• Journal of Periodontal and Implant Science
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• v.44 no.6
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• pp.266-273
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• 2014

Purpose: We previously reported that human serum significantly reduces the invasion of various oral bacterial species into gingival epithelial cells in vitro. The aims of the present study were to characterize the serum component(s) responsible for the inhibition of bacterial invasion of epithelial cells and to examine their effect on periodontitis induced in mice. Methods: Immortalized human gingival epithelial (HOK-16B) cells were infected with various 5- (and 6-) carboxy-fluorescein diacetate succinimidyl ester-labeled oral bacteria, including Fusobacterium nucleatum, Provetella intermedia, Porphyromonas gingivalis, and Treponiema denticola, in the absence or presence of three major serum components (human serum albumin [HSA], pooled human IgG [phIgG] and ${\alpha}1$-antitrypsin). Bacterial adhesion and invasion were determined by flow cytometry. The levels of intracellular reactive oxygen species (ROS) and activation of small GTPases were examined. Experimental periodontitis was induced by oral inoculation of P. gingivalis and T. denticola in Balb/c mice. Results: HSA and phIgG, but not ${\alpha}1$-antitrypsin, efficiently inhibited the invasion of various oral bacterial species into HOK-16B cells. HSA but not phIgG decreased the adhesion of F. nucleatum onto host cells and the levels of intracellular ROS in HOK-16B cells. N-acetyl-cysteine (NAC), a ROS scavenger, decreased both the levels of intracellular ROS and invasion of F. nucleatum into HOK-16B cells, confirming the role of ROS in bacterial invasion. Infection with F. nucleatum activated Rac1, a regulator of actin cytoskeleton dynamics. Not only HSA and NAC but also phIgG decreased the F. nucleatum-induced activation of Rac1. Furthermore, both HSA plus phIgG and NAC significantly reduced the alveolar bone loss in the experimental periodontitis induced by P. gingivalis and T. denticola in mice. Conclusions: NAC and the serum components HSA and phIgG, which inhibit bacterial invasion of oral epithelial cells in vitro, can successfully prevent experimental periodontitis.

• Polymer(Korea)
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• v.31 no.5
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• pp.399-403
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• 2007

Trans-esterification behavior of polycarbonate/poly(butylene terephthalate) (PC/PBT) blends was investigated during the melt mixing process. Rheological and fracture behaviors, and fracture morphology were also investigated as a function of PC/PBT blend ratio. Based on FT-IR and $^1H-NMR$ results, a trans-esterification reaction was confirmed to occur between PC and PBT during the melt mixing process. The melt index(MI) decreased with increased PC content, indicating the higher flow resistance of PC. The storage and loss moduli were increased by increasing the PC loading, and the PC/PBT blends were rheologically incompatible based on the Cole-Cole plot. The tensile property increased linearly with the increased PC content. However, the impact strength increased until 50 wt% of PC loading, notably around $30{\sim}40wt%$, and then was levelled off at 50 wt%. Rough ridges were formed on the impact fracture surfaces above the 40 wt% of PC content, supporting the observed higher impact strength in this range.

• Magazine of the Korean Society of Agricultural Engineers
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• v.29 no.4
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• pp.59-72
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• 1987

Although long-term runoff analysis is important as much as flood analysis in the design of water works, the technological level of the former is relatively lower than that of the latter. In this respect, the precise estimation model for the volume of successive runoff should he developed as soon as possible. Up to now, in Korea, Gajiyama's formula has been widely used in long-term runoff analysis, which has many problems in applying in real situation. On the other hand, in flood analysis, unit hydrograph method has been exclusively used. Therefore, this study aims at trying to apply unit hydrograph method in long-term runoff analysis for the betterment of its estimation. Four test catchment areas were selected ; Maesan area in Namlum river as a representative area of Han river system, Cheongju area in Musim river as one of Geum river system, Hwasun area in Hwasun river as one of Yongsan river system, and Supyung area in Geum river as one of Nakdong river system. In the analysis of unit hydrograph, seperation of effective rainfall was carried out firstly. Considering that effective rainfall and moisture condition of catchrnent area are inside and outside of a phenomenon respectively and the latter is not considered in the analysis, Initial base flow(qb)was selected as an index of moisture condition. At the same time, basic equation(Eq.7) was established, in which qb can take a role as a parameter in relating between cumulative rainfall(P) and cumulative loss of rainfall(Ld). Based on the above equation, computer program for estimation model of qbwas seperately developed according to the range of qb, Developed model was applied to measured hydrographs and hyetographs for total 10 years in 4 test areas and effective rainfall was estimated. Estimation precision of model was checked as shown in Tab- 6 and Fig.8. In the next stage, based on the estimated effective rainfall(R) and runoff(Qd), a runoff distribution ratio was calculated for each teat area using by computerised least square method and used in making unit hydrographs in each test area. Significance of induced hydrographs was tested by checking the relative errors between estimated and measured runoff volume(Tab-9, 10). According to the results, runoff estimation error by unit hydrograph itself was merely 2 or 3 %, but other 2 or 3 % of error proved to be transferred error in the seperation of effective rainfall. In this study, special attentioning point is that, in spite of different river systems and forest conditions of test areas, standardized unit hydrographs for them have very similar curve shape, which can be explained by having similar catchinent characteristics such as stream length, catchinent area, slope, and vegetation intensity. That fact should be treated as important factor ingeneralization of unit hydrograph method.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.3
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• pp.175-180
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• 2015

With progress in industrialization, facilities for generating, delivering, and receiving high levels of electric power are in great demand. The scale of electric power equipment is increasing in both size and complexity. This has contributed to the development of our modern, high-tech and information-based society. However, if the generation of electric power is suspended due to unexpected accidents at power facilities or power stations, a range of equipment the operations of which are dependent on electric power can be damaged, causing substantial socioeconomic losses in an industrial society. A great deal of time and money would be expended to repair damaged facilities at a power station, causing enormous economic loss.In order to detect the deterioration processes of power cables, and to prevent the destruction of power cables, the operation status of power cables should be monitored on a regular basis. We have installed equipment at Korea Western Power Co., Ltd., located in Taean, in order to predict and prevent the destruction of power cables. This is an entirely new installation: a set of equipment invented specifically to measure the insulation resistance of power cables. Installation of the equipment does not cause the flow of earth fault current. This ensures accurate measurement of insulation resistance values by the equipment. We have been studying this equipment in order to develop preventive technology that would show the deterioration processes of power cables.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.9
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• pp.799-804
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• 2016

Broadband powerline communication (BPLC) uses distribution lines as a medium for achieving effective bidirectional data communication along with electric current flow. As the material characteristics of power lines are not good at the communication channel, the development of power line communication (PLC) systems for internet, voice, and data services requires measurement-based models of the transfer characteristics of the network suitable for performance analysis by simulation. In this paper, an analytic model describing a complex transfer function is presented to obtain the attenuation and path parameters for a multipath power line model. The calculated results demonstrated frequency-selective fading in multipath channels and signal attenuation with frequency, and were in good agreement with the experimental results. Inductive coupling units are used as couplers for coupling the signal to the power line to avoid physical connections to the distribution line. The inductance of the ferrite core, which depends on the frequency, determines the cut-off frequency of the inductive coupler. Coupling loss can be minimized by increasing the number of windings around the coupler. Coupling efficiency was improved by more than 6 dB with three windings compared to the results obtained with one winding.

• Korean Chemical Engineering Research
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• v.48 no.2
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• pp.185-192
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• 2010

The chemical-looping combustion(CLC) has advantages of no energy loss for separation of $CO_2$ without $NO_x$ formation. This CLC system consists of oxidation and reduction reactors where metal oxides particles are circulating through these two reactors. In the present study, the reaction kinetic equations of iron oxide oxygen carriers supported on bentonite have been determined by the shrinking core model. Based on the reactivity data, design values of solid circulation rate and solids inventory were determined for the rector. Two types of interconnected fluidized bed systems were designed for CLC application, one system consists of a riser and a bubbling fluidized bed, and the other one has a riser and two bubbling fluidized beds. Solid circulation rates were varied to about $30kg/m^2s$ by aeration into a loop-seal. Solid circulation rate increases with increasing aeration velocity and it increases further with an auxiliary gas flow into the loop-seal. As solid circulation rate is increased, solid hold up in the riser increases. A typical gas leakage from the riser to the fluidized bed is found to be less than 1%.

• Journal of Navigation and Port Research
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• v.39 no.4
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• pp.285-291
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• 2015

Exposure to cold sea water can be life-threatening to the drowned individual. Although appropriate life jacket can be usually be provided for the buoyance at the drowning accident, heat loss can make the drowned individual experience the hypothermia. Inflatable life jackets filled with inflatable air pocket can increase the thermal protection as well as the buoyancy force. Because it is important to know how the human body behaves unde the different life jacket, present study compares the thermal insulation capacity of solid type life jacket with that of inflatable life jacket. In order to represent the insulation capacity of life jacket, thermal resistance is estimated based on the assumption of steady-state. Also, a transient three-dimensional thermal distribution of the thigh is analyzed by using finite element method implementing the Pennes bioheat equation. The finite element model is a segmental, multi-layered representation of the body section which considers the heat conduction within tissue, bone, fat and local blood flow rate.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.443-449
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• 2017

The imbalance of air supply and the exhaust on subway platforms has led to the installation of platform screen doors in underground subway stations. This imbalance causes the accumulation of pollutants on the platform and loss of comfort due to the lack of ventilation. In this study, a floor exhaust system was optimized using computational fluid dynamics (CFD) and an optimization program. The optimized floor exhaust system was manufactured and tested experimentally to evaluate the particle collection efficiency. CFX 17.0 and HEEDS were used to analyze the flow field and optimize the principal dimensions of the exhaust system. As a result of the three-step optimization, the optimized floor exhaust system had a total height of 1.78 m, pressure drop of 430 Pa, and particle collection capability of 61%. A fine dust particle collection experiment was conducted using a floor exhaust system that was manufactured at full scale based on the optimized design. The experiment indicated about 65% particle collection efficiency. Therefore, the optimized design can be applied to subway platforms to draw in exhaust air and remove particulate matter at the same time.

• Nutrition Research and Practice
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• v.12 no.2
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• pp.129-134
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• 2018

BACKGROUND/OBJECTIVES: Although several recent studies have reported the anti-cancer effects of extracts or components of Citrus unshiu peel, which has been used for various purposes in traditional medicine, the molecular mechanisms for their effects remain unclear. In the present study, the anti-cancer activity of a water-soluble extract of C. unshiu peel (WECU) in MDA-MB-231 human breast carcinoma cells at the level of apoptosis induction was investigated. MATERIALS/METHODS: Cytotoxicity was evaluated using the MTT assay. Apoptosis was detected using DAPI staining and flow cytometry analyses. Mitochondrial membrane potential, reactive oxygen species (ROS) assay, caspase activity and Western blotting were used to confirm the basis of apoptosis. RESULTS: The results indicated that WECU-induced apoptosis was related to the activation of caspase-8, and -9, representative initiator caspases of extrinsic and intrinsic apoptosis pathways, respectively, and caspase-3 accompanied by proteolytic degradation of poly(ADP-ribose) polymerase and down-regulation of the inhibitors of apoptosis protein family members. WECU also increased the pro-apoptotic BAX to anti-apoptotic BCL-2 ratio, loss of mitochondrial membrane potential and cytochrome c release from mitochondria to cytoplasm. Furthermore, WECU provoked the generation of ROS, but the reduction of cell viability and induction of apoptosis by WECU were prevented when ROS production was blocked by antioxidant N-acetyl cysteine. CONCLUSIONS: These results suggest that WECU suppressed proliferation of MDA-MB-231 cells by activating extrinsic and intrinsic apoptosis pathways in a ROS-dependent manner.

• Nuclear Engineering and Technology
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• v.27 no.4
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• pp.470-482
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• 1995

The Ulchin 3&4, which are 2825 MWt PWRs, adopted Safety Depressurization System (SDS) to mitigate the beyond design basis event of Total Less of Feedwater(TLOFW). In this study the results and methodology of the analyses for the determination of SDS bleed capacity are discussed. The SDS design bleed capacity has been determined from the CEFLASH-4AS/REM simulation according to the following design criteria : 1) Each SDS flow path, in conjunction with one of two High Pressure Safety Injection (HPSI) pumps, is designed to have a sufficient capacity to prevent core uncovery if one SDS path is opened simultaneously with the opening of the Pressurizer Safety Valves (PSVs). 2) Both SDS bleed paths are designed to have sufficient total capacity with both HPSI pumps operating to prevent core uncovery if the Feed and Bleed (F&B) initiation is delayed up to thirty minutes from the time of the PSVs lift. To verify the results of CEFLASH-4AS/REM simulation a comparative analysis kas also been per-formed by more sophisticated computer code, RELAP5/MOD3. The TLOFW event without operator recovery and TLOFW event with F&B are analyzed. The predictions by the CEFLASH-4AS/REM of the transient too phase system behavior are in good qualitative and quantitative agreement with those by the RELAP5/MOD3 simulation. Both of the results of analyses by CEFLASH-4AS/REM and RELAP5/MOD3 have demonstrated that decay heat removal and core inventory make-up can be successfully accomplished by F&B operation during now event for the Ulchin 3&4.