• Journal of Life Science
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• v.21 no.4
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• pp.616-620
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• 2011

Lysine residues of histone H3 and H4 are covalently modified in the chromatin of eukaryotic cells. Lysine 27 in histone H3 was acetylated (H3K27ac) or methylated at three levels; mono-, di-, and trimethylation (H3K27me1, H3K27me2, and H3K27me3). These modifications at H3K27 were related with gene transcription and/or chromatin structure in distinct patterns. Generally, H3K27ac and H3K27me1 were enriched in active chromatin, such as the locus control region or transcriptionally active genes, while transcriptionally inactive genes were highly marked by H3K27me2 and H3K27me3. These modifications appear to have been catalyzed by distinct histone-modifying enzymes. Recent studies suggest that the four kinds of modifications at H3K27 have inter-correlation in gene transcription or chromatin structure formation.

• Survey Research
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• v.1 no.2
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• pp.59-87
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• 2000

The hypothesis of this study is that change acceptance and work adaptation of change agents are influenced by positive self-image and risk tolerance. In order to examine the hypothesis, this study was performed with 305 change agents from six branches of a conglomerate company. Specifically, self-image was measured by locus of control, self-efficacy, self-esteem, and positive affectivity; risk tolerance was measured by tolerance for ambiguity, risk aversion, and openness to experience. The result of this study indicated that self-image and risk tolerance significantly predicted change acceptance and work adaptation. Especially, the results of structural model revealed that change acceptance mediated the relationship between characteristic variables (such as self image and risk tolerance in this study) and work adaptation. Based on the results, we suggest that change agents keep developing positive self-image and risk tolerance in order to play the key role in leading organizational change.

• Genomics & Informatics
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• v.9 no.2
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• pp.52-58
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• 2011

Osteoporotic fracture (OF), along with bone mineral density (BMD), is an important diagnostic parameter and a clinical predictive risk factor in the assessment of osteoporosis in the elderly population. However, a genome-wide association study (GWAS) on OF has not yet been clarified sufficiently. To identify OF-associated genetic variants and candidate genes, we conducted a GWAS in a population-based cohort (Korean Association Resource [KARE], n=1,427 [case: 288 and control: 1139]) and performed a de novo replication study in hospital-based individuals (Asan and Catholic Medical Center [ACMC], n=1,082 [case: 272 and control: 810]). In a combined meta-analysis, a newly identified genetic locus in an intergenic region at 10p11.2 (near genes FZD8 and ANKRD30A ) showed the most significant association (odd ratio [OR] = 2.00, 95% confidence interval [CI] = 1.47~2.74, p=$1.27{\times}10^{-6}$) in the same direction. We provide the first evidence for a common genetic variant influencing OF and genetic information for further investigation in bone metabolism.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.13 no.1
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• pp.15-23
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• 2002

Knowledge regarding the resilience factors and risk factors of the childhood trauma on the developental trajectory is in its infancy due to the lack of prospective follow-up studies in the childhood trauma and limited understanding of the complex reciprocal interactions between childhood trauma, develop-ent and various aspects of children's environment. These difficulties in the conceptual framework and research methods in the childhood trauma are partly reflected in the inconsistencies, even controversies, of the results in the childhood trauma researches. Despite these difficulties, common aspects of the risk factors and resilience of the childhood trauma on the development can be identified from the previous studies. The resilience to the negative outcome on the development by childhood trauma includes：sex female before puberty, male after puberty or infancy), high socioeconomic status, no organic problem, easy temperament, no previous experience with early loss or separation, younger age at the trauma, better problem solving capacity, high self-esteem, internal locus of control, high coping skills, ability to identify interpersonal relationships, ability to play, sense of humor, having capable parents, having a warm relaionship with at least one of the parents, high education and participating in the organized religious activities. These commonalities of the results suggest that risk and resilient factors of the childhood trauma are interdependent, each factor has multiplicity in the impacts on the children's development according to the developmental stage of the child, family and children's other environment, trauma and stressor have diverse effects according to their intensity and risk and resilience factors could have synergistic or antagonistic effects to each other. To develop comprehensive understanding on the relationship between childhood trauma and developmental psychopathology, risk and resilience factors and to develop effective and efficient prevention and intervention, research on the effect of the stress on the neurodevelopment, on the individual differences of the response to the trauma including genetic factors and constitution, and on the brain plasticity should be accompanied in the future.

• Journal of Preventive Medicine and Public Health
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• v.28 no.2 s.50
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• pp.334-346
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• 1995

To investigate the factors influencing workers' perception and attitude toward special periodic health screening test for workers, a survey with self-administered questionnaires was performed on 779 workers who had special periodic health screening test from September 1 to October 15, 1994. A study model was developed by modifying the health belief model. The end and intermediate response variables of the model were the voluntary participation and necessity perception on the special screening for workers. The result of analysis was consistent with the study model. Rates for the necessity perception and voluntary participation on the special screening for workers were 77.2%, 79.2%, respectively. Factors influencing on the voluntary participation were necessity perception, benefit of special screening for workers, and cue to action. And on the necessity perception were susceptibility and severity to occupational disease, knowledge to special screening for workers, and support of company. General and occupational characteristics influencing on the susceptibility and severity to occupational disease were sex, age, educational level, work duration, and health education. On the knowledge to special screening for workers were age, educational level, work duration, and locus-of-control. On the benefit of special screening for workers were age, locus-of-control, pride on health, and health education. Therefore, to increase the voluntary participation and necessity perception on the special periodic health screening for workers, 1) if a worker is judged as occupational disease, the judgment should be widely known in his workplace, 2) the screening result forms should be directly sent to the workers themselves, 3) for the positivity of employers, the campaign and education program subjected to them should be planned, 4) health education should give the first consideration to the younger, lower educational level, and newly employed women, and its frequency should be increased and it should be more frequently dealt with occupation-related subjects, and 5) the employers should have a careful concern in not being disadvantageous to workers due to result of screening.

• 한국벤처창업학회:학술대회논문집
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• 2016.04a
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• pp.221-223
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• 2016

동아시아 경제권의 국가들 중에서도 한국과 중국의 잠재적 기업가정신을 측정하고 양국 잠재적 기업가정신에 영향을 미치는 문화적 요인에 대해 비교하고자 하였다. 이를 위해 잠재적 기업가라고 여길 수 있는 한국과 중국의 대학생들을 대상으로 하여 설문조사를 실시하였다. 210명의 한국 대학생들과 157명의 중국 대학생들이 본 설문에 응하였다. 설문은 크게 두 가지 영역으로 구분되어 있는데, 개인의 기업가적 지향성을 측정하기 위한 질문과 개인의 기업가적 성향에 영향을 주는 문화적 요인들을 측정하는 질문으로 나누어져 있다. 개인의 기업가적 지향성을 측정하기 위하여 자기통제력(Locus of Control)과 혁신성(Innovativeness)을 묻는 세부 질문을 만들었고, 문화적 요인을 측정하기 위해서 대학생들이 느끼는 경제적자유(Economic Freedom), 개인주의(Individualism) 그리고 불확실성 회피성(Uncertatinty Avoidance)의 정도를 묻는 질문을 만들어 설문을 실시하였다. 첫 번째 연구가설은 '한국의 대학생들이 경제적 자유, 개인주의, 불확실성 회피성이 더 높다고 인식한다'이며, 두 번째 연구가설은 '경제적 자유가 보장되고 더 개인주의적인 문화에서 기업가적 성향이 더 높게 나타나며 확실성 회피성이 높을수록 기업가적 성향은 더 낮게 나타난다, 세 번째 연구가설은 '한국 대학생들의 기업가적 지향성 정도가 중국 대학생들의 그것보다 더 높다'이다. 설문조사는 가설과는 다른 결과를 보여주고 있다. 중국의 대학생들이 한국의 대학생들 보다 자국의 문화에 대해 더 경제적 자유가 보장되며 개인주의적이라는 인식을 가지고 있었다. 불확실성 회피성에 있어서는 가설과 동일하게 중국 대학생들보다 한국의 대학생들이 자국에 대해 불확실성 회피성이 더 높다고 인식하고 있다. 또한 양국의 대학생들은 기업가정신 형성에 있어서 각각 다른 문화적 변수에 의해서 영향을 받는다는 사실을 알 수 있었다. 한국의 대학생들은 경제적 자유의 정도에 의해 영향을 받으며, 중국의 대학생들은 불확실성 회피성에 의해서 영향을 받는다. 마지막으로, 세 번째 가설과 달리 기업가적 지향성은 중국의 대학생들이 한국의 대학생들보다 더 높은 수치를 보인다. 혁신성에 있어서는 양국 대학생들 간의 유의한 차이를 발견하기 어려웠으나 내재적 통제력에 있어서 중국의 대학생들은 한국의 대학생들보다 높은 수치를 나타냈다.

• Journal of the Korean Society of School Health
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• v.11 no.2
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• pp.171-187
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• 1998

In recent years, adolescent issues including smoking, drinking, drug abuse, juvenile delinquency, deviant sexual behavior, mental health problems, high suicide rate, juvenile delinquency and absence without due notice, etc are emerging as serious social problems and the debate on these controversial issues is heating up. The previous studies on adolescent health behavior and social juvenile delinquency such as run-away from home and absence without due notice have been conducted mostly by cause analysis utilizing social demographic factors or biological factors. In other words, the main factors analyzed were demographic and economic factors or parent's educational level, etc, which were the fixed environmental ones that were unable to cause the change in the health behavior. Accordingly, the purpose of this study is to analyze factors which are changeable and fixable among the factors influencing the adolescent's health behavior and misconducts and, eventually influencing factors which can be used as the basis to establish health policies and health promotion program to reduce the health risk behavior and misconducts of adolescents. The study subjects were selected by dividing senior high school student in Seoul by region and through random sampling. The 890 subjects were selected from 10 schools including the preparatory school, vocational schools and institutional schools. The duration of the study was for July 1-5, 1997 for the first survey and the second one, for August 25-September 10. Regarding the analysis method, the SAS program was used. The adoptablity of theoretical model was tested through covariance structural analysis utilizing PC-LISREL 8.12 Program. The major findings of the study are as follows: As a result of establishing the model of factors influencing health behavior and juvenile delinquency, in case of male students as the health behavior self-efficacy, education level of fathers, economic level, self-control and the health interest of parent were higher, students were more likely to practice the health promoting behavior. Juvenile delinquency and health risk behavior were prevalent among those with the less shyness, the lower health behavior self-efficacy, lower self-control, lower self-assertiveness, lower economic level. The self-control was the most powerful factor. In case of female students, those with higher health behavior self-efficacy were more likely to practice the health promoting behavior whereas those with lower health behavior self-efficacy, lower self-control, lower self- assertiveness, less shyness were more likely to practice health risk behavior and juvenile delinquency. In case of prep schools, those with higher health behavior self-efficacy and better perceived health status were more likely to practice the health promoting behavior while those with less shyness, lower health behavior self-efficacy and lower academic achievement were more likely to engage in health risk behavior and juvenile delinquency. In case of vocational schools, as health behavior self-efficacy and economic level were higher, the practice rate of health promoting behavior was higher. As the self-control, shyness, self-assertiveness, health behavior self-efficacy were lower, the rate of health risk behavior and juvenile delinquency were higher. In case of social institutional schools, as, the health behavior self-efficacy, social support and economic level, health interest of parents were higher, the rate of health promoting behavior were higher. As the self-control, shyness, self-assertiveness, health behavior self-efficacy and social support were lower, the rate of health risk behavior and juvenile delinquency were higher. So the health promoting behavior was positively related to the health behavior self-efficacy, health interest of parents, social support, education level of fathers, level of perceived health status, economic level. The health risk behavior and juvenile delinquency were higher with the lower health behavior self-efficacy, self-control and self-assertiveness, lower health locus control, less shyness and loneliness, lower economic level and academic achievement. In conclusion, the health risk behavior and juvenile delinquency can be reduced by enhancing self-control, self-assertiveness, health behavior self-efficacy and social support. According to the final model drawn by connecting health behavior and juvenile delinquency, the reduction of health risk behavior can greatly contribute to decreasing social juvenile delinquency as the process of juvenile delinquency was extended from common behaviors to problem behaviors and further into juvenile delinquency.

• Korean Journal of Adult Nursing
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• v.13 no.3
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• pp.431-440
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• 2001

The purpose of this study was to identify the factors influencing health promoting behavior of college students to develop health promoting interventions of young adults. The subjects of this study were 176 women college students, living in a small city in Korea. The data were collected by interviews and a self-report questionnaire, during the period from September, 1999 to December, 1999. The instruments for this study were the PRQ-II by Weinert(1988), the scale of Locus of Control by Wallstone et al.(1978), the scale of self efficacy by Sherer & Maddux(1982), 10 points visual analogue scale for perceived health status and the importance of health, the health promoting behavior scale by Walker et al.(1987), and the scales developed by the authors for the perceived benefits of health promoting behavior, and perceived barriers to health promoting behavior. Cronbach 's alpha of these scales were .68 ~.89. The data were analyzed using descriptive statistics, Pearson's correlation coefficients, and stepwise multiple regression. The results of this study were as follows: 1. Among cognitive perceptual factors of the Health Promotion Model by Pender(1987), the scores of the importance of health, the perceived internal control of health, self efficacy, the perceived health status, and the perceived benefits had a significantly positive correlation with the scores of the health promoting behavior of college students. In addition, the scores of the perceived barriers had a significantly negative correlation with the scores of the health promoting behavior of college students. 2. Among modifying factors of the Health Promotion Model by Pender(1987), the extent of religious activities of college students and the scores of social support had a significantly positive correlation with the scores of health promoting behavior of college students. 3. Stepwise multiple regression analysis revealed that the most powerful predictor of health promoting behavior was self-efficacy. A combination of self-efficacy, the perceived benefits, the perceived barriers, the perceived health status, and the importance of health accounted for 45.1% of the variance in health promoting behavior in college students From the results of this study, we concluded that the Health Promotion Model by Pender can be used to explain health promoting behavior of college students. In addition, we suggested that the results of this study be considered in developing health promoting programs of young adults.

• Journal of agricultural medicine and community health
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• v.33 no.2
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• pp.204-220
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• 2008

Objectives: This study was performed to determine the levels of depression symptoms among the community elderlies and to reveal its related factors, specifically aimed at revealing psycho-social factors such as social support net-work, sense of self-esteem, state anxiety, interpersonal behavior trait and locus of control. Methods: The interviews were performed during the period from April 1st to June 30th, 2007 to the 790 elderlies in urban and rural areas. Results: The mean scores of depression (CES-D) among all subjects were 16.65±10.97(urban: 18.81±10.31, rural: 14.49±11.20) and they were higher in urban than rural. The level of depression symptoms was influenced by the variables of educational level, with or without spouse, bear for living expenses, sense of satisfaction in daily life. As for health related behaviors, they were influenced by the variables of with or without regular exercise. As for health status, they were influenced by the subjective health status, with or without disability of body, visual acuity, hearing ability, ability of food mastication, urinary incontinence, with or without help in activity of daily living (ADL) and instrumental activity of daily living (IADL). As for social support net-work and social activities, they were influenced by number of offspring, frequency of offspring contents, frequency of going out and activity of hobbies. As for psycho-social factors, they were influenced by sense of self-esteem, state anxiety and social support, especially, the level of depression symptoms was higher influenced by the variables of psycho-social factors than other variables. Conclusions: Lower of the level of depression symptoms among the community elderlies would require development and application of programs to keep under management psycho-social factors as well as looking for ways to promoting the present health status.

• Korean Journal of Health Education and Promotion
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• v.18 no.2
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• pp.65-82
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• 2001

The purpose of this study is to find out how well the middle school students are practicing the health promotion behaviors and the factors relating their health promotion behavior. Questionnaire survey on 922 middle school students attending 6 middle schools (three middle schools for each sex) located in Taegu City from the 7th through 19th of Feb. 2000 were conducted. The following were as follows; 1. The perceived health status is higher in male students than in female students(p〈0.01). And the ratio of the students' feeling that they are healthy becomes also high in proportion to their economic status, and their mothers' educational level, and their parents' interest in health(p〈0.01). The perceived importance of health is high in proportion to the students' economic status, and their parent's interest in health. 2. In case of the Health Locus of Control in Personality, the students with both parents have higher trend of inner control than the students with single mother or single father. The perceived self efficacy is significantly higher in male students than in female students(p〈0.01). And it becomes significantly high in-proportion to the students' economic status and their parents' educational level and interest in health(p〈0.01). It is also higher in the students who had no diseases. 3. In case of the perceived benefit of the health promotion behavior, the ratio of the students responding that it is high is higher in male students than in female students(p〈0.01). It also becomes high in proportion to the students' economic status, and their parent's educational level and interest in health(p〈0.01). The barriers of the health promotion behavior was found to have no variables that are related to itself. 4. According to the data from Multiple Regression of Analysis which has the health promotion behavior practice as a subordinate variable, in male students' case the degree of health promotion behavior practice becomes high in proportion to their parents' interest in health, and the perceived health status. Their degree of health promotion behavior practice is also in proportion to their perceived self efficacy and the perceived benefit of the health promotion behavior practice. But in case of the barriers of the health promotion behavior practice, the result is the opposite. As to the female students, their health behavior practice becomes high in proportion to their parents' interest in health. It also becomes high in proportion to the perceived health status, the understanding of the importance of the health, the perceived self efficacy and the perceived benefit of the health promotion behavior. But in case of the barriers of the health promotion behavior, it was the same as the male students' case.