• Restorative Dentistry and Endodontics
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• v.24 no.1
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• pp.187-199
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• 1999

Bone remodeling is characterized by the continuing processes of osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Bone metabolism is tightly regulated at the local level by networks of hormones, cytokines, and other factors. In pathological conditions of bone remodeling, including osteoporosis and periodontal diseases, inflammatory cytokines and local mediators are responsible for enhancement of osteoclast resorption and inhibition of repair at the sites of bone resorption. TNF-${\alpha}$ is a pleiotropic hormone with actions on the differentiation, growth, and functional activities of normal and malignant cells from numerous tissues. TNF-${\alpha}$ has been proposed as a local mediator of the control of bone turnover in situations of chronic inflammation, and it has been assumed that the local source of TNF-${\alpha}$ is the monocyte in the adjacent bone marrow or the local circulation. TNF-${\alpha}$ is a potent inducer of bone resorption. TNF-${\alpha}$ is known to induce the activation of apoptotic signaling pathway, which leads to the apoptosis of bone cells. We demonstrated that treatment of murine osteoblastic MC3T3E1 cells with TNF-${\alpha}$ decreases proliferation as well as alkaline phosphatase (ALP) activity in a dose depenent manner. In addition, TNF-${\alpha}$ increases osteoclast-like cell formation in $1{\alpha}$, 25(OH)2D3 or PGE2-treated bone marrow cell culture. When cells were cultured in TNF-${\alpha}$ free ${\alpha}$-MEM, this inhibitory effect of ALP activity was reversible up to 10 ng/ml TNF-${\alpha}$, in contrast, at the 20 ng/ml TNF-${\alpha}$, irreversible. In this concentration, TNF-${\alpha}$ may induce apoptosis in MC3T3E1 cells. In this study, TNF-${\alpha}$ induces apoptosis resulting in chromosomal DNA fragmentation, preceded by JNK/SAPKs and caspase-3 activation. Our present results show that JNK/SAPKs and caspase-3 are activated by TNF-${\alpha}$, suggesting that the JNK/SAPKs and caspase-3 participate in the bone resorption, associated with apoptosis.

• Bulletin of the Society of Naval Architects of Korea
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• v.26 no.3
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• pp.41-50
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• 1989

A basic formulation of the panel method, which is based on the potential field formulation, is reviewed for the case of two-dimensional hydrofoil problems. Numerical procedures to improve the computational efficiency of the panel method are suggested. By investigating local behavior of the flow around the trailing edge, a wedge type Kutta condition is formulated. By subdividing the trailing edge panels, where dipole strengths of the subdivided panels follow the local behavior of the potential values of the flow outside a wedge, the circulation around a hydrofoil is calculated accurately with a relatively small number of panels. The subdividing technique to improve the accuracy of the numerical Kutta condition is proved to be efficient. A local behavior of the flow around the leading edge is also investigated. By matching the flow around the leading edge with that around a parabola, a very accurate velocity distribution is obtained with relatively small number of panels. An accurate prediction of the stagnation point and the pressure distribution near the leading edge may contribute to improve the accuracy of cavity predictions and boundary layer calculations around hydrofoils.

• Korean Institute of Interior Design Journal
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• v.21 no.5
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• pp.399-410
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• 2012

Due to development of modern medical services and economics, people raised expectation and demand about medical services from previous disease treatment to comprehensive health care covering prevention and health care. Responses of each medical facility to these social needs and the evolution of concept of medicine rapidly occur. The health examination centers are being operated with the purpose of health examination and this trend is reflected on several aspects such as the size of the facilities, function and configuration of space in health examination centers. Thus, health examination centers consisting of various space systems appear, but this trend and interpretations are lacking. Therefore, the purpose of this study is to draw trends of system through analysis of types and its evolved space systematic analysis and establish it. Analysis targets were classified into small, medium and large groups by sizes based on number of space and a total of 12 health examination centers in four for each category were selected. As research methods, functional relationship of space was examined through analysis of type in which segmentalized type tools were applied in local units. The flow diagram was established based on direction turning point and was classified into sub-flow and main-flow in local units and the systems between local units were derived. Finally, the results of this study can be summarized as the following three results. 1) The space connection system of health examination center showed four systems such as circulation, independence, continuation, and network. 2) Local type indicators and global type indicators which were evolved more from limitation of type analysis tools in existing research were derived so that more systematic analysis could be made. 3) Network system is distributed approach system and space for each function is formed around public space.

• Korean Journal of Remote Sensing
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• v.38 no.6_1
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• pp.1245-1255
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• 2022

Terra Nova Bay polynya (TNBP) is a representative coastal polynya in East Antarctica, which is formed by strong katabatic winds. As the TNBP is one of the major sea ice factory in East Antarctica and has a great impact on regional ocean circulation and surrounding marine ecosystem, it is very important to analyze its area change and development characteristics. In this study, we detected the TNBP from synthetic aperture radar (SAR) and optical images obtained from April 2007 to April 2022 by visually analyzing the stripes caused by the Langmuir circulation effect and the boundary between the polynya and surrounding sea ice. Then, we analyzed the area change and development characteristics of the TNBP. The TNBP occurred frequently but in a small size during the Antarctic winter (April-July) when strong katabatic winds blow, whereas it developed in a large size in March and November when sea ice thickness is thin. The 12-hour mean wind speed before the satellite observations showed a correlation coefficient of 0.577 with the TNBP area. This represents that wind has a significant effect on the formation of TNBP, and that other environmental factors might also affect its development process. The direction of TNBP expansion was predominantly determined by the wind direction and was partially influenced by the local ocean current. The results of this study suggest that the influences of environmental factors related to wind, sea ice, ocean, and atmosphere should be analyzed in combination to identify the development characteristics of TNBP.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.12 no.3
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• pp.219-224
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• 2007

Two monitoring buoys equipped with ADCP were deployed at the deepest positions along the trough of the central Gwangyang Bay in spring 2006 in order to study the circulation in the bay. Northward velocity is commonly dominant at both stations located in the eastern part of the channel, which supports the cyclonic circulation accompanied by the southward flow in the western part. The southern station has a distinct two-layer structure with current reversal at 14 m depth and increasing northward velocity in the lower layer to 36 m depth close to the bottom. At the northern station the northward flow becomes accelerated due to the decrease in the cross-sectional area and this northward current is dominant even in the upper layer. In the modal structure from the EOF analysis, the first mode has 74% of total variance at the northern station whereas it is 67% but the baroclinic portion increases at the southern station. The typical northward velocity is about 10 cm/s which is associated with the cyclonic circulation. Subtidal variability due to the local wind effect is negligible, but the nonlocal response associated with offshore Ekman flux by the zonal wind is found during strong wind events.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.23 no.5
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• pp.461-470
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• 2001

A unhealthy 58-year-old male patient required extraction of left upper second molar due to advanced periodontitis. Lidocaine contained 1 : 100000 epinephrine for left posterior superior alveolar nerve block was administered in the mucobuccal fold above the second molar to be treated at the local private dental clinic. After four hours of posterior superior alveolar block anesthesia, patient feeled double vision and discomfort of eyeball movement. At next day, he complained difficulty of left eyeball movement, vertigo and diplopia. He was referred to our department via local clinic and department of ophthalomology of our hospital. He was treated by medication and eyeball exercise, and then follow up check. The double vision and medial rectus muscle palsy disappeared patially after 2 months of block anesthesia. We described herein an ocular complication of diplopia and inferior rectus muscle palsy after posterior superior alveolar nerve block for extraction of left upper second molar, and review the cause or origin of this case. The autonomic nervous system is presented as the logical basis for the untoward systems of ophthalmologic sign likely to diplopia and inferior rectus muscle palsy, rather then simple circulation of anesthetic solution in the vascular network.

• 한국신재생에너지학회:학술대회논문집
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• 2008.05a
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• pp.324-326
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• 2008

When we urgently need to develop and supply an alternative energy, wind power is growing with much interest because it has relative low cost of power and area of tower. To estimate the wind power resource, it is necessary to make an wind resource map first. On the study of wind resource map in the Korean peninsula, Southern coast was needed to investigate the possibility of developing wind power complex because of good wind resources. In this study, we made a vertical observation to analyze the properties of wind in coastal area. From tethered sonde observation, we knew that synoptic effect had an influence higher in second day than first day. This means local wind circulation is generated on first day but not second day. The local wind made vertical wind shear strong in first day. Also, there was large difference of wind speed between layers at night time by analysis of SODAR observation.

• Journal of Chest Surgery
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• v.20 no.4
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• pp.683-687
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• 1987

Bleeding from bone marrow after sternotomy for open cardiac surgery can be sometimes difficult to control and even lead to reoperation for hemostasis. A clinical comparative study was carried out to demonstrate the hemostatic effect of fibrin glue [Beriplast] for sternal marrow bleeding after sternotomy for open heart surgery. Postoperative blood loss was measured in two patient groups, group A included 19 patients operated upon from June to October 1987 and the fibrin glue was applied to the sternal marrow together with collagen fleece and group B consisted of 22 patients from January to May 1987 and only collagen fleece was applied without fibrin glue. There was no difference between two groups in age and sex distributions, coagulation state, method of extracorporeal circulation and operative management. The blood loss one hour after operation was 2.04 ml/hr/kg in group A and 3.55 ml/hr/kg in group B [P<0.001]. The most significant difference was observed during the first 4 hours after surgery with 1.34 ml/hr/kg versus 2.05 ml/hr/kg. over the following 20 hours the amount of drainage from the chest tubes was identical in both groups. Fibrin glue reduces blood loss after open heart surgery by local hemostasis at sternum. Our study has shown that local application of fibrin glue to sternal marrow is an effective method of controlling the sternal bleedings. No side effect or complication of fibrin glue was noted.

• Journal of Environmental Science International
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• v.16 no.1
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• pp.103-119
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• 2007

We have analysed the observed surface and vertical meteorological data to get atmospheric information over the Busan metropolitan area. For this, we have selected 10 days in all season such as spring, summer I(Jangma season), summer II(hot season), autumn and winter. The result which have performed cluster analysis using atmospheric data represented that these days are included to most frequently appeared synoptic cluster. We have simulated wind field around Busan metropolitan area which is assigned as $1km^2$ using RAMS. The calculated air temperature and the wind speed was similar to the observed the that, and the trends of daily variation showed good agreement. RMSE and IOA also showed reliable value. These results indicated the RAMS is able to simulate and predict detailed atmospheric phenomenon.

• Korean Journal of Organic Agriculture
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• v.22 no.4
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• pp.561-579
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• 2014

This research estimates the necessity of a better governance plan on the purpose of fulfillment energy recovery by building resource recycling system for biomass resources and waste resources that derive from agricultural and mountain village areas. The utilization of new renewable energy technology which uses waste and biomass sources diverse as variety of resources, collecting method, operator etc. and is structurally complicated the formation of policy is also very difficult. There is failure because of the problems which occurs from the policy led by government. Biomass Town Development Project should be made through the central government and the local government integrated support system and should be formed a consultative group in order to process the project mutually with these two department including the experts from the related areas. This consultative group, while government organizations carry out the hub function of strategic knowledge management, should carry out the control tower function to be able to be net working transfer the information with the cooperation of private and government so vitalize the communication area among the related actors. And to be able to increase the participation rate of the local people the consistent and various educations should be given so a smooth business promotion progress will be desired through the change of perception and coactive participation of people.