• YAKHAK HOEJI
• /
• v.38 no.6
• /
• pp.637-645
• /
• 1994

The effect of various drugs on the stability of the liposomal membrane of phosphatidylcholine and cholesterol was studied, employing the fluorescence self-quenching method. Calcein was entrapped into the phospholipid small unilamellar vesicles and the leakage of the fluorescence probe was monitored on adding the drug to the system. The results of the experiments showed that phenothiazine derivatives, some potent local anesthetics and surface active agents were very effective in inducing the leakage of calcein from the liposome. The leakage-inducing activity of these drug substances has been ascribed to their surface activity and the perturbation of the liposomal membrane by these substances. On the other hand drug substance with low surface activity or without amphiphilic moieties did not show any effect or only small effect on the leakage of calcein from the liposomes. The effect of lipid concentration on the stability of the liposomes was also investigated to show that the higher concentrations of lipid more drug was required to induce the leakage. The effect of surface charges of vesicles was also studied, and the results showed that the charge on the liposomes enhanced the stability of the liposomes against the leakage-inducing activity of these drug substances.

• Journal of Ecology and Environment
• /
• v.39 no.1
• /
• pp.11-16
• /
• 2016

Declines in amphibian populations are occurring worldwide, and have been attributed to many factors, including anthropogenic environmental changes. One of the ramifications of such declines is abnormalities in many amphibian species. A strong association has been detected between human activities and abnormalities in amphibian populations, but studies on this association are largely focused on lentic species. In this study, it was analyzed whether the degree of local human activity was associated with the rate of abnormalities in Bombina orientalis which inhabited lotic environments. We found that the proportions of abnormalities in wild populations of B. orientalis increased, when i) the closest human land use was located within 100 m from the frogs' habitat, and ii) the proportion of human land use within a 300-m radius was high. Our findings suggest that human activity has a negative impact on the fitness of nearby amphibian populations, and that wild populations very close to human-induced disturbance are affected.

• Journal of Astronomy and Space Sciences
• /
• v.36 no.3
• /
• pp.149-157
• /
• 2019

In this study, we investigate the associations between the solar variability and teleconnection indices, which influence atmospheric circulation and subsequently, the spatial distribution of the global pressure system. A study of the link between the Sun and a large-scale mode of climate variability, which may indirectly affect the Earth's climate and weather, is crucial because the feedbacks of solar variability to an autogenic or internal process should be considered with due care. We have calculated the normalized cross-correlations of the total sunspot area, the total sunspot number, and the solar North-South asymmetry with teleconnection indices. We have found that the Southern Oscillation Index (SOI) index is anti-correlated with both solar activity and the solar North-South asymmetry, with a ~3-year lag. This finding not only agrees with the fact that El $Ni{\tilde{n}}o$ episodes are likely to occur around the solar maximum, but also explains why tropical cyclones occurring in the solar maximum periods and in El $Ni{\tilde{n}}o$ periods appear similar. Conversely, other teleconnection indices, such as the Arctic Oscillation (AO) index, the Antarctic Oscillation (AAO) index, and the Pacific-North American (PNA) index, are weakly or only slightly correlated with solar activity, which emphasizes that response of terrestrial climate and weather to solar variability are local in space. It is also found that correlations between teleconnection indices and solar activity are as good as correlations resulting from the teleconnection indices themselves.

• The Korean Journal of Physiology and Pharmacology
• /
• v.28 no.2
• /
• pp.165-181
• /
• 2024

The slow and regular pacemaking activity of midbrain dopamine (DA) neurons requires proper spatial organization of the excitable elements between the soma and dendritic compartments, but the somatodendritic organization is not clear. Here, we show that the dynamic interaction between the soma and multiple proximal dendritic compartments (PDCs) generates the slow pacemaking activity in DA neurons. In multipolar DA neurons, spontaneous action potentials (sAPs) consistently originate from the axon-bearing dendrite. However, when the axon initial segment was disabled, sAPs emerge randomly from various primary PDCs, indicating that multiple PDCs drive pacemaking. Ca²⁺ measurements and local stimulation/perturbation experiments suggest that the soma serves as a stably-oscillating inertial compartment, while multiple PDCs exhibit stochastic fluctuations and high excitability. Despite the stochastic and excitable nature of PDCs, their activities are balanced by the large centrally-connected inertial soma, resulting in the slow synchronized pacemaking rhythm. Furthermore, our electrophysiological experiments indicate that the soma and PDCs, with distinct characteristics, play different roles in glutamate-induced burst-pause firing patterns. Excitable PDCs mediate excitatory burst responses to glutamate, while the large inertial soma determines inhibitory pause responses to glutamate. Therefore, we could conclude that this somatodendritic organization serves as a common foundation for both pacemaker activity and evoked firing patterns in midbrain DA neurons.

• Progress in Superconductivity
• /
• v.6 no.1
• /
• pp.13-18
• /
• 2004

High-.ate in-situ$ YBa_2$Cu$Cu_3$$O_{7-x}$ (YBCO) film growth was demonstrated by means of the electron beam co-evaporation. Even though our oxygen pressure is low, ∼$5 ${\times}$10^{-5}$ Torr, we can synthesize as-grown superconducting YBCO films at a deposition rate of around 10 nm/s. Relatively high temperatures of around 90$0^{\circ}C$ was necessary in this process so far, and it suggests that this temperature at a given oxygen activity allows a Ba-Cu-O liquid formation along with an YBCO epitaxy. Local critical current density shows a clear correlation with local resistivity. Homogeneous transport properties with a large critical current density ($4 ∼ 5 MA/\textrm{cm}^2$ at 77K, 0T) are observed in top faulted region while it is found that the bottom part carries little supercurrent with a large local resistivity. Therefore, it is possible that thickness dependence of critical current density is closely related with a topological variation of good superconducting paths and/or grains in the film bodies. The information derived from it may be useful in the characterization and optimization of superconducting films for electrical power and other applications.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.11 no.4
• /
• pp.2075-2092
• /
• 2017

Person re-identification is to match pedestrians observed from non-overlapping camera views. It has important applications in video surveillance such as person retrieval, person tracking, and activity analysis. However, it is a very challenging problem due to illumination, pose and viewpoint variations between non-overlapping camera views. In this work, we propose a viewpoint invariant method for matching pedestrian images using orientation of pedestrian. First, the proposed method divides a pedestrian image into patches and assigns angle to a patch using the orientation of the pedestrian under the assumption that a person body has the cylindrical shape. The difference between angles are then used to compute the similarity between patches. We applied the proposed method to real-time global multi-object tracking across multiple disjoint cameras with non-overlapping field of views. Re-identification algorithm makes global trajectories by connecting local trajectories obtained by different local trackers. The effectiveness of the viewpoint invariant method for person re-identification was validated on the VIPeR dataset. In addition, we demonstrated the effectiveness of the proposed approach for the inter-camera multiple object tracking on the MCT dataset with ground truth data for local tracking.

• The Korean Journal of Pain
• /
• v.20 no.2
• /
• pp.246-250
• /
• 2007

We report here on a case of right side spasmodic torticollis (ST) that was refractory to botulinum toxin type A injection and medication. The patient finally underwent a selective ramisectomy with ipsilateral sternocleidomastoid muscle (SCM) resection, but the remaining symptoms slowly aggravated, and a contralateral left side SCM spasm began. As conservative therapy for reducing the spasmodic symptoms, accessory nerve block, upper cervical plexus block and stellate ganglion block were performed twice in a week. After 6 months, the spasmodic symptoms significantly decreased. The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) decreased by more than 70%. After one year of serial intermittent local anesthetic blockade therapy, the patient became almost free from the original ST symptoms (TWSTRS = 1). Serial local anesthetic interventions for the ST patient may have a beneficial role on the pathological peripherocentral neural activity of the ST patient and can modulate motor-sensory integration in the patient.

• The Korean Journal of Physiology and Pharmacology
• /
• v.10 no.6
• /
• pp.343-347
• /
• 2006

The present study was designed to investigate the effects renin-angiotensin-aldosterone system (RAAS), endothelin (ET) and local natriuretic peptide (NP) system for glomerulopathy induced in the experimental bilateral ureteral obstructive rats. Sprague-Dawley male rats ($200{\sim}220g$ body weight) were bilaterally obstructed by ligation of the proximal ureters for 24 hours. Control rats were treated in the same ways, except that no ligature was made. The glomeruli were isolated from cortex by graded sieve methods, and the mRNA expressions of local renin-angiotensin system (RAS), aldosterone synthase (CYP11B2), endothelin-1 (ET-1) and NP system were determined by real-time polymerase chain reaction. Following the bilateral ureteral obstruction, the mRNA expressions of renin, angiotensin converting enzyme 1 as well as ET-1 were increased, while that of angiotensin converting enzyme 2 was not changed. The expressions of CYP11B2 and angiotensin II receptors were not changed. C-type natriuretic peptide (CNP) expression was increased, while its receptors (natriuretic peptide receptor-B) were not changed. We suggest that the upregulation of local RAS and ET playa role in the progressive glomerular injury, and that the enhanced CNP activity also plays a compensatory role in obstructive uropathy in the glomerulus.

• Bulletin of the Korean Space Science Society
• /
• 2008.10a
• /
• pp.24.3-24.3
• /
• 2008

The signals transmitted from satellites of Global Navigation Satellite System (GNSS) interact with the plasma of the ionosphere. To study the impact of the ionospheric plasma on GNSS applications a comprehensive knowledge of the ionosphere is required. Especially the correct measurement of the ionosphere such as the peak height of the F2 layer peak electron density (hmF2) is important for the GNSS ionospheric model. Anyang ionosonde station ($37.39^{\circ}N$, $126.95^{\circ}E$) has been operating from October 2000 and the accumulated data for 8 years may allow us to obtain climatological characteristics of middle latitude ionospheric F region for GNSS application. We analyzed the variations of the hmF2 and NmF2 over Anyang station for different conditions of solar activity, geomagnetic activity, season, and local time, and we compared our results with the IRI model.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.25 no.1
• /
• pp.132-143
• /
• 2001

The purpose of this study was to observe cospla subculture in 1990s new generation of Korean youth, focused on activity that was reproducing the appearance of individual characters in animation, comic books and computer games, and to understand the representing process and meaning of appearance. The ethnographic methods including in-depth interviews and observation were used to approach such cultural form more closely from the youth generations perspective and their language. The results were as follows: 1. Although the cospla is originated from Japan, the local experience of Koreans make it the special youth subculture of Korea. 2. There are homological features and hierachical structure among group members of cospla subculture. The core values of Korean cospla are that they are realizing their ideal and elevating their own self-esteem. 3. Their appearance has connotation as symbolic resistance. The cultural activity of cospla is non-realistic, non-productive, but cosplayers conform to the social norm, too.