• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.837-842
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• 2010

The purpose of this study is to develop bathing aids as a strategic products to promote the medical tourism in Sancheong Jirisan Oriental medicinal herbs special district using medicinal herbs produced in Sancheong province, and to verify the effect of the bathing aids in vitro. We investigated the cytotoxicity activity, antioxidant activity, antiaging and whitening effects of Sanchung-PNU 1 (SP1) and Sanchung-PNU 2 (SP2) made with traditional medicinal herbs. The cytotoxicity activity was measured by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Antioxidant activities were determined by DPPH (1.1-diphenyl-2-picrylhydrazyl) radical scavenging capacity assay. We measured the inhibitory effect against tyrosinase activity to prove the whitening effect, and the inhibitory effect against elastase activity to prove the anti-aging effect. Two proposed prescriptions, SP1 and SP2, showed not significant cytotoxicity but significant (p<0.001) improvement in anti-oxidation, anti-wrinkle, and whitening effects compared to the control group. The result shows that these bathing aids have excellent DPPH radical scavenging effect and significant inhibitory effect against elastase and tyrosinase activity. These findings suggest that these bathing aids have a strong antioxidant, anti-aging, and whitening effect.

• Journal of Life Science
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• v.22 no.10
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• pp.1428-1433
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• 2012

Longevity is an exciting but difficult subject to study because it is determined by complex processes that require the coordinated action of several genetic factors as well as physiological and environmental influences. Genetic approaches have been applied to animal models to identify the molecular mechanism responsible for longevity. Several experimental model organisms obtained over the last decades suggest that the complete deletion of a single gene by gene targeting has proven to be an invaluable tool for the discovery of the mechanisms underlying longevity. The first discovery of long-lived mutants came from Caenorhabditis elegans research, which identified the insulin/IGF-1 pathway as responsible for longevity in this worm. IGF-1 is a multifunctional polypeptide that has sequence similarity to insulin and is involved in normal growth and development of cells. Several factors in the IGF-1 system have since been studied by gene targeting in the control of longevity in lower species, including nematode and fruit fly. In addition, significant progress has been made using mice models to extend the lifespan by targeted mutations that interfere with growth hormone/IGF-1 and IGF-1 signaling cascades. A recent finding that IGF-1 is involved in aging in mice was achieved by using liver-specific knockout mutant mice, and this clearly demonstrated that the IGF-1 signal pathway can extend the lifespan in both invertebrates and vertebrate models. Although the underlying molecular mechanisms for the control of longevity are not fully understood, it is widely accepted that reduced IGF-1 signaling plays an important role in the control of aging and longevity. Several genes involved in the IGF-1 signaling system are reviewed in relation to longevity in genetically modified mice models.

• Journal of the Korea Fashion and Costume Design Association
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• v.12 no.1
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• pp.131-139
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• 2010

The ten traditional symbols of longevity are represented as 10 which means perfection in oriental philosophy, the sun, mountain, water, cloud, rock, pine tree, elixir plant, tortoise, crane and deer. each subjects symbolizing longevity had used in isolation. unlike China and Japan, the ten symbols of longevity became a fixed form and was widely used in paintings, household effects and clothes in Korea. therefore, It will be a meaningful study how the ten symbols of longevity, as one of subjects in painting, changed into a pattern on clothes. The ten symbols of longevity was affected by various philosophies and religion. especially, it laid emphasis on order by Yin-Yang and the Five Elements theory. the order was applied to arrange each subjects and use colors carefully. the sun colored with red and was on the upper. the pine tree colored with green meaned tree and was on the left. the earth and the mountain meaned the soil and was on the center. the rock meaned the iron and was on the right. the water meaned the water and was on the bottom. The subjects of the study were embroideries like spectacle cases, spoon cases and pouches. the scope of study was the Latter Part of the Joseon Dynasty because there are more relics in the Joseon Dynasty than any other times.

• Biomolecules & Therapeutics
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• v.26 no.6
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• pp.568-575
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• 2018

In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.

• Korean Journal of Oriental Medicine
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• v.16 no.3
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• pp.107-113
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• 2010

Objective : Active treatment for a skin condition has produced a substantial change in the history of allergic contact or wound induced dermatitis. The frequency of opportunistic contacts and allergen-related dermatitis has increased, though new skin treatments have developed. Especially, there has been a interest in the korean herbal bathing. This study was performed to investigate the effects of the korean herbal bathing candidates on skin lesions in mice model. These candidates are Korea's representative herbs on skin lesions. Method : ICR mice were divided into five groups : naive, control, experimental group A and B and C. Control and experimental groups induced skin lesions by DNFB and TMA. Each experimental group was pasted with corresponding korean herbal bathing candidates on skin lesions. Result : Significant improvements in skin wound index, epidermal thickness associated with skin lesions were seen with the korean herbal bathing candidates. Conclusion : These results suggest that the korean herbal bathing candidates could be at least as effective as steroid, anti-histamine for the treatment of skin lesions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.4
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• pp.295-304
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• 2015

The purpose of this study was to systematically review published articles on Yaksun studies and provide understanding on current and future studies with Yaksun and medical treatment with food. We performed systematic review on the Yaksun studies published recent 16 years from 2000 to 2016 using seven Korean database on research articles. We found 90 articles are relevant for the analysis. The articles on Yaksun were significantly increased since 2005. As for the research field, Food Science (39 articles, 31.0%) and Tourism (20 articles, 15.9%) were dominant throughout the years. Researchers from Science of cookery (35 articles, 35.0%) and Food and Nutrition (32 articles, 32.0%) were found to be most frequent. The prime type of research on Yaksun were the We found that the Survey (49 articles, 52.7%) was the most frequent research method and basic research for providing related data (41 articles, 45.6%) was easily found as for the purpose of the article. We found that there were insufficient reports on clinical efficacy of Yaksun, especially with the treatment of diseases. The interest of medical professionals is needed for the better understanding on the medical use of Yaksun and therapeutic diet which has potentials for integrative medicine.

• Korean Journal of Agricultural Science
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• v.42 no.3
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• pp.245-251
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• 2015

Records of 490,767 cows collected from 1990 to 2012 by dairy herd milk test of National Agriculture Cooperative Federation The pedigree of dairy cattle were provided by Korea Animal Improvement Association. The data were used to analyze the longevity of dairy cows with the life traits such as days in milk, number of lactation, productive life, and life span. The data were also used to investigate genetic relationship of these longevity traits with profitability of dairy cows, including heritability and genetic correlation. The profitability was calculated with simulation of milk income and production costs for individual cows. Days in milk among the traits had -0.287, -0.572 and -0.536 of genetic correlation with number of lactations, productive life and lifespan, respectively. The heritabilities of life span, number of lactations, productive life, and days in milk were found to be 0.045, 0.047, 0.059 and 0.081, respectively. Genetic correlations of profit with productive life, number of lactations, and days in milk were identified as 0.072, 0.080, 0.098 and 0.101. These results suggested that days in milk was most desirable traits to represent longevity of Holstein dairy cattle. In general, since longevity and profitability were close genetic relationship each other, genetic improvement of longevity is necessary for better profitable cows.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.484-489
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• 2010

Allergic contact or wound induced dermatitis are common environmental health issue and seriously affect the patient's quality of life. In now, people are interested in the korean herbal bathing that get better the skin conditions. This study was performed to investigate the effect of korean herbal bathing candidates extract on allergic contact or wound induced dermatitis. ICR mice were divided into four groups: naive, control, experimental group A and B. Control and experimental groups induced allergic contact or wound induced dermatitis by DNFB and TMA. Since then, each experimental group was pasted with corresponding korean herbal bathing extract into the skin. All groups were observed after 5 days. When the korean herbal bathing extract was applied, arbitrary skin wound index and epidermal thickness were significantly decreased compared to that of control. These data suggest that these korean herbal bathing candidates may be an effective therapeutic supplements for the treatment of skin.

• Journal of Digital Convergence
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• v.13 no.1
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• pp.85-92
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• 2015

Recently more and more shortened of corporation's sustainable longevity at the enterprise, and enterprise environment is also changing drastically. In this study, we wanted to obtain a solution that enable to continue the company's corporate longevity through critical factor analysis of the Japan Shinise. In the analysis results of Japan corporation as Doraya, Deicoko, Shinise longevity, we can explain about critical factors like that credit, tradition, customization, products development, changes of management methods and finding a global new markets. Also, In this study, analyzed a significance of critical factors for focusing on each cases and theories using Analytic Hierarchy Process(AHP), and did prediction and analysis about critical longevity factors. However, it need to collect sufficient data and a lots of variables for input. because the sample may be it insufficient. Results of the study, will be expected to be a useful guide for analysis of longevity factors at the company in the future.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.4
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• pp.350-361
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• 2013

aksun(藥饍), or 'Traditional oriental medicine nutrition therapy', is expected to be an effective nutritional intervention for the patients suffering from chronic diseases. However, there are no systemized protocol that utilize Yaksun as an effective nutrition therapy for Asian patients even though they are accustomed to traditional oriental diet. We investigated the possibility of using Yaksun for developing an effective Medical Nutrition Therapy for Asian patients and proposed factors that have to be considered. Articles published between 1995-2012 about MNT (Medical Nutrition Therapy) and Yaksun were reviewed. Male and female patients of two Korean Medicine Hospitals (n=93) and one Korean Medicine Clinic (n=20) answered a questionnaire asking about their thoughts on the effectiveness of nutritional intervention for their disease management and about their expectations toward Medical Nutrition Therapy on Korean Medicine. 92.9% of the patients have perceived that nutritional intervention is important in disease management. 79.6% of the patients have positively responded that they are willing to use the Medical Nutrition Therapy on Korean Medicine as a clinical nutrition therapy if developed. Female patients, aged in their forties and fifties, educated equivalent to high school graduates and more, and who visited Korean medicine clinic were most interested in the Medical Nutritional Therapy on Korean Medicine. The factors considered in developing the protocol are 1. effectiveness 2. safety 3. expense, in order of importance. Nutritional intervention protocol using Yacksun is necessary for the patients. Medical Nutrition Therapy on Korean Medicine is in need of development. Accumulated case-control studies, cost effectiveness studies, and studies about programming and systemizing the protocol are needed.