• 비파괴검사학회지
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• 제22권5호
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• pp.516-522
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• 2002

발전소의 터빈 로터강의 수명을 평가하기 위하여 $630^{\circ}C$에서 등온 열처리된 7가지의 서로 다른 시편을 준비하였다. 탄소강, 스테인레스강 등의 금속재료의 유동특성을 평가하기 위하여 개발된 구형압입 시험을 통하여 서로 다르게 열화된 1Cr-1Mo-0.25V강의 기계적 물성을 측정하고 이를 인장시험에서의 결과와 비교하였다. 유동특성을 결정짓는 요소로 재료항복기울기와 구속인자지수를 사용하였다. 이는 가공경화지수의 변화가 매우 작고 불규칙적으로 나타났기 때문이다. 또한 재료항복기울기의 영향을 고려하였을 때 구속인자지수의 영향은 적은 것으로 나타났다.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2010년도 춘계학술발표대회 초록집
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• pp.61-61
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• 2010

The purpose of this study is to prevent the unstable fracture at the FCA butt weldment of hatch coaming deck in the ultra large containership during service life. In order to do it, the behavior of the embedded crack at the weldment under design loading conditions was evaluated in accordance with BS7910. Here, the level of primary stress induced by ship motion was evaluated by the design code of classification society and FEA. The level of residual stress as secondary stress was calculated in consideration of the restraint degree of weldment and welding heat input by using the predictive equation proposed by authors in the previous study. The fatigue crack growth rate at the weldment was evaluated using CT specimen in accordance with ASTM E647. According to the results, although the allowable defect for embedded crack specified in the classification society exists at the weldment, the occurrence possibility of unstable fracture at the weldment could not be negligible, regardless of CTOD value given in this study. So, in this study, the effect of initial defect size, welding heat input, restraint degree and CTOD on the fracture mechanical characteristics of embedded crack at the weldment was evaluated by the comprehensive fracture assessment. Based on the results, the design criteria including allowable defect, residual stress level and CTOD value was established to prevent the unstable fracture at the FCA butt weldment of hatch coaming deck in an ultra large containership during service life of 20years.

• 한국미생물·생명공학회지
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• 제9권3호
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• pp.165-171
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• 1981

E. coil ATCC 9637의 균체를 젤라틴과 DEAE-cellulose의 혼합 성형 후 글루트알데히드 가교법으로 제조론 고정화 penicillin amidase의 differential column reactor에서의 반응속도를 논의하였다. 이러한 반응조의 최적 조작조건은 효소충진량 1g, 기질농도30mM(0.1M 인산완충액, pH8.0), 유출속도 4 $m\ell$/min, 온도 4$0^{\circ}C$이었다. 이 최적조건에서 고정화효소의 일반적인 성질을 조사하였다. Km 상수는 4.8mM 이었고 specific activity 308 units/g 고정화 효소이 었다. 또한 고정화효소에서는 기질에 의한 효소반응 저해효과가 보이지 않았다. 이러한 differential column reactor에서는 column내에서의 pH 감소효과 및 외부 화산효과가 없어지기 때문에 이러한 외부적 영향을 받지 않는 고정화효소의 반응 속도론적 연구에 적합함을 알았다.

• 한국자동차공학회논문집
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• 제19권3호
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• pp.138-145
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• 2011

Diesel particulate filter (DPF) systems are being used to reduce the particulate matter emission of diesel vehicles. The DPF should be regenerated after certain driving hours or distance to eliminate soot in the filter. The most widely used method is active regeneration with oxygen at $550{\sim}650^{\circ}C$. Syngas (synthetic gas) can be used to lower the regeneration temperature of Catalyzed DPF (CDPF). The syngas is formed by fuel reforming process of CPOx (Catalytic Partial Oxidation) at specific engine condition (1500rpm, 2bar) using 1wt.% $Rh/CeO_2-ZrO_2$ catalyst. The oxidation characteristics of PM with syngas supplied to filter were studied using partial flow system that can control temperature and flow rate independently. The filter is coated with washcoat loading of $25g/ft^3$ $Pt/Al_2O_3-CeO_2$, and multi-channel CDPF (MC-CDPF) was used. The filter regeneration experiments were performed to investigate the effect of syngas exothermic reaction on soot oxidation in the filter. For this purpose, before oxidation experiment, PM was collected about 8g/L to the filter at engine condition of 1500rpm, bmep 8bar and flow temperature of $200^{\circ}C$ Various conditions of temperature and concentration of syngas were used for the tests. Regeneration of filter started at 2% $H_2$ and CO concentration respectively and inlet temperature of $260^{\circ}C$. Filter Regeneration occurs more actively as the syngas concentration becomes higher.

• 한국전자파학회논문지
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• 제13권7호
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• pp.693-701
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• 2002

본 논문에서는 간섭제거기(IC: Interference Cancellation or MUD; Multi-User Detector)를 적용한 WCDMA (Wideband Code Division Multiple Access)방식 의 비동기식 IMT(International Mobile Telecommunication)-2000 시스템에서 역방향 링크의 통화권에 대해 분석하였다. 간섭제거기는 역방향 링크의 통화권 확장을 위해 사용되었으며, 시스템 용량과 통화권의 관계를 대수-정규(log-normal)분포의 전파음영 환경에서 경로손실과 전파음영감쇠를 포함하는 전파손실모델 및 간섭의 영향을 고려하였다. 간섭량은 정량 산출이 어렵기 때문에 본 논문에서는 전체 셀의 간섭 대 내부 셀의 간섭비를 이용하였다. 간섭제거기를 사용하여 다중접속간섭(MAI; Multiple Access Interference)의 제거를 통한 시스템의 성능향상을 비교 분석하기 위해 간섭제거기 효율($\beta$)을 이용하였다. 모의실험은 실제 무선전파환경에 근접한 전파예측 모델인 Hata모델을 이용하여 반송파 주파수 800 MHz와 1900 MHz에서 음성서비스와 데이터서비스의 전송속도(bit rate)에 따라 동일한 대역폭(3.84 MHz)에서의 통화권을 분석하고, 내부셀에 간섭제거기를 적용하여, 용량 및 통화권의 성능을 비교 분석하여 실제 시스템에서의 성능을 예측하였다.

• 대한의용생체공학회:의공학회지
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• 제40권1호
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• pp.7-14
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• 2019

The microencapsulation of nifedipine (NF) with 4 wt% of poly(${\varepsilon}-caprolactone$) (PCL)/polyvinylpyrollidone (PVP) or PCL/polyethylene glycol (PEG) was carried out by solvent evaporation method in oil in water emulsion system to investigate the effect of PVP and PEG addition on drug release behavior of the microcapsules. The PVA (emulsifier) concentration of 1.0 wt% was chosen for the formation of PCL capsule having an average size of $154{\pm}25{\mu}m$ due to nearly spherical shape with a narrow size distribution. As PCL/PVP and PCL/PEG ratios were raised from 10/0 to 6/4, the capsule size increased gradually from $154{\pm}25{\mu}m$ to $236{\pm}32{\mu}m$ and $248{\pm}56{\mu}m$, respectively. The drug release rate of PCL/PVP and PCL/PEG capsules increased dramatically from 0 to 4 h at the beginning and then reached the plateau region from 20 h. As the concentration of PVP or PEG increased, the amount of drug release increased, suggesting that the larger capsule size was attributed to the higher drug content. However, the drug release behavior remained almost constant. The PCL capsules exhibited no evidence of causing cell lysis or toxicity regardless of NF loading, implying that the microcapsules are clinically suitable for use as drug delivery systems.

• Structural Engineering and Mechanics
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• 제69권2호
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• pp.193-204
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• 2019

This paper presents results from experimental and numerical studies on the response of steel-concrete composite box bridge girders under certain localized fire exposure conditions. Two composite box bridge girders, a simply supported girder and a continuous girder respectively, were tested under simultaneous loading and fire exposure. The simply supported girder was exposed to fire over 40% of its span length in the middle zone, and the two-span continuous girder was exposed to fire over 38% of its length of the first span and full length of the second span. A measurement method based on comparative rate of deflection was provided to predict the failure time in the hogging moment zone of continuous composite box bridge girders under certain localized fire exposure condition. Parameters including transverse and longitudinal stiffeners and fire scenarios were introduced to investigate fire resistance of the composite box bridge girders. Test results show that failure of the simply supported girder is governed by the deflection limit state, whereas failure of the continuous girder occurs through bending buckling of the web and bottom slab in the hogging moment zone. Deflection based criterion may not be reliable in evaluating failure of continuous composite box bridge girder under certain fire exposure condition. The fire resistance (failure time) of the continuous girder is higher than that of the simply supported girder. Data from fire tests is successfully utilized to validate a finite element based numerical model for further investigating the response of composite box bridge girders exposed to localized fire. Results from numerical analysis show that fire resistance of composite box bridge girders can be highly influenced by the spacing of longitudinal stiffeners and fire severity. The continuous composite box bridge girder with closer longitudinal stiffeners has better fire resistance than the simply composite box bridge girder. It is concluded that the fire resistance of continuous composite box bridge girders can be significantly enhanced by preventing the hogging moment zone from exposure to fire. Longitudinal stiffeners with closer spacing can enhance fire resistance of composite box bridge girders. The increase of transverse stiffeners has no significant effect on fire resistance of composite box bridge girders.

• Journal of Veterinary Science
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• 제23권3호
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• pp.48.1-48.12
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• 2022

Background: The poor intracellular concentration of enrofloxacin might lead to treatment failure of cow mastitis caused by Staphylococcus aureus small colony variants (SASCVs). Objectives: In this study, enrofloxacin composite nanogels were developed to increase the intracellular therapeutic drug concentrations and enhance the efficacy of enrofloxacin against cow mastitis caused by intracellular SASCVs. Methods: Enrofloxacin composite nanogels were formulated by an electrostatic interaction between gelatin (positive charge) and sodium alginate (SA; negative charge) with the help of CaCl₂ (ionic crosslinkers) and optimized by a single factor test using the particle diameter, zeta potential (ZP), polydispersity index (PDI), loading capacity (LC), and encapsulation efficiency (EE) as indexes. The formation mechanism, structural characteristics, bioadhesion ability, cellular uptake, and the antibacterial activity of the enrofloxacin composite nanogels against intracellular SASCVs strain were studied systematically. Results: The optimized formulation was comprised of 10 mg/mL (gelatin), 5 mg/mL (SA), and 0.25 mg/mL (CaCl₂). The size, LC, EE, PDI, and ZP of the optimized enrofloxacin composite nanogels were 323.2 ± 4.3 nm, 15.4% ± 0.2%, 69.6% ± 1.3%, 0.11 ± 0.02, and -34.4 ± 0.8 mV, respectively. Transmission electron microscopy showed that the enrofloxacin composite nanogels were spherical with a smooth surface and good particle size distributions. In addition, the enrofloxacin composite nanogels could enhance the bioadhesion capacity of enrofloxacin for the SASCVs strain by adhesive studies. The minimum inhibitory concentration, minimum bactericidal concentration, minimum biofilm inhibitory concentration, and minimum biofilm eradication concentration were 2, 4, 4, and 8 ㎍/mL, respectively. The killing rate curve had a concentration-dependent bactericidal effect as increasing drug concentrations induced swifter and more radical killing effects. Conclusions: This study provides a good tendency for developing enrofloxacin composite nanogels for treating cow mastitis caused by intracellular SASCVs and other intracellular bacterial infections.

• Journal of Dental Anesthesia and Pain Medicine
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• 제23권3호
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• pp.153-162
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• 2023

Background: Recent animal studies have suggested the role of GABA type A (GABA-_A) receptors in salivation, showing that GABA-_A receptor agonists inhibit salivary secretion. This study aimed to evaluate the effects of propofol (a GABA-_A agonist) on salivary secretions from the submandibular, sublingual, and labial glands during intravenous sedation in healthy volunteers. Methods: Twenty healthy male volunteers participated in the study. They received a loading dose of propofol 6 mg/kg/h for 10 min, followed by 3 mg/kg/h for 15 min. Salivary flow rates in the submandibular, sublingual, and labial glands were measured before, during, and after propofol infusion, and amylase activity was measured in the saliva from the submandibular and sublingual glands. Results: We found that the salivary flow rates in the submandibular, sublingual, and labial glands significantly decreased during intravenous sedation with propofol (P < 0.01). Similarly, amylase activity in the saliva from the submandibular and sublingual glands was significantly decreased (P < 0.01). Conclusion: It can be concluded that intravenous sedation with propofol decreases salivary secretion in the submandibular, sublingual, and labial glands via the GABA-_A receptor. These results may be useful for dental treatment when desalivation is necessary.

• Journal of Veterinary Science
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• 제23권1호
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• pp.1.1-1.11
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• 2022

Background: The poor bioadhesion capacity of tilmicosin resulting in treatment failure for Staphylococcus aureus small colony variants (SASCVs) mastitis. Objectives: This study aimed to increase the bioadhesion capacity of tilmicosin for the SASCVs strain and improve the antibacterial effect of tilmicosin against cow mastitis caused by the SASCVs strain. Methods: Tilmicosin-loaded chitosan oligosaccharide (COS)-sodium carboxymethyl cellulose (CMC) composite nanogels were formulated by an electrostatic interaction between COS (positive charge) and CMC (negative charge) using sodium tripolyphosphate (TPP) (ionic crosslinkers). The formation mechanism, structural characteristics, bioadhesion, and antibacterial activity of tilmicosin composite nanogels were studied systematically. Results: The optimized formulation was comprised of 50 mg/mL (COS), 32 mg/mL (CMC), and 0.25 mg/mL (TPP). The size, encapsulation efficiency, loading capacity, polydispersity index, and zeta potential of the optimized tilmicosin composite nanogels were 357.4 ± 2.6 nm, 65.4 ± 0.4%, 21.9 ± 0.4%, 0.11 ± 0.01, and -37.1 ± 0.4 mV, respectively; the sedimentation rate was one. Scanning electron microscopy showed that tilmicosin might be incorporated in nano-sized crosslinked polymeric networks. Moreover, adhesive studies suggested that tilmicosin composite nanogels could enhance the bioadhesion capacity of tilmicosin for the SASCVs strain. The inhibition zone of native tilmicosin, tilmicosin standard, and tilmicosin composite nanogels were 2.13 ± 0.07, 3.35 ± 0.11, and 1.46 ± 0.04 cm, respectively. The minimum inhibitory concentration of native tilmicosin, tilmicosin standard, and tilmicosin composite nanogels against the SASCVs strain were 2, 1, and 1 ㎍/mL, respectively. The in vitro time-killing curves showed that the tilmicosin composite nanogels increased the antibacterial activity against the SASCVs strain. Conclusions: This study provides a potential strategy for developing tilmicosin composite nanogels to treat cow mastitis caused by the SASCVs strain.