• Journal of Korean Neurosurgical Society
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• 제63권6호
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• pp.814-820
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• 2020

Objective : Trigeminal neuralgia (TN) is a severe neuropathic condition that affects several elderly patients. It is characterized by uncontrolled pain that significantly impacts the quality of life of patients. Therefore, the condition should be treated as an emergency. In the majority of patients, pain can be controlled with medication; however, other treatment modalities are being explored in those who become refractory to drug treatment. The use of the trigeminal nerve block with a local anesthetic serves as an excellent adjunct to drug treatment. This technique rapidly relieves the patient of pain while medications are being titrated to effective levels. We report the efficacy and safety of percutaneous trigeminal nerve block in elderly patients with TN at our outpatient clinic. Methods : Twenty-one patients older than 65 years with TN received percutaneous nerve block at our outpatient clinic. We used bupivacaine (1 mL/injection site) to block the supraorbital, infraorbital, superior alveolar, mental, and inferior alveolar nerves according to pain sites of patients. Results : All patients reported relief from pain, which decreased by approximately 78% after 2 weeks of nerve block. The effect lasted for more than 4 weeks in 12 patients and for 6 weeks in two patients. There were no complications. Conclusion : Percutaneous nerve block procedure performed at our outpatient clinic provided immediate relief from pain to elderly patients with TN. The procedure is simple, has no serious side effects, and is easy to apply.

• 한국조경학회지
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• 제30권5호
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• pp.89-97
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• 2002

This report describes the first prize design of Midongsan Eco-park, which is located in Chungcheongbuk-do (North Chungcheong) province. Criteria of the winning design are as follows: 1) The design should include a neighborhood park as well as a portion of a green zone, in order to harmonize the area ecosystem, gradually assimilate the surroundings, and serve as an education tool for the public. 2) According to an analysis of area maps and a site-inspection, a preserved area, a buffer area, a restored area, and a developed area should be developed. In the buffer and restored areas, major facilities and activity spaces should be set up. 3) Observation trails should be accessible to visitors, and a variety of adventure programs should be available. 4) The eco-park should be designed to provide a habitat for the Gorani (Chinese water deer) which used to live around Midongsan. 5) For sensuous and vivid visitor experiences, diverse programs are to be designed to accommodate different seasons, visitor ages, and required time. Environment and eco-education are to be emphasized to maximize the effect of the eco-programs. 6) Optimal activities for visitors of different ages, optimal time intervals and eco-programs by age are also suggested. 7) Facilities are zoned into three sections according to level of development. Each section has a main area and supplementary areas for better understanding. 8) Nature-friendly arrangement of facilities and construction should minimize earthwork and adverse effects on the local ecology. Throughout the planning, the following things were learned: longer-term analysis including all season's observation is essential; planning, designing, bui Iding and managing should be based on this careful, extended observation. The contest should have taken plate over a longer period of time in order enable more detailed planing of the eco-park For improved management and activities, a volunteer system in linked with schools eco-institutions and NGOs should be developed with eco-interpreters.

• 한국지구과학회지
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• 제24권4호
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• pp.325-336
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• 2003

관측지점의 위치를 살펴보면 해안으로부터 수영은 약 5m정도이고 해운대는 약 1km정도 떨어져 있다. 하지만 해운대에서의 해풍시작시간이 수영보다 빨리 나타난다. 따라서 국지순환모형인 LCM을 이용하여 수영과 해운대에서 해풍시작시간에 대한 지형의 효과를 수치모의 하였다. 이러한 현상은 야간의 복사냉각에 의해 형성된 흐름에 의한 것으로 분석되었는데, 도심지를 둘러싸고 있는 고지대의 경사면을 따라서 수렴된 공기가 가장 저지대인 수영지역으로 흘러가기 때문에 나타난 것으로 이러한 현상은 일출 후에도 나타난다. AWS자료를 분석한 결과, 수영에서 해운대에 비해 약 3배정도 강한 강풍현상이 나타났는데, 이는 수영지역이 야간공기의 유출구이기 때문이다. 이를 통해 지형조건이 해풍의 시작에 중요한 역할을 한다는 것을 알 수 있었다.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 1998년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Spring 1998
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• pp.210-221
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• 1998

In the period from the year 1500 to 1980. at least 14 large earthquake with epicenters in the northeastern China and Yellow Sea were felt or destructive in the Korean Peninsula. The most sigmificant events among them were the 1668 July 25 Tancheng earthquake of mamnitude 8.5, and the 1975 Feb. 4 Haicheng earthquake of magnitude 7.3. The Haicheng earthquake of the year 1975 in am extraordinary one among those occurred in the northeastern China in the 20th century in the sense the Shake of the event affected all over the Korean Peninsula. The tremor was felt even at the southeastern tip of the Korea and northern part of Kyushu 700km far away from the epicenter. In order to see the variation and trend of the effect of the Haicheng earthquake on the Korean Peninsula, the two data sets of the northern and southern parts of the peninsula were merged into one combined data set. The spatial variation of intensity shows smooth decrease from the value 4 of the northwestern region near the source to the value 1 of the Cheju Island and Kjushu. However, there are four regions of locally high intensity value. They are the region along downstream of Abrok(Yalu) River with intensity 5, the region around Shinpo of intensity 4, the area comprising Seoul and Chuncheon Cities of intensity 4, and Pohang-Pusan area of intensity 3. We suppose that there might be three types of possible mechanisms. The first one is concerned with the lateral inhomogeneity of velocity in the crust caused by wide distribution of relatively fractured rock. The second one is related with reflections of surface waves caused by the crestal thinning effect at border regions of the Peninsular in contact with the Ulleung Basin and the Japan Basin. The third possibility is local site effect caused by thick Tertiary or Quaternary rocks and soil layers.

• 한국해안·해양공학회논문집
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• 제33권5호
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• pp.179-186
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• 2021

재생에너지 3020 이행계획, 한국판 뉴딜 계획 등에 따라 신재생에너지 생산 비중 증가 대응과 해상풍력발전 12GW 건설을 위해 어업생활권 점유 대안 마련과 주민 수용성 제고를 위한 방안이 요구된다. 본 연구는 동해에 적합한 해상풍력발전단지와 연계한 수산자원 공존모델의 차별방안을 제시하였다. 동해는 부유식 해상풍력 발전단지 조성의 최적지로 단지 내 공유수면을 활용하여 외해양식에 적합한 고부가가치 어종인 참다랑어를 양식함으로써 에너지 생산, 수산자원 개발, 관광산업화를 통한 이익 창출로 경제적 효과 발생을 예측하였다. 또한, 운영관리 기술 공유 등으로 예산 감축, 스마트 관리 추진과 어민소득 증대 가능성을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.4031-4036
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• 2012

Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권6호
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• pp.274-282
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• 2013

Objectives: The posterior maxillary region often provides a limited bone volume for dental implants. Maxillary sinus elevation via inserting a bone graft through a window opened in the lateral sinus wall has become the most common surgical procedure for increasing the alveolar bone height in place of dental implants in the posterior maxillary region. The purpose of this article is to assess the change of bone volume and the clinical effects of dental implant placement in sites with maxillary sinus floor elevation and autogenous bone graft through the lateral window approach. Materials and Methods: In this article, the analysis data were collected from 64 dental implants that were placed in 24 patients with 29 lacks of the bone volume posterior maxillary region from June 2004 to April 2011, at the Department of Oral and Maxillofacial Surgery, Inha University Hospital. Panoramic views were taken before the surgery, after the surgery, 6 months after the surgery, and at the time of the final follow-up. The influence of the factors on the grafted bone material resorption rate was evaluated according to the patient characteristics (age and gender), graft material, implant installation stage, implant size, implant placement region, local infection, surgical complication, and residual alveolar bone height. Results: The bone graft resorption rate of male patients at the final follow-up was significantly higher than the rate of female patients. The single autogenous bone-grafted site was significantly more resorbed than the autogenous bone combined with the Bio-Oss grafted site. The implant installation stage and residual alveolar height showed a significant correlation with the resorption rate of maxillary sinus bone graft material. The success rate and survival rate of the implant were 92.2% and 100%, respectively. Conclusion: Maxillary sinus elevation procedure with autogenous bone graft or autogenous bone in combination with Bio-Oss is a predictable treatment method for implant rehabilitation.

• 지적과 국토정보
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• 제50권2호
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• pp.237-254
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• 2020

빈집문제에 대한 사회적 관심이 높아지면서 국가와 지자체 차원에서 문제를 해소하기 위한 노력을 지속하고 있다. 문제에 대한 적절한 처방을 위해서는 빈집 발생의 원인에 대한 분석이 선행되어야 한다. 본 연구는 인천광역시 원도심을 대상으로 빈집 발생 영향요인을 분석하는 데 목적을 두었다. 특히, 주택, 근린 차원의 미시적 환경과 지역 차원의 거시적 환경의 영향을 종합적으로 살펴보는데 집중하였다. 분석에 앞서 문헌 고찰을 통해 빈집 발생의 다양한 영향요인을 탐색하였으며, 주택(1수준), 근린(2수준), 지역(3수준) 3개의 수준으로 구성된 다층모형(multi-level model)을 구축하고 분석을 수행하였다. 분석 결과 주택 부지의 규모, 형상, 접도 여부가 빈집 발생과 밀접하며, 근린 내 경사도와 정비구역 지정의 영향이 작용하는 것으로 나타났다. 또한, 독거노인 가구 비율과 공시지가, 지가변화율, 신규 주택 비율 등 지역 수준의 영향도 유의한 것으로 나타났다. 이러한 결과는 주택 부지와 근린환경의 물리적 열악함, 지역의 경제적·사회적 취약성이 복합적으로 작용하여 빈집 발생 가능성을 높인다는 것을 보여준다. 본 연구에서는 분석 결과를 토대로 빈집문제 해소를 위한 다차원적 대응 전략이 필요하며, 정비구역 지정이나 신규주택 공급 등의 정책 결정으로 인해 빈집이 발생하지 않도록 하여야 한다는 시사점을 제시하였다.

• 대한두경부종양학회지
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• 제17권2호
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• pp.174-178
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• 2001

Background and Objective: Percutaneous ethanol injection therapy has been used in the treatment of the benign thyroid diseases. Although the reported side-effects of the therapy was mild and transient, some side-effects including local or radiating pain are troublesome to the patients. Radioactive iodine-131($Ra-^{131}I$) also has been effectively and safely used for management of the benign thyroid diseases. So we developed the percutaneous intranodular injection therapy of $Ra-^{131}I$ as an alternative of percutaneous ethanol injection therapy. Materials and Methods: From December 1998 to October 1999, we treated 29 outpatients (25 women and 4 men, mean age: $47{\pm}12$ years). Inclusion criteria were follows; age >30 years, cytologically benign, with normal thyroid function, cold nodule on thyroid scintigram, solid or mixed natured nodules in sonographical evaluation. Nodular volume was estimated by sonography according to the ellipsoid formula. $Ra-^{131}I$(0.1mCi/ml) was administered in a single dose injection. Follow-up studies every 3 months consisted of full history, thyroid function test, and sonography. We determined the therapeutic response is effective if the volume reduction of the nodule occurred above 30%. Results: After at least 3 months follow-up, 11 patients showed effective response, 12 patients showed minimal or unchanged response and 6 patients showed progression. Although side-effects such as injection pain, febrile reaction, and hormonal changes were absent, an infectious complication in injection site was developed from 1 case. Conclusion: Although we need a more prolonged follow-up to evaluate the delayed sequelae, we can suggest that percutaneous intranodular injection therapy of $Ra-^{131}I$ may be an attractive non-surgical treatment in selected cases of benign thyroid nodules.

• 한국도로학회논문집
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• 제13권1호
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• pp.119-127
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• 2011

본 연구는 생활도로 속도관리 방안으로 선진국에서 추진되고 있는 Zone 30 제도를 우리나라의 도로 및 교통여건에 맞게 도입하고, 시범운영을 통해 시행의 효과를 분석하는 동시에 시행상의 문제점을 분석하여 향후 제도 확산을 사전에 대비하고자 하였다. 시범운영지역으로 선정된 곳은 경찰청 T/F에서 현장 조사 및 전문가 의견을 수렴하여 상가 밀집지역 주변도로 중 편도 2차로 이내의 도로이며, 보행자 통행량이 많고 보행자 사고율 또는 위험성이 높은 경기 고양시 일산구 장항2동 (면적 $0.65km^2$)이다. 우선 Zone 30 제도 검토 측면에서 생활도로와 생활도로구역의 용어를 정의하고, 생활도로 유형화 및 운영방안을 수립하였으며, 시범사업은 대상지에 대한 정밀 조사를 통해 문제점 및 개선점을 도출하고, 그에 따른 시설개선도면을 작성하여 해당 지자체와 협의하여 시설을 설치완료하였다. 시설 설치 전과 후로 나누어 효과분석을 수행한 결과 차량 속도는 시행전에 비해 가로별로 5~15km/h 감소하였으며, 교통사고의 경우도 시행전 25건에서 시행후 19건으로 24%가 감소한 것으로 나타났다. 또한 속도관리 사업의 시행과정이 빠르고 시설비용이 저렴해 전국적인 확산시행이 유리하여 보행자사고 감소에 실질적 기여가 가능한 것으로 나타났다. 시범사업 연구결과를 토대로 생활도로구역 속도관리 사업추진 방안 등을 제시하였다.