• Earthquakes and Structures
• /
• v.3 no.1
• /
• pp.1-15
• /
• 2012

An empirical predictive relationship correlating bracketed duration to earthquake magnitude, site-to-source distance, and local site conditions (i.e. rock vs. stiff soil) for stable continental regions of North America is presented herein. The correlation was developed from data from 620 horizontal motions for central and eastern North America (CENA), consisting of 28 recorded motions and 592 scaled motions. The bracketed duration data was comprised of nonzero and zero durations. The non-linear mixed-effects regression technique was used to fit a predictive model to the nonzero duration data. To account for the zero duration data, logistic regression was conducted to model the probability of zero duration occurrences. Then, the probability models were applied as weighting functions to the NLME regression results. Comparing the bracketed durations for CENA motions with those from active shallow crustal regions (e.g. western North America: WNA), the motions in CENA have longer bracketed durations than those in the WNA. Especially for larger magnitudes at far distances, the bracketed durations in CENA tend to be significantly longer than those in WNA.

• Ocean Systems Engineering
• /
• v.10 no.1
• /
• pp.25-47
• /
• 2020

A study of the wave conditions for the Asabo offshore location at the Qua Iboe oil field in Eastern Nigeria has been carried out. Statistical analysis was applied to three (3) years of data comprising spectral periods, Tp and significant wave heights, H_s. The data was divided into two (2); data from October to April represents one set of data and data from May to September represents another set of data. The results were compared with similar studies at other locations offshore of West Africa. It was found that there is an absence of direct swellwaves from the Southern Ocean reaching the location under study (the Asabo site). This work suggests that the wave system is largely emanating from the North Atlantic storms. The presence of numerous islands near the Asabo location shields the site from effects of storms from south west and therefore swells from the Southern Ocean. It is noted that the local wind has little or no contribution. An H_s maximum of 2 m is noted at the Asabo offshore location. It is found that the Weibull distribution best describes the wave distribution at Asabo. Thus, the Weibull distribution is suggested to be adequate for long term prediction of extreme waves needed for offshore design and operations at this location.

• The Journal of the Korean bone and joint tumor society
• /
• v.13 no.1
• /
• pp.14-21
• /
• 2007

Bone is a common site for metastatic spread from many kinds of malignancies. The morbidity associated with this metastatic spread can be significant, including severe pain. When it comes to spinal metastasis, occupying nearly 40% of skeletal metastases, the risks of complications, such as vertebral body collapse, nerve root impingement, or spinal cord compression, are also significant. Because of the necessity of preserving the integrity of the spinal column and the proximity of critical structures, surgical treatment has limitations when durable local control is desired. Radiotherapy, therefore, is often used as an adjunct treatment or as a sole treatment. A considerable limitation of standard radiotherapy is the reported recurrence rate or ineffective palliation of pain, either clinically or symptomatically. This may be due to limited radiation doses to tumor itself because of the proximity of critical structures. CyberKnife is an image-guided robotic radiosurgical system. The image guidance system includes a kilovoltage X-ray imaging source and amorphous silica detectors. The radiation delivery device is a mobile X-band linear accelerator (6 MV) mounted on a robotic arm. Highly conformal fields and hypofractionated radiotherapy schedules are increasingly being used as a means to achieve biologic dose escalation for body tumors. Therefore, we can give much higher doses to the targeted tumor volume with minimizing doses to the surrounding critical structures, resulting in more effective local control and less severe side effects, compared to conventional fractionated radiotherapy. A description of this technology and a review of clinical applications to bone metastases are detailed herein.

• Journal of Agricultural Extension & Community Development
• /
• v.23 no.4
• /
• pp.361-374
• /
• 2016

This study examined the regulation status on wastewater treatment in agro-food processing and a case study on effluent treatment m ethods was carried out to evaluate any change after the mitigation of regulation. First, in order to clarify the area of investigation, the definition of small-scale agro-processing facilities was reviewed through literature survey and local government ordinance. The current law were separately analyzed into four areas; effluent treatment facilities, development of agro-processing industries, land use and food processes equipment. The exclusion clauses on wastewater discharging facility in the enforcement regulation were defined in detail, which can be served in practice. Site survey, after the questionnaire survey of the person in charge of the local unit, was carried out. As the result, this survey confirmed the positive effects of the deregulation on promoting sewer system service in rural areas, introducing the new processing construction and so on. In addition, it was found that some matters to be considered to determine whether to introduce wastewater treatment plan for public food processing facilities.

• Journal of the Korean earth science society
• /
• v.25 no.8
• /
• pp.784-798
• /
• 2004

Microscale wind fields were simulated by MUKLIMO at the Naro Space Center, where complicated mountainous terrain and trees exist. In order to test the model's sensitivity with the effects of terrain and trees, experimental simulations were conducted under the various initial conditions. The experiments showed that the effects of trees were more significant on flat surfaces than on mountain cliffs. Based on the results, an actual 10 m level microscale wind field was simulated at the Naro Space Center, which has complicated mountainous terrain. Simulations of wind fields before and after the construction of the launching site were also conducted. It was found that MUKLIMO was of the mesoscale wind fields at the Naro Space Center.

• Archives of Pharmacal Research
• /
• v.22 no.3
• /
• pp.279-287
• /
• 1999

Therapeutic use of anti-inflammatory steroids is limited due primarily to their systemic suppressive effects on pituitary function and the immune system.. To overcome the clinical limitation, a new approach toward the discovery of non-systemic anti-inflammatory steroids is based upon the antedrug concept introduced by this laboratory. The new concept describes locally active agents which are designed to undergo a predictable biotransformation to inactive metabolites upon entry into systemic circulation from the applied site. Thus, true antedrugs are devoid of systemic adverse effects. In a continuing effort, 16$\alpha$-carboxylate and isoxazoline derivatives of prednisolone have been synthesized and screened. In the croton oil-induced ear edema bioassay, the following relative potencies were obtained setting hydrocortisone=1.0; 3a, 1.5; 3b, 3.1; 4a, 4.0; 4b, 12.2; 5b, 8.2; 6b, 11.2; 7a, 1.9; 7b, 4.1; 8a, 3.3; 8b 6.8; 9a, 0.7; 9b 8.6; 10a 2.6; 10b, 7.4. Results of the five-day bioassay indicated that, in contrast to the parent compound, the novel steroidal antedrugs did not significantly alter body weight gain, thymus weights, adrenal weights or plasma corticosterone levels. Taken together, the antedrug concept appears to be a fundamentally sound strategy for the separation of local anti-inflammatory activity form systemic adverse effects.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.35 no.4
• /
• pp.759-768
• /
• 2015

The ground motions of large dimensional structures such as long span bridges at different stations during an earthquake, are inevitably different, which is known as the ground motion spatial variation effect. There are many causes that may result in the spatial variability in seismic ground motion, e.g., the wave passage effect due to the different arrival times of waves at different locations; the loss of coherency due to seismic waves scattering in the heterogeneous medium of the ground; the site amplification effect owing to different local soil properties. In previous researches, the site amplification effects have not been considered or considered by a single-layered soil model only. In this study, however, the ground motion amplification and filtering effects are evaluated by multi-layered soil model. Spatially varying ground motion at the sites with different number of layers, depths, and soil characteristics are generated and the variation characteristics of ground motion time histories according to the correlation of coherency loss function and soil conditions are evaluated. For the bridge system composed of two unit bridges, seismic behavior characteristics are analyzed using the generated seismic waves as input ground motion. Especially, relative displacement due to coherency loss and site effect which can cause the unseating and pounding between girders are evaluated. As a result, considering the soil conditions of each site are always important and should not be neglected for an accurate structural response analysis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.32 no.2
• /
• pp.117-128
• /
• 2006

Free flap transplantation with microvascular anastomosis has been successfully performed by development of surgical technique, materials and postoperative monitoring equipments of flap. But success rate of microvascular anastomosis is influenced by various factors, and failure rate is about 5-10%. The most influential factor for success rate is surgical technique and other factors that influence failure of microvascular anastomosis are ischemic time of free flap, thrombus formation of anastomosis region and vascular spasm. Many studies has been published in microvascular anastomosis with histologic effect for irrigating solution. But local irrigation solution has been used clinically in microvascular anastomosis, the comparison with each solution, microhistological study for endothelial cell repair and vascular patency has not been reported. The heparin which is anti-thrombotic agent, and urokinase which is fibrinolytic agent are used for this study. Vascular patency and thrombus formation in experimental micro-arterial anastomosis, and endothelial repair were observed with histologic analysis, scanning electron microscopy, transmission electron microscopic examination. The results were obtained as follows: 1. In vascular patency test in 30 minute and 7 days after micro-arterial anastomosis, equal effects of good vascular patency were obtained in group of local irrigation with heparin and urokinase. 2. In thrombus formation in 7 days after micro-arterial anastomosis, equal effects of minimal thrombus formation were obtained in group of local irrigation with heparin and urokinase. 3. In toluidin blue staining in 7 days after micro-arterial anastomosis, local destruction of endothelial cell and inner elastic lamina were seen and endothelial repair was not seen. 4. In scanning electron microscope examination in 7 days after micro-arterial anastomosis, endothelial cell was not seen in peripheral to suture materials, thrombus associated fibrin network was observed. 5. In transmission electron microscope examination in 7 days after micro-arterial anastomosis, inflammatory cell was seen within smooth muscle cells in site of endothelial cell destruction, smooth muscle cell around suture material were arranged irregularly, some collagenous change were seen. From the results obtained in this study, same results of good vascular patency and anti-thrombotic effect of heparin and urokinase were obtained as a local irrigation solution, and repair of endothelial cell was not seen in 7 days after micro-arterial anastomosis.

• 지역과문화
• /
• v.8 no.1
• /
• pp.1-23
• /
• 2021

This study examined at an exploratory level what should be considered for developing underdeveloped areas using local cultural resources. This study analyzed the psychological and behavioral differences between those who have visited underdeveloped areas developed using local cultural resources and those who haven't, to draw out the implications for the urban regeneration. The results showed that there were differences in respondents' motivation to visit, perception of what needs to be done for the tourism development of underdeveloped areas, perception of the expected effects of developing cultural contents, and consumption behaviors. In other words, those who have visited the tourist sites where had been underdeveloped areas have a more positive attitude toward visit motivations, needs for tourist site development, expected effects of local cultural content development, and consumption behaviors than those who haven't. It means that it is of the utmost importance to induce as many people as possible into tourist sites in underdeveloped areas. This exploratory study is expected to offer some implications for developing underdeveloped areas as tourist sites, a form of urban regeneration.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2004.03b
• /
• pp.897-903
• /
• 2004

Waste lime used in this study is producted as a by-product in the manufacturing process of making $Na_2CO_3$ from local chemical factory in Incheon. Currently about 320 millon tons of waste lime are accumulated and annually 100,000 tons are producted. Reuse of waste lime mixed with soil for banking and backfill materia in civil works was analysed in this study. This study was Carried out to investigate the geotechnical and environmental characteristics on field application. Field investigations were conducted on the road construction site in Incheon. This study presents the results of the engineering characteristics in field test and the leaching characteristic of waste lime in laboratory column tests. Countermeasure for reduction of environmental effects was suggested from the test results.