sum of the normalized tire forces. Next, the longitudinal/lateral tire forces of each wheel are converted into the reference torque inputs and the steering wheel angle inputs. The proposed method was tested through a simulation, and its effectiveness was verified.

• 한국주거학회논문집
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• 제20권6호
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• pp.145-155
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• 2009

The purpose of this study is to examine the awareness of apartment residents on their using tendency of community facilities established in apartment complex in order to verify a role that such facilities play in making contributions to lives of apartment dwellers and to analyze their using tendency of the facilities and subsequent problems. The study produced the important findings as follows. First, the level of exchange among residents and their satisfaction were raised high in the apartment complex that offered substantial community facilities. Second, in regard to physical aspect, community activities among dwellers were brisk in the apartment complex where community facilities were organically connected. Third, fitness center, shower room and golf course were excessive in terms of space provided while the space alloted for G.X room, a place used exclusively for class, was insufficient. Fourth, the analysis of using tendency and preference level showed that fitness center, shower room and G.X room were the required facilities. The rooms for using PCs and watching DVDs and the singing room were found to be unnecessary because such facilities were low in the effectiveness when the operating cost was considered.

• 전력전자학회논문지
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• 제2권4호
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• pp.36-44
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• 1997

본 논문에서는 유도전동기의 속도 센서리스 벡터 제어에서의 운전특성 개선을 위하여 최근에 제시된 상태 방정식을 이용한 속도 추정 알고리즘을 살펴보고 이 방식이 갖고 있는 문제점들을 해결할 수 있는 새로운 추정 방법을 제안한다. 또한 폐루프 적분 방식의 고정자 자속 추정 알고리즘을 도입하여 고정자 자속 추정의 정확도를 높였다. 특히, 모든 미분항과 적분항들을 등가의 표현식을 통해 나타내어 실제 구현에 있어서 빠른 응답 특성과 잡음에 대한 안정성을 높였다. 시뮬레이션과 실험을 통하여 본 논문에서 제안한 속도 추정기의 타당성을 입증하였다.

• Journal of Electrical Engineering and Technology
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• 제13권3호
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• pp.1185-1201
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• 2018

This paper presents a sensorless direct torque control (DTC) combined with sliding mode approach (SM) and space vector modulation (SVM) to achieve mainly a high performance and reduce torque and flux ripples of a parallel-connected two five-phase permanent magnet synchronous machine (PMSM) drive system. In order to increase the proposed drive robustness and decrease its complexity and cost, the rotor speeds, rotor positions, fluxes as well as torques are estimated by using a sliding mode observer (SMO) scheme. The effectiveness of the proposed sliding mode observer in conjunction with the sliding mode control based DTC is confirmed through the application of different load torques for wide speed range operation. Comparison between sliding mode control and proportional integral (PI) control based DTC of the proposed two-motor drive is provided. The obtained speeds, torques and fluxes responses follow their references; even in low and reverse speed operations, load torques changes, and machines parameters variations. Simulation results confirm also that, the ripples of the torques and fluxes are reduced more than 3.33% and 16.66 %, respectively, and the speed overshoots and speed drops are reduced about 99.85% and 92.24%, respectively.

• Nuclear Engineering and Technology
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• 제51권3호
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• pp.825-836
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• 2019

One of the most challenging safety precautions for workers in dynamic, radioactive environments is avoiding radiation sources and sustaining low exposure. This paper presents a sampling-based algorithm, DL-RRT*, for minimum dose walk-path re-planning in radioactive environments, expedient for occupational workers in nuclear facilities to avoid unnecessary radiation exposure. The method combines the principle of random tree star ($RRT^*$) and $D^*$ Lite, and uses the expansion strength of grid search strategy from $D^*$ Lite to quickly find a high-quality initial path to accelerate convergence rate in $RRT^*$. The algorithm inherits probabilistic completeness and asymptotic optimality from $RRT^*$ to refine the existing paths continually by sampling the search-graph obtained from the grid search process. It can not only be applied to continuous cost spaces, but also make full use of the last planning information to avoid global re-planning, so as to improve the efficiency of path planning in frequently changing environments. The effectiveness and superiority of the proposed method was verified by simulating radiation field under varying obstacles and radioactive environments, and the results were compared with $RRT^*$ algorithm output.

• Journal of Mechanical Science and Technology
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• 제19권3호
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• pp.778-791
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• 2005

A novel pneumatic artificial muscle actuator (PAM actuator), which has achieved increased popularity to provide the advantages such as high strength and high power/weight ratio, low cost, compactness, ease of maintenance, cleanliness, readily available and cheap power source, inherent safety and mobility assistance to humans performing tasks, has been regarded during the recent decades as an interesting alternative to hydraulic and electric actuators. However, some limitations still exist, such as the air compressibility and the lack of damping ability of the actuator bring the dynamic delay of the pressure response and cause the oscillatory motion. Then it is not easy to realize the performance of transient response of pneumatic artificial muscle manipulator (PAM manipulator) due to the changes in the external inertia load with high speed. In order to realize satisfactory control performance, a variable damper-Magneto­Rheological Brake (MRB), is equipped to the joint of the manipulator. Superb mixture of conventional PID controller and a phase plane switching control method brings us a novel controller. This proposed controller is appropriate for a kind of plants with nonlinearity, uncertainties and disturbances. The experiments were carried out in practical PAM manipulator and the effectiveness of the proposed control algorithm was demonstrated through experiments, which had proved that the stability of the manipulator can be improved greatly in a high gain control by using MRB with phase plane switching control method and without regard for the changes of external inertia loads.